Sphingosine kinase 2 and sphingosine-1-phosphate promotes mitochondrial function in dopaminergic neurons of mouse model of Parkinson's disease and in MPP+-treated MN9D cells in vitro

Neuroscience

Volumn 290, Issue , 2015, Pages 636-648

  Sivasubramanian, M ^a   Kanagaraj, N ^a   Dheen, S T ^a   Tay, S S W ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Nuclear respiratory factor 1 (NRF 1); Parkinson's disease; Peroxisome proliferator activated receptor coactivator 1 (PGC 1 ); Sphingosine kinase 2 (Sphk2); Sphingosine 1 phosphate (S1P)

Indexed keywords

1 METHYL 4 PHENYLPYRIDINIUM; 1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; ADENOSINE TRIPHOSPHATE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; MANGANESE SUPEROXIDE DISMUTASE; MITOCHONDRIAL TRANSCRIPTION FACTOR A; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; REACTIVE OXYGEN METABOLITE; SPHINGOSINE 1 PHOSPHATE; SPHINGOSINE 1 PHOSPHATE RECEPTOR; SPHINGOSINE KINASE 2; TRANSCRIPTION FACTOR NRF1; ACTIN; CREB1 PROTEIN, MOUSE; DNA BINDING PROTEIN; HIGH MOBILITY GROUP PROTEIN; LYSOPHOSPHOLIPID; MESSENGER RNA; NRF1 PROTEIN, MOUSE; NUCLEAR RESPIRATORY FACTOR 1; PHOSPHOTRANSFERASE; PPARGC1A PROTEIN, MOUSE; SPHINGOSINE; SPHINGOSINE 1-PHOSPHATE; SPHINGOSINE KINASE 2, MOUSE; TFAM PROTEIN, MOUSE; TRANSCRIPTION FACTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN MITOCHONDRION; CELL SURVIVAL; CONTROLLED STUDY; DOPAMINERGIC NERVE CELL; DOWN REGULATION; ENZYME INHIBITION; ENZYME LOCALIZATION; IN VITRO STUDY; MOUSE; NERVE CELL CULTURE; NEUROPROTECTION; NONHUMAN; PARKINSON DISEASE; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; SUBSTANTIA NIGRA; ANALOGS AND DERIVATIVES; ANIMAL; C57BL MOUSE; CELL LINE; GENE SILENCING; GENETICS; INTOXICATION; METABOLISM; MITOCHONDRION; PATHOLOGY; PATHOPHYSIOLOGY; PHOSPHORYLATION; PHYSIOLOGY;

ACTINS; ADENOSINE TRIPHOSPHATE; ANIMALS; CELL LINE; CELL SURVIVAL; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; DNA-BINDING PROTEINS; DOPAMINERGIC NEURONS; GENE KNOCKDOWN TECHNIQUES; HIGH MOBILITY GROUP PROTEINS; LYSOPHOSPHOLIPIDS; MICE, INBRED C57BL; MITOCHONDRIA; MPTP POISONING; NUCLEAR RESPIRATORY FACTOR 1; PHOSPHORYLATION; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); RECEPTORS, LYSOSPHINGOLIPID; RNA, MESSENGER; SPHINGOSINE; SUBSTANTIA NIGRA; TRANSCRIPTION FACTORS;

EID: 84923291958     PISSN: 03064522     EISSN: 18737544     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2015.01.032     Document Type: Article

References (25)

