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Volumn 50, Issue 16, 2014, Pages 2866-2876

A molecular model for the mechanism of acquired tamoxifen resistance in breast cancer

Author keywords

Focal adhesion molecules; Insulin like growth factor 1 receptor beta (IGF 1R ); Non genomic pathway; Resistance; Selective oestrogen receptor modulator (SERM)

Indexed keywords

AFIMOXIFENE; BAZEDOXIFENE; ENDOXIFEN; ESTROGEN RECEPTOR; ESTROGEN RECEPTOR ALPHA; FOCAL ADHESION KINASE; FULVESTRANT; INSULIN LIKE GROWTH FACTOR 1 RECEPTOR BETA; MESSENGER RNA; PROTEIN PS2; RALOXIFENE; RECEPTOR; STEROID RECEPTOR COACTIVATOR 3; UNCLASSIFIED DRUG; ESTROGEN; SELECTIVE ESTROGEN RECEPTOR MODULATOR; SOMATOMEDIN C RECEPTOR; TAMOXIFEN;

EID: 84923200015     PISSN: 09598049     EISSN: 18790852     Source Type: Journal    
DOI: 10.1016/j.ejca.2014.08.011     Document Type: Article
Times cited : (45)

References (47)
  • 1
    • 84903597977 scopus 로고    scopus 로고
    • Tamoxifen as the first targeted long-term adjuvant therapy for breast cancer
    • V.C. Jordan Tamoxifen as the first targeted long-term adjuvant therapy for breast cancer Endocr Relat Cancer 21 2014 R235 R246
    • (2014) Endocr Relat Cancer , vol.21 , pp. R235-R246
    • Jordan, V.C.1
  • 2
    • 85203363507 scopus 로고    scopus 로고
    • Relevance of breast cancer hormone receptors and other factors to the efficacy of adjuvant tamoxifen: Patient-level meta-analysis of randomised trials
    • C. Davies, J. Godwin, and R. Gray Relevance of breast cancer hormone receptors and other factors to the efficacy of adjuvant tamoxifen: patient-level meta-analysis of randomised trials Lancet 378 2011 771 784
    • (2011) Lancet , vol.378 , pp. 771-784
    • Davies, C.1    Godwin, J.2    Gray, R.3
  • 3
    • 84874745627 scopus 로고    scopus 로고
    • Long-term effects of continuing adjuvant tamoxifen to 10 years versus stopping at 5 years after diagnosis of oestrogen receptor-positive breast cancer: ATLAS, a randomised trial
    • C. Davies, H. Pan, and J. Godwin Long-term effects of continuing adjuvant tamoxifen to 10 years versus stopping at 5 years after diagnosis of oestrogen receptor-positive breast cancer: ATLAS, a randomised trial Lancet 381 2013 805 816
    • (2013) Lancet , vol.381 , pp. 805-816
    • Davies, C.1    Pan, H.2    Godwin, J.3
  • 4
    • 75749092296 scopus 로고    scopus 로고
    • Meta-analysis of breast cancer outcomes in adjuvant trials of aromatase inhibitors versus tamoxifen
    • M. Dowsett, J. Cuzick, and J. Ingle Meta-analysis of breast cancer outcomes in adjuvant trials of aromatase inhibitors versus tamoxifen J Clin Oncol 28 2010 509 518
    • (2010) J Clin Oncol , vol.28 , pp. 509-518
    • Dowsett, M.1    Cuzick, J.2    Ingle, J.3
  • 5
    • 34249936011 scopus 로고    scopus 로고
    • Efficacy of letrozole extended adjuvant therapy according to estrogen receptor and progesterone receptor status of the primary tumor: National Cancer Institute of Canada Clinical Trials Group MA.17
    • P.E. Goss, J.N. Ingle, and S. Martino Efficacy of letrozole extended adjuvant therapy according to estrogen receptor and progesterone receptor status of the primary tumor: National Cancer Institute of Canada Clinical Trials Group MA.17 J Clin Oncol 25 2007 2006 2011
    • (2007) J Clin Oncol , vol.25 , pp. 2006-2011
    • Goss, P.E.1    Ingle, J.N.2    Martino, S.3
  • 6
    • 0023760993 scopus 로고
    • Development of tamoxifen-stimulated growth of MCF-7 tumors in athymic mice after long-term antiestrogen administration
