메뉴 건너뛰기




Volumn 62, Issue 3, 2015, Pages 657-663

Circulating triacylglycerol signatures and insulin sensitivity in NAFLD associated with the E167K variant in TM6SF2

Author keywords

Glucose production; Lipolysis; Magnetic resonance spectroscopy; Mass spectrometry

Indexed keywords

GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; LIPIDOME; LIVER ENZYME; LOW DENSITY LIPOPROTEIN; MEMBRANE PROTEIN; TRANSMEMBRANE 6 SUPERFAMILY MEMBER 2 PROTEIN; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; ADIPONUTRIN, HUMAN; TM6SF2 PROTEIN, HUMAN; TRIACYLGLYCEROL LIPASE;

EID: 84923064699     PISSN: 01688278     EISSN: 16000641     Source Type: Journal    
DOI: 10.1016/j.jhep.2014.10.010     Document Type: Article
Times cited : (100)

References (21)
  • 1
    • 56749096610 scopus 로고    scopus 로고
    • Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease
    • S. Romeo, J. Kozlitina, C. Xing, A. Pertsemlidis, D. Cox, and L.A. Pennacchio Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease Nat Genet 40 2008 1461 1465
    • (2008) Nat Genet , vol.40 , pp. 1461-1465
    • Romeo, S.1    Kozlitina, J.2    Xing, C.3    Pertsemlidis, A.4    Cox, D.5    Pennacchio, L.A.6
  • 2
    • 84902672359 scopus 로고    scopus 로고
    • Non-alcoholic fatty liver disease as a cause and a consequence of metabolic syndrome
    • H. Yki-Jarvinen Non-alcoholic fatty liver disease as a cause and a consequence of metabolic syndrome Lancet Diabetes Endocrinol 2 2014 901 910
    • (2014) Lancet Diabetes Endocrinol , vol.2 , pp. 901-910
    • Yki-Jarvinen, H.1
  • 3
    • 84898058711 scopus 로고    scopus 로고
    • Exome-wide association study identifies a TM6SF2 variant that confers susceptibility to nonalcoholic fatty liver disease
    • J. Kozlitina, E. Smagris, S. Stender, B.G. Nordestgaard, H.H. Zhou, and A. Tybjaerg-Hansen Exome-wide association study identifies a TM6SF2 variant that confers susceptibility to nonalcoholic fatty liver disease Nat Genet 46 2014 352 356
    • (2014) Nat Genet , vol.46 , pp. 352-356
    • Kozlitina, J.1    Smagris, E.2    Stender, S.3    Nordestgaard, B.G.4    Zhou, H.H.5    Tybjaerg-Hansen, A.6
  • 4
    • 84891810442 scopus 로고    scopus 로고
    • Circulating triacylglycerol signatures in nonalcoholic fatty liver disease associated with the I148M variant in PNPLA3 and with obesity
    • J. Hyysalo, P. Gopalacharyulu, H. Bian, T. Hyotylainen, M. Leivonen, and N. Jaser Circulating triacylglycerol signatures in nonalcoholic fatty liver disease associated with the I148M variant in PNPLA3 and with obesity Diabetes 63 2014 312 322
    • (2014) Diabetes , vol.63 , pp. 312-322
    • Hyysalo, J.1    Gopalacharyulu, P.2    Bian, H.3    Hyotylainen, T.4    Leivonen, M.5    Jaser, N.6
  • 5
    • 79953754873 scopus 로고    scopus 로고
    • Liquid chromatography-mass spectrometry (LC-MS)-based lipidomics for studies of body fluids and tissues
    • H. Nygren, T. Seppanen-Laakso, S. Castillo, T. Hyotylainen, and M. Oresic Liquid chromatography-mass spectrometry (LC-MS)-based lipidomics for studies of body fluids and tissues Methods Mol Biol 708 2011 247 257
    • (2011) Methods Mol Biol , vol.708 , pp. 247-257
    • Nygren, H.1    Seppanen-Laakso, T.2    Castillo, S.3    Hyotylainen, T.4    Oresic, M.5
  • 6
    • 77954772536 scopus 로고    scopus 로고
    • MZmine 2: Modular framework for processing, visualizing, and analyzing mass spectrometry-based molecular profile data
    • T. Pluskal, S. Castillo, A. Villar-Briones, and M. Oresic MZmine 2: modular framework for processing, visualizing, and analyzing mass spectrometry-based molecular profile data BMC Bioinformatics 11 2010 395
