Dioscorea batatas extract attenuates high-fat diet-induced obesity in mice by decreasing expression of inflammatory cytokines

Medical Science Monitor

Volumn 21, Issue , 2015, Pages 489-495

  Gil, Hyo Wook ^a   Lee, Eun Young ^a   Lee, Ji Hye ^a   Kim, Yong Sik ^a   Lee, Byung Eui ^a   Suk, Jeong Woo ^b   Song, Ho Yeon ^a  

^a Soonchunhyang University   (South Korea)

^b Soonchunhyang University Choenan Hospital ^*  (South Korea)

Author keywords

Adipogenesis; Diet; Dioscorea; High Fat; Obesity

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR; COMPLEMENTARY DNA; DIOSCOREA POLYSTACHYA EXTRACT; HIGH DENSITY LIPOPROTEIN; INTERLEUKIN 6; LEPTIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MONOCYTE CHEMOTACTIC PROTEIN 1; NUCLEAR RECEPTOR NR1D1; PLANT EXTRACT; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; BIOLOGICAL MARKER; CYTOKINE; THYROID HORMONE RECEPTOR ALPHA;

ADIPOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; DIET INDUCED OBESITY; DIOSCOREA POLYSTACHYA; DOWN REGULATION; EPIDIDYMIS FAT; EXPERIMENTAL OBESITY; INFLAMMATION; INTRAABDOMINAL FAT; LIVER HISTOLOGY; MALE; MICRO-COMPUTED TOMOGRAPHY; MOUSE; NONALCOHOLIC FATTY LIVER; NONHUMAN; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA EXTRACTION; ANIMAL; BODY WEIGHT; C57BL MOUSE; CHEMISTRY; DRUG EFFECTS; GENE EXPRESSION REGULATION; LIPID DIET; METABOLISM; OBESITY; YAM;

ADIPOGENESIS; ANIMALS; BIOMARKERS; BODY WEIGHT; CYTOKINES; DIET, HIGH-FAT; DIOSCOREA; GENE EXPRESSION REGULATION; INTRA-ABDOMINAL FAT; MALE; MICE; MICE, INBRED C57BL; OBESITY; PLANT EXTRACTS; THYROID HORMONE RECEPTORS ALPHA; X-RAY MICROTOMOGRAPHY;

EID: 84922972151     PISSN: 12341010     EISSN: 16433750     Source Type: Journal    
DOI: 10.12659/MSM.891306     Document Type: Article

References (30)

