Hypothesizing repetitive paraphilia behavior of a medication refractive Tourette's syndrome patient having rapid clinical attenuation with KB220Z-nutrigenomic amino-acid therapy (NAAT)

Journal of Behavioral Addictions

Volumn 2, Issue 2, 2013, Pages 117-124

  McLaughlin, Thomas ^a   Oscar Berman, Marlene ^b,c   Simpatico, Thomas ^d   Giordano, John ^e   Jones, Scot ^e   Barh, Debmayla ^f   Downs, William B ^g   Waite, Roger L ^g   Madigan, Margaret ^g   Dushaj, Kristina ⁱ   Lohmann, Raquel ⁱ   Braverman, Eric R ⁱ   Han, David ^j   Blum, Kenneth ^{d,e,f,g,h,i,k,l}  

^a Center for Psychiatric Medicine   (United States)

^b Anatomy and Neurobiology ^*  (United States)

^c Boston University Medical Campus   (United States)

^d UNIVERSITY OF VERMONT COLLEGE OF MEDICINE   (United States)

^e G and G Health Care Services   (United States)

^f Institute of Integrative Omics and Applied Biotechnology (IIOAB)   (India)

^g LifeGen Inc   (United States)

^h UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

ⁱ Path Foundation NY   (United States)

^j UNIVERSITY OF TEXAS AT SAN ANTONIO   (United States)

^k Dominion Diagnostics   (United States)

^l Malibu Beach Recovery Center   (United States)

more..

Author keywords

Aggressive sexual behavior; Dopamine activation; NAAT; Repetitive paraphilia behavior; Reward deficiency syndrome (RDS); Tourette's

Indexed keywords

EID: 84923231096     PISSN: 20625871     EISSN: 20635303     Source Type: Journal    
DOI: 10.1556/JBA.2.2013.2.8     Document Type: Article

References (37)