    • M.M. Gottardis, and V.C. Jordan Development of tamoxifen-stimulated growth of MCF-7 tumors in athymic mice after long-term antiestrogen administration Cancer Res 48 1988 5183 5187
    • (1988) Cancer Res , vol.48 , pp. 5183-5187
    • Gottardis, M.M.1    Jordan, V.C.2
  • 7
    • 0024316533 scopus 로고
    • Differential ability of antiestrogens to stimulate breast cancer cell (MCF-7) growth in vivo and in vitro
    • M.M. Gottardis, R.J. Wagner, E.C. Borden, and V.C. Jordan Differential ability of antiestrogens to stimulate breast cancer cell (MCF-7) growth in vivo and in vitro Cancer Res 49 1989 4765 4769
    • (1989) Cancer Res , vol.49 , pp. 4765-4769
    • Gottardis, M.M.1    Wagner, R.J.2    Borden, E.C.3    Jordan, V.C.4
  • 8
    • 0034066141 scopus 로고    scopus 로고
    • Antitumor action of physiological estradiol on tamoxifen-stimulated breast tumors grown in athymic mice
    • K. Yao, E.S. Lee, and D.J. Bentrem Antitumor action of physiological estradiol on tamoxifen-stimulated breast tumors grown in athymic mice Clin Cancer Res 6 2000 2028 2036
    • (2000) Clin Cancer Res , vol.6 , pp. 2028-2036
    • Yao, K.1    Lee, E.S.2    Bentrem, D.J.3
  • 9
    • 46449134193 scopus 로고    scopus 로고
    • The 38th David A. Karnofsky lecture: The paradoxical actions of estrogen in breast cancer-survival or death?
    • V.C. Jordan The 38th David A. Karnofsky lecture: the paradoxical actions of estrogen in breast cancer-survival or death? J Clin Oncol 26 2008 3073 3082
    • (2008) J Clin Oncol , vol.26 , pp. 3073-3082
    • Jordan, V.C.1
  • 10
    • 82755168809 scopus 로고    scopus 로고
    • Estrogen induces apoptosis in estrogen deprivation-resistant breast cancer through stress responses as identified by global gene expression across time
    • E.A. Ariazi, H.E. Cunliffe, and J.S. Lewis-Wambi Estrogen induces apoptosis in estrogen deprivation-resistant breast cancer through stress responses as identified by global gene expression across time Proc Natl Acad Sci USA 108 2011 18879 18886
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 18879-18886
    • Ariazi, E.A.1    Cunliffe, H.E.2    Lewis-Wambi, J.S.3
  • 11
    • 0019382847 scopus 로고
    • Randomized clinical trial of diethylstilbestrol versus tamoxifen in postmenopausal women with advanced breast cancer
    • J.N. Ingle, D.J. Ahmann, and S.J. Green Randomized clinical trial of diethylstilbestrol versus tamoxifen in postmenopausal women with advanced breast cancer N Engl J Med 304 1981 16 21
    • (1981) N Engl J Med , vol.304 , pp. 16-21
    • Ingle, J.N.1    Ahmann, D.J.2    Green, S.J.3
  • 12
    • 0037102126 scopus 로고    scopus 로고
    • Double-blind, randomized trial comparing the efficacy and tolerability of fulvestrant versus anastrozole in postmenopausal women with advanced breast cancer progressing on prior endocrine therapy: Results of a North American trial
    • C.K. Osborne, J. Pippen, and S.E. Jones Double-blind, randomized trial comparing the efficacy and tolerability of fulvestrant versus anastrozole in postmenopausal women with advanced breast cancer progressing on prior endocrine therapy: results of a North American trial J Clin Oncol 20 2002 3386 3395
    • (2002) J Clin Oncol , vol.20 , pp. 3386-3395
    • Osborne, C.K.1    Pippen, J.2    Jones, S.E.3
  • 13
    • 0037102121 scopus 로고    scopus 로고
    • Fulvestrant, formerly ICI 182,780, is as effective as anastrozole in postmenopausal women with advanced breast cancer progressing after prior endocrine treatment
