A new gene for Parkinson's disease: Should we care?

The Lancet Neurology

Volumn 14, Issue 3, 2015, Pages 238-239

  Singleton, Andrew ^a  

^a NATIONAL INSTITUTE ON AGING   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LEVODOPA; CHCHD2 PROTEIN, HUMAN; MITOCHONDRIAL PROTEIN; TRANSCRIPTION FACTOR;

ARTICLE; CHCHD2 GENE; CLINICAL GENETICS; EXOME; GENETIC ASSOCIATION; GENOME; HEREDITARY MOTOR SENSORY NEUROPATHY; HUMAN; MULTIGENE FAMILY; MUTATOR GENE; PARKINSON DISEASE; PARKINSONISM; PHENOTYPE; PRIORITY JOURNAL; RISK FACTOR; DNA SEQUENCE; FEMALE; GENETIC LINKAGE; GENETICS; MALE; MISSENSE MUTATION; PROCEDURES;

FEMALE; GENETIC LINKAGE; GENOME-WIDE ASSOCIATION STUDY; HUMANS; MALE; MITOCHONDRIAL PROTEINS; MUTATION, MISSENSE; PARKINSONIAN DISORDERS; SEQUENCE ANALYSIS, DNA; TRANSCRIPTION FACTORS;

EID: 84923225369     PISSN: 14744422     EISSN: 14744465     Source Type: Journal    
DOI: 10.1016/S1474-4422(14)70270-4     Document Type: Note

References (8)

1. Funayama M, Ohe K, Amo T, et al. CHCHD2 mutations in autosomal dominant late-onset Parkinson's disease: a genome-wide linkage and sequencing study. Lancet Neurol 2015, 14:274-282.
2. Nalls MA, Pankratz N, Lill CM, et al. Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease. Nat Genet 2014, 46:989-993.
3. Novarino G, Fenstermaker AG, Zaki MS, et al. Exome sequencing links corticospinal motor neuron disease to common neurodegenerative disorders. Science 2014, 343:506-511.
4. Beilina A, Rudenko IN, Kaganovich A, et al. Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease. Proc Natl Acad Sci USA 2014, 111:2626-2631.
5. Macleod DA, Rhinn H, Kuwahara T, et al. RAB7L1 interacts with LRRK2 to modify intraneuronal protein sorting and Parkinson's disease risk. Neuron 2013, 77:425-439.
6. Clark IE, Dodson MW, Jiang C, et al. Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin. Nature 2006, 441:1162-1166.
7. Park J, Lee SB, Lee S, et al. Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin. Nature 2006, 441:1157-1161.
8. Burchell VS, Nelson DE, Sanchez-Martinez A, et al. The Parkinson's disease-linked proteins Fbxo7 and Parkin interact to mediate mitophagy. Nat Neurosci 2013, 16:1257-1265.