1. Aloisi, G., Silvano, E., Rossi, M., Millan, M. J. & Maggio, R. (2011). Differential induction of adenylyl cyclase supersensitivity by antiparkinson drugs acting as agonists at dopamine D1/D2/D3 receptors vs D2/D3receptors only: Parallel observations from co-transfected human and native cerebral receptors. Neuropharmacology, 60, 439-445.
2. American Psychiatric Association (2000-2006). Diagnostic and statistical manual of mental disorders-IV (text revision). Arlington, VA: American Psychiatric Publishing, Inc.
3. Banerjee, U. (1974). Modification of the isolation-induced abnormal behavior in male Wistar rats by destructive manipulation of the central monoaminergic systems. Behavioral Biology, 11, 573-577.
4. Bhugra, D., Popelyuk, D. & McMullen, I. (2010). Paraphilias across cultures: Contexts and controversies. Journal of Sex Research, 47, 242-256.
5. Blum, K., Chen, A. L., Chen, T. J., Braverman, E. R., Reinking, J., Blum, S. H., Cassel, K., Downs, B. W., Waite, R. L., Williams, L., Prihoda, T. J., Kerner, M. M., Palomo, T., Comings, D. E., Tung, H., Rhoades, P. & Oscar-Berman, M. (2008). Activation instead of blocking mesolimbic dopaminergic reward circuitry is a preferred modality in the long term treatment of reward deficiency syndrome (RDS):Acommentary. Theoretical Biology and Medical Modelling, 12, 24.
6. Blum, K., Chen, T. J., Downs, B. W., Bowirrat, A., Waite, R. L., Braverman, E. R., Madigan, M., Oscar-Berman, M., DiNubile, N., Stice, E., Giordano, J., Morse, S. & Gold, M. (2009). Neurogenetics of dopaminergic receptor supersensitivity in activation of brain reward circuitry and relapse: Proposing "de-privation-amplification relapse therapy" (DART). Postgraduate Medicine, 121 (6), 176-196.
7. 2 agonist therapy: Part 2. Postgraduate Medicine, 122, 214-226.
8. Blum, K., Gardner, E., Oscar-Berman, M. & Gold, M. (2012). "Liking" and "wanting" linked to reward deficiency syndrome (RDS): Hypothesizing differential responsivity in brain reward circuitry. Current Pharmaceutical Design, 18, 113-118.
9. Blum, K., Giordano, J., Oscar-Berman, M., Bowirrat, A., Simpatico, T. & Barh, D. (2012). Diagnosis and healing in veterans suspected of suffering from post-traumatic stress disorder (PTSD) using reward gene testing and reward circuitry natural dopaminergic activation. Journal of Genetic Syndrome and Gene Therapy, 3, 1000116.
10. Blum, K. & Gold, M. S. (2011). Neuro-chemical activation of brain reward meso-limbic circuitry is associated with relapse prevention and drug hunger: A hypothesis. Medical Hypotheses, 76, 576-584.
11. Blum, K., Liu, Y., Shriner, R. & Gold, M. S. (2011). Reward circuitry dopaminergic activation regulates food and drug craving behavior. Current Pharmaceutical Design, 17, 1158-1167.
12. Blum, K., Oscar-Berman, M., Giordano, J., Downs, B., Simpatico, T., Han, D. & Femino, J. (2012). Neurogenetic impairments of brain reward circuitry links to reward deficiency syndrome (RDS): Potential nutrigenomic induced dopaminergic activation. Journal of Genetic Syndrome and Gene Therapy, 17, 4.
13. Blum, K., Sheridan, P. J., Wood, R. C., Braverman, E. R., Chen, T. J., Cull, J. G. & Comings, D. E. (1996). The D2 dopamine receptorgene as a determinant of reward deficiency syndrome. Journal of the Royal Society of Medicine, 89, 396-400.
14. Blum, K., Stice, E., Liu, Y., Giordano, J., Morse, S., Downs, B. W., Waite, R. L., Madigan, M., Braverman, E. R., Kerner, M., Oscar-Berman,M., Miller, D., Stokes, S., Gant, C., Thompson, T., Allen, C., Smilen, A., Bowirrat, A. & Gold, M. (2011). "Dopamine Resistance" in brain reward circuitry as a function of DRD2 gene receptor polymorphisms in RDS: Synaptamine complex variant (KB220) induced "Dopamine Sensitivity" and enhancement of happiness. Washington, D.C.: XIX World Congress of Psychiatric Genetics, September 10-14.
15. Blum, K., Werner, T., Carnes, S., Carnes, P., Bowirrat, A., Giordano, J., Oscar-Berman, M. & Gold, M. (2012). Sex, drugs, and rock 'n' roll: Hypothesizing common mesolimbic activation as a function of reward gene polymorphisms. Journal of Psychoactive Drugs, 44, 38-55.
16. Chen, B., Liu, H., Ren, J. & Guo, A. (2012). Mutation of drosophila dopamine receptor DopR leads to male-male courtship behavior. Biochemical and Biophysical Research Communications, 423, 557-563.