    • A. Howell, J.F. Robertson, and J. Quaresma Albano Fulvestrant, formerly ICI 182,780, is as effective as anastrozole in postmenopausal women with advanced breast cancer progressing after prior endocrine treatment J Clin Oncol 20 2002 3396 3403
    • (2002) J Clin Oncol , vol.20 , pp. 3396-3403
    • Howell, A.1    Robertson, J.F.2    Quaresma Albano, J.3
  • 14
    • 28944444552 scopus 로고    scopus 로고
    • Intrinsic mechanism of estradiol-induced apoptosis in breast cancer cells resistant to estrogen deprivation
    • J.S. Lewis, K. Meeke, and C. Osipo Intrinsic mechanism of estradiol-induced apoptosis in breast cancer cells resistant to estrogen deprivation J Natl Cancer Inst 97 2005 1746 1759
    • (2005) J Natl Cancer Inst , vol.97 , pp. 1746-1759
    • Lewis, J.S.1    Meeke, K.2    Osipo, C.3
  • 15
    • 0035930095 scopus 로고    scopus 로고
    • Effect of long-term estrogen deprivation on apoptotic responses of breast cancer cells to 17beta-estradiol
    • R.X. Song, G. Mor, and F. Naftolin Effect of long-term estrogen deprivation on apoptotic responses of breast cancer cells to 17beta-estradiol J Natl Cancer Inst 93 2001 1714 1723
    • (2001) J Natl Cancer Inst , vol.93 , pp. 1714-1723
    • Song, R.X.1    Mor, G.2    Naftolin, F.3
  • 16
    • 68949102467 scopus 로고    scopus 로고
    • Lower-dose vs high-dose oral estradiol therapy of hormone receptor-positive, aromatase inhibitor-resistant advanced breast cancer: A phase 2 randomized study
    • M.J. Ellis, F. Gao, and F. Dehdashti Lower-dose vs high-dose oral estradiol therapy of hormone receptor-positive, aromatase inhibitor-resistant advanced breast cancer: a phase 2 randomized study JAMA 302 2009 774 780
    • (2009) JAMA , vol.302 , pp. 774-780
    • Ellis, M.J.1    Gao, F.2    Dehdashti, F.3
  • 17
    • 84860474009 scopus 로고    scopus 로고
    • Conjugated equine oestrogen and breast cancer incidence and mortality in postmenopausal women with hysterectomy: Extended follow-up of the Women's Health Initiative randomised placebo-controlled trial
    • G.L. Anderson, R.T. Chlebowski, and A.K. Aragaki Conjugated equine oestrogen and breast cancer incidence and mortality in postmenopausal women with hysterectomy: extended follow-up of the Women's Health Initiative randomised placebo-controlled trial Lancet Oncol 13 2012 476 486
    • (2012) Lancet Oncol , vol.13 , pp. 476-486
    • Anderson, G.L.1    Chlebowski, R.T.2    Aragaki, A.K.3
  • 18
    • 84880899869 scopus 로고    scopus 로고
    • C-Src modulates estrogen-induced stress and apoptosis in estrogen-deprived breast cancer cells
    • P. Fan, O.L. Griffith, and F.A. Agboke c-Src modulates estrogen-induced stress and apoptosis in estrogen-deprived breast cancer cells Cancer Res 73 2013 4510 4520
    • (2013) Cancer Res , vol.73 , pp. 4510-4520
    • Fan, P.1    Griffith, O.L.2    Agboke, F.A.3
  • 19
    • 84891828889 scopus 로고    scopus 로고
    • Inhibition of c-Src blocks oestrogen-induced apoptosis and restores oestrogen-stimulated growth in long-term oestrogen-deprived breast cancer cells
    • P. Fan, F.A. Agboke, and R.E. McDaniel Inhibition of c-Src blocks oestrogen-induced apoptosis and restores oestrogen-stimulated growth in long-term oestrogen-deprived breast cancer cells Eur J Cancer 50 2014 457 468
    • (2014) Eur J Cancer , vol.50 , pp. 457-468
    • Fan, P.1    Agboke, F.A.2    McDaniel, R.E.3
  • 20
    • 84908703414 scopus 로고    scopus 로고
