Glucocorticoids and the non-steroidal selective glucocorticoid receptor modulator, compound A, differentially affect colon cancer-derived myofibroblasts

Journal of Steroid Biochemistry and Molecular Biology

Volumn 149, Issue , 2015, Pages 92-105

  Drebert, Zuzanna ^a   Bracke, Marc ^a   Beck, Ilse M ^a  

^a GHENT UNIVERSITY   (Belgium)

Author keywords

Cancer; Compound A; Glucocorticoid; Glucocorticoid receptor; Myofibroblast; Selective glucocorticoid receptor modulator (SEGRM)

Indexed keywords

CELL PROTEIN; COMPOUND A; DEXAMETHASONE; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; MESSENGER RNA; MIFEPRISTONE; SCATTER FACTOR; TENASCIN; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; 2-(4-ACETOXYPHENYL)-2-CHLORO-N-METHYLETHYLAMINE; ACETIC ACID DERIVATIVE; ANTIINFLAMMATORY AGENT; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; TYRAMINE;

ARTICLE; CANCER GROWTH; CELL DENSITY; CELL FUNCTION; CELL GROWTH; CELL INVASION; CELL PROLIFERATION; CELL VIABILITY; CELLULAR DISTRIBUTION; COLON CANCER; CONTROLLED STUDY; GENE EXPRESSION; HUMAN; HUMAN CELL; MYOFIBROBLAST; PARACRINE SIGNALING; PROTEIN EXPRESSION; TRANSACTIVATION; TUMOR MICROENVIRONMENT; UPREGULATION; WESTERN BLOTTING; ANALOGS AND DERIVATIVES; CELL SURVIVAL; COLONIC NEOPLASMS; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; IMMUNOLOGY; PATHOLOGY; TRANSCRIPTION INITIATION; TUMOR CELL LINE;

ACETATES; ANTI-INFLAMMATORY AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; COLONIC NEOPLASMS; DEXAMETHASONE; GENE EXPRESSION REGULATION; GLUCOCORTICOIDS; HUMANS; MYOFIBROBLASTS; NF-KAPPA B; RECEPTORS, GLUCOCORTICOID; TRANSCRIPTIONAL ACTIVATION; TYRAMINE;

EID: 84923095268     PISSN: 09600760     EISSN: 18791220     Source Type: Journal    
DOI: 10.1016/j.jsbmb.2015.02.002     Document Type: Article

References (63)

