Measuring the effects of aging and sex on regional brain stiffness with MR elastography in healthy older adults

NeuroImage

Volumn 111, Issue , 2015, Pages 59-64

  Arani, Arvin ^a   Murphy, Matthew C ^a   Glaser, Kevin J ^a   Manduca, Armando ^b   Lake, David S ^b   Kruse, Scott A ^a   Jack, Clifford R ^a   Ehman, Richard L ^a   Huston, John ^a  

^a MAYO CLINIC   (United States)

^b MAYO GRADUATE SCHOOL   (United States)

Author keywords

Aging; Brain MRE; Brain stiffness; Elastography; Gender bias; Sexual dimorphism

Indexed keywords

ADULT; AGED; AGING; ARTICLE; BIOMECHANICS; BRAIN; BRAIN FUNCTION; BRAIN REGION; BRAIN STIFFNESS; CEREBELLUM; CONTROLLED STUDY; ELASTOGRAPHY; FEMALE; FRONTAL LOBE; GRAY MATTER; HUMAN; HUMAN EXPERIMENT; IMAGE ANALYSIS; IMAGE PROCESSING; INSULA; MAGNETIC RESONANCE ELASTOGRAPHY; MALE; NORMAL HUMAN; OCCIPITAL LOBE; PARIETAL LOBE; RIGIDITY; SENSORIMOTOR CORTEX; SEX DIFFERENCE; TEMPORAL LOBE; VERY ELDERLY; WHITE MATTER; AGE; MIDDLE AGED; NUCLEAR MAGNETIC RESONANCE IMAGING; PHYSIOLOGY; PROCEDURES;

AGE FACTORS; AGED; AGED, 80 AND OVER; AGING; BIOMECHANICAL PHENOMENA; CEREBELLUM; CEREBRUM; ELASTICITY IMAGING TECHNIQUES; FEMALE; GRAY MATTER; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; SEX FACTORS; WHITE MATTER;

EID: 84923112379     PISSN: 10538119     EISSN: 10959572     Source Type: Journal    
DOI: 10.1016/j.neuroimage.2015.02.016     Document Type: Article

References (34)