    • Acquired resistance to selective estrogen receptor modulators (SERMs) in clinical practice (tamoxifen & raloxifene) by selection pressure in breast cancer cell populations
    • [Epub ahead of print]
    • P. Fan, and V.C. Jordan Acquired resistance to selective estrogen receptor modulators (SERMs) in clinical practice (tamoxifen & raloxifene) by selection pressure in breast cancer cell populations Steroids 2014 [Epub ahead of print]
    • (2014) Steroids
    • Fan, P.1    Jordan, V.C.2
  • 21
    • 84876260390 scopus 로고    scopus 로고
    • Molecular mechanism of action of bisphenol and bisphenol A mediated by oestrogen receptor alpha in growth and apoptosis of breast cancer cells
    • S. Sengupta, I. Obiorah, P.Y. Maximov, R. Curpan, and V.C. Jordan Molecular mechanism of action of bisphenol and bisphenol A mediated by oestrogen receptor alpha in growth and apoptosis of breast cancer cells Br J Pharmacol 169 2013 167 178
    • (2013) Br J Pharmacol , vol.169 , pp. 167-178
    • Sengupta, S.1    Obiorah, I.2    Maximov, P.Y.3    Curpan, R.4    Jordan, V.C.5
  • 22
    • 80053199540 scopus 로고    scopus 로고
    • The selective estrogen receptor modulator bazedoxifene inhibits hormone-independent breast cancer cell growth and down-regulates estrogen receptor α and cyclin D1
    • J.S. Lewis-Wambi, H. Kim, R. Curpan, R. Grigg, M.A. Sarker, and V.C. Jordan The selective estrogen receptor modulator bazedoxifene inhibits hormone-independent breast cancer cell growth and down-regulates estrogen receptor α and cyclin D1 Mol Pharmacol 80 2011 610 620
    • (2011) Mol Pharmacol , vol.80 , pp. 610-620
    • Lewis-Wambi, J.S.1    Kim, H.2    Curpan, R.3    Grigg, R.4    Sarker, M.A.5    Jordan, V.C.6
  • 23
    • 3342932419 scopus 로고    scopus 로고
    • Pharmacological characterization of 4-hydroxy-N-desmethyl tamoxifen, a novel active metabolite of tamoxifen
    • M.D. Johnson, H. Zuo, and K.H. Lee Pharmacological characterization of 4-hydroxy-N-desmethyl tamoxifen, a novel active metabolite of tamoxifen Breast Cancer Res Treat 85 2004 151 159
    • (2004) Breast Cancer Res Treat , vol.85 , pp. 151-159
    • Johnson, M.D.1    Zuo, H.2    Lee, K.H.3
  • 24
    • 0344931629 scopus 로고    scopus 로고
    • The interaction of raloxifene and the active metabolite of the antiestrogen EM-800 (SC 5705) with the human estrogen receptor
    • J.I. Schafer, H. Liu, D.A. Tonetti, and V.C. Jordan The interaction of raloxifene and the active metabolite of the antiestrogen EM-800 (SC 5705) with the human estrogen receptor Cancer Res 59 1999 4308 4313
    • (1999) Cancer Res , vol.59 , pp. 4308-4313
    • Schafer, J.I.1    Liu, H.2    Tonetti, D.A.3    Jordan, V.C.4
  • 25
    • 0034614098 scopus 로고    scopus 로고
    • Oxidative stress and AP-1 activity in tamoxifen-resistant breast tumors in vivo
    • R. Schiff, P. Reddy, and M. Ahotupa Oxidative stress and AP-1 activity in tamoxifen-resistant breast tumors in vivo J Natl Cancer Inst 92 2000 1926 1934
    • (2000) J Natl Cancer Inst , vol.92 , pp. 1926-1934
    • Schiff, R.1    Reddy, P.2    Ahotupa, M.3
  • 26
    • 0037192501 scopus 로고    scopus 로고
    • Molecular determinants for the tissue specificity of SERMs
    • Y. Shang, and M. Brown Molecular determinants for the tissue specificity of SERMs Science 295 2002 2465 2468
    • (2002) Science , vol.295 , pp. 2465-2468
    • Shang, Y.1    Brown, M.2
  • 27
    • 13444262274 scopus 로고    scopus 로고
    • Identification of target genes in breast cancer cells directly regulated by the SRC-3/AIB1 coactivator