1. D. Hanahan, and R.A. Weinberg Hallmarks of cancer: the next generation Cell 144 2011 646 674
2. O. De Wever, and M. Mareel Role of tissue stroma in cancer cell invasion J. Pathol. 200 2003 429 447
3. T.W. Armstrong, Y. Liang, Y. Hetherington, S.M. Bowes 3rd., and O. Wong Retrospective occupational exposure assessment for case-control and case-series epidemiology studies based in Shanghai China J. Occup. Environ. Hyg. 8 2011 561 572
4. D. Cunningham, W. Atkin, H.J. Lenz, H.T. Lynch, and B. Minsky Colorectal cancer Lancet 375 2015 1030 1047
5. B. Hinz, S.H. Phan, V.J. Thannickal, A. Galli, and M.L. Bochaton-Piallat The myofibroblast: one function, multiple origins Am. J. Pathol. 170 2007 1807 1816
6. O. De Wever, P. Demetter, M. Mareel, and M. Bracke Stromal myofibroblasts are drivers of invasive cancer growth Int. J. Cancer 123 2008 2229 2238
7. O. De Wever, and M. Mareel Role of myofibroblasts at the invasion front Biol. Chem. 383 2002 55 67
8. P.J. Barnes Corticosteroids: the drugs to beat Eur. J. Pharmacol. 533 2006 2 14
9. N. Ahmad, and R. Kumar Steroid hormone receptors in cancer development: a target for cancer therapeutics Cancer Lett. 300 2011 1 9
10. H.M. Reichardt, J.P. Tuckermann, A. Bauer, and G. Schutz Molecular genetic dissection of glucocorticoid receptor function in vivo Z. Rheumatol. 59 Suppl. 2 2000 1 5 II
11. K. De Bosscher, W. Vanden Berghe, and G. Haegeman The interplay between the glucocorticoid receptor and nuclear factor-kappaB or activator protein-1: molecular mechanisms for gene repression Endocr. Rev. 24 2003 488 522
12. I.M. Beck, W. Vanden Berghe, L. Vermeulen, K.R. Yamamoto, and G. Haegeman Crosstalk in inflammation: the interplay of glucocorticoid receptor-based mechanisms and kinases and phosphatases Endocr. Rev. 30 2009 830 882
13. K. De Bosscher Selective glucocorticoid receptor modulators J. Steroid Biochem. Mol. Biol. 120 2010 96 104
14. H. Schacke, W.D. Docke, and K. Asadullah Mechanisms involved in the side effects of glucocorticoids Pharmacol. Ther. 96 2002 23 43
15. K. De Bosscher, I.M. Beck, and G. Haegeman Classic glucocorticoids versus non-steroidal glucocorticoid receptor modulators: survival of the fittest regulator of the immune system? Brain Behav. Immun. 24 2010 1035 1042
16. K.C. Reuter, S.M. Loitsch, A.U. Dignass, D. Steinhilber, and J. Stein Selective non-steroidal glucocorticoid receptor agonists attenuate inflammation but do not impair intestinal epithelial cell restitution in vitro PLoS One 7 2012 e29756
17. K. De Bosscher, W. Vanden Berghe, I.M. Beck, W. Van Molle, and N. Hennuyer A fully dissociated compound of plant origin for inflammatory gene repression Proc. Natl. Acad. Sci. U. S. A. 102 2005 15827 15832
18. E.A. Lesovaya, A.Y. Yemelyanov, K.I. Kirsanov, M.G. Yakubovskaya, and I.V. Budunova Antitumor effect of non-steroid glucocorticoid receptor ligand CpdA on leukemia cell lines CEM and K562 Biochemistry (Mosc) 76 2011 1242 1252
19. A. Louw, and P. Swart Salsola tuberculatiformis Botschantzev and an aziridine precursor analog mediate the in vivo increase in free corticosterone and decrease in corticosteroid-binding globulin in female Wistar rats Endocrinology 140 1999 2044 2053
20. V. Gossye, D. Elewaut, K. Van Beneden, P. Dewint, and G. Haegeman A plant-derived glucocorticoid receptor modulator attenuates inflammation without provoking ligand-induced resistance Ann. Rheum. Dis. 69 2010 291 296
21. A. Yemelyanov, J. Czwornog, L. Gera, S. Joshi, and R.T. Chatterton Jr. Novel steroid receptor phyto-modulator compound a inhibits growth and survival of prostate cancer cells Cancer Res. 68 2008 4763 4773
22. I. Herr, and J. Pfitzenmaier Glucocorticoid use in prostate cancer and other solid tumours: implications for effectiveness of cytotoxic treatment and metastases Lancet Oncol. 7 2006 425 430
23. M. Shi, L. Du, D. Liu, L. Qian, and M. Hu Glucocorticoid regulation of a novel HPV-E6-p53-miR-145 pathway modulates invasion and therapy resistance of cervical cancer cells J. Pathol. 228 2012 148 157
