Three-dimensional structural modelling and calculation of electrostatic potentials of HLA Bw4 and Bw6 epitopes to explain the molecular basis for alloantibody binding: Toward predicting HLA antigenicity and immunogenicity

Transplantation

Volumn 99, Issue 2, 2015, Pages 385-390

  Mallon, Dermot H ^a   Bradley, J Andrew ^a   Winn, Peter J ^b   Taylor, Craig J ^c   Kosmoliaptsis, Vasilis ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^c ADDENBROOKE S HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALLOANTIBODY; EPITOPE; HLA ANTIGEN; HLA ANTIGEN CLASS 1; HLA B ANTIGEN; HLA-BW4 ANTIGEN; HLA-BW6 ANTIGEN;

ALPHA HELIX; AMINO ACID SEQUENCE; ANTIGEN BINDING; ANTIGEN DETECTION; ANTIGEN STRUCTURE; ARTICLE; B LYMPHOCYTE; BINDING AFFINITY; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; GENE; GENE EXPRESSION; GENE FREQUENCY; GENE FUNCTION; GENE IDENTIFICATION; HLA CLASS I GENE; IMMUNOGENICITY; MATHEMATICAL ANALYSIS; MATHEMATICAL MODEL; MOLECULAR DYNAMICS; PREDICTION; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; SEQUENCE ANALYSIS; STATIC ELECTRICITY; THREE DIMENSIONAL STRUCTURAL MODELING; ANTIBODY COMBINING SITE; CHEMISTRY; EPITOPE MAPPING; HISTOCOMPATIBILITY; HUMAN; IMMUNOLOGY; METABOLISM; PROCEDURES; PROTEIN DOMAIN; PROTEIN MOTIF; PROTEIN SECONDARY STRUCTURE; STRUCTURE ACTIVITY RELATION; SURFACE PROPERTY;

AMINO ACID MOTIFS; BINDING SITES, ANTIBODY; EPITOPE MAPPING; EPITOPES; HISTOCOMPATIBILITY; HLA-B ANTIGENS; HUMANS; ISOANTIBODIES; MOLECULAR DYNAMICS SIMULATION; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN STRUCTURE, SECONDARY; STATIC ELECTRICITY; STRUCTURE-ACTIVITY RELATIONSHIP; SURFACE PROPERTIES;

EID: 84923013700     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/TP.0000000000000546     Document Type: Article

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