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Volumn 5, Issue , 2015, Pages

Variant allele frequency enrichment analysis in vitro reveals sonic hedgehog pathway to impede sustained temozolomide response in GBM

Author keywords

[No Author keywords available]

Indexed keywords

ANILIDE; DACARBAZINE; PYRIDINE DERIVATIVE; SHH PROTEIN, HUMAN; SONIC HEDGEHOG PROTEIN; TEMOZOLOMIDE; TUMOR PROTEIN; VISMODEGIB;

EID: 84923100326     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep07915     Document Type: Article
Times cited : (13)

References (36)
  • 1
    • 20044366163 scopus 로고    scopus 로고
    • Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma
    • Stupp, R. et al. Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. The New England journal of medicine. 352, 987-996 (2005).
    • (2005) The New England Journal of Medicine , vol.352 , pp. 987-996
    • Stupp, R.1
  • 3
    • 0028133013 scopus 로고
    • NMRand molecular modeling investigation of the mechanism of activation of the antitumor drug temozolomide and its interaction with DNA
    • Denny, B. J., Wheelhouse, R. T., Stevens, M. F., Tsang, L. L.&Slack, J. A.NMRand molecular modeling investigation of the mechanism of activation of the antitumor drug temozolomide and its interaction with DNA. Biochemistry. 33, 9045-9051 (1994).
    • (1994) Biochemistry , vol.33 , pp. 9045-9051
    • Denny, B.J.1    Wheelhouse, R.T.2    Stevens, M.F.3    Tsang, L.L.4    Slack, J.A.5
  • 4
    • 33747884339 scopus 로고    scopus 로고
    • DNA damage-induced cell death by apoptosis
    • Roos, W. P.&Kaina, B. DNA damage-induced cell death by apoptosis. Trends in molecular medicine 12, 440-450 (2006).
    • (2006) Trends in Molecular Medicine , vol.12 , pp. 440-450
    • Roos, W.P.1    Kaina, B.2
  • 5
    • 78649336706 scopus 로고    scopus 로고
    • The DNA damage response: Making it safe to play with knives
    • Ciccia, A.&Elledge, S. J. The DNA damage response: making it safe to play with knives. Molecular cell. 40, 179-204 (2010).
    • (2010) Molecular Cell. , vol.40 , pp. 179-204
    • Ciccia, A.1    Elledge, S.J.2
  • 6
    • 33847419142 scopus 로고    scopus 로고
    • Molecular definition of breast tumor heterogeneity
    • Shipitsin, M. et al.Molecular definition of breast tumor heterogeneity. Cancer cell. 11, 259-273 (2007).
    • (2007) Cancer Cell , vol.11 , pp. 259-273
    • Shipitsin, M.1
  • 7
    • 67349284051 scopus 로고    scopus 로고
    • Non-genetic heterogeneity - A mutationindependent driving force for the somatic evolution of tumours
    • Brock, A., Chang, H.&Huang, S. Non-genetic heterogeneity-a mutationindependent driving force for the somatic evolution of tumours. Nat Rev Genet. 10, 336-342 (2009).
    • (2009) Nat Rev Genet. , vol.10 , pp. 336-342
    • Brock, A.1    Chang, H.2    Huang, S.3
  • 8
    • 84860214990 scopus 로고    scopus 로고
    • Intra-tumour heterogeneity: A looking glass for cancer?
    • Marusyk, A., Almendro, V.&Polyak, K. Intra-tumour heterogeneity: a looking glass for cancer? Nature reviews. 12, 323-334 (2012).
    • (2012) Nature Reviews. , vol.12 , pp. 323-334
    • Marusyk, A.1    Almendro, V.2    Polyak, K.3
  • 9
  • 10
    • 84902668801 scopus 로고    scopus 로고
    • Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma
    • New York, N.Y. 344
