High-resolution, three-dimensional modeling of human leukocyte antigen class I structure and surface electrostatic potential reveals the molecular basis for alloantibody binding epitopes

Human Immunology

Volumn 72, Issue 11, 2011, Pages 1049-1059

  Kosmoliaptsis, Vasilis ^a,b   Dafforn, Timothy R ^c   Chaudhry, Afzal N ^a   Halsall, David J ^a   Bradley, J Andrew ^b   Taylor, Craig J ^a  

^a ADDENBROOKE S HOSPITAL   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

Alloantigen immunogenicity; HLA antibodies

Indexed keywords

ALLOANTIBODY; BW4 EPITOPE; BW6 EPITOPE; EPITOPE; HLA ANTIGEN CLASS 1; HLA B ANTIGEN; UNCLASSIFIED DRUG;

ALLELE; AMINO ACID COMPOSITION; ANTIGEN BINDING; ANTIGEN STRUCTURE; ARTICLE; B LYMPHOCYTE; CROSS REACTION; ELECTRIC POTENTIAL; HUMAN; IMMUNOGENICITY; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; STATIC ELECTRICITY; STEREOCHEMISTRY; SURFACE ELECTROSTATIC POTENTIAL;

ALLELES; CHEMISTRY, PHYSICAL; CROSS REACTIONS; HLA-B ANTIGENS; HUMANS; IMAGING, THREE-DIMENSIONAL; IMMUNODOMINANT EPITOPES; ISOANTIBODIES; MODELS, CHEMICAL; MODELS, STRUCTURAL; ORGAN TRANSPLANTATION; POLYMORPHISM, GENETIC; PROTEIN BINDING; PROTEIN CONFORMATION; SENSITIVITY AND SPECIFICITY; SOFTWARE; STATIC ELECTRICITY;

EID: 80054115346     PISSN: 01988859     EISSN: 18791166     Source Type: Journal    
DOI: 10.1016/j.humimm.2011.07.303     Document Type: Article

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