Glucose induces intestinal human UDP-glucuronosyltransferase (UGT) 1A1 to prevent neonatal hyperbilirubinemia

Scientific Reports

Volumn 4, Issue , 2015, Pages

  Aoshima, Naoya ^a   Fujie, Yoshiko ^a   Itoh, Tomoo ^a   Tukey, Robert H ^b   Fujiwara, Ryoichi ^a  

^a KITASATO UNIVERSITY   (Japan)

^b San Diego   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BILIRUBIN; GLUCOSE; GLUCURONOSYLTRANSFERASE; UGT1A1 ENZYME;

ANIMAL; BIOSYNTHESIS; BLOOD; C57BL MOUSE; CACO 2 CELL LINE; GENETICS; HUMAN; HYPERBILIRUBINEMIA, NEONATAL; LIVER; METABOLISM; MOUSE; NEWBORN; SMALL INTESTINE; TUMOR CELL LINE;

ANIMALS; BILIRUBIN; CACO-2 CELLS; CELL LINE, TUMOR; GLUCOSE; GLUCURONOSYLTRANSFERASE; HUMANS; HYPERBILIRUBINEMIA, NEONATAL; INFANT, NEWBORN; INTESTINE, SMALL; LIVER; MICE; MICE, INBRED C57BL;

EID: 84923281016     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep06343     Document Type: Article

References (42)

