Mass treatment with single-dose azithromycin for yaws

New England Journal of Medicine

Volumn 372, Issue 8, 2014, Pages 703-710

  Mitjà, Oriol ^a,d   Houinei, Wendy ^b   Moses, Penias ^a   Kapa, August ^a   Paru, Raymond ^a   Hays, Russell ^e   Lukehart, Sheila ^g   Godornes, Charmie ^g   Bieb, Sibauk Vivaldo ^b   Grice, Tim ^f   Siba, Peter ^c   Mabey, David ^h   Sanz, Sergi ^d   Alonso, Pedro L ^d   Asiedu, Kingsley ⁱ   Bassat, Quique ^d  

^a Lihir Medical Center International SOS Department of Community Health   (Papua New Guinea)

^b National Department for Health   (Papua New Guinea)

^c PAPUA NEW GUINEA INSTITUTE OF MEDICAL RESEARCH   (Papua New Guinea)

^d CENTRE FOR RESEARCH IN ENVIRONMENTAL EPIDEMIOLOGY CREAL   (Spain)

^e JAMES COOK UNIVERSITY   (Australia)

^f UNIVERSITY OF QUEENSLAND   (Australia)

^g UNIVERSITY OF WASHINGTON   (United States)

^h LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

ⁱ WORLD HEALTH ORGANIZATION   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

AZITHROMYCIN; ANTIINFECTIVE AGENT;

ADOLESCENT; ADULT; ARTICLE; CAUSAL ATTRIBUTION; CHILD; CLINICAL EFFECTIVENESS; CLINICAL TRIAL; DIARRHEA; DISEASE SEVERITY; DOSE RESPONSE; DRUG EFFECT; DRUG SAFETY; ENDEMIC DISEASE; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; NAUSEA; OUTCOME ASSESSMENT; PRESCHOOL CHILD; SCHOOL CHILD; SINGLE DRUG DOSE; SKIN ULCER; TREATMENT DURATION; TREATMENT OUTCOME; TREPONEMA PALLIDUM; VOMITING; YAWS; YOUNG ADULT; AGE DISTRIBUTION; ANTIBIOTIC RESISTANCE; CHANCROID; CROSS-SECTIONAL STUDY; GENETICS; HAEMOPHILUS DUCREYI; INFANT; ISOLATION AND PURIFICATION; PAPUA NEW GUINEA; POLYMERASE CHAIN REACTION; PREVALENCE;

ADOLESCENT; ADULT; AGE DISTRIBUTION; ANTI-BACTERIAL AGENTS; AZITHROMYCIN; CHANCROID; CHILD; CHILD, PRESCHOOL; CROSS-SECTIONAL STUDIES; DRUG RESISTANCE, BACTERIAL; ENDEMIC DISEASES; HAEMOPHILUS DUCREYI; HUMANS; INFANT; PAPUA NEW GUINEA; POLYMERASE CHAIN REACTION; PREVALENCE; TREPONEMA PALLIDUM; YAWS; YOUNG ADULT;

EID: 84923013619     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJMoa1408586     Document Type: Article

References (21)

1. Mitjà O, Asiedu K, Mabey D. Yaws. Lancet 2013;381:763-73.
2. Global Health Observatory Data Repository: yaws. Geneva: World Health Organization, 2013 (http://apps.who.int/gho/data/node.main.NTDYAWS).
3. Meheus A, Antal GM. The endemic treponematoses: not yet eradicated. World Health Stat Q 1992;45:228-37.
4. Mitjà O, Hays R, Ipai A, et al. Singledose azithromycin versus benzathine benzylpenicillin for treatment of yaws in children in Papua New Guinea: an open-label, non-inferiority, randomised trial. Lancet 2012;379:342-7.
5. Eradication of yaws - the Morges strategy. Wkly Epidemiol Rec 2012;87:189-94.
6. Mabey D. Oral azithromycin for treatment of yaws. Lancet 2012;379:295-7.
7. Report of Second International Conference on Control of Yaws: Nigeria, 1955. J Trop Med Hyg 1957;60:62-73.
8. Li HY, Soebekti R. Serological study of yaws in Java. Bull World Health Organ 1955;12:905-43.
9. Hackett CJ. Some epidemiological aspects of yaws eradication. Bull World Health Organ 1960;23:739-61.
10. Zahra A. Yaws eradication campaign in Nsukka Division, Eastern Nigeria. Bull World Health Organ 1956;15:911-35.
11. Samame GE. Treponematosis eradication, with special reference to yaws eradication in Haiti. Bull World Health Organ 1956;15:897-910.
12. Hackett CJ, Guthe T. Some important aspects of yaws eradication. Bull World Health Organ 1956;15:869-96.
13. Mitjà O, Hays R, Ipai A, et al. Outcome predictors in treatment of yaws. Emerg Infect Dis 2011;17:1083-5.
14. Yaws: recognition booklet for communities. Geneva: World Health Organization, 2013 (http://apps.who.int/iris/bitstream/10665/75360/1/9789241504096-eng.pdf ?ua=1).
15. Summary report of a consultation on the eradication of yaws: 5-7 March 2012, Morges, Switzerland. Geneva: World Health Organization, 2012 (http://apps .who.int/iris/bitstream/10665/75528/1/WHO-HTM-NTD-IDM-2012.2-eng.pdf).
16. Mitjà O, Lukehart SA, Pokowas G, et al. Haemophilus ducreyi as a cause of skin ulcers in children from a yaws-endemic area of Papua New Guinea: a prospective cohort study. Lancet Glob Health 2014; 2(4):e235-e241.
17. Centurion-Lara A, Castro C, Shaffer JM, et al. Detection of Treponema pallidum by a sensitive reverse transcriptase PCR. J Clin Microbiol 1997;35:1348-52.
18. Marra CM, Sahi SK, Tantalo LC, et al. Enhanced molecular typing of Treponema pallidum: geographical distribution of strain types and association with neurosyphilis. J Infect Dis 2010;202:1380-8.
19. Centurion-Lara A, Giacani L, Godornes C, Molini BJ, Brinck Reid T, Lukehart SA. Fine analysis of genetic diversity of the tpr gene family among treponemal species, subspecies and strains. PLoS Negl Trop Dis 2013;7(5):e2222.
20. Lukehart SA, Godornes C, Molini BJ, et al. Macrolide resistance in Treponema pallidum in the United States and Ireland. N Engl J Med 2004;351:154-8.
21. Hill KR. Non-specific factors in the epidemiology of yaws. Bull World Health Organ 1953;8:17-51.