-
1
-
-
80054856209
-
RAS oncogenes: Weaving a tumorigenic web
-
Pylayeva-Gupta, Y., Grabocka, E. & Bar-Sagi, D. RAS oncogenes: weaving a tumorigenic web. Nat. Rev. Cancer 11, 761-774 (2011).
-
(2011)
Nat. Rev. Cancer
, vol.11
, pp. 761-774
-
-
Pylayeva-Gupta, Y.1
Grabocka, E.2
Bar-Sagi, D.3
-
2
-
-
0037264633
-
Targeting RAS signalling pathways in cancer therapy
-
Downward, J. Targeting RAS signalling pathways in cancer therapy. Nat. Rev. Cancer 3, 11-22 (2003).
-
(2003)
Nat. Rev. Cancer
, vol.3
, pp. 11-22
-
-
Downward, J.1
-
3
-
-
79960051265
-
Therapeutic strategies for targeting ras proteins
-
Gysin, S., Salt, M., Young, A. & McCormick, F. Therapeutic strategies for targeting ras proteins. Genes Cancer 2, 359-372 (2011).
-
(2011)
Genes Cancer
, vol.2
, pp. 359-372
-
-
Gysin, S.1
Salt, M.2
Young, A.3
McCormick, F.4
-
4
-
-
34249018367
-
GEFs and GAPs: Critical elements in the control of small G proteins
-
Bos, J. L., Rehmann, H. &Wittinghofer, A. GEFs and GAPs: critical elements in the control of small G proteins. Cell 129, 865-877 (2007).
-
(2007)
Cell
, vol.129
, pp. 865-877
-
-
Bos, J.L.1
Rehmann, H.2
Wittinghofer, A.3
-
5
-
-
78649487698
-
Ras superfamily GEFs and GAPs: Validated and tractable targets for cancer therapy?
-
Vigil, D., Cherfils, J., Rossman, K. L. & Der, C. J. Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy? Nat. Rev. Cancer 10, 842-857 (2010).
-
(2010)
Nat. Rev. Cancer
, vol.10
, pp. 842-857
-
-
Vigil, D.1
Cherfils, J.2
Rossman, K.L.3
Der, C.J.4
-
6
-
-
3242832595
-
Redox regulation of cell signalling
-
Lander, H. M. et al. Redox regulation of cell signalling. Nature 381, 380-381 (1996).
-
(1996)
Nature
, vol.381
, pp. 380-381
-
-
Lander, H.M.1
-
7
-
-
34250778409
-
Nitric oxide cell signaling: S-nitrosation of Ras superfamily GTPases
-
Raines, K. W., Bonini, M. G. & Campbell, S. L. Nitric oxide cell signaling: S-nitrosation of Ras superfamily GTPases. Cardiovas. Res. 75, 229-239 (2007).
-
(2007)
Cardiovas. Res.
, vol.75
, pp. 229-239
-
-
Raines, K.W.1
Bonini, M.G.2
Campbell, S.L.3
-
8
-
-
84874653606
-
Glutathiolated Ras: Characterization and implications for Ras activation
-
Hobbs, G. A., Bonini, M. G., Gunawardena, H. P., Chen, X. & Campbell, S. L. Glutathiolated Ras: characterization and implications for Ras activation. Free Radic. Biol. Med. 57, 221-229 (2013).
-
(2013)
Free Radic. Biol. Med.
, vol.57
, pp. 221-229
-
-
Hobbs, G.A.1
Bonini, M.G.2
Gunawardena, H.P.3
Chen, X.4
Campbell, S.L.5
-
9
-
-
48749099188
-
Endothelial nitric oxide synthase regulates N-Ras activation on the Golgi complex of antigen-stimulated T cells
-
Ibiza, S. et al. Endothelial nitric oxide synthase regulates N-Ras activation on the Golgi complex of antigen-stimulated T cells. Proc. Natl. Acad. Sci. USA 105, 10507-10512 (2008).