1. Gourley, G. R. Bilirubin metabolism and kernicterus. Adv. Pediatr. 44, 173-229 (1997).
2. Newman, A. J. & Gross, S. Hyperbilirubinemia in breast-fed infants. Pediatrics 32, 995-1001 (1963).
3. Arias, I. M., Gartner, L. M., Seifter, S. & Furman, M. Prolonged neonatal unconjugated hyperbilirubinemia associated with breast feeding and a steriod, pregnane-3(alpha), 20(beta)-diol, in maternal milk that inhibits glucuronide formation in vitro. J. Clin. Invest. 43, 2037-2047 (1964).
4. Schneider, A. P. Breast milk jaundice in the newborn: A real entity. JAMA 255, 3270-3274 (1986).
5. American Academy of Pediatrics, Subcommittee on Hyperbilirubinemia. Management of hyperbilirubinemia in the newborn infant 35 or more weeks of gestation. Pediatrics 114, 297-316 (2004).
6. Ip, S. et al. An Evidence-Based Review of Important Issues Concerning Neonatal Hyperbilirubinemia. Pediatrics 114, e130-e153 (2004).
7. Maisels, M. J. et al. Hyperbilirubinemia in the newborn infant . or 535 weeks' gestation: an update with clarifications. Pediatrics 124, 1193-1198 (2009).
8. Maruo, Y. et al. Bilirubin uridine diphosphate-glucuronosyltransferase variation is a genetic basis of breast milk jaundice. J Pediatr. 165, 36-41 (2014).
9. Shibuya, A., Itoh, T., Tukey, R. H. & Fujiwara, R. Impact of fatty acids on human UDP-glucuronosyltransferase 1A1 activity and its expression in neonatal hyperbilirubinemia. Sci. Rep. 3, 2903 (2013).
10. Fujiwara, R., Chen, S., Karin, M. & Tukey, R. H. Reduced expression of UGT1A1 in intestines of humanized UGT1 mice via inactivation of NF-kB leads to hyperbilirubinemia. Gastroenterology 142, 109-18 (2012).
11. Tan, K. L. The nature of the dose-response relationship of phototherapy for neonatal hyperbilirubinemia. J. Pediatr. 90, 448-452 (1977).
12. Wananukul, S. & Praisuwanna, P. Clear topical ointment decreases transepidermal water loss in jaundiced preterm infants receiving phototherapy. J. Med. Assoc. Thai. 85, 102-106 (2002).
13. Kumar, P. et al. Light emitting diodes versus compact fluorescent tubes for phototherapy in neonatal jaundice: a multi center randomized controlled trial. Indian. Pediatr. 47, 131-137 (2010).
14. Newman, A. J.&Gross, S. Hyperbilirubinemia in breast-fed infants. Pediatrics. 32, 995-1001 (1963).
15. Sato, H. et al. Association of breast-fed neonatal hyperbilirubinemia with UGT1A1 polymorphisms: 211G.A (G71R) mutation becomes a risk factor under inadequate feeding. J. Hum. Genet. 58, 7-10 (2013).
16. Bosma, P. J. et al. Bilirubin UDP-glucuronosyltransferase 1 is the only relevant bilirubin glucuronidating isoform in man. J. Biol. Chem. 269, 17960-17964 (1994).
17. Fujiwara, R., Nguyen, N., Chen, S. & Tukey, R. H. Developmental hyperbilirubinemia and CNS toxicity in mice humanized with the UDP glucuronosyltransferase 1 (UGT1) locus. Proc. Natl. Acad. Sci. U.S.A. 107, 5024-9 (2010).
18. Nakamura, A., Nakajima, M., Yamanaka, H., Fujiwara, R. & Yokoi, T. Expression of UGT1A and UGT2B mRNA in human normal tissues and various cell lines. Drug Metab. Dispos. 36, 1461-1464 (2008).
19. Tom, B. H. et al. Human colonic adenocarcinoma cells. I. Establishment and description of a new line. In Vitro 12, 180-91 (1976).
20. Artursson, P. Epithelial transport of drugs in cell culture. I: A model for studying the passive diffusion of drugs over intestinal absorptive (Caco-2) cells. J. Pharm. Sci. 79, 476-82 (1990).
21. Hunter, J., Jepson, M. A., Tsuruo, T., Simmons, N. L. & Hirst, B. H. Functional expression of P-glycoprotein in apical membranes of human intestinal Caco-2 cells. Kinetics of vinblastine secretion and interaction with modulators. J. Biol. Chem. 268, 14991-14997 (1993).
22. Meunier, V., Bourrié, M., Berger, Y. & Fabre, G. The human intestinal epithelial cell line Caco-2; pharmacological and pharmacokinetic applications. Cell Biol. Toxicol. 11, 187-94 (1995).
23. Walle, U. K., Galijatovic, A. &Walle, T. Transport of the flavonoid chrysin and its conjugated metabolites by the human intestinal cell line Caco-2. Biochem Pharmacol. 58, 431-8 (1999).
24. Li, T., Bai, L., Li, J., Igarashi, S. & Ghishan, F. K. Sp1 is required for glucoseinduced transcriptional regulation of mouse vesicular glutamate transporter 2 gene. Gastroenterology. 134, 1994-2003 (2008).
25. Kamisako, T. et al. Recent advances in bilirubin metabolism research: the molecular mechanism of hepatocyte bilirubin transport and its clinical relevance. J Gastroenterol. 35, 659-664 (2000).
26. Beutler, E., Gelbart, T. & Demina, A. Racial variability in the UDPglucuronosyltransferase 1 (UGT1A1) promoter: a balanced polymorphism for regulation of bilirubin metabolism? Proc. Natl. Acad. Sci. U.S.A. 95, 8170-4 (1998).
27. Medley, M. M., Hooker, R. L., Rabinowitz, S., Holton, R. & Jaffe, B. M. Correction of congenital indirect hyperbilirubinemia by small intestinal transplantation. Am. J. Surg. 169, 20-27 (1995).
28. Sumida, K. et al. Importance of UDP-glucuronosyltransferase 1A1 expression in skin and its induction by UVB in neonatal hyperbilirubinemia. Mol. Pharmacol. 84, 679-86 (2013).
29. Krüger, K. A., Blum, J. W. & Greger, D. L. Expression of nuclear receptor and target genes in liver and intestine of neonatal calves fed colostrum and vitamin A. J. Dairy Sci. 88, 3971-81 (2005).
30. de Carvalho, M., Hall, M. & Harvey, D. Effects of water supplementation on physiological jaundice in breast-fed babies. Arch. Dis. Child. 56, 568-9 (1981).
31. Nicoll, A., Ginsburg, R. & Tripp, J. H. Supplementary feeding and jaundice in newborns. Acta. Paediatr. Scand. 71, 759-61 (1982).
32. Maglich, J. M. et al. Nuclear pregnane X receptor and constitutive androstane receptor regulate overlapping but distinct sets of genes involved in xenobiotic detoxification. Mol. Pharmacol. 62, 638-646 (2002).
33. Sugatani, J. et al. Transcriptional regulation of human UGT1A1 gene expression: activated glucocorticoid receptor enhances constitutive androstane receptor/ pregnane X receptor-mediated UDP-glucuronosyltransferase 1A1 regulation with glucocorticoid receptor-interacting protein 1. Mol. Pharmacol. 67, 845-855 (2005).
34. Usui, T., Kuno, T. & Mizutani, T. Induction of human UDPglucuronosyltransferase 1A1 by cortisol-GR. Mol. Biol. Rep. 33, 91-96 (2006).
35. Senekeo-Effenberger, K. et al. Expression of the Human UGT1 Locus in Transgenic Mice by 4-Chloro-6-(2,3-xylidino)-2-pyrimidinylthioacetic Acid (WY-14643) and Implications on Drug Metabolism through Peroxisome Proliferator-Activated Receptor a Activation. Drug Metab. Dispos. 35, 419-27 (2007).
36. Landers, J. P. & Bunce, N. J. The Ah receptor and the mechanism of dioxin toxicity. Biochem. J. 276, 273-287 (1991).
37. Yueh, M. F. & Tukey, R. H. Nrf2-Keap1 Signaling Pathway Regulates Human UGT1A1 Expression in Vitro and in Transgenic UGT1 Mice. J. Biol. Chem. 282, 8749-8758 (2007).
38. McDonagh, A. F. Bile pigments: bilatrienes and 5,15-biladienes. In: Dolphin D (ed). The Porphyrins. New York, NY: Academic Press 293-491 (1979).
39. Tenhunen, R., Ross, M. E., Marver, H. S. & Schmid, R. Reduced nicotinamideadenine dinucleotide phosphate dependent biliverdin reductase: partial purification and characterization. Biochemistry. 9, 298-303 (1970).
40. Gartner, L. M., Lee, K. S., Vaisman, S., Lane, D. & Zarafu, I. Development of bilirubin transport and metabolism in the newborn rhesus monkey. J Pediatr. 90, 513-31 (1977).
41. Gartner, L. M. & Lane, D. L. The physiology of physiologic hyperbilirubinemia of the newborn. Medical primatology. 237-247 (1972).
42. Temme, E. H., Zhang, J., Schouten, E. G. & Kesteloot, H. Serum bilirubin and 10- year mortality risk in a Belgian population. Cancer Causes Control. 12, 887-894 (2001).