17. Chen, T. J. H., Blum, K., Chen, L. C. H., Bowirrat, A., Downs, B. W., Madigan, M. A., Waite, R. L., Bailey, J. A., Kerner, M., Yelandi, S., Giordano, J., Morse, S., Miller, D. & Braverman, E. R. (2011). Neurogenetics and clinical evidence for the putative activation of the brain reward circuitry by amino-acid pre-cursor-catabolic enzyme inhibition therapeutic agent (a neuroadaptogen): Proposing an addiction candidate gene panel map. Journal of Psychoactive Drugs, 43, 108-127.
18. Comings, D. E. (1994). Role of genetic factors in human sexual behavior based on studies of Tourette syndrome and ADHD probands and their relatives. American Journal of Medical Genetics, 54, 227-241.
19. Comings, D. E. & Blum, K. (2000). Reward deficiency syndrome: Genetic aspects of behavioral disorders. Progress in Brain Research, 126, 325-341.
20. Cross-Disorder Group of the Psychiatric Genomics Consortium, Smoller, J. W., Craddock, N., Kendler, K., Lee, P. H., Neale, B. M., Nurnberger, J. I., Ripke, S., Santangelo, S. & Sullivan, P. F. (2013). Identification of risk loci with shared effects on five major psychiatric disorders: A genome-wide analysis. The Lancet, 381, 1371-1379.
21. Daw, J. & Guo, G. (2011). The influence of three genes on whether adolescents use contraception, USA 1994-2002. Population Studies (Camb), 65, 253-271.
22. Derosa, G. & Maffioli, P. (2012). Anti-obesity drugs: A review about their effects and their safety. Expert Opinion on Drug Safety, 11, 459-471.
23. Eden, R. J., Costall, B., Domeney, A. M., Gerrard, P. A., Harvey, C. A., Kelly, M. E., Naylor, R. J., Owen, D. A. A. & Wright, A. (1991). "Preclinical pharmacology of ropinirole (SK&F 101468-A) a novel dopamine D2 agonist". Pharmacology Biochemistry and Behavior, 38, 147-154.
24. Gardner, E. L. (2011). Addiction and brain reward and antireward pathways. Advances in Psychosomatic Medicine, 30, 22-60.
25. Guo, G. & Tong, Y. (2006). Age at first sexual intercourse, genes, and social context: Evidence from twins and the dopamine D4 receptor gene. Demography, 43, 747-769.
26. James, W. H. (1995). Sexual expression, genetics, and testosterone in Tourette syndrome. American Journal of Medical Genetics, 60, 593.
27. Kerbeshian, J. & Burd, L. (1991). Tourette syndrome and recurrent paraphilic masturbatory fantasy. Canadian Journal of Psychiatry, 36, 155-157.
28. Li, M. F. & Cheung, B. M. (2011). Rise and fall of anti-obesity drugs. World Journal of Diabetes, 2, 19-23.
29. Mack, H., Fullana, M. A., Russell, A. J., Mataix-Cols, D., Nakatani, E. & Heyman, I. (2010). Obsessions and compulsions in children with Asperger's syndrome or high-functioning autism: A case-control study. The Australian and New Zealand Journal of Psychiatry, 44, 1082-1088.
30. Miller, D. K., Bowirrat, A., Manka, M., Miller, M., Stokes, S., Manka, D., Allen, C., Gant, C., Downs, B. W., Smolen, A., Stevens, E., Yeldandi, S. & Blum, K. (2010). Acute intravenous synaptamine complex variant KB220™ "normalizes"neurological dysregulation in patients during protracted abstinence from alcohol and opiates as observed using quantitative electroencephalographic and genetic analysis for reward polymorphisms: Part 1, pilot study with 2 case reports. Postgraduate Medicine, 122, 188-213.
31. Miller, W. B., Pasta, D. J., MacMurray, J., Chiu, C., Wu, H. & Comings, D. E. (1999). Dopamine receptor genes are associated with age at first sexual intercourse. Journal of Biosocial Science, 31, 43-54.
32. Money, J. (1990). Gay, straight, and in-between: The sexology of erotic orientation. New York: Oxford University Press.
33. Moser, C. & Kleinplatz, P. J. (2005). DSM-IV-TR and the paraphilias: An argument for removal. Journal of Psychology and Human Sexuality, 17, 91-109.
34. Sandyk, R. (1988). Naltrexone suppresses abnormal sexual behavior in Tourette's syndrome. The International Journal of Neuroscience, 43, 107-110.
35. Spitzer, R. L. (1981). The diagnostic status of homosexuality in DSM-III: A reformulation of the issues. The American Journal of Psychiatry, 138, 210-215.
36. Stekel, W. (1930). Sexual aberrations: The phenomenon of fetishism in relation to sex disorders of the instincts and emotions the parapathiac disorders. New York: Liveright Publishing.
37. Wang, Z. & Aragona, B. J. (2004). Neurochemical regulation of pair bonding in male prairie voles. Physiology and Behavior, 83, 319-328.