The PKA RIα/A-kinase anchoring proteins 10 signaling pathway and the prognosis of colorectal cancer

Journal of Gastroenterology and Hepatology (Australia)

Volumn 30, Issue 3, 2015, Pages 496-503

  Wang, Mojin ^a   Li, Yuan ^a   Wang, Rui ^a   Wang, Ziqiang ^a   Chen, Keling ^a   Zhou, Bin ^a   Zhou, Zongguang ^a   Sun, Xiaofeng ^b  

^a SICHUAN UNIVERSITY   (China)

^b LINKÖPING UNIVERSITY   (Sweden)

Author keywords

Colorectal cancer (CRC); PKA RI AKAP10 signaling pathway; Prognosis

Indexed keywords

CARRIER PROTEINS AND BINDING PROTEINS; CYCLIC AMP DEPENDENT PROTEIN KINASE ANCHORING PROTEIN 10; UNCLASSIFIED DRUG; AKAP10 PROTEIN, HUMAN; CYCLIC AMP DEPENDENT PROTEIN KINASE ANCHORING PROTEIN; CYCLIC AMP DEPENDENT PROTEIN KINASE REGULATORY SUBUNIT IALPHA; MESSENGER RNA;

ADULT; ARTICLE; CANCER CELL LINE SW480; CANCER PROGNOSIS; CANCER SURVIVAL; COLON MUCOSA; COLORECTAL CANCER; COLORECTAL CANCER CELL LINE; CONTROLLED STUDY; FEMALE; HCT116 CELL LINE; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; OVERALL SURVIVAL; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; AGED; CELL TRANSFORMATION; COLORECTAL TUMOR; DISEASE COURSE; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENETICS; METASTASIS; MIDDLE AGED; MORTALITY; PATHOLOGY; PHYSIOLOGY; PROGNOSIS; PROPORTIONAL HAZARDS MODEL; SURVIVAL; TUMOR CELL LINE; TUMOR INVASION; UPREGULATION;

A KINASE ANCHOR PROTEINS; AGED; CELL LINE, TUMOR; CELL TRANSFORMATION, NEOPLASTIC; COLORECTAL NEOPLASMS; CYCLIC AMP-DEPENDENT PROTEIN KINASE RIALPHA SUBUNIT; DISEASE PROGRESSION; FEMALE; GENE EXPRESSION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MALE; MIDDLE AGED; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS; PROGNOSIS; PROPORTIONAL HAZARDS MODELS; RNA, MESSENGER; SIGNAL TRANSDUCTION; SURVIVAL; UP-REGULATION;

EID: 84923223061     PISSN: 08159319     EISSN: 14401746     Source Type: Journal    
DOI: 10.1111/jgh.12689     Document Type: Article

References (28)

