A systematic review and meta-analysis of Ginsenoside-Rg1 (G-Rg1) in experimental ischemic stroke

Scientific Reports

Volumn 5, Issue , 2015, Pages

  Xie, Cheng Long ^a   Wang, Wen Wen ^b   Xue, Xiao Dong ^c   Zhang, Su Fang ^a   Gan, Jing ^a   Liu, Zhen Guo ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b THE SECOND AFFILIATED HOSPITAL AND YUYING CHILDREN S HOSPITAL OF WENZHOU MEDICAL UNIVERSITY   (China)

^c Cang Nan County Hospital   (China)

Author keywords

[No Author keywords available]

Indexed keywords

GINSENOSIDE; GINSENOSIDE RG 1; NEUROPROTECTIVE AGENT;

ANIMAL; BRAIN ISCHEMIA; DISEASE MODEL; HUMAN; META ANALYSIS; MOUSE; PATHOLOGY; RAT; STROKE;

ANIMALS; BRAIN ISCHEMIA; DISEASE MODELS, ANIMAL; GINSENOSIDES; HUMANS; MICE; NEUROPROTECTIVE AGENTS; RATS; STROKE;

EID: 84923102592     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep07790     Document Type: Article

References (36)

1. Kidwell, C. S., Liebeskind, D. S., Starkman, S. & Saver, J. L. Trends in acute ischemic stroke trials through the 20th century. Stroke 32, 1349-1359 (2001).
2. Simon, R. P., Greenberg, D. A. & Aminoff, M. J. Clinical Neurology. 7th Edition. (McGraw-Hill Publishing House, New York, 2009).
3. O'Collins, V. E. et al. 1,026 experimental treatments in acute stroke. Ann Neurol 59, 467-477 (2006).
4. Muir, K. W. & Lees, K. R. Excitatory amino acid antagonists for acute stroke. Cochrane Database Syst Rev 3, CD001244 (2003).
5. van, der, Worp, H. B. et al. Can animal models of disease reliably inform human studies? PLoS Med 7, e1000245 (2010).
6. Wright, L. et al. National Stroke Foundation Stroke Guidelines Expert Working Group. Stroke management: updated recommendations for treatment along the care continuum. Intern Med J 42, 562-569 (2012).
7. Sena, E., van, der, Worp, H. B., Howells, D. & Macleod, M. How can we improve the pre-clinical development of drugs for stroke? Trends Neurosci 30, 433-439 (2007).
8. Ellis, J. M. & Reddy, P. Effects of Panax ginseng on quality of life. Ann Pharmacother 36, 375-379 (2002).
9. Jiang, B. et al. Antidepressant-like effects of ginsenoside Rg1 are due to activation of the BDNF signalling pathway and neurogenesis in the hippocampus. Br J Pharmacol 166, 1872-1887 (2012).
10. Shen, L. & Zhang, J. NMDA receptor and iNOS are involved in the effects of ginsenoside Rg1 on hippocampal neurogenesis in ischemic gerbils. Neurol Res 29, 270-273 (2007).
11. Zhou, Y. et al. Ginsenoside Rg1 provides neuroprotection against blood brain barrier disruption and neurological injury in a rat model of cerebral ischemia/ reperfusion through downregulation of aquaporin 4 expression. Phytomedicine 21, 998-1003 (2014).
12. Zheng, G. Q. et al. Ginseng total saponins enhance neurogenesis after focal cerebral ischemia. J Ethnopharmacol 133, 724-728 (2011).
13. Rausch, W. D., Liu, S., Gille, G. & Radad, K. Neuroprotective effects of ginsenosides. Acta Neurobiol Exp (Wars) 66, 369-375 (2006).
14. Hu, X.M., Yan, C. K., Xu, S. Q., Hu, X. M. & Zeng, F. D. Effects of ginsenoside Rg1 on endothelial cell adhesion after cerebral ischemia-reperfusion in rats. Chin J Pharmacol Toxicol 20, 19-25 (2006).
15. Hu, M. X., Yan, C. K. & Hu, X. M. Effects of ginsenoside Rg1 on Cell apoptosis after cerebral ischemia-reperfusion in rats. Chin J Clin Pharmacol Ther 11, 11192-196 (2006).
16. Hu,M. X., Yan, C. K.,Hu, X. M. & Zeng, F. D. Protection of cerebral mitochondria function of rats from impairment by cerebral ischemia-reperfhsion with ginsenoside Rg 1. Chin J New Drugs. 15, 514-517 (2006).
