A-kinase anchoring proteins 10 expression in relation to 2073A/G polymorphism and tumor progression in patients with colorectal cancer

Pathology and Oncology Research

Volumn 19, Issue 3, 2013, Pages 521-527

  Wang, Mojin ^a   Zhang, Dan ^a   Wang, Rui ^b   Rui, Yuanyi ^a   Zhou, Jin ^a   Wang, Rong ^a   Zhou, Bin ^a   Huang, Xiaoran ^b   Yang, Lie ^a   Li, Yuan ^a   Hu, Jiankun ^a   Zhou, Zongguang ^a   Sun, Xiaofeng ^c  

^a SICHUAN UNIVERSITY   (China)

^b SICHUAN UNIVERSITY   (China)

^c LINKÖPING UNIVERSITY   (Sweden)

Author keywords

A kinase anchoring proteins 10; Colorectal cancer; Immunohistochemical staining; Polymorphism; Western blot

Indexed keywords

CYCLIC AMP DEPENDENT PROTEIN KINASE ANCHORING PROTEIN; CYCLIC AMP DEPENDENT PROTEIN KINASE ANCHORING PROTEIN 10; UNCLASSIFIED DRUG; AKAP10 PROTEIN, HUMAN;

ADULT; ARTICLE; CANCER GROWTH; CANCER PATIENT; CANCER STAGING; CARCINOGENESIS; COHORT ANALYSIS; COLON MUCOSA; COLORECTAL ADENOMA; COLORECTAL CANCER; COLORECTAL SURGERY; CONTROLLED STUDY; FEMALE; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; RECTUM MUCOSA; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR DIFFERENTIATION; TUMOR INVASION; WESTERN BLOTTING; BIOSYNTHESIS; CHI SQUARE DISTRIBUTION; COLORECTAL TUMOR; DISEASE COURSE; GENETIC PREDISPOSITION; GENETICS; INTESTINE MUCOSA; METABOLISM; MIDDLE AGED; PATHOLOGY;

A KINASE ANCHOR PROTEINS; CHI-SQUARE DISTRIBUTION; COHORT STUDIES; COLORECTAL NEOPLASMS; DISEASE PROGRESSION; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; IMMUNOHISTOCHEMISTRY; INTESTINAL MUCOSA; MALE; MIDDLE AGED; POLYMORPHISM, GENETIC;

EID: 84880331411     PISSN: 12194956     EISSN: 15322807     Source Type: Journal    
DOI: 10.1007/s12253-013-9612-6     Document Type: Article

References (25)