1. Garcia M, Jemal A, Ward EM etal. Global Cancer Facts & Figures. Atlanta, GA: American Cancer Society, 2007.
2. American Cancer Society. Cancer Facts & Figures. Atlanta, GA: American Cancer Society, 2010.
3. Sung JJ, Lau JY, Goh KL etal. Increasing incidence of colorectal cancer in Asia: implications for screening. Lancet Oncol. 2005; 6: 871-876.
4. Lynch HT, de la Chapelle A. Hereditary colorectal cancer. N. Engl. J. Med. 2003; 348: 919-932.
5. Heavey PM, McKenna D, Rowland IR. Colorectal cancer and the relationship between genes and the environment. Nutr. Cancer 2004; 48: 124-141.
6. Huang L, Durick K, Weiner JA etal. D-AKAP2, a novel protein kinase A anchoring protein with a putative RGS domain. Proc. Natl. Acad. Sci. U S A. 1997; 94: 11184-11189.
7. Wang L, Sunahara RK, Krumins A etal. Cloning and mitochondrial localization of full-length D-AKAP2, a protein kinase A anchoring protein. Proc. Natl. Acad. Sci. U S A. 2001; 98: 3220-3225.
8. Watson N, Linder ME, Druey KM etal. RGS family members: GTPase-activating proteins for heterotrimeric G-protein alpha-subunits. Nature 1996; 383: 172-175.
9. Wong W, Scott JD. AKAP signalling complexes: focal points in space and time. Nat. Rev. Mol. Cell Biol. 2004; 5: 959-971.
10. Skalhegg BS, Tasken K. Specificity in the cAMP/PKA signaling pathway. Differential expression, regulation, and subcellular localization of subunits of PKA. Front. Biosci. 2000; 5: 678-693.
11. Neary CL, Nesterova M, Cho YS etal. Protein kinase A isozyme switching: eliciting differential cAMP signaling and tumor reversion. Oncogene 2004; 23: 8847-8856.
12. Cross TG, Scheel-Toellner D, Henriquez NV etal. Serine/threonine protein kinases and apoptosis. Exp. Cell Res. 2000; 256: 34-41.
13. Cho YS, Park YG, Lee YN etal. Extracellular protein kinase A as a cancer biomarker: its expression by tumor cells and reversal by a myristatelacking Ca and RIIβ subunit overexpression. Proc. Natl. Acad. Sci. U S A. 2000; 97: 835-840.
14. Cho-Chung YS, Peep S, Clair T etal. cAMPdependent protein kinase: role in normal and malignant growth. Crit. Rev. Oncol. Hematol 1995; 21: 33-61.
15. Bradbury AW, Carter DC, Miller WR etal. Protein kinase A (PKA) regulatory subunit expression in colorectal cancer and related mucosa. Br. J. Cancer 1994; 69: 738-742.
16. Gordge PC, Hulme MJ, Clegg RA etal. Elevation of protein kinase A and protein kinase C activities in malignant as compared with normal human breast tissue. Eur. J. Cancer 1996; 32: 2120-2126.
17. Yee Sook C, Meyoung-Kon K, Langzhu T etal. Protein kinase A RIα antisense inhibition of PC3M prostate cancer cell growth: Bcl-2 hyperphosphorylation, Bax up-regulation, and Bad-hypophosphorylation. Clin. Cancer Res. 2002; 8: 607-614.
18. Nesterova MV, Johnson NR, Stewart T. CpG immunomer DNA enhances antisense protein kinase A RI alpha inhibition of multidrug-resistant colon carcinoma growth in nude mice: molecular basis for combinatorial therapy. Clin. Cancer Res. 2005; 11: 5950-5955.
19. Wang MJ, Zhou ZG, Wang L etal. The Ile646Val (2073A>G) polymorphism in the kinase-binding domain of A-kinase anchoring protein 10 and the risk of colorectal cancer. Oncology 2009; 76: 199-204.
20. Wang MJ, Zhang D, Wang R etal. A-kinase anchoring proteins 10 expression in relation to 2073A/G polymorphism and tumor progression in patients with colorectal cancer. Pathol. Oncol. Res. 2013; 19: 521-527.
21. Morikawa K, Walker SM, Nakajima M etal. Influence of organ environment on the growth, selection, and metastasis of human colon carcinoma cells in nude mice. Cancer Res. 1988; 48: 6863-6871.
22. Edge SB, Byrd DR, Carducci MA etal. AJCC Cancer Staging Manual, 7th edn. New York: Springer, 2010.
23. Wirtenberger M, Schmutzhard J, Hemminki1 K etal. The functional genetic variant Ile646Val located in the kinase binding domain of the A-kinase anchoring protein 10 is associated with familial breast cancer. Carcinogenesis 2007; 28: 423-426.
24. Nesterova MV, Johnson N, Cheadle C etal. Autoantibody cancer biomarker: extracellular protein kinase A. Cancer Res. 2006; 66: 8971-8974.
25. Hensley HH, Hannoun-Levi JM, Hachem P etal. PKA knockdown enhances cell killing in response to radiation and androgen deprivation. Int. J. Cancer 2011; 128: 962-973.
26. Wang H, Cai QY, Zeng XF etal. Antitumor activity and pharmacokinetics of a mixed-backbone antisense oligonucleotide targeted to the RIα subunit of protein kinase A after oral administration. Proc. Natl Acad. Sci. U S A. 1999; 96: 13989-13994.
27. Siddappa R, Mulder W, Steeghs I etal. cAMP/PKA signaling inhibits osteogenic differentiation and bone formation in rodent models. Tissue Eng. Par. A 2009; 15: 2135-2143.
28. Loilome W, Juntana S, Namwat N etal. PRKAR1A is overexpressed and represents a possible therapeutic target in human cholangiocarcinoma. Int. J. Cancer 2011; 129: 34-44.