1. Alemany R., Koppen C., Danneberg K., ter Braak M., Meyer zu Heringdorf D. Regulation and functional roles of sphingosine kinases. Naunyn-Schmied Arch Pharmacol 2007, 374:413-428.
2. Bazan N. Lipid signaling in neural plasticity, brain repair, and neuroprotection. Mol Neurobiol 2005, 32:89-103.
3. Blondeau N., Lai Y., Tyndall S., Popolo M., Topalkara K., Pru J.K., Zhang L., Kim H., Liao J.K., Ding K., Waeber C. Distribution of sphingosine kinase activity and mRNA in rodent brain. J Neurochem 2007, 103:509-517.
4. Chun J., Hla T., Lynch K.R., Spiegel S., Moolenaar W.H. International Union of basic and clinical pharmacology. LXXVIII. Lysophospholipid receptor nomenclature. Pharmacol. Rev. 2010, 62:579-587.
5. Colombaioni L., Garcia-Gil M. Sphingolipid metabolites in neural signalling and function. Brain Res Rev 2004, 46:328-355.
6. Cuvillier O. Sphingosine in apoptosis signaling. Biochim Biophys Acta 2002, 1585:153-162.
7. Edsall L.C., Cuvillier O., Twitty S., Spiegel S., Milstien S. Sphingosine kinase expression regulates apoptosis and caspase activation in PC12 cells. J Neurochem 2001, 76:1573-1584.
8. Fukae J., Mizuno Y., Hattori N. Mitochondrial dysfunction in Parkinson's disease. Mitochondrion 2007, 7:58-62.
9. Fukuda Y., Kihara A., Igarashi Y. Distribution of sphingosine kinase activity in mouse tissues: contribution of SPHK1. Biochem Biophys Res Commun 2003, 309:155-160.
10. Haughey N.J., Bandaru V.V.R., Bae M., Mattson M.P. Roles for dysfunctional sphingolipid metabolism in Alzheimer's disease neuropathogenesis. Biochim Biophys Acta 2010, 1801:878-886.
11. Hirabayashi Y. A world of sphingolipids and glycolipids in the brain-novel functions of simple lipids modified with glucose. Proc Jpn Acad Ser B 2012, 88:129-143.
12. Jackson-Lewis V., Przedborski S. Protocol for the MPTP mouse model of Parkinson's disease. Nat Protoc 2007, 2:141-151.
13. Liu H., Chakravarty D., Maceyka M., Milstien S., Spiegel S. Sphingosine kinases: a novel family of lipid kinases. Progress in nucleic acid research and molecular biology 2002, vol. 71:493-511. Academic Press.
14. Maceyka M., Sankala H., Hait N.C., Le Stunff H., Liu H., Toman R., Collier C., Zhang M., Satin L.S., Merrill A.H., Milstien S., Spiegel S. SphK1 and SphK2, sphingosine kinase isoenzymes with opposing functions in sphingolipid metabolism. J Biol Chem 2005, 280:37118-37129.
15. Mizuno Y., Ohta S., Tanaka M., Takamiya S., Suzuki K., Sato T., Oya H., Ozawa T., Kagawa Y. Deficiencies in complex I subunits of the respiratory chain in Parkinson's disease. Biochem Biophys Res Commun 1989, 163:1450-1455.
16. Pyszko J., Strosznajder J. Sphingosine kinase 1 and sphingosine-1-phosphate in oxidative stress evoked by 1-methyl-4-phenylpyridinium (MPP+) in human dopaminergic neuronal cells. Mol Neurobiol 2014, 50:38-48.
17. Shen Z., Liu C., Liu P., Zhao J., Xu W. Sphingosine 1-phosphate (S1P) promotes mitochondrial biogenesis in Hep G2 cells by activating Peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α). Cell Stress Chaperones 2014, 19:541-548.
18. Shinpo K., Kikuchi S., Moriwaka F., Tashiro K. Protective effects of the TNF-ceramide pathway against glutamate neurotoxicity on cultured mesencephalic neurons. Brain Res 1999, 819:170-173.
19. Simunovic F., Yi M., Wang Y., Macey L., Brown L.T., Krichevsky A.M., Andersen S.L., Stephens R.M., Benes F.M., Sonntag K.C. Gene expression profiling of substantia nigra dopamine neurons: further insights into Parkinson's disease pathology. Brain 2009, 132:1795-1809.
20. Spiegel S., Milstien S. Sphingosine-1-phosphate: an enigmatic signalling lipid. Nat Rev Mol Cell Biol 2003, 4:397-407.
21. Strub G.M., Paillard M., Liang J., Gomez L., Allegood J.C., Hait N.C., Maceyka M., Price M.M., Chen Q., Simpson D.C., Kordula T., Milstien S., Lesnefsky E.J., Spiegel S. Sphingosine-1-phosphate produced by sphingosine kinase 2 in mitochondria interacts with prohibitin 2 to regulate complex IV assembly and respiration. FASEB J 2011, 25:600-612.
22. Takasugi N., Sasaki T., Suzuki K., Osawa S., Isshiki H., Hori Y., Shimada N., Higo T., Yokoshima S., Fukuyama T., Lee V.M.-Y., Trojanowski J.Q., Tomita T., Iwatsubo T. BACE1 activity is modulated by cell-associated sphingosine-1-phosphate. J Neurosci 2011, 31:6850-6857.
23. Wang J., Duhart H.M., Xu Z., Patterson T.A., Newport G.D., Ali S.F. Comparison of the time courses of selective gene expression and dopaminergic depletion induced by MPP+ in MN9D cells. Neurochem Int 2008, 52:1037-1043.
24. Wu Y.-P., Mizugishi K., Bektas M., Sandhoff R., Proia R.L. Sphingosine kinase 1/S1P receptor signaling axis controls glial proliferation in mice with Sandhoff disease. Hum Mol Genet 2008, 17:2257-2264.
25. Yamanaka M., Shegogue D., Pei H., Bu S., Bielawska A., Bielawski J., Pettus B., Hannun Y.A., Obeid L., Trojanowska M. Sphingosine kinase 1 (SPHK1) is induced by transforming growth factor-β and mediates TIMP-1 up-regulation. J Biol Chem 2004, 279:53994-54001.