Protein Surface Softness Is the Origin of Enzyme Cold-Adaptation of Trypsin

PLoS Computational Biology

Volumn 10, Issue 8, 2014, Pages

  Isaksen, Geir Villy ^a   Åqvist, Johan ^b   Brandsdal, Bjørn Olav ^a  

^a UNIVERSITY OF TROMSØ   (Norway)

^b UPPSALA UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION ANALYSIS; ARRHENIUS PLOTS; BIOLOGY; CATALYST ACTIVITY; CHEMICAL ACTIVATION; ENTHALPY; ENZYMES; FREE ENERGY; GIBBS FREE ENERGY; MOLECULAR DYNAMICS; REACTION RATES; TEMPERATURE DISTRIBUTION;

% REDUCTIONS; ACTIVATION ENTHALPY AND ENTROPIES; CATALYTIC EFFICIENCIES; COLD-ACTIVE ENZYMES; CONDITION; HIGH SPECIFIC ACTIVITIES; LOWS-TEMPERATURES; MESOPHILIC; PROTEIN SURFACE; REACTIONS RATES;

ENTROPY;

TRYPSIN;

ARTICLE; COLD ACCLIMATIZATION; ENTHALPY; ENTROPY; ENZYME ACTIVATION; ENZYME ACTIVITY; LOW TEMPERATURE; MOLECULAR DYNAMICS; POINT MUTATION; PROTEIN EXPRESSION; REDUCTION KINETICS; STRUCTURE ANALYSIS; SURFACE PROPERTY; TEMPERATURE DEPENDENCE; TEMPERATURE SENSITIVITY; BIOLOGY; CHEMISTRY; COLD; GENETICS; METABOLISM; MUTATION; PROTEIN STABILITY; THERMODYNAMICS;

COLD TEMPERATURE; COMPUTATIONAL BIOLOGY; MOLECULAR DYNAMICS SIMULATION; MUTATION; PROTEIN STABILITY; SURFACE PROPERTIES; THERMODYNAMICS; TRYPSIN;

EID: 84923152178     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.1003813     Document Type: Article

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