17. Liu, X., Bao, C. F., Liang, J., Wei, J. & Qin, S. J. Effects of ginsenoside Rg1 on caspase-3 in rats brain tissue after cerebral ischemia reperfhsion. Chin JHistochem Cytochem 19, 88-92 (2010).
18. Wang, Q. Y. & Wu, F. J. Effects of ginsenoside Rg1 on activity and protein expression of NOS in rats with cerebral ischemic reperfusion injury. Chin J Pathophysiol 27, 2328-2332 (2011).
19. Zou, X. L., Du, J. W., Liang, J., Wei, J. & Bao, C. F. Effects of ginsenoside Rg1 on iNOS and eNOS expression after cerebral ischemia-reperfusion in rats. Shandong Medical Journal 52, 44-45 (2012).
20. Bao, C. F., Bao, C. F., Li, L. & Liu, X. Effects of ginsenoside Rgl joint BMSCs on cerebral ischemia and reperfusion injury in rats. Shandong Medical Journal 52, 9-11 (2012).
21. Wang, Q. Y., Liu, F., Wu, F. J. & Li, J. L. Effects of Ginsenoside Rgl on the expressions of P-ERKl/2 and p-JNK in local cerebraI ischemia/reperfusion injury rats. Chin J integrative medicine 33, 229-234 (2013).
22. Yu, L., Liu, X., Bao, C. F. & Ji, H. C. Effects of ginsenoside Rg1 on cell death model in brain tissue after cerebral ischemia-reperfusion in rats. Chin J Clin Anat 31, 555-559 (2013).
23. Zeng, X. S. et al. Comparative analysis of the neuroprotective effects of ginsenosides Rg1 and Rb1 extracted from Panax notoginseng against cerebral ischemia. Can J Physiol Pharmacol 92, 102-108 (2014).
24. Longa, E. Z., Weinstein, P. R., Carlson, S. & Cummins, R. Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke 20, 84-91 (1989).
25. Guyatt, G. H. et al. GRADE guidelines: 5 Rating the quality of evidence - publication bias. J Clin Epidemiol 64, 1277-1282 (2011).
26. Furlan, A. D., Pennick, V., Bombardier, C. & van, Tulder. M. Editorial Board, Cochrane Back Review Group. 2009 updated method guidelines for systematic reviews in the Cochrane Back Review Group. Spine 34, 1929-41 (2009).
27. Xie, C. L. et al. Efficacy and safety of Suanzaoren decoction for primary insomnia: a systematic review of randomized controlled trials. BMC Complement Altern Med 13, 18 (2013).
28. De, Angelis, C. et al. International Committee of Medical Journal Editors. Clinical trial registration: a statement from the International Committee of Medical Journal Editors. Circulation 111, 1337-1338 (2005).
29. Macleod, M. R., O'Collins, T., Howells, D. W. & Donnan, G. A. Pooling of animal experimental data reveals influence of study design and publication bias. Stroke 35, 1203-1208 (2004).
30. Moher, D. et al. Does quality of reports of randomised trials affect estimates of intervention efficacy reported in meta-analyses? Lancet 352, 609-613 (1998).
31. Bebarta, V., Luyten, D. & Heard, K. Emergency medicine animal research: does use of randomization and blinding affect the results? Acad Emerg Med 10, 684-687 (2003).
32. Wiebers, D. O., Adams, H. P. Jr. & Whisnant, J.P. Animal models of stroke: are they relevant to human disease? Stroke 21, 1-3 (1990).
33. Liu, X. et al. Efficacy and safety of ginsenoside-Rd for acute ischaemic stroke: a randomized, double-blind, placebo-controlled, phase II multicenter trial. Eur J Neurol 16, 569-575 (2009).
34. Liu, X. et al. Ginsenoside-Rd improves outcome of acute ischaemic stroke-a randomized, double-blind, placebo-controlled, multicenter trial. Eur J Neurol 19, 855-863 (2012).
35. Wang, W. W., Xie, C. L., Lu, L. & Zheng, G. Q. A systematic review and metaanalysis of Baihui (GV20)-based scalp acupuncture in experimental ischemic stroke. Sci Rep 4, 3981 (2014).
36. Vesterinen, H. M. et al. Meta-analysis of data from animal studies: a practical guide. J Neurosci Methods 221, 92-102 (2013).