1. Vogelstein B, Fearon ER, Hamilton SR, et al. (1988) Genetic alterations during colorectal-tumor development. N Engl J Med 319:525-532
2. Cho YS, Park YG, Lee YN, et al. (2000) Extracellular protein kinase A as a cancer biomarker: its expression by tumor cells and reversal by a myristatelacking Ca and RIIβ subunit overexpression. Proc Natl Acad Sci USA 97:835-840
3. Wong W, Scott JD (2004) AKAP signalling complexes: focal points in space and time. Nat Rev Mol Cell Biol 5:959-970
4. Huang L, Durick K, Weiner JA, Chun J, Taylor SS (1997) D-AKAP2, a novel protein kinase A anchoring protein with a putative RGS domain. Proc Natl Acad Sci USA 94:11184-11189
5. Hamuro Y, Burns L, Canaves J, Hoffman R, Taylor SS, Woods V (2002) Domain organization of D-AKAP2 revealed by enhanced deuterium exchange-mass spectrometry (DXMS). J Mol Biol 321:703-714
6. Sheng M, Sala C (2001) PDZ domains and the organization of supramolecular complexes. Annu Rev Neurosci 24:1-29
7. Wang L, Sunahara RK, Krumins A, et al. (2001) Cloning and mitochondrial localization of full-length D-AKAP2, a protein kinase A anchoring protein. Proc Natl Acad Sci USA 98:3220-3225
8. Burns-Hamuro LL, Barraclough DM, Taylor SS (2004) Identification and functional analysis of dual-specific A kinase-anchoring protein-2. Methods Enzymol 390:354-374
9. Neary CL, Nesterova M, Cho YS, Cheadle C, Becker KG, Cho-Chung YS (2004) Protein kinase A isozyme switching: eliciting differential cAMP signaling and tumor reversion. Oncogene 23:8847-8856
10. Cross TG, Scheel-Toellner D, Henriquez NV, Deacon E, Salmon M, Lord JM (2000) Serine/threonine protein kinases and apoptosis. Exp Cell Res 256:34-41
11. Tasken K, Skalhegg BS, Tasken KA, et al. (1997) Structure, function, and regulation of human cAMP-dependent protein kinases. Adv Second Messenger Phosphoprotein Res 31:191-204
12. Wirtenberger M, Schmutzhard J, Hemminkil K, et al. (2007) The functional genetic variant Ile646Val located in the kinase binding domain of the A-kinase anchoring protein 10 is associated with familial breast cancer. Carcinogenesis 28:423-426
13. Wang MJ, Zhou ZG, Wang L, et al. (2009) The Ile646Val (2073A>G) Polymorphism in the kinase-binding domain of A-kinase anchoring protein 10 and the risk of colorectal cancer. Oncology 76:199-204
14. Compton CC, Greene FL (2004) The staging of colorectal cancer: 2004 and beyond. CA Cancer J Clin 54:295-308
15. Yang L, Zhang H, Zhou ZG, Yan H, Adell G, Sun XF (2011) Biological function and prognostic significance of peroxisome proliferator-activated receptor δ in rectal cancer. Clin Cancer Res 17:3760-3770
16. Dodge-Kafka KL, Soughayer J, Pare GC, et al. (2005) The protein kinase A anchoring protein mAKAP coordinates two integrated cAMP effector pathways. Nature 437:574-578
17. Bradbury AW, Carter DC, Miller WR, Cho-Chung YS, Clair T (1994) Protein kinase A (PKA) regulatory subunit expression in colorectal cancer and related mucosa. Br J Cancer 69:738-742
18. Bold RJ, Alpard S, Ishizuka J, Townsend CM Jr, Thompson JC (1994) Growth-regulatory effect of gastrin on human colon cancer cell lines is determined by protein kinase a isoform content. Regul Pept 53:61-70
19. Nesterova MV, Johnson N, Cheadle C, et al. (2006) Autoantibody cancer biomarker: extracellular protein kinase A. Cancer Res 66:8971-8974
20. Hensley HH, Hannoun-Levi JM, Hachem P, et al. (2011) PKA knockdown enhances cell killing in response to radiation and androgen deprivation. Int J Cancer 128:962-973
21. Chen TC, Hinton DR, Zidovetzki R, Hofman FM (1998) Upregulation of the cAMP/PKA pathway inhibits proliferation, induces differentiation, and leads to apoptosis in malignant gliomas. Lab Invest 78:165-174
22. Siddappa R, Mulder W, Steeghs I, et al. (2009) cAMP/PKA signaling inhibits osteogenic differentiation and bone formation in rodent models. Tissue Eng Part A 15:2135-2143
23. Loniewska B, Clark JS, Kaczmarczyk M, et al. (2012) Possible counter effect in newborns of 1936A>G (I646V) polymorphism in the AKAP10 gene encoding A-kinase-anchoring protein 10. J Perinatol 32:230-234
24. Zukowski M, Bohatyrewicz R, Biernawska J, et al. (2009) Association of the A1936G (rs203462) of A-kinase anchoring protein 10 polymorphisms with QT interval prolongation during kidney transplantation. Transplant Proc 41:3036-3038
25. Kammerer S, Burns-Hamuro LL, Ma Y, et al. (2003) Amino acid variant in the kinase binding domain of dual-specific A kinase-anchoring protein 2: a disease susceptibility polymorphism. Proc Natl Acad Sci USA 100:4066-4071