Transport domain unlocking sets the uptake rate of an aspartate transporter

Nature

Volumn 518, Issue 7537, 2015, Pages 68-73

  Akyuz, Nurunisa ^a   Georgieva, Elka R ^b   Zhou, Zhou ^a   Stolzenberg, Sebastian ^a   Cuendet, Michel A ^a,c   Khelashvili, George ^a   Altman, Roger B ^a   Terry, Daniel S ^a   Freed, Jack H ^b   Weinstein, Harel ^a   Boudker, Olga ^a   Blanchard, Scott C ^a,d  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b Department of Molecular Biology and Genetics   (United States)

^c SWISS INSTITUTE OF BIOINFORMATICS   (Switzerland)

^d Tri Institutional Training Program in Computational Biology and Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ASPARTATE TRANSPORTER; ASPARTIC ACID; EXCITATORY AMINO ACID TRANSPORTER; ION; PROTEOLIPOSOME; SOLVENT; UNCLASSIFIED DRUG; AMINO ACID TRANSPORTER; DETERGENT; LIGAND; MUTANT PROTEIN; PROTEOLIPID; PROTEOLIPOSOMES; SODIUM;

CRYSTALLOGRAPHY; CYTOPLASM; IMAGING METHOD; MUTATION; NEUROLOGY; PROKARYOTE;

ARTICLE; CONFORMATION; CRYSTAL STRUCTURE; CRYSTALLOGRAPHY; FLUORESCENCE RESONANCE ENERGY TRANSFER; GAIN OF FUNCTION MUTATION; MOLECULAR DYNAMICS; MOTION; PRIORITY JOURNAL; SINGLE MOLECULE FLUORESCENCE RESONANCE ENERGY TRANSFER; AMINO ACID SEQUENCE; CHEMICAL STRUCTURE; CHEMISTRY; GENETICS; HUMAN; KINETICS; METABOLISM; MOLECULAR GENETICS; MOVEMENT (PHYSIOLOGY); MUTATION; PROTEIN STABILITY; PROTEIN TERTIARY STRUCTURE; PYROCOCCUS HORIKOSHII; THERMODYNAMICS; TRANSPORT AT THE CELLULAR LEVEL; X RAY CRYSTALLOGRAPHY;

ARCHAEA; PYROCOCCUS HORIKOSHII;

AMINO ACID SEQUENCE; AMINO ACID TRANSPORT SYSTEMS, ACIDIC; ASPARTIC ACID; BIOLOGICAL TRANSPORT; CRYSTALLOGRAPHY, X-RAY; DETERGENTS; FLUORESCENCE RESONANCE ENERGY TRANSFER; HUMANS; KINETICS; LIGANDS; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; MOLECULAR SEQUENCE DATA; MOVEMENT; MUTANT PROTEINS; MUTATION; PROTEIN STABILITY; PROTEIN STRUCTURE, TERTIARY; PROTEOLIPIDS; PYROCOCCUS HORIKOSHII; SODIUM; SOLVENTS; THERMODYNAMICS;

EID: 84923107452     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature14158     Document Type: Article

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