    • Patel, A. P. et al. Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma. Science (New York, N.Y. 344, 1396-1401 (2014).
    • (2014) Science , pp. 1396-1401
    • Patel, A.P.1
  • 11
    • 0026513077 scopus 로고
    • Phase i trial of temozolomide (CCRG 81045: M&B 39831: NSC 362856)
    • Newlands, E. S. et al. Phase I trial of temozolomide (CCRG 81045: M&B 39831: NSC 362856). British journal of cancer. 65, 287-291 (1992).
    • (1992) British Journal of Cancer. , vol.65 , pp. 287-291
    • Newlands, E.S.1
  • 12
    • 69449096005 scopus 로고    scopus 로고
    • Heterogeneity in cancer: Cancer stem cells versus clonal evolution
    • Shackleton, M., Quintana, E., Fearon, E. R.&Morrison, S. J. Heterogeneity in cancer: cancer stem cells versus clonal evolution. Cell. 138, 822-829 (2009).
    • (2009) Cell. , vol.138 , pp. 822-829
    • Shackleton, M.1    Quintana, E.2    Fearon, E.R.3    Morrison, S.J.4
  • 13
    • 84874354257 scopus 로고    scopus 로고
    • The implications of clonal genome evolution for cancer medicine
    • Aparicio, S.&Caldas, C. The implications of clonal genome evolution for cancer medicine. The New England journal of medicine. 368, 842-851 (2013).
    • (2013) The New England Journal of Medicine. , vol.368 , pp. 842-851
    • Aparicio, S.1    Caldas, C.2
  • 14
    • 77955275305 scopus 로고    scopus 로고
    • Clinically relevant doses of chemotherapy agents reversibly block formation of glioblastoma neurospheres
    • Mihaliak, A. M. et al. Clinically relevant doses of chemotherapy agents reversibly block formation of glioblastoma neurospheres. Cancer letters. 296, 168-177 (2010).
    • (2010) Cancer Letters. , vol.296 , pp. 168-177
    • Mihaliak, A.M.1
  • 15
    • 84887512714 scopus 로고    scopus 로고
    • Unraveling the therapeutic potential of the Hedgehog pathway in cancer
    • Amakye, D., Jagani, Z.&Dorsch, M. Unraveling the therapeutic potential of the Hedgehog pathway in cancer. Nature medicine. 19, 1410-1422 (2013).
    • (2013) Nature Medicine. , vol.19 , pp. 1410-1422
    • Amakye, D.1    Jagani, Z.2    Dorsch, M.3
  • 16
    • 84877089372 scopus 로고    scopus 로고
    • Food and Drug Administration approval: Vismodegib for recurrent, locally advanced, or metastatic basal cell carcinoma
    • Axelson, M. et al. U.S. Food and Drug Administration approval: vismodegib for recurrent, locally advanced, or metastatic basal cell carcinoma. Clin Cancer Res. 19, 2289-2293 (2013).
    • (2013) Clin Cancer Res. , vol.19 , pp. 2289-2293
    • Axelson, M.1    Et Al., U.S.2
  • 17
    • 84885074034 scopus 로고    scopus 로고
    • The somatic genomic landscape of glioblastoma
    • Brennan, C. W. et al. The somatic genomic landscape of glioblastoma. Cell. 155, 462-477 (2013).
    • (2013) Cell. , vol.155 , pp. 462-477
    • Brennan, C.W.1
  • 18
    • 84899714966 scopus 로고    scopus 로고
    • Sustained activation of DNA damage response in irradiated apoptosis-resistant cells induces reversible senescence associated with mTOR downregulation and expression of stem cell markers
    • Georgetown, Tex.
    • Chitikova, Z. V. et al. Sustained activation of DNA damage response in irradiated apoptosis-resistant cells induces reversible senescence associated with mTOR downregulation and expression of stem cell markers. Cell cycle (Georgetown, Tex. 13, 1424-1439 (2014).
    • (2014) Cell Cycle , vol.13 , pp. 1424-1439
    • Chitikova, Z.V.1
  • 19