    • P. Labhart, S. Karmakar, and E.M. Salicru Identification of target genes in breast cancer cells directly regulated by the SRC-3/AIB1 coactivator Proc Natl Acad Sci USA 102 2005 1339 1344
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 1339-1344
    • Labhart, P.1    Karmakar, S.2    Salicru, E.M.3
  • 28
    • 1242341918 scopus 로고    scopus 로고
    • The role of Shc and insulin-like growth factor 1 receptor in mediating the translocation of estrogen receptor alpha to the plasma membrane
    • R.X. Song, C.J. Barnes, Z. Zhang, Y. Bao, R. Kumar, and R.J. Santen The role of Shc and insulin-like growth factor 1 receptor in mediating the translocation of estrogen receptor alpha to the plasma membrane Proc Natl Acad Sci USA 101 2004 2076 2081
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 2076-2081
    • Song, R.X.1    Barnes, C.J.2    Zhang, Z.3    Bao, Y.4    Kumar, R.5    Santen, R.J.6
  • 29
    • 33847023585 scopus 로고    scopus 로고
    • Long-term treatment with tamoxifen facilitates translocation of estrogen receptor alpha out of the nucleus and enhances its interaction with EGFR in MCF-7 breast cancer cells
    • P. Fan, J. Wang, R.J. Santen, and W. Yue Long-term treatment with tamoxifen facilitates translocation of estrogen receptor alpha out of the nucleus and enhances its interaction with EGFR in MCF-7 breast cancer cells Cancer Res 67 2007 1352 1360
    • (2007) Cancer Res , vol.67 , pp. 1352-1360
    • Fan, P.1    Wang, J.2    Santen, R.J.3    Yue, W.4
  • 30
    • 67349143116 scopus 로고    scopus 로고
    • Dual targeting of Src and ER prevents acquired antihormone resistance in breast cancer cells
    • S. Hiscox, N.J. Jordan, and C. Smith Dual targeting of Src and ER prevents acquired antihormone resistance in breast cancer cells Breast Cancer Res Treat 115 2009 57 67
    • (2009) Breast Cancer Res Treat , vol.115 , pp. 57-67
    • Hiscox, S.1    Jordan, N.J.2    Smith, C.3
  • 31
    • 59349115555 scopus 로고    scopus 로고
    • Mislocalization of cell-cell adhesion complexes in tamoxifen-resistant breast cancer cells with elevated c-Src tyrosine kinase activity
    • Y. Zhao, and M.D. Planas-Silva Mislocalization of cell-cell adhesion complexes in tamoxifen-resistant breast cancer cells with elevated c-Src tyrosine kinase activity Cancer Lett 275 2009 204 212
    • (2009) Cancer Lett , vol.275 , pp. 204-212
    • Zhao, Y.1    Planas-Silva, M.D.2
  • 32
    • 84869489330 scopus 로고    scopus 로고
    • Modulating therapeutic effects of the c-Src inhibitor via oestrogen receptor and human epidermal growth factor receptor 2 in breast cancer cell lines
    • P. Fan, R.E. McDaniel, H.R. Kim, D. Clagett, B. Haddad, and V.C. Jordan Modulating therapeutic effects of the c-Src inhibitor via oestrogen receptor and human epidermal growth factor receptor 2 in breast cancer cell lines Eur J Cancer 48 2012 3488 3498
    • (2012) Eur J Cancer , vol.48 , pp. 3488-3498
    • Fan, P.1    McDaniel, R.E.2    Kim, H.R.3    Clagett, D.4    Haddad, B.5    Jordan, V.C.6
  • 33
    • 0024319781 scopus 로고
    • Inhibition of tamoxifen-stimulated growth of an MCF-7 tumor variant in athymic mice by novel steroidal antiestrogens
    • M.M. Gottardis, S.Y. Jiang, M.H. Jeng, and V.C. Jordan Inhibition of tamoxifen-stimulated growth of an MCF-7 tumor variant in athymic mice by novel steroidal antiestrogens Cancer Res 49 1989 4090 4093
    • (1989) Cancer Res , vol.49 , pp. 4090-4093
    • Gottardis, M.M.1    Jiang, S.Y.2    Jeng, M.H.3    Jordan, V.C.4
  • 34
    • 0034490211 scopus 로고    scopus 로고