24. N. Ferrand, E. Stragier, G. Redeuilh, and M. Sabbah Glucocorticoids induce CCN5/WISP-2 expression and attenuate invasion in oestrogen receptor-negative human breast cancer cells Biochem. J. 447 2012 71 79
25. Y. Zheng, K. Izumi, Y. Li, H. Ishiguro, and H. Miyamoto Contrary regulation of bladder cancer cell proliferation and invasion by dexamethasone-mediated glucocorticoid receptor signals Mol. Cancer Ther. 11 2012 2621 2632
26. O. De Wever, Q.D. Nguyen, L. Van Hoorde, M. Bracke, and E. Bruyneel Tenascin-C and SF/HGF produced by myofibroblasts in vitro provide convergent pro-invasive signals to human colon cancer cells through RhoA and Rac FASEB J. 18 2004 1016 1018
27. W. Vanden Berghe, S. Plaisance, E. Boone, K. De Bosscher, and M.L. Schmitz p38 and extracellular signal-regulated kinase mitogen-activated protein kinase pathways are required for nuclear factor-kappaB p65 transactivation mediated by tumor necrosis factor J. Biol. Chem. 273 1998 3285 3290
28. C. Wong, E.M. Rougier-Chapman, J.P. Frederick, M.B. Datto, and N.T. Liberati Smad3-Smad4 and AP-1 complexes synergize in transcriptional activation of the c-Jun promoter by transforming growth factor beta Mol. Cell. Biol. 19 1999 1821 1830
29. W. Vanden Berghe, E. Francesconi, K. De Bosscher, M. Resche-Rigon, and G. Haegeman Dissociated glucocorticoids with anti-inflammatory potential repress interleukin-6 gene expression by a nuclear factor-kappaB-dependent mechanism Mol. Pharmacol. 56 1999 797 806
30. I.M. Beck, W.V. Berghe, S. Gerlo, N. Bougarne, and L. Vermeulen Glucocorticoids and mitogen- and stress-activated protein kinase 1 inhibitors: possible partners in the combat against inflammation Biochem. Pharmacol. 77 2009 1194 1205
31. S. Plaisance, W. Vanden Berghe, E. Boone, W. Fiers, and G. Haegeman Recombination signal sequence binding protein Jkappa is constitutively bound to the NF-kappaB site of the interleukin-6 promoter and acts as a negative regulatory factor Mol. Cell. Biol. 17 1997 3733 3743
32. S. Blockhuys, B. Vanhoecke, L. Paelinck, M. Bracke, and C. De Wagter Development of in vitro models for investigating spatially fractionated irradiation: physics and biological results Phys. Med. Biol. 54 2009 1565 1578
33. P. Skehan, R. Storeng, D. Scudiero, A. Monks, and J. McMahon New colorimetric cytotoxicity assay for anticancer-drug screening J. Natl. Cancer Inst. 82 1990 1107 1112
34. C.A. Schneider, W.S. Rasband, and K.W. Eliceiri NIH image to ImageJ: 25 years of image analysis Nat. Methods 9 2012 671 675
35. K. De Bosscher, W. Vanden Berghe, L. Vermeulen, S. Plaisance, and E. Boone Glucocorticoids repress NF-kappaB-driven genes by disturbing the interaction of p65 with the basal transcription machinery, irrespective of coactivator levels in the cell Proc. Natl. Acad. Sci. U. S. A. 97 2000 3919 3924
36. E.M. King, J.E. Chivers, C.F. Rider, A. Minnich, and M.A. Giembycz Glucocorticoid repression of inflammatory gene expression shows differential responsiveness by transactivation- and transrepression-dependent mechanisms PLoS One 8 2013 e53936
37. K. De Bosscher, I.M. Beck, L. Dejager, N. Bougarne, and A. Gaigneaux Selective modulation of the glucocorticoid receptor can distinguish between transrepression of NF-kappaB and AP-1 Cell. Mol. Life Sci. 71 2014 143 163
38. M.M. Nachlas, S.I. Margulies, J.D. Goldberg, and A.M. Seligman The determination of lactic dehydrogenase with a tetrazolium salt Anal. Biochem. 1 1960 317 326
39. T.F. Slater Studies on a succinate-neotetrazolium reductase system of rat liver: II. Points of coupling with the respiratory chain Biochim. Biophys. Acta 77 1963 365 382
40. R.H. Oakley, and J.A. Cidlowski Homologous down regulation of the glucocorticoid receptor: the molecular machinery Crit. Rev. Eukaryot. Gene Expr. 3 1993 63 88
41. M. Kadmiel, and J.A. Cidlowski Glucocorticoid receptor signaling in health and disease Trends Pharmacol. Sci. 34 2013 518 530
42. V. Gossye, D. Elewaut, N. Bougarne, D. Bracke, and S. Van Calenbergh Differential mechanism of NF-kappaB inhibition by two glucocorticoid receptor modulators in rheumatoid arthritis synovial fibroblasts Arthritis Rheum. 60 2009 3241 3250
