Obesity and metabolomics: Metallothioneins protect against high-fat diet-induced consequences in metallothionein knockout mice

OMICS A Journal of Integrative Biology

Volumn 19, Issue 2, 2015, Pages 92-103

  Lindeque, Jeremie Z ^a   Van Rensburg, Peet J Jansen ^a   Louw, Roan ^a   Van Der Westhuizen, Francois H ^a   Florit, Sergi ^b   Ramírez, Lorena ^b   Giralt, Mercedes ^b   Hidalgo, Juan ^b  

^a NORTH WEST UNIVERSITY   (South Africa)

^b INSTITUT DE NEUROCIÈNCIES   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

METALLOTHIONEIN; GLUCOSE BLOOD LEVEL; INSULIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN METABOLISM; BRAIN TISSUE; CONTROLLED STUDY; FEMALE; INSULIN RESISTANCE; INSULIN TOLERANCE TEST; LIPID DIET; MALE; METABOLOME; METABOLOMICS; MITOCHONDRION; MOUSE; NONHUMAN; OBESITY; ORAL GLUCOSE TOLERANCE TEST; PHENOTYPE; PRIORITY JOURNAL; PROTEIN FUNCTION; WEIGHT GAIN; ADIPOSE TISSUE; ANATOMY AND HISTOLOGY; ANIMAL; BODY WEIGHT; BRAIN CORTEX; DISEASE MODEL; GENETICS; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE TEST; KNOCKOUT MOUSE; METABOLISM; PROCEDURES;

MUS;

ADIPOSE TISSUE; ANIMALS; BLOOD GLUCOSE; BODY WEIGHT; CEREBRAL CORTEX; DIET, HIGH-FAT; DISEASE MODELS, ANIMAL; FEMALE; GLUCOSE TOLERANCE TEST; INSULIN; INSULIN RESISTANCE; MALE; METABOLOME; METABOLOMICS; METALLOTHIONEIN; MICE; MICE, KNOCKOUT; OBESITY;

EID: 84923172132     PISSN: 15362310     EISSN: 15578100     Source Type: Journal    
DOI: 10.1089/omi.2014.0087     Document Type: Article

References (40)