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, pp. 10507-10512
-
-
Ibiza, S.1
-
10
-
-
0031054520
-
A molecular redox switch on p21(ras). Structural basis for the nitric oxide-p21(ras) interaction
-
Lander, H. M. et al. A molecular redox switch on p21(ras). Structural basis for the nitric oxide-p21(ras) interaction. J. Biol. Chem. 272, 4323-4326 (1997).
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 4323-4326
-
-
Lander, H.M.1
-
11
-
-
0029807306
-
Differential activation of mitogen-activated protein kinases by nitric oxide-related species
-
Lander, H. M., Jacovina, A. T., Davis, R. J. & Tauras, J. M. Differential activation of mitogen-activated protein kinases by nitric oxide-related species. J. Biol. Chem. 271, 19705-19709 (1996).
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 19705-19709
-
-
Lander, H.M.1
Jacovina, A.T.2
Davis, R.J.3
Tauras, J.M.4
-
12
-
-
33746085669
-
Neuronal nitric oxide synthase-induced S-nitrosylation of H-Ras inhibits calcium ionophore-mediated extracellular-signal-regulated kinase activity
-
Raines, K. W., Cao, G. L., Lee, E. K., Rosen, G. M. & Shapiro, P. Neuronal nitric oxide synthase-induced S-nitrosylation of H-Ras inhibits calcium ionophore-mediated extracellular-signal-regulated kinase activity. Biochem. J. 397, 329-336 (2006).
-
(2006)
Biochem. J.
, vol.397
, pp. 329-336
-
-
Raines, K.W.1
Cao, G.L.2
Lee, E.K.3
Rosen, G.M.4
Shapiro, P.5
-
13
-
-
84866022996
-
Ets-1 is a transcriptional mediator of oncogenic nitric oxide signaling in estrogen receptor-negative breast cancer
-
Switzer, C. H. et al. Ets-1 is a transcriptional mediator of oncogenic nitric oxide signaling in estrogen receptor-negative breast cancer. Breast Cancer Res. 14, R125 (2012).
-
(2012)
Breast Cancer Res.
, vol.14
, pp. R125
-
-
Switzer, C.H.1
-
14
-
-
2442717744
-
NO stimulation of ATP-sensitive potassium channels: Involvement of Ras/mitogen-activated protein kinase pathway and contribution to neuroprotection
-
Lin, Y. F., Raab-Graham, K., Jan, Y. N. & Jan, L. Y. NO stimulation of ATP-sensitive potassium channels: Involvement of Ras/mitogen-activated protein kinase pathway and contribution to neuroprotection. Proc. Natl Acad. Sci. USA 101, 7799-7804 (2004).
-
(2004)
Proc. Natl Acad. Sci. USA
, vol.101
, pp. 7799-7804
-
-
Lin, Y.F.1
Raab-Graham, K.2
Jan, Y.N.3
Jan, L.Y.4
-
15
-
-
84878380012
-
Positive feedback regulation of human inducible nitric-oxide synthase expression by Ras protein S-nitrosylation
-
Lee, M. & Choy, J. C. Positive feedback regulation of human inducible nitric-oxide synthase expression by Ras protein S-nitrosylation. J. Biol. Chem. 288, 15677-15686 (2013).
-
(2013)
J. Biol. Chem.
, vol.288
, pp. 15677-15686
-
-
Lee, M.1
Choy, J.C.2
-
16
-
-
84870657502
-
S-Nitrosoglutathione and endothelial nitric oxide synthasederived nitric oxide regulate compartmentalized ras S-nitrosylation and stimulate cell proliferation
-
Batista, W. et al. S-Nitrosoglutathione and endothelial nitric oxide synthasederived nitric oxide regulate compartmentalized ras S-nitrosylation and stimulate cell proliferation. Antioxid. Redox Signal. 18, 221-238 (2013).
-
(2013)
Antioxid. Redox Signal.