43. B.J. Deroo, and T.K. Archer Glucocorticoid receptor activation of the I kappa B alpha promoter within chromatin Mol. Biol. Cell. 12 2001 3365 3374
44. K. De Bosscher, M.L. Schmitz, W. Vanden Berghe, S. Plaisance, and W. Fiers Glucocorticoid-mediated repression of nuclear factor-kappaB-dependent transcription involves direct interference with transactivation Proc. Natl. Acad. Sci. U. S. A. 94 1997 13504 13509
45. O. De Wever, W. Westbroek, A. Verloes, N. Bloemen, and M. Bracke Critical role of N-cadherin in myofibroblast invasion and migration in vitro stimulated by colon-cancer-cell-derived TGF-beta or wounding J. Cell. Sci. 117 2004 4691 4703
46. P. Dewint, V. Gossye, K. De Bosscher, W. Vanden Berghe, and K. Van Beneden A plant-derived ligand favoring monomeric glucocorticoid receptor conformation with impaired transactivation potential attenuates collagen-induced arthritis J. Immunol. 180 2008 2608 2615
47. G. Schlossmacher, A. Stevens, and A. White Glucocorticoid receptor-mediated apoptosis: mechanisms of resistance in cancer cells J. Endocrinol. 211 2011 17 25
48. J. Camara, and G. Jarai Epithelial-mesenchymal transition in primary human bronchial epithelial cells is Smad-dependent and enhanced by fibronectin and TNF-alpha Fibrogenesis Tissue Repair 3 2010 2
49. M. Sabbah, S. Emami, G. Redeuilh, S. Julien, and G. Prevost Molecular signature and therapeutic perspective of the epithelial-to-mesenchymal transitions in epithelial cancers Drug Resist. Updat. 11 2008 123 151
50. U. Cavallaro, and G. Christofori Cell adhesion in tumor invasion and metastasis: loss of the glue is not enough Biochim. Biophys. Acta 1552 2001 39 45
51. A. Zeitvogel, R. Baumann, and A. Starzinski-Powitz Identification of an invasive, N-cadherin-expressing epithelial cell type in endometriosis using a new cell culture model Am. J. Pathol. 159 2001 1839 1852
52. H. Williams, J.L. Johnson, C.L. Jackson, S.J. White, and S.J. George MMP-7 mediates cleavage of N-cadherin and promotes smooth muscle cell apoptosis Cardiovasc. Res. 87 2010 137 146
53. E. Gherardi, and M. Stoker Hepatocyte growth factor-scatter factor: mitogen, motogen, and met Cancer Cells 3 1991 227 232
54. L. Trusolino, and P.M. Comoglio Scatter-factor and semaphorin receptors: cell signalling for invasive growth Nat. Rev. Cancer 2 2002 289 300
55. K. Matsumoto, H. Tajima, H. Okazaki, and T. Nakamura Negative regulation of hepatocyte growth factor gene expression in human lung fibroblasts and leukemic cells by transforming growth factor-beta 1 and glucocorticoids J. Biol. Chem. 267 1992 24917 24920
56. S. Skrtic, and C. Ohlsson Cortisol decreases hepatocyte growth factor levels in human osteoblast-like cells Calcif. Tissue Int. 66 2000 108 112
57. N. Hanamura, T. Yoshida, E. Matsumoto, Y. Kawarada, and T. Sakakura Expression of fibronectin and tenascin-C mRNA by myofibroblasts, vascular cells and epithelial cells in human colon adenomas and carcinomas Int. J. Cancer. 73 1997 10 15
58. C.S. Swindle, K.T. Tran, T.D. Johnson, P. Banerjee, and A.M. Mayes Epidermal growth factor (EGF)-like repeats of human tenascin-C as ligands for EGF receptor J. Cell. Biol. 154 2001 459 468
59. M. Schulz, M. Eggert, A. Baniahmad, A. Dostert, and T. Heinzel RU486-induced glucocorticoid receptor agonism is controlled by the receptor N terminus and by corepressor binding J. Biol. Chem. 277 2002 26238 26243
60. R. Derynck, R.J. Akhurst, and A. Balmain TGF-beta signaling in tumor suppression and cancer progression Nat. Genet. 29 2001 117 129
61. D.W. Powell, R.C. Mifflin, J.D. Valentich, S.E. Crowe, and J.I. Saada Myofibroblasts. I. Paracrine cells important in health and disease Am. J. Physiol. 277 1999 C1 C9
62. L. Gorelik, and R.A. Flavell Immune-mediated eradication of tumors through the blockade of transforming growth factor-beta signaling in T cells Nat. Med. 7 2001 1118 1122
63. B.D. Keith Systematic review of the clinical effect of glucocorticoids on nonhematologic malignancy BMC Cancer 8 2008 84