ERK1/2 pathway is involved in renal gluconeogenesis inhibition under conditions of lowered NADPH oxidase activity

Free Radical Biology and Medicine

Volumn 81, Issue , 2015, Pages 13-21

  Winiarska, Katarzyna ^a   Jarzyna, Robert ^a   Dzik, Jolanta M ^b   Jagielski, Adam K ^a   Grabowski, Michal ^a   Nowosielska, Agata ^a   Focht, Dorota ^a   Sierakowski, Bartosz ^a  

^a UNIVERSITY OF WARSAW   (Poland)

^b WARSAW UNIVERSITY OF LIFE SCIENCES   (Poland)

Author keywords

Diabetes; ERK1 2 pathway; Gluconeogenesis; NADPH oxidase; Phosphoenolpyruvate carboxykinase; Renal proximal tubules; ZDF rat

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2,4 THIAZOLIDINEDIONE; 3 (2 AMINOETHYL) 5 [(4 ETHOXYPHENYL)METHYLENE] 2,4 THIAZOLIDINEDIONE; APOCYNIN; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE 1; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP); REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; TEMPOL; UNCLASSIFIED DRUG; 1,3 BUTADIENE DERIVATIVE; 2,4 THIAZOLIDINEDIONE DERIVATIVE; ACETOPHENONE DERIVATIVE; AMINE OXIDE; ANTIDIABETIC AGENT; ANTIOXIDANT; MITOGEN ACTIVATED PROTEIN KINASE 3; NITRILE; PHOSPHOENOLPYRUVATE CARBOXYKINASE 1 (SOLUBLE) PROTEIN, RAT; PROTEIN KINASE INHIBITOR; REACTIVE OXYGEN METABOLITE; SIGNAL PEPTIDE; SPIN LABELING;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIDIABETIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVITY; GLUCONEOGENESIS; HYPERGLYCEMIA; IN VITRO STUDY; KIDNEY PROXIMAL TUBULE; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; ANIMAL; ANTAGONISTS AND INHIBITORS; DIABETES MELLITUS, EXPERIMENTAL; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PATHOLOGY; PRIMARY CELL CULTURE; SIGNAL TRANSDUCTION; SPIN LABELING; ZUCKER RAT;

ANIMALIA; RATTUS;

ACETOPHENONES; ANIMALS; ANTIOXIDANTS; BUTADIENES; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; CYCLIC N-OXIDES; DIABETES MELLITUS, EXPERIMENTAL; GENE EXPRESSION REGULATION; GLUCONEOGENESIS; HYPOGLYCEMIC AGENTS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; KIDNEY TUBULES, PROXIMAL; MALE; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; NADPH OXIDASE; NITRILES; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP); PRIMARY CELL CULTURE; PROTEIN KINASE INHIBITORS; RATS; RATS, ZUCKER; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; SPIN LABELS; THIAZOLIDINEDIONES;

EID: 84923233384     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2014.12.024     Document Type: Article

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