    • (2010) BMC Bioinformatics , vol.11 , pp. 395
    • Pluskal, T.1    Castillo, S.2    Villar-Briones, A.3    Oresic, M.4
  • 8
    • 12144259379 scopus 로고    scopus 로고
    • Magnetic resonance spectroscopy to measure hepatic triglyceride content: Prevalence of hepatic steatosis in the general population
    • L.S. Szczepaniak, P. Nurenberg, D. Leonard, J.D. Browning, J.S. Reingold, and S. Grundy Magnetic resonance spectroscopy to measure hepatic triglyceride content: prevalence of hepatic steatosis in the general population Am J Physiol Endocrinol Metab 288 2005 E462 E468
    • (2005) Am J Physiol Endocrinol Metab , vol.288 , pp. E462-E468
    • Szczepaniak, L.S.1    Nurenberg, P.2    Leonard, D.3    Browning, J.D.4    Reingold, J.S.5    Grundy, S.6
  • 9
    • 46049089412 scopus 로고    scopus 로고
    • Increased liver fat, impaired insulin clearance, and hepatic and adipose tissue insulin resistance in type 2 diabetes
    • A. Kotronen, L. Juurinen, M. Tiikkainen, S. Vehkavaara, and H. Yki-Jarvinen Increased liver fat, impaired insulin clearance, and hepatic and adipose tissue insulin resistance in type 2 diabetes Gastroenterology 135 2008 122 130
    • (2008) Gastroenterology , vol.135 , pp. 122-130
    • Kotronen, A.1    Juurinen, L.2    Tiikkainen, M.3    Vehkavaara, S.4    Yki-Jarvinen, H.5
  • 11
    • 0021813187 scopus 로고
    • Homeostasis model assessment: Insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man
    • D.R. Matthews, J.P. Hosker, A.S. Rudenski, B.A. Naylor, D.F. Treacher, and R.C. Turner Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man Diabetologia 28 1985 412 419
    • (1985) Diabetologia , vol.28 , pp. 412-419
    • Matthews, D.R.1    Hosker, J.P.2    Rudenski, A.S.3    Naylor, B.A.4    Treacher, D.F.5    Turner, R.C.6
  • 12
    • 84896396831 scopus 로고    scopus 로고
    • A population-based study on the prevalence of NASH using scores validated against liver histology
    • J. Hyysalo, V.T. Mannisto, Y. Zhou, J. Arola, V. Karja, and M. Leivonen A population-based study on the prevalence of NASH using scores validated against liver histology J Hepatol 60 2014 839 846
    • (2014) J Hepatol , vol.60 , pp. 839-846
    • Hyysalo, J.1    Mannisto, V.T.2    Zhou, Y.3    Arola, J.4    Karja, V.5    Leivonen, M.6
  • 13
    • 0025066941 scopus 로고
    • More powerful procedures for multiple significance testing
    • Y. Hochberg, and Y. Benjamini More powerful procedures for multiple significance testing Stat Med 9 1990 811 818
    • (1990) Stat Med , vol.9 , pp. 811-818
    • Hochberg, Y.1    Benjamini, Y.2
  • 14
    • 84898058547 scopus 로고    scopus 로고
    • Systematic evaluation of coding variation identifies a candidate causal variant in TM6SF2 influencing total cholesterol and myocardial infarction risk
    • O.L. Holmen, H. Zhang, Y. Fan, D.H. Hovelson, E.M. Schmidt, and W. Zhou Systematic evaluation of coding variation identifies a candidate causal variant in TM6SF2 influencing total cholesterol and myocardial infarction risk Nat Genet 46 2014 345 351
    • (2014) Nat Genet , vol.46 , pp. 345-351
    • Holmen, O.L.1    Zhang, H.2    Fan, Y.3    Hovelson, D.H.4    Schmidt, E.M.5    Zhou, W.6
  • 15
    • 63249121641 scopus 로고    scopus 로고
    • Hepatic stearoyl-CoA desaturase (SCD)-1 activity and diacylglycerol but not ceramide concentrations are increased in the nonalcoholic human fatty liver
