Recurrent somatic mutations underlie corticotropin-independent Cushing's syndrome

Science

Volumn 344, Issue 6186, 2014, Pages 917-920

  Sato, Yusuke ^a,b   Maekawa, Shigekatsu ^b   Ishii, Ryohei ^c   Sanada, Masashi ^a   Morikawa, Teppei ^b   Shiraishi, Yuichi ^c   Yoshida, Kenichi ^a   Nagata, Yasunobu ^a   Sato Otsubo, Aiko ^a   Yoshizato, Tetsuichi ^a   Suzuki, Hiromichi ^a   Shiozawa, Yusuke ^a   Kataoka, Keisuke ^a   Kon, Ayana ^a   Aoki, Kosuke ^a   Chiba, Kenichi ^c   Tanaka, Hiroko ^c   Kume, Haruki ^b   Miyano, Satoru ^c   Fukayama, Masashi ^b   Nureki, Osamu ^c   Homma, Yukio ^b   Ogawa, Seishi ^a   more..

^a KYOTO UNIVERSITY   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CORTICOTROPIN; HYDROCORTISONE; CYCLIC AMP DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; PRKACA PROTEIN, HUMAN;

CATALYSIS; ENZYME ACTIVITY; HORMONE; MUTATION; PATHOGENICITY;

ADENOHYPOPHYSIS HYPERFUNCTION; ADRENAL CORTEX ADENOMA; ARTICLE; BINDING AFFINITY; CATALYSIS; CONTROLLED STUDY; CUSHING DISEASE; ENZYME ACTIVATION; GENE; GENE FREQUENCY; GUANINE NUCLEOTIDE BINDING PROTEIN SUBUNIT ALPHA GENE; HORMONE SYNTHESIS; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PRKACA GENE; SINGLE NUCLEOTIDE POLYMORPHISM; SOMATIC MUTATION; 3T3 CELL LINE; ADRENAL CORTEX TUMOR; ANIMAL; CUSHING SYNDROME; DNA MUTATIONAL ANALYSIS; ENZYME ACTIVE SITE; GENETICS; HEK293 CELL LINE; METABOLISM; MOUSE; MUTATION; PC12 CELL LINE; RAT;

ADRENAL CORTEX NEOPLASMS; ADRENOCORTICAL ADENOMA; ADRENOCORTICOTROPIC HORMONE; ANIMALS; CATALYTIC DOMAIN; CUSHING SYNDROME; CYCLIC AMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNITS; DNA MUTATIONAL ANALYSIS; GTP-BINDING PROTEIN ALPHA SUBUNITS; HEK293 CELLS; HUMANS; MICE; MUTATION; NIH 3T3 CELLS; PC12 CELLS; RATS;

EID: 84901217805     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1252328     Document Type: Article

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