, vol.18
, pp. 221-238
-
-
Batista, W.1
-
17
-
-
3142663363
-
S-Glutathiolation of Ras mediates redox-sensitive signaling by angiotensin II in vascular smooth muscle cells
-
Adachi, T. et al. S-Glutathiolation of Ras mediates redox-sensitive signaling by angiotensin II in vascular smooth muscle cells. J. Biol. Chem. 279, 29857-29862 (2004).
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 29857-29862
-
-
Adachi, T.1
-
18
-
-
33645806282
-
S-Glutathiolation by peroxynitrite of p21ras at cysteine-118 mediates its direct activation and downstream signaling in endothelial cells
-
Clavreul, N. et al. S-Glutathiolation by peroxynitrite of p21ras at cysteine-118 mediates its direct activation and downstream signaling in endothelial cells. FASEB J. 20, 518-520 (2006).
-
(2006)
FASEB J.
, vol.20
, pp. 518-520
-
-
Clavreul, N.1
-
19
-
-
33144464485
-
The regulation and pharmacology of endothelial nitric oxide synthase
-
Dudzinski, D. M., Igarashi, J., Greif, D. & Michel, T. The regulation and pharmacology of endothelial nitric oxide synthase. Annu. Rev. Pharmacol. Toxicol. 46, 235-276 (2006).
-
(2006)
Annu. Rev. Pharmacol. Toxicol.
, vol.46
, pp. 235-276
-
-
Dudzinski, D.M.1
Igarashi, J.2
Greif, D.3
Michel, T.4
-
20
-
-
41649108639
-
Tumour maintenance is mediated by eNOS
-
Lim, K. H., Ancrile, B. B., Kashatus, D. F. & Counter, C. M. Tumour maintenance is mediated by eNOS. Nature 452, 646-649 (2008).
-
(2008)
Nature
, vol.452
, pp. 646-649
-
-
Lim, K.H.1
Ancrile, B.B.2
Kashatus, D.F.3
Counter, C.M.4
-
21
-
-
34247897276
-
Dose-dependent oncogene-induced senescence in vivo and its evasion during mammary tumorigenesis
-
Sarkisian, C. J. et al. Dose-dependent oncogene-induced senescence in vivo and its evasion during mammary tumorigenesis. Nat. Cell Biol. 9, 493-505 (2007).
-
(2007)
Nat. Cell Biol.
, vol.9
, pp. 493-505
-
-
Sarkisian, C.J.1
-
22
-
-
1442300935
-
Mechanism of p21Ras S-nitrosylation and kinetics of nitric oxide-mediated guanine nucleotide exchange
-
Heo, J. & Campbell, S. L. Mechanism of p21Ras S-nitrosylation and kinetics of nitric oxide-mediated guanine nucleotide exchange. Biochemistry 43, 2314-2322 (2004).
-
(2004)
Biochemistry
, vol.43
, pp. 2314-2322
-
-
Heo, J.1
Campbell, S.L.2
-
23
-
-
0031000742
-
Structural and functional analysis of a mutant Ras protein that is insensitive to nitric oxide activation
-
Mott, H. R., Carpenter, J. W. & Campbell, S. L. Structural and functional analysis of a mutant Ras protein that is insensitive to nitric oxide activation. Biochemistry 36, 3640-3644 (1997).
-
(1997)
Biochemistry
, vol.36
, pp. 3640-3644
-
-
Mott, H.R.1
Carpenter, J.W.2
Campbell, S.L.3
-
24
-
-
0037975678
-
Structural and biochemical studies of p21Ras S-nitrosylation and nitric oxide-mediated guanine nucleotide exchange
-
Williams, J. G., Pappu, K. & Campbell, S. L. Structural and biochemical studies of p21Ras S-nitrosylation and nitric oxide-mediated guanine nucleotide exchange. Proc. Natl Acad. Sci. USA 100, 6376-6381 (2003).
-
(2003)
Proc. Natl Acad. Sci. USA
, vol.100
, pp. 6376-6381
-
-
Williams, J.G.1
Pappu, K.2
Campbell, S.L.3
-
25
-
-
39649125571
-
Mutationally activated K-ras 4A and 4B both mediate lung carcinogenesis
-
Patek, C. E. et al. Mutationally activated K-ras 4A and 4B both mediate lung carcinogenesis. Exp. Cell Res. 314, 1105-1114 (2008).