1. Allen J.S., Damasio H., Grabowski T.J., Bruss J., Zhang W. Sexual dimorphism and asymmetries in the gray-white composition of the human cerebrum. NeuroImage 2003, 18:880-894.
2. Allen J.S., Bruss J., Brown C.K., Damasio H. Normal neuroanatomical variation due to age: the major lobes and a parcellation of the temporal region. Neurobiol. Aging 2005, 26:1245-1260.
3. Ashburner J., Friston K.J. Unified segmentation. NeuroImage 2005, 26:839-851.
4. Bao A.M., Swaab D.F. Sex differences in the brain, behavior, and neuropsychiatric disorders. Neuroscientist 2010, 16:550-565.
5. Baron-Cohen S., Lombardo M.V., Auyeung B., Ashwin E., Chakrabarti B., Knickmeyer R. Why are autism spectrum conditions more prevalent in males?. PLoS Biol. 2011, 9:e1001081.
6. Filipek P.A., Richelme C., Kennedy D.N., Caviness V.S. The young adult human brain: an MRI-based morphometric analysis. Cereb. Cortex 1994, 4:344-360.
7. Finan J.D., Elkin B.S., Pearson E.M., Kalbian I.L., Morrison B. Viscoelastic properties of the rat brain in the sagittal plane: effects of anatomical structure and age. Ann. Biomed. Eng. 2012, 40:70-78.
8. Gefen A., Gefen N., Zhu Q., Raghupathi R., Margulies S.S. Age-dependent changes in material properties of the brain and braincase of the rat. J. Neurotrauma 2003, 20:1163-1177.
9. Goldstein J.M., Seidman L.J., Horton N.J., Makris N., Kennedy D.N., Caviness V.S., Faraone S.V., Tsuang M.T. Normal sexual dimorphism of the adult human brain assessed by in vivo magnetic resonance imaging. Cereb. Cortex 2001, 11:490-497.
10. Good C.D., Johnsrude I.S., Ashburner J., Henson R.N.A., Friston K.J., Frackowiak R.S.J. A voxel-based morphometric study of ageing in 465 normal adult human brains. NeuroImage 2001, 14:21-36.
11. Guo J., Hirsch S., Fehlner A., Papazoglou S., Scheel M., Braun J., Sack I. Towards an elastographic atlas of brain anatomy. PLoS One 2013, 8:e71807.
12. Gur R.C., Turetsky B.I., Matsui M., Yan M., Bilker W., Hughett P., Gur R.E. Sex differences in brain gray and white matter in healthy young adults: correlations with cognitive performance. J. Neurosci. 1999, 19:4065-4072.
13. Huse J.T., Holland E.C. Targeting brain cancer: advances in the molecular pathology of malignant glioma and medulloblastoma. Nat. Rev. Cancer 2010, 10:319-331.
14. Jack C.R., Wiste H.J., Vemuri P., Weigand S.D., Senjem M.L., Zeng G., Bernstein M.A., Gunter J.L., Pankratz V.S., Aisen P.S., Weiner M.W., Petersen R.C., Shaw L.M., Trojanowski J.Q., Knopman D.S. Brain beta-amyloid measures and magnetic resonance imaging atrophy both predict time-to-progression from mild cognitive impairment to Alzheimer's disease. Brain 2010, 133:3336-3348.
15. Johnson C.L., McGarry M.D., Gharibans A.A., Weaver J.B., Paulsen K.D., Wang H., Olivero W.C., Sutton B.P., Georgiadis J.G. Local mechanical properties of white matter structures in the human brain. NeuroImage 2013, 79:145-152.
16. McKhann G.M., Knopman D.S., Chertkow H., Hyman B.T., Jack C.R., Kawas C.H., Klunk W.E., Koroshetz W.J., Manly J.J., Mayeux R., Mohs R.C., Morris J.C., Rossor M.N., Scheltens P., Carrillo M.C., Thies B., Weintraub S., Phelps C.H. The diagnosis of dementia due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement. 2011, 7:263-269.
17. Murphy M.C., Huston J., Jack C.R., Glaser K.J., Manduca A., Felmlee J.P., Ehman R.L. Decreased brain stiffness in Alzheimer's disease determined by magnetic resonance elastography. J. Magn. Reson. Imaging 2011, 34:494-498.
18. Murphy M.C., Huston J., Jack C.R., Glaser K.J., Senjem M.L., Chen J., Manduca A., Felmlee J.P., Ehman R.L. Measuring the characteristic topography of brain stiffness with magnetic resonance elastography. PLoS One 2013, 8:e81668.
19. Pittock S.J., Lucchinetti C.F. The pathology of MS: new insights and potential clinical applications. Neurologist 2007, 13:45-56.
20. Qin E.C., Sinkus R., Geng G.Q., Cheng S., Green M., Rae C.D., Bilston L.E. Combining MR elastography and diffusion tensor imaging for the assessment of anisotropic mechanical properties: a phantom study. J. Magn. Reson. Imaging 2013, 37:217-226.
21. Roberts R.O., Geda Y.E., Knopman D.S., Cha R.H., Pankratz V.S., Boeve B.F., Ivnik R.J., Tangalos E.G., Petersen R.C., Rocca W.A. The Mayo Clinic Study of Aging: design and sampling, participation, baseline measures and sample characteristics. Neuroepidemiology 2008, 30:58-69.
22. Romano A., Scheel M., Hirsch S., Braun J., Sack I. In vivo waveguide elastography of white matter tracts in the human brain. Magn. Reson. Med. 2012, 68:1410-1422.
23. Romano A., Guo J., Prokscha T., Meyer T., Hirsch S., Braun J., Sack I., Scheel M. In vivo waveguide elastography: effects of neurodegeneration in patients with amyotrophic lateral sclerosis. Magn. Reson. Med. 2014, 72:1755-1761.
24. Ruigrok A.N., Salimi-Khorshidi G., Lai M.C., Baron-Cohen S., Lombardo M.V., Tait R.J., Suckling J. A meta-analysis of sex differences in human brain structure. Neurosci. Biobehav. Rev. 2014, 39C:34-50.
25. Sack I., Beierbach B., Wuerfel J., Klatt D., Hamhaber U., Papazoglou S., Martus P., Braun J. The impact of aging and gender on brain viscoelasticity. NeuroImage 2009, 46:652-657.
26. Sack I., Streitberger K.J., Krefting D., Paul F., Braun J. The influence of physiological aging and atrophy on brain viscoelastic properties in humans. PLoS One 2011, 6:e23451.
27. Sowell E.R., Peterson B.S., Kan E., Woods R.P., Yoshii J., Bansal R., Xu D., Zhu H., Thompson P.M., Toga A.W. Sex differences in cortical thickness mapped in 176 healthy individuals between 7 and 87years of age. Cereb. Cortex 2007, 17:1550-1560.
28. Streitberger K.J., Wiener E., Hoffmann J., Freimann F.B., Klatt D., Braun J., Lin K., McLaughlin J., Sprung C., Klingebiel R., Sack I. In vivo viscoelastic properties of the brain in normal pressure hydrocephalus. NMR Biomed. 2011, 24:385-392.
29. Streitberger K.J., Sack I., Krefting D., Pfuller C., Braun J., Paul F., Wuerfel J. Brain viscoelasticity alteration in chronic-progressive multiple sclerosis. PLoS One 2012, 7:e29888.
30. Witelson S.F., Glezer I.I., Kigar D.L. Women have greater density of neurons in posterior temporal cortex. J. Neurosci. 1995, 15:3418-3428.
31. Witte A.V., Savli M., Holik A., Kasper S., Lanzenberger R. Regional sex differences in grey matter volume are associated with sex hormones in the young adult human brain. NeuroImage 2010, 49:1205-1212.
32. Wuerfel J., Paul F., Beierbach B., Hamhaber U., Klatt D., Papazoglou S., Zipp F., Martus P., Braun J., Sack I. MR-elastography reveals degradation of tissue integrity in multiple sclerosis. NeuroImage 2010, 49:2520-2525.
33. Xu L., Lin Y., Han J.C., Xi Z.N., Shen H., Gao P.Y. Magnetic resonance elastography of brain tumors: preliminary results. Acta Radiol. 2007, 48:327-330.
34. Zhang J., Green M.A., Sinkus R., Bilston L.E. Viscoelastic properties of human cerebellum using magnetic resonance elastography. J. Biomech. 2011, 44:1909-1913.