    • Cross-resistance of triphenylethylene-type antiestrogens but not ICI 182,780 in tamoxifen-stimulated breast tumors grown in athymic mice
    • E.S. Lee, J.M. Schafer, and K. Yao Cross-resistance of triphenylethylene-type antiestrogens but not ICI 182,780 in tamoxifen-stimulated breast tumors grown in athymic mice Clin Cancer Res 6 2000 4893 4899
    • (2000) Clin Cancer Res , vol.6 , pp. 4893-4899
    • Lee, E.S.1    Schafer, J.M.2    Yao, K.3
  • 35
    • 84877091558 scopus 로고    scopus 로고
    • Bazedoxifene exhibits antiestrogenic activity in animal models of tamoxifen-resistant breast cancer: Implications for treatment of advanced disease
    • S.E. Wardell, E.R. Nelson, C.A. Chao, and D.P. McDonnell Bazedoxifene exhibits antiestrogenic activity in animal models of tamoxifen-resistant breast cancer: implications for treatment of advanced disease Clin Cancer Res 19 2013 2420 2431
    • (2013) Clin Cancer Res , vol.19 , pp. 2420-2431
    • Wardell, S.E.1    Nelson, E.R.2    Chao, C.A.3    McDonnell, D.P.4
  • 36
    • 34047274789 scopus 로고    scopus 로고
    • Role for HER2/neu and HER3 in fulvestrant-resistant breast cancer
    • C. Osipo, K. Meeke, and D. Cheng Role for HER2/neu and HER3 in fulvestrant-resistant breast cancer Int J Oncol 30 2007 509 520
    • (2007) Int J Oncol , vol.30 , pp. 509-520
    • Osipo, C.1    Meeke, K.2    Cheng, D.3
  • 37
    • 0041736202 scopus 로고    scopus 로고
    • Oestrogen receptor-mediated modulation of the EGFR/MAPK pathway in tamoxifen-resistant MCF-7 cells
    • I.R. Hutcheson, J.M. Knowlden, and T.A. Madden Oestrogen receptor-mediated modulation of the EGFR/MAPK pathway in tamoxifen-resistant MCF-7 cells Breast Cancer Res Treat 81 2003 81 93
    • (2003) Breast Cancer Res Treat , vol.81 , pp. 81-93
    • Hutcheson, I.R.1    Knowlden, J.M.2    Madden, T.A.3
  • 38
    • 33746883110 scopus 로고    scopus 로고
    • Physical and functional interactions between Cas and c-Src induce tamoxifen resistance of breast cancer cells through pathways involving epidermal growth factor receptor and signal transducer and activator of transcription 5b
    • R.B. Riggins, K.S. Thomas, and H.Q. Ta Physical and functional interactions between Cas and c-Src induce tamoxifen resistance of breast cancer cells through pathways involving epidermal growth factor receptor and signal transducer and activator of transcription 5b Cancer Res 66 2006 7007 7015
    • (2006) Cancer Res , vol.66 , pp. 7007-7015
    • Riggins, R.B.1    Thomas, K.S.2    Ta, H.Q.3
  • 39
    • 38849091433 scopus 로고    scopus 로고
    • Tamoxifen resistance in breast tumors is driven by growth factor receptor signaling with repression of classic estrogen receptor genomic function
    • S. Massarweh, C.K. Osborne, and C.J. Creighton Tamoxifen resistance in breast tumors is driven by growth factor receptor signaling with repression of classic estrogen receptor genomic function Cancer Res 68 2008 826 833
    • (2008) Cancer Res , vol.68 , pp. 826-833
    • Massarweh, S.1    Osborne, C.K.2    Creighton, C.J.3
  • 40
    • 26844487041 scopus 로고    scopus 로고
    • Insulin-like growth factor-I receptor signaling in tamoxifen-resistant breast cancer: A supporting role to the epidermal growth factor receptor
    • J.M. Knowlden, I.R. Hutcheson, D. Barrow, J.M. Gee, and R.I. Nicholson Insulin-like growth factor-I receptor signaling in tamoxifen-resistant breast cancer: a supporting role to the epidermal growth factor receptor Endocrinology 146 2005 4609 4618