1. Ahola-ErkkilaS, Carroll CJ, Peltola-Mjosund K, et al. (2010). Ketogenic diet slows down mitochondrial myopathy progression in mice. Hum Mol Genet 19, 1974-1984.
2. Beattie JH, Wood AM, Newman AM, et al. (1998). Obesity and hyperleptinemia in metallothionein (-I and-II) null mice. Proc Natl Acad Sci USA 95, 358-363.
3. Brown AM, Kristal BS, Eeffron MS, et al. (2000). Zn2 + inhibits alpha-ketoglutarate-stimulated mitochondrial respirationand the isolated alpha-ketoglutarate dehydrogenase complex. J Biol Chem 275, 13441-13447.
4. Byun HR, Kim DK, and Koh JY. (2011). Obesity and downregulated hypothalamic leptin receptors in male metallothionein-3-null mice. Neurobiol Dis 44, 125-132.
5. Carrasco J, Penkowa M, Hadberg H, Molinero A, and Hidalgo J. (2000). Enhanced seizures and hippocampal neurodegeneration following kainic acid-induced seizures in metallothioneins-I + II deficient mice. Eur J Neurosci 12, 2311-2322.
6. Carrasco J, Penkowa M, Giralt M, et al. (2003). Role of metallothionein-III following central nervous system damage. J Neurobiol Dis 13, 22-36.
7. Ciapaite J, van den Broek NM, Te Brinke H, et al. (2011). Differential effects of short-And long-Term high-fat diet feeding on hepatic fatty acid metabolism in rats. Biochim Biophys Acta 1811, 441-451.
8. Connor SC, Hansen MK, Corner A, Smith RF, and Ryan TE. (2010). Integration of metabolomics and transcriptomics data to aid biomarker discovery in type 2 diabetes. Mol Biosyst 6, 909-921.
9. Dineley KE, Votyakova TV, and Reynolds IJ. (2003). Zinc inhibition of cellular energy production: Implications for mitochondria and neurodegeneration. J Neurochem 85, 563-570.
10. Dong F, Li Q, Sreejayan N, Nunn JM, and Ren J. (2007). Metallothionein prevents high-fat diet induced cardiac contractile dysfunction: Role of peroxisome proliferator activated receptor gamma coactivator 1alpha and mitochondrial biogenesis. Diabetes 56, 2201-2212.
11. Dumas J, Simard G, Flamment M, Ducluzeau P, and Ritz P. (2009). Is skeletal muscle mitochondrial dysfunction a cause or an indirect consequence of insulin resistance in humans? Diabetes Metab J35, 159-167.
12. Dupuy J, Darnault C, Brazzolotto X, et al. (2005). Crystallization and preliminary X-ray diffraction data for theaconitase form of human iron-regulatory protein 1. Acta Crystallogr F 61, 482-485.
13. Fisher-Wellman KH, and Neufer PD. (2012). Linking mitochondrial bioenergetics to insulin resistance via redox biology. Trends Endocrinol Metab 23, 142-153.
14. Giacconi R, Bonfigli AR, Testa R, et al. (2008). + 647 A/C and + 1245 MT1A polymorphisms in the susceptibility of diabetes mellitus and cardiovascular complications. Mol Genet Metab 94, 98-104.
15. Haynes V, Connor T, Tchernof A, Vidal H, and Dubols S. (2012). Metallothionein 2a gene expression is increased in subcutaneous adipose tissue of type 2 diabetic patients. Mol Genet Metab 108, 90-94.
16. Ivanina AV, Cherasov AS, and Sokolova IM. (2008). Effects of cadmium on cellular protein and glutathione synthesis and expression of stress proteins in eastern oysters, Crassostrea virginica gmelin. J Exp Biol 211, 577-586.
17. Jiang L, Maret W, and Vallee BL. (1998) the glutathione redox couple modulates zinc transfer frommetallothionein to zinc-depleted sorbitol dehydrogenase. Proc Natl Acad Sci USA 95, 3483-3488.
18. Kelley DE, He J, Menshikova EV and Ritov VB. (2002). Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes. Diabetes 51, 2944-2950.
19. Kim HJ, Kim JH, Noh S, et al. (2011). Metabolomic analysis of livers and serum from high-fat diet induced obese mice. J Proteome Res 10, 722-731.
20. Kleinridders A, Lauritzen HPMM, Ussar S, et al. (2013). Leptin regulation of Hsp60 impacts hypothalamic insulin signaling. J Clin Invest 123, 4667-4680.
21. Kurbat M, and Lelevich V. (2009). Metabolism of amino acids in the brain. Neurochem J 3, 23-28.
22. Li LO, Hu YF, Wang L, Mitchell M, Berger A, and Coleman RA. (2010). Early hepatic insulin resistance in mice: A metabolomics analysis. Mol Endocrinol 24, 657-666.
23. Lindeque JZ, Levanets O, Louw R, and van der Westhuizen FH. (2010) the involvement of metallothioneins in mitochondrial function and disease. Curr Protein Pept Sci 11, 292-309.
24. Lindeque JZ, Hidalgo J, Louw R, and van der Westhuizen FH. (2013). Systemic and organ specific metabolic variation in metallothionein knockout mice challenged with swimming exercise. Metabolomics 9, 418-432.
25. Maret W, Jacob C, Vallee BL, and Fischer EH. (1999). Inhibitory sites in enzymes: Zinc removal and reactivation by thionein. Proc Natl Acad Sci USA 96, 1936-1940.
26. Maret W, Yetman CA, and Jiang L. (2001). Enzyme regulation by reversible zinc inhibition:glycerol phosphate dehydrogenase as anexample. Chem-Biol Interact 130-132, 891-901.
27. Mochel F, Slama A, Touati G, et al. (2005). Respiratory chain defects may present only with hypoglycaemia. J Clin Endocrinol Metab 90, 3780-3785.
28. Pomytkin IA. (2012). H2O2 signalling pathway: A possible bridge between insulin receptor and mitochondria. Curr Neuropharmacol 10: 311-320.
29. Reinecke F, Levanets O, Olivier Y, et al. (2006). Metallothionein isoform 2A expression is inducible and protects against ROS-mediated cell death in rotenone-Treated HeLa cells. Biochem J 395, 405-415.
30. Reinecke CJ, Koekemoer G, van der Westhuizen FH, et al. (2012). Metabolomics of urinary organic acids in respiratory chain deficiencies in children. Metabolomics 8, 264-283.
31. Rofe AM, Philcox JC, and Coyle P. (2000). Activation of glycolysis by zinc is diminished in hepatocytes from metallothionein-null mice. Biol Trace Elem Res 75, 87-97.
32. Sato M, Kawakami T, Kondoh M, et al. (2010). Development of high-fat-diet-induced obesity in female metallothionein-null mice. FASEB J 24, 2375-2384.
33. Schrauwen P, van Marken Lichtenbelt W, Saris W, and Westerterp K. (1997). Changes in fat oxidation in response to a high-fat diet. Am J Clin Nutr 66, 276-282.
34. Shaham O, Slate NG, Goldberger O, et al. (2010). A plasma signature of human mitochondrial disease revealed through metabolic profiling of spent media from cultured muscle cells. Proc Natl Acad Sci USA 107, 1571-1575.
35. Smith SR, De Jonge L, Zachwieja JJ, et al. (2000). Fat and carbohydrate balances during adaptation to a high-fat. Am J Clin Nutr 71, 450-457.
36. Thaler JP, Yi CX, Schur EA, et al. (2012). Obesity is associated with hypothalamic injury in rodents and humans. J Clin Invest 122, 156-162.
37. Vial G, Dubouchaud H, Couturier K, et al. (2011). Effects of a high-fat diet on energy metabolism and ROS production in rat liver. J Hepatol 54, 348-356.
38. Wang Y, Feng W, Xue W, et al. (2009). Inactivation of GSK-3b by metallothioneins prevents diabetes-related changes in cardiac energy metabolism, inflammation, nitrosative damage, and remodeling. Diabetes 58, 1391-1402.
39. West AK, Hidalgo J, Eddins D, Levin ED, and Aschner M. (2008). Metallothionein in the central nervous system: Roles in protection, regeneration and cognition. Neurotoxicology 29, 489-503.
40. Xu Y, and Goodacre R. (2012). Multiblock principal component analysis: An efficient tool for analyzing metabolomics data which contain two influential factors. Metabolomics 8, 37-51.