1. Goodpaster BH, Krishnaswami S, Harris TB et al: Obesity, regional body fat distribution, and the metabolic syndrome in older men and women. Arch Intern Med, 2005; 165(7): 777-83
2. Blumentals WA, Hwu P, Kobayashi N, Ogura E: Obesity in hospitalized type 2 diabetes patients: A descriptive study. Med Sci Monit 2013; 19: 359-65
3. Oliveira Junior SA, Dal Pai-Silva M, Martinez PF et al: Diet-induced obesity causes metabolic, endocrine and cardiac alterations in spontaneously hypertensive rats. Med Sci Monit. 2010; 16(12): BR367-73
4. Diamantis T, Apostolou KG, Alexandrou A et al: Review of long-term weight loss results after laparoscopic sleeve gastrectomy. Surg Obes Relat Dis, 2014; 10(1): 177-83
5. Kelley GA, Kelley KS: Effects of exercise in the treatment of overweight and obese children and adolescents: a systematic review of meta-analyses. J Obes, 2013; 2013783103
6. Rhines SD, Heins JR: Pharmacotherapy for obesity and weight loss. S D Med, 2013; 66(11): 471, 73
7. Sharma M, Branscum P: Novel and emerging approaches to combat adolescent obesity. Adolesc Health Med Ther, 2010; 19-19
8. Stern JS, Peerson J, Mishra AT et al: Efficacy and tolerability of a novel herbal formulation for weight management. Obesity (Silver Spring), 2013; 21(5): 921-27
9. Sengupta K, Mishra AT, Rao MK et al: Efficacy and tolerability of a novel herbal formulation for weight management in obese subjects: a randomized double blind placebo controlled clinical study. Lipids Health Dis, 2012; 11: 122
10. Ouchi N, Parker JL, Lugus JJ, Walsh K: Adipokines in inflammation and metabolic disease. Nat Rev Immunol, 2011; 11(2): 85-97
11. Hotamisligil GS: Inflammation and metabolic disorders. Nature, 2006; 444(7121): 860-67
12. Upadhyaya S, Kadamkode V, Mahammed R et al: Adiponectin and IL-6: Mediators of inflammation in progression of healthy to type 2 diabetes in Indian population. Adipocyte, 2014; 3(1): 39-45
13. Araghiniknam M, Chung S, Nelson-White T et al: Antioxidant activity of dioscorea and dehydroepiandrosterone (DHEA) in older humans. Life Sci, 1996; 59(11): Pl147-57
14. Kim S, Jwa H, Yanagawa Y, Park T: Extract from Dioscorea batatas ameliorates insulin resistance in mice fed a high-fat diet. J Med Food, 2012; 15(6): 527-34
15. Ikeoka D, Mader JK, Pieber TR: Adipose tissue, inflammation and cardiovascular disease. Rev Assoc Med Bras, 2010; 56(1): 116-21
16. Johnson RJ, Nakagawa T, Sanchez-Lozada LG et al: Sugar, uric acid, and the etiology of diabetes and obesity. Diabetes, 2013; 62(10): 3307-15
17. Yang Z, Huffman SL: Nutrition in pregnancy and early childhood and associations with obesity in developing countries. Matern Child Nutr, 2013; 9(Suppl.1): 105-19
18. Schrauwen P, Westerterp KR: The role of high-fat diets and physical activity in the regulation of body weight. Br J Nutr, 2000; 84(4): 417-27
19. Jequier E: Pathways to obesity. Int J Obes Relat Metab Disord, 2002; 26(Suppl.2): S12-17
20. Gao X, Li B, Jiang H et al: Dioscorea opposita reverses dexamethasone induced insulin resistance. Fitoterapia, 2007; 78(1): 12-15
21. Dubern B, Clement K: Leptin and leptin receptor-related monogenic obesity. Biochimie, 2012; 94(10): 2111-15
22. Alfadda AA: Circulating Adipokines in Healthy versus Unhealthy Overweight and Obese Subjects. Int J Endocrinol, 2015; 2114: 170434
23. de Queiroz KB, Guimaraes JB, Coimbra CC et al: Endurance training increases leptin expression in the retroperitoneal adipose tissue of rats fed with a high-sugar diet. Lipids, 2014; 49(1): 85-96
24. Munzberg H, Flier JS, Bjorbaek C: Region-specific leptin resistance within the hypothalamus of diet-induced obese mice. Endocrinology, 2004; 145(11): 4880-89
25. Hotamisligil GS, Shargill NS, Spiegelman BM: Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science, 1993; 259(5091): 87-91
26. Lucas R, Parikh SJ, Sridhar S et al: Cytokine profiling of young overweight and obese female African American adults with prediabetes. Cytokine, 2013; 64(1): 310-15
27. Ruan H, Hacohen N, Golub TR et al: Tumor necrosis factor-alpha suppresses adipocyte-specific genes and activates expression of preadipocyte genes in 3T3-L1 adipocytes: nuclear factor-kappaB activation by TNF-alpha is obligatory. Diabetes, 2002; 51(5): 1319-36
28. Suganami T, Nishida J, Ogawa Y: A paracrine loop between adipocytes and macrophages aggravates inflammatory changes: role of free fatty acids and tumor necrosis factor alpha. Arterioscler Thromb Vasc Biol, 2005; 25(10): 2062-68
29. Darlington GJ, Ross SE, MacDougald OA: The role of C/EBP genes in adipocyte differentiation. J Biol Chem, 1998; 273(46): 30057-60
30. Coburn CT, Knapp FF Jr, Febbraio M et al: Defective uptake and utilization of long chain fatty acids in muscle and adipose tissues of CD36 knockout mice. J Biol Chem, 2000; 275(42): 32523-29