    • (2005) Endocrinology , vol.146 , pp. 4609-4618
    • Knowlden, J.M.1    Hutcheson, I.R.2    Barrow, D.3    Gee, J.M.4    Nicholson, R.I.5
  • 41
    • 84863584930 scopus 로고    scopus 로고
    • Acquired resistance to tamoxifen is associated with loss of the type i insulin-like growth factor receptor: Implications for breast cancer treatment
    • D.H. Fagan, R.R. Uselman, D. Sachdev, and D. Yee Acquired resistance to tamoxifen is associated with loss of the type I insulin-like growth factor receptor: implications for breast cancer treatment Cancer Res 72 2012 3372 3380
    • (2012) Cancer Res , vol.72 , pp. 3372-3380
    • Fagan, D.H.1    Uselman, R.R.2    Sachdev, D.3    Yee, D.4
  • 42
    • 0033305004 scopus 로고    scopus 로고
    • Enhancement of insulin-like growth factor signaling in human breast cancer: Estrogen regulation of insulin receptor substrate-1 expression in vitro and in vivo
    • A.V. Lee, J.G. Jackson, and J.L. Gooch Enhancement of insulin-like growth factor signaling in human breast cancer: estrogen regulation of insulin receptor substrate-1 expression in vitro and in vivo Mol Endocrinol 13 1999 787 796
    • (1999) Mol Endocrinol , vol.13 , pp. 787-796
    • Lee, A.V.1    Jackson, J.G.2    Gooch, J.L.3
  • 43
    • 79952135852 scopus 로고    scopus 로고
    • The IGF pathway regulates ERα through a S6K1-dependent mechanism in breast cancer cells
    • M.A. Becker, Y.H. Ibrahim, X. Cui, A.V. Lee, and D. Yee The IGF pathway regulates ERα through a S6K1-dependent mechanism in breast cancer cells Mol Endocrinol 25 2011 516 528
    • (2011) Mol Endocrinol , vol.25 , pp. 516-528
    • Becker, M.A.1    Ibrahim, Y.H.2    Cui, X.3    Lee, A.V.4    Yee, D.5
  • 44
    • 80054921787 scopus 로고    scopus 로고
    • Changes in breast cancer biomarkers in the IGF1R/PI3K pathway in recurrent breast cancer after tamoxifen treatment
    • S.C. Drury, S. Detre, and A. Leary Changes in breast cancer biomarkers in the IGF1R/PI3K pathway in recurrent breast cancer after tamoxifen treatment Endocr Relat Cancer 18 2011 565 577
    • (2011) Endocr Relat Cancer , vol.18 , pp. 565-577
    • Drury, S.C.1    Detre, S.2    Leary, A.3
  • 45
    • 84885976825 scopus 로고    scopus 로고
    • Combating resistance to anti-IGFR antibody by targeting the integrin β3-Src pathway
    • D.H. Shin, H.J. Lee, and H.Y. Min Combating resistance to anti-IGFR antibody by targeting the integrin β3-Src pathway J Natl Cancer Inst 105 2013 1558 1570
    • (2013) J Natl Cancer Inst , vol.105 , pp. 1558-1570
    • Shin, D.H.1    Lee, H.J.2    Min, H.Y.3
  • 46
    • 84880263301 scopus 로고    scopus 로고
    • Models and mechanisms of acquired antihormone resistance in breast cancer: Significant clinical progress despite limitations
    • E.E. Sweeney, R.E. McDaniel, P.Y. Maximov, P. Fan, and V.C. Jordan Models and mechanisms of acquired antihormone resistance in breast cancer: significant clinical progress despite limitations Horm Mol Biol Clin Investig 9 2012 143 163
    • (2012) Horm Mol Biol Clin Investig , vol.9 , pp. 143-163
    • Sweeney, E.E.1    McDaniel, R.E.2    Maximov, P.Y.3    Fan, P.4    Jordan, V.C.5
  • 47
    • 0030802967 scopus 로고    scopus 로고
    • MCF-7: The first hormone-responsive breast cancer cell line
    • A.S. Levenson, and V.C. Jordan MCF-7: the first hormone-responsive breast cancer cell line Cancer Res 57 1997 3071 3078
    • (1997) Cancer Res , vol.57 , pp. 3071-3078
    • Levenson, A.S.1    Jordan, V.C.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.