-
(2008)
Exp. Cell Res.
, vol.314
, pp. 1105-1114
-
-
Patek, C.E.1
-
26
-
-
52949118488
-
Kras regulatory elements and exon 4A determine mutation specificity in lung cancer
-
To, M. D. et al. Kras regulatory elements and exon 4A determine mutation specificity in lung cancer. Nat. Genet. 40, 1240-1244 (2008).
-
(2008)
Nat. Genet.
, vol.40
, pp. 1240-1244
-
-
To, M.D.1
-
27
-
-
0033542476
-
Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation
-
Dimmeler, S. et al. Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation. Nature 399, 601-605 (1999).
-
(1999)
Nature
, vol.399
, pp. 601-605
-
-
Dimmeler, S.1
-
28
-
-
0033542414
-
Regulation of endothelium-derived nitric oxide production by the protein kinase Akt
-
Fulton, D. et al. Regulation of endothelium-derived nitric oxide production by the protein kinase Akt. Nature 399, 597-601 (1999).
-
(1999)
Nature
, vol.399
, pp. 597-601
-
-
Fulton, D.1
-
29
-
-
0030829782
-
K-ras is essential for the development of the mouse embryo
-
Koera, K. et al. K-ras is essential for the development of the mouse embryo. Oncogene 15, 1151-1159 (1997).
-
(1997)
Oncogene
, vol.15
, pp. 1151-1159
-
-
Koera, K.1
-
30
-
-
0007142725
-
Activation of the Ki-ras protooncogene in spontaneously occurring and chemically induced lung tumors of the strain A mouse
-
You, M., Candrian, U., Maronpot, R. R., Stoner, G. D. & Anderson, M. W. Activation of the Ki-ras protooncogene in spontaneously occurring and chemically induced lung tumors of the strain A mouse. Proc. Natl Acad. Sci. USA 86, 3070-3074 (1989).
-
(1989)
Proc. Natl Acad. Sci. USA
, vol.86
, pp. 3070-3074
-
-
You, M.1
Candrian, U.2
Maronpot, R.R.3
Stoner, G.D.4
Anderson, M.W.5
-
31
-
-
54549094903
-
Somatic mutations affect key pathways in lung adenocarcinoma
-
Ding, L. et al. Somatic mutations affect key pathways in lung adenocarcinoma. Nature 455, 1069-1075 (2008).
-
(2008)
Nature
, vol.455
, pp. 1069-1075
-
-
Ding, L.1
-
32
-
-
3042578627
-
Haplotype sharing suggests that a genomic segment containing six genes accounts for the pulmonary adenoma susceptibility 1 (Pas1) locus activity in mice
-
Manenti, G. et al. Haplotype sharing suggests that a genomic segment containing six genes accounts for the pulmonary adenoma susceptibility 1 (Pas1) locus activity in mice. Oncogene 23, 4495-4504 (2004).
-
(2004)
Oncogene
, vol.23
, pp. 4495-4504
-
-
Manenti, G.1
-
33
-
-
36749000596
-
Epithelial NF-kappaB activation promotes urethaneinduced lung carcinogenesis
-
Stathopoulos, G. T. et al. Epithelial NF-kappaB activation promotes urethaneinduced lung carcinogenesis. Proc. Natl Acad. Sci. USA 104, 18514-18519 (2007).
-
(2007)
Proc. Natl Acad. Sci. USA
, vol.104
, pp. 18514-18519
-
-
Stathopoulos, G.T.1
-
34
-
-
6444220002
-
Increased susceptibility to urethane-induced lung tumors in mice with decreased expression of connexin43
-
Avanzo, J. L. et al. Increased susceptibility to urethane-induced lung tumors in mice with decreased expression of connexin43. Carcinogenesis 25, 1973-1982 (2004).
