PKA catalytic subunit mutations in adrenocortical Cushing's adenoma impair association with the regulatory subunit

Nature Communications

Volumn 5, Issue , 2014, Pages

  Calebiro, Davide ^a,b   Hannawacker, Annette ^a   Lyga, Sandra ^a,b   Bathon, Kerstin ^a,b   Zabel, Ulrike ^a   Ronchi, Cristina ^a   Beuschlein, Felix ^c   Reincke, Martin ^c   Lorenz, Kristina ^a,d   Allolio, Bruno ^a   Kisker, Caroline ^b   Fassnacht, Martin ^a   Lohse, Martin J ^a,b,d  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b UNIVERSITY OF WÜRZBURG   (Germany)

^c LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^d UNIVERSITY HOSPITAL WÜRZBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP DEPENDENT PROTEIN KINASE; HOLOENZYME; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT; CYCLIC AMP DEPENDENT PROTEIN KINASE REGULATORY SUBUNIT IALPHA; CYCLIC AMP DEPENDENT PROTEIN KINASE REGULATORY SUBUNIT IIBETA; PRKACA PROTEIN, HUMAN; PRKAR1A PROTEIN, HUMAN; PRKAR2B PROTEIN, HUMAN; PROTEIN BINDING;

BIOCHEMICAL COMPOSITION; CATALYSIS; ENERGY FLUX; ENZYME ACTIVITY; FLUORESCENCE; MUTATION; PROTEIN; SECRETION;

ANIMAL CELL; ARTICLE; COMPUTER MODEL; CONTROLLED STUDY; CUSHING DISEASE; ENZYME ACTIVE SITE; ENZYME REGULATION; FLUORESCENCE RESONANCE ENERGY TRANSFER; GENE MUTATION; HUMAN; HUMAN CELL; IN VITRO STUDY; MUTANT; NONHUMAN; ADRENAL CORTEX ADENOMA; ADRENAL CORTEX TUMOR; CHEMISTRY; CUSHING SYNDROME; ENZYMOLOGY; GENETICS; METABOLISM; MUTATION; PATHOLOGY; PROTEIN STABILITY; TUMOR CELL LINE;

ADRENAL CORTEX NEOPLASMS; ADRENOCORTICAL ADENOMA; CATALYTIC DOMAIN; CELL LINE, TUMOR; CUSHING SYNDROME; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNITS; CYCLIC AMP-DEPENDENT PROTEIN KINASE RIALPHA SUBUNIT; CYCLIC AMP-DEPENDENT PROTEIN KINASE RIIBETA SUBUNIT; CYCLIC AMP-DEPENDENT PROTEIN KINASES; HUMANS; MUTATION; PROTEIN BINDING; PROTEIN STABILITY;

EID: 84923279889     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms6680     Document Type: Article

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