Evaluating health risks from inhaled polychlorinated biphenyls: Research needs for addressing uncertainty

Environmental Health Perspectives

Volumn 123, Issue 2, 2015, Pages 109-113

  Lehmann, Geniece M ^a   Christensen, Krista ^b   Maddaloni, Mark ^b   Phillips, Linda J ^b  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^b U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

POLYCHLORINATED BIPHENYL;

ARTICLE; BUILDING; ENVIRONMENTAL EXPOSURE; FOOD CONTAMINATION; HEALTH HAZARD; HEALTH IMPACT ASSESSMENT; PRIORITY JOURNAL; STUDY DESIGN; TOXIC INHALATION; ADVERSE EFFECTS; ANALYSIS; EXPOSURE; HUMAN; INDOOR AIR POLLUTION; METHODOLOGY; PROCEDURES; RISK ASSESSMENT; STATISTICS AND NUMERICAL DATA; UNCERTAINTY; UNITED STATES;

AIR POLLUTION, INDOOR; ENVIRONMENTAL EXPOSURE; HUMANS; INHALATION EXPOSURE; POLYCHLORINATED BIPHENYLS; RESEARCH DESIGN; RISK ASSESSMENT; UNCERTAINTY; UNITED STATES;

EID: 84922965323     PISSN: 00916765     EISSN: 15529924     Source Type: Journal    
DOI: 10.1289/ehp.1408564     Document Type: Article

References (42)

1. ATSDR (Agency for Toxic Substances and Disease Registry). 2000. Toxicological profile for Polychlorinated Biphenyls (PCBs). Atlanta, GA:ATSDR. Available: http://www.atsdr.cdc.gov/toxprofiles/tp17.pdf [accessed 6 January 2015].
2. Carpenter DO. 2006. Polychlorinated biphenyls (PCBs): routes of exposure and effects on human health. Rev Environ Health 21:1-23.
3. Casey AC, Berger DF, Lombardo JP, Hunt A, Quimby F. 1999. Aroclor 1242 inhalation and ingestion by Sprague-Dawley rats. J Toxicol Environ Health A 56:311-342.
4. Chiarenzelli J, Pagano J, Scrudato R, Falanga L, Migdal K, Hartwell A, et al. 2001. Enhanced airborne polychlorinated biphenyl (PCB) concentrations and chlorination downwind of Lake Ontario. Environ Sci Technol 35:3280-3286.
5. Dhakal K, He X, Lehmler HJ, Teesch LM, Duffel MW, Robertson LW. 2012. Identification of sulfated metabolites of 4-chlorobiphenyl (PCB3) in the serum and urine of male rats. Chem Res Toxicol 25:2796-2804.
6. Erickson MD, Kaley RG II. 2011. Applications of polychlorinated biphenyls. Environ Sci Pollut Res Int 18:135-151.
7. Hansen LG. 1998. Stepping backward to improve assessment of PCB congener toxicities. Environ Health Perspect 106:171-189.
8. Harper N, Connor K, Steinberg M, Safe S. 1995. Immunosuppressive activity of polychlorinated biphenyl mixtures and congeners: nonadditive (antagonistic) interactions. Fundam Appl Toxicol 27:131-139.
9. Harrad S, Ibarra C, Robson M, Melymuk L, Zhang X, Diamond M, et al. 2009. Polychlorinated biphenyls in domestic dust from Canada, New Zealand, United Kingdom and United States: implications for human exposure. Chemosphere 76:232-238.
10. Heinzow B, Mohr S, Ostendorp G, Kerst M, Körner W. 2007. PCB and dioxin-like PCB in indoor air of public buildings contaminated with different PCB sources-deriving toxicity equivalent concentrations from standard PCB congeners. Chemosphere 67:1746-1753.
11. Herrick RF, McClean MD, Meeker JD, Baxter LK, Weymouth GA. 2004. An unrecognized source of PCB contamination in schools and other buildings. Environ Health Perspect 112:1051-1053; doi:10.1289/ehp.6912.
12. Herrick RF, Meeker JD, Altshul L. 2011. Serum PCB levels and congener profiles among teachers in PCB-containing schools: a pilot study. Environ Health 10:56; doi:10.1186/1476-069X-10-56.
13. Hu D, Martinez A, Hornbuckle K. 2008. Discovery of non-aroclor PCB (3,3’-dichlorobiphenyl) in Chicago air. Environ Sci Technol 42:7873-7877.
14. Hu X, Adamcakova-Dodd A, Lehmler HJ, Hu D, Hornbuckle K, Thorne PS. 2012. Subchronic inhalation exposure study of an airborne polychlorinated biphenyl mixture resembling the Chicago ambient air congener profile. Environ Sci Technol 46:9653-9662.
15. International Programme on Chemical Safety. 2012. Guidance for Immunotoxicity Risk Assessment for Chemicals. IPCS Harmonization Project document No. 10. Geneva:World Health Organization. Available: http://www.inchem.org/documents/harmproj/harmproj/harmproj10.pdf [accessed 6 January 2015].
16. Kohler M, Tremp J, Zennegg M, Seiler C, Minder-Kohler S, Beck M, et al. 2005. Joint sealants: an overlooked diffuse source of poly-chlorinated biphenyls in buildings. Environ Sci Technol 39:1967-1973.
17. Kostyniak PJ, Hansen LG, Widholm JJ, Fitzpatrick RD, Olson JR, Helferich JL, et al. 2005. Formulation and characterization of an experimental PCB mixture designed to mimic human exposure from contaminated fish. Toxicol Sci 88:400-411.
18. Lauby-Secretan B, Loomis D, Grosse Y, Ghissassi FE, Bouvard V, Benbrahim-Tallaa L, et al. 2013. Carcinogenicity of polychlorinated biphenyls and polybrominated biphenyls. Lancet Oncol 14:287-288.
19. Lehmann GM, Verner MA, Luukinen B, Henning C, Assimon SA, LaKind JS, et al. 2014. Improving the risk assessment of lipophilic persistent environmental chemicals in breast milk. Crit Rev Toxicol 44:600-617.
20. Li MH, Hansen LG. 1996. Enzyme induction and acute endocrine effects in prepubertal female rats receiving environmental PCB/PCDF/PCDD mixtures. Environ Health Perspect 104:712-722.
21. MacIntosh DL, Minegishi T, Fragala MA, Allen JG, Coghlan KM, Stewart JH, et al. 2012. Mitigation of building-related polychlorinated biphenyls in indoor air of a school. Environ Health 11:24; doi:10.1186/1476-069X-11-24.
22. Makris SL, Thompson CM, Euling SY, Selevan SG, Sonawane B. 2008. A lifestage-specific approach to hazard and dose-response characterization for children’s health risk assessment. Birth Defects Res B Dev Reprod Toxicol 83:530-546.
23. Mayes BA, McConnell EE, Neal BH, Brunner MJ, Hamilton SB, Sullivan TM, et al. 1998. Comparative carcinogenicity in Sprague-Dawley rats of the polychlorinated biphenyl mixtures Aroclