Strain engineering to prevent norleucine incorporation during recombinant protein production in Escherichia coli

Biotechnology Progress

Volumn 31, Issue 1, 2015, Pages 204-211

  Veeravalli, Karthik ^a   Laird, Michael W ^a   Fedesco, Mark ^a   Zhang, Yu ^a   Yu, X Christopher ^a  

^a GENENTECH INC   (United States)

Author keywords

Fermentation; Incorporation; Methionine; Norleucine; Recombinant protein; Sequence variant

Indexed keywords

AMINO ACIDS; ESCHERICHIA COLI; FEEDING; FERMENTATION; PROTEINS;

CHROMOSOMAL MUTATION; FERMENTATION PERFORMANCE; INCORPORATION; METHIONINE; NORLEUCINE; OPERATIONAL COMPLEXITY; RECOMBINANT PROTEIN PRODUCTIONS; SEQUENCE VARIANTS;

RECOMBINANT PROTEINS;

ESCHERICHIA COLI;

METHIONINE; NORLEUCINE; PHOSPHATE; RECOMBINANT PROTEIN;

AMINO ACID SEQUENCE; CHEMISTRY; ESCHERICHIA COLI; EXTRACELLULAR SPACE; FERMENTATION; GENETICS; METABOLIC ENGINEERING; METABOLISM; MOLECULAR GENETICS; PROCEDURES;

AMINO ACID SEQUENCE; ESCHERICHIA COLI; EXTRACELLULAR SPACE; FERMENTATION; METABOLIC ENGINEERING; METHIONINE; MOLECULAR SEQUENCE DATA; NORLEUCINE; PHOSPHATES; RECOMBINANT PROTEINS;

EID: 84923270798     PISSN: 87567938     EISSN: 15206033     Source Type: Journal    
DOI: 10.1002/btpr.1999     Document Type: Article

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