    • 0033561619 scopus 로고    scopus 로고
    • Expression of an isoform of the novel signal transduction protein ST5 is linked to cell morphology
    • Hubbs, A. E.,Majidi, M. &Lichy, J. H. Expression of an isoform of the novel signal transduction protein ST5 is linked to cell morphology. Oncogene. 18, 2519-2525 (1999).
    • (1999) Oncogene. , vol.18 , pp. 2519-2525
    • Hubbs, A.E.1    Majidi, M.2    Lichy, J.H.3
  • 20
    • 84881255212 scopus 로고    scopus 로고
    • Spatial dynamics of chromosome translocations in living cells
    • New York, N.Y
    • Roukos, V. et al. Spatial dynamics of chromosome translocations in living cells. Science (New York, N.Y. 341, 660-664 (2013).
    • (2013) Science , vol.341 , pp. 660-664
    • Roukos, V.1
  • 21
    • 84878589114 scopus 로고    scopus 로고
    • DNA-dependent protein kinase and its inhibition in support of radiotherapy
    • Novotna, E. et al. DNA-dependent protein kinase and its inhibition in support of radiotherapy. International journal of radiation biology. 89, 416-423 (2013).
    • (2013) International Journal of Radiation Biology. , vol.89 , pp. 416-423
    • Novotna, E.1
  • 22
    • 33749077086 scopus 로고    scopus 로고
    • A RSK(y) relationship with promiscuous PKA
    • Houslay, M. D. A RSK(y) relationship with promiscuous PKA. Sci STKE. 2006, pe32 (2006).
    • (2006) Sci STKE. , vol.2006 , pp. e32
    • Houslay, M.D.1
  • 24
    • 0033781026 scopus 로고    scopus 로고
    • Gli regulation by the opposing activities of fused and suppressor of fused
    • Murone, M. et al. Gli regulation by the opposing activities of fused and suppressor of fused. Nature cell biology. 2, 310-312 (2000).
    • (2000) Nature Cell Biology. , vol.2 , pp. 310-312
    • Murone, M.1
  • 25
    • 65549170297 scopus 로고    scopus 로고
    • Fused has evolved divergent roles in vertebrate Hedgehog signalling and motile ciliogenesis
    • Wilson, C. W. et al. Fused has evolved divergent roles in vertebrate Hedgehog signalling and motile ciliogenesis. Nature. 459, 98-102 (2009).
    • (2009) Nature. , vol.459 , pp. 98-102
    • Wilson, C.W.1
  • 26
    • 71549158803 scopus 로고    scopus 로고
    • Metabolism of lysine in alpha-aminoadipic semialdehyde dehydrogenase-deficient fibroblasts: Evidence for an alternative pathway of pipecolic acid formation
    • Struys, E. A.&Jakobs, C. Metabolism of lysine in alpha-aminoadipic semialdehyde dehydrogenase-deficient fibroblasts: evidence for an alternative pathway of pipecolic acid formation. FEBS letters. 584, 181-186 (2010).
    • (2010) FEBS Letters. , vol.584 , pp. 181-186
    • Struys, E.A.1    Jakobs, C.2
  • 27
    • 33947254016 scopus 로고    scopus 로고
    • Blockade of hedgehog signaling inhibits pancreatic cancer invasion and metastases: A new paradigm for combination therapy in solid cancers
    • Feldmann, G. et al. Blockade of hedgehog signaling inhibits pancreatic cancer invasion and metastases: a new paradigm for combination therapy in solid cancers. Cancer research. 67, 2187-2196 (2007).
    • (2007) Cancer Research. , vol.67 , pp. 2187-2196
    • Feldmann, G.1
  • 28
    • 6044243650 scopus 로고    scopus 로고
    • Hedgehog signalling in prostate regeneration, neoplasia and metastasis
    • Karhadkar, S. S. et al. Hedgehog signalling in prostate regeneration, neoplasia and metastasis. Nature. 431, 707-712 (2004).
    • (2004) Nature. , vol.431 , pp. 707-712