    • A. Kotronen, T. Seppanen-Laakso, J. Westerbacka, T. Kiviluoto, J. Arola, and A.L. Ruskeepaa Hepatic stearoyl-CoA desaturase (SCD)-1 activity and diacylglycerol but not ceramide concentrations are increased in the nonalcoholic human fatty liver Diabetes 58 2009 203 208
    • (2009) Diabetes , vol.58 , pp. 203-208
    • Kotronen, A.1    Seppanen-Laakso, T.2    Westerbacka, J.3    Kiviluoto, T.4    Arola, J.5    Ruskeepaa, A.L.6
  • 16
    • 78649695476 scopus 로고    scopus 로고
    • Splanchnic balance of free fatty acids, endocannabinoids, and lipids in subjects with nonalcoholic fatty liver disease
    • J. Westerbacka, A. Kotronen, B.A. Fielding, J. Wahren, L. Hodson, and J. Perttila Splanchnic balance of free fatty acids, endocannabinoids, and lipids in subjects with nonalcoholic fatty liver disease Gastroenterology 139 2010 e1
    • (2010) Gastroenterology , vol.139 , pp. e1
    • Westerbacka, J.1    Kotronen, A.2    Fielding, B.A.3    Wahren, J.4    Hodson, L.5    Perttila, J.6
  • 17
    • 61449266414 scopus 로고    scopus 로고
    • Serum saturated fatty acids containing triacylglycerols are better markers of insulin resistance than total serum triacylglycerol concentrations
    • A. Kotronen, V.R. Velagapudi, L. Yetukuri, J. Westerbacka, R. Bergholm, and K. Ekroos Serum saturated fatty acids containing triacylglycerols are better markers of insulin resistance than total serum triacylglycerol concentrations Diabetologia 52 2009 684 690
    • (2009) Diabetologia , vol.52 , pp. 684-690
    • Kotronen, A.1    Velagapudi, V.R.2    Yetukuri, L.3    Westerbacka, J.4    Bergholm, R.5    Ekroos, K.6
  • 18
    • 84868609657 scopus 로고    scopus 로고
    • Chronic overexpression of PNPLA3I148M in mouse liver causes hepatic steatosis
    • J.Z. Li, Y. Huang, R. Karaman, P.T. Ivanova, H.A. Brown, and T. Roddy Chronic overexpression of PNPLA3I148M in mouse liver causes hepatic steatosis J Clin Invest 122 2012 4130 4144
    • (2012) J Clin Invest , vol.122 , pp. 4130-4144
    • Li, J.Z.1    Huang, Y.2    Karaman, R.3    Ivanova, P.T.4    Brown, H.A.5    Roddy, T.6
  • 19
    • 84869224701 scopus 로고    scopus 로고
    • Patatin-like phospholipase domain-containing 3 (PNPLA3) I148M (rs738409) affects hepatic VLDL secretion in humans and in vitro
    • C. Pirazzi, M. Adiels, M.A. Burza, R.M. Mancina, M. Levin, and M. Stahlman Patatin-like phospholipase domain-containing 3 (PNPLA3) I148M (rs738409) affects hepatic VLDL secretion in humans and in vitro J Hepatol 57 2012 1276 1282
    • (2012) J Hepatol , vol.57 , pp. 1276-1282
    • Pirazzi, C.1    Adiels, M.2    Burza, M.A.3    Mancina, R.M.4    Levin, M.5    Stahlman, M.6
  • 20
    • 84860455885 scopus 로고    scopus 로고
    • The problem of establishing relationships between hepatic steatosis and hepatic insulin resistance
    • R.V. Farese Jr., R. Zechner, C.B. Newgard, and T.C. Walther The problem of establishing relationships between hepatic steatosis and hepatic insulin resistance Cell Metab 15 2012 570 573
    • (2012) Cell Metab , vol.15 , pp. 570-573
    • Farese, Jr.R.V.1    Zechner, R.2    Newgard, C.B.3    Walther, T.C.4
  • 21
    • 84903708160 scopus 로고    scopus 로고
    • TM6SF2 rs58542926 influences hepatic fibrosis progression in patients with non-alcoholic fatty liver disease
    • Y.L. Liu, H.L. Reeves, A.D. Burt, D. Tiniakos, S. McPherson, and J.B. Leathart TM6SF2 rs58542926 influences hepatic fibrosis progression in patients with non-alcoholic fatty liver disease Nat Commun 5 2014 4309
    • (2014) Nat Commun , vol.5 , pp. 4309
    • Liu, Y.L.1    Reeves, H.L.2    Burt, A.D.3    Tiniakos, D.4    McPherson, S.5    Leathart, J.B.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.