-
(2004)
Carcinogenesis
, vol.25
, pp. 1973-1982
-
-
Avanzo, J.L.1
-
35
-
-
17944369909
-
Wildtype Kras2 can inhibit lung carcinogenesis in mice
-
Zhang, Z. et al. Wildtype Kras2 can inhibit lung carcinogenesis in mice. Nat. Genet. 29, 25-33 (2001).
-
(2001)
Nat. Genet.
, vol.29
, pp. 25-33
-
-
Zhang, Z.1
-
36
-
-
0035893252
-
Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras
-
Jackson, E. L. et al. Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras. Genes Dev. 15, 3243-3248 (2001).
-
(2001)
Genes Dev.
, vol.15
, pp. 3243-3248
-
-
Jackson, E.L.1
-
37
-
-
84879383599
-
Andrographolide derivatives inhibit guanine nucleotide exchange and abrogate oncogenic Ras function
-
Hocker, H. J. et al. Andrographolide derivatives inhibit guanine nucleotide exchange and abrogate oncogenic Ras function. Proc. Natl Acad. Sci. USA 110, 10201-10206 (2013).
-
(2013)
Proc. Natl Acad. Sci. USA
, vol.110
, pp. 10201-10206
-
-
Hocker, H.J.1
-
38
-
-
84897019899
-
Oncogenic K-Ras requires activation for enhanced activity
-
Huang, H. et al. Oncogenic K-Ras requires activation for enhanced activity. Oncogene 33, 532-535 (2014).
-
(2014)
Oncogene
, vol.33
, pp. 532-535
-
-
Huang, H.1
-
39
-
-
84869447282
-
Sos-mediated cross-activation of wildtype Ras by oncogenic Ras is essential for tumorigenesis
-
Jeng, H. H., Taylor, L. J. & Bar-Sagi, D. Sos-mediated cross-activation of wildtype Ras by oncogenic Ras is essential for tumorigenesis. Nat. Commun. 3, 1168 (2012).
-
(2012)
Nat. Commun.
, vol.3
, pp. 1168
-
-
Jeng, H.H.1
Taylor, L.J.2
Bar-Sagi, D.3
-
40
-
-
33745559710
-
The role of nitric oxide in tumour progression
-
Fukumura, D., Kashiwagi, S. & Jain, R. K. The role of nitric oxide in tumour progression. Nat. Rev. Cancer 6, 521-534 (2006).
-
(2006)
Nat. Rev. Cancer
, vol.6
, pp. 521-534
-
-
Fukumura, D.1
Kashiwagi, S.2
Jain, R.K.3
-
41
-
-
0036709862
-
Metabolism of carcinogenic urethane to nitric oxide is involved in oxidative DNA damage
-
Sakano, K., Oikawa, S., Hiraku, Y. & Kawanishi, S. Metabolism of carcinogenic urethane to nitric oxide is involved in oxidative DNA damage. Free Radic. Biol. Med. 33, 703-714 (2002).
-
(2002)
Free Radic. Biol. Med.
, vol.33
, pp. 703-714
-
-
Sakano, K.1
Oikawa, S.2
Hiraku, Y.3
Kawanishi, S.4
-
42
-
-
0036896004
-
Genetic ablation of inducible nitric oxide synthase decreases mouse lung tumorigenesis
-
Kisley, L. R. et al. Genetic ablation of inducible nitric oxide synthase decreases mouse lung tumorigenesis. Cancer Res. 62, 6850-6856 (2002).
-
(2002)
Cancer Res.
, vol.62
, pp. 6850-6856
-
-
Kisley, L.R.1
-
43
-
-
27644525734
-
A genetically defined normal human somatic cell system to study ras oncogenesis in vivo and in vitro
-
O'Hayer, K. M. & Counter, C. M. A genetically defined normal human somatic cell system to study ras oncogenesis in vivo and in vitro. Methods Enzymol. 407, 637-647 (2006).
-
(2006)
Methods Enzymol.
, vol.407
, pp. 637-647
-
-
O'hayer, K.M.1
Counter, C.M.2
|