    • Karhadkar, S.S.1
  • 29
    • 43249085571 scopus 로고    scopus 로고
    • A synthetic lethal siRNA screen identifying genes mediating sensitivity to a PARP inhibitor
    • Turner, N. C. et al. A synthetic lethal siRNA screen identifying genes mediating sensitivity to a PARP inhibitor. The EMBO journal. 27, 1368-1377 (2008).
    • (2008) The EMBO Journal , vol.27 , pp. 1368-1377
    • Turner, N.C.1
  • 30
    • 20044372154 scopus 로고    scopus 로고
    • MGMT gene silencing and benefit from temozolomide in glioblastoma
    • Hegi, M. E. et al. MGMT gene silencing and benefit from temozolomide in glioblastoma. The New England journal of medicine. 352, 997-1003 (2005).
    • (2005) The New England Journal of Medicine. , vol.352 , pp. 997-1003
    • Hegi, M.E.1
  • 31
    • 84863011588 scopus 로고    scopus 로고
    • Phase II and pharmacogenomics study of enzastaurin plus temozolomide during and following radiation therapy in patients with newly diagnosed glioblastoma multiforme and gliosarcoma
    • Butowski, N. et al. Phase II and pharmacogenomics study of enzastaurin plus temozolomide during and following radiation therapy in patients with newly diagnosed glioblastoma multiforme and gliosarcoma. Neuro-oncology. 13, 1331-1338 (2011).
    • (2011) Neuro-oncology. , vol.13 , pp. 1331-1338
    • Butowski, N.1
  • 32
    • 84903773686 scopus 로고    scopus 로고
    • The sonic hedgehog factor GLI1 imparts drug resistance through inducible glucuronidation
    • Zahreddine, H. A. et al. The sonic hedgehog factor GLI1 imparts drug resistance through inducible glucuronidation. Nature. 511, 90-93 (2014).
    • (2014) Nature. , vol.511 , pp. 90-93
    • Zahreddine, H.A.1
  • 33
    • 84887473986 scopus 로고    scopus 로고
    • Coordinate activation of Shh and PI3K signaling in PTENdeficient glioblastoma: New therapeutic opportunities
    • Gruber Filbin, M. et al. Coordinate activation of Shh and PI3K signaling in PTENdeficient glioblastoma: new therapeutic opportunities. Nature medicine. 19, 1518-1523 (2013).
    • (2013) Nature Medicine. , vol.19 , pp. 1518-1523
    • Gruber Filbin, M.1
  • 34
    • 17344392308 scopus 로고    scopus 로고
    • A new mathematical model for relative quantification in real-time RT-PCR
    • Pfaffl, M. W. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic acids research. 29, e45 (2001).
    • (2001) Nucleic Acids Research , vol.29 , pp. e45
    • Pfaffl, M.W.1
  • 35
    • 84890177607 scopus 로고    scopus 로고
    • Mutational landscape of gingivo-buccal oral squamous cell carcinoma reveals new recurrently-mutated genes and molecular subgroups
    • Maitra, A. et al. Mutational landscape of gingivo-buccal oral squamous cell carcinoma reveals new recurrently-mutated genes and molecular subgroups. Nature communications. 4, 2873 (2013).
    • (2013) Nature Communications. , vol.4 , pp. 2873
    • Maitra, A.1
  • 36
    • 0001677717 scopus 로고
    • Yosef Controlling the false discovery rate: A practical and powerful approach to multiple testing
    • Benjamini, Y. H. Yosef Controlling the false discovery rate: a practical and powerful approach to multiple testing. Journal of the Royal Statistical Society. 57, 289-300 (1995).
    • (1995) Journal of the Royal Statistical Society. , vol.57 , pp. 289-300
    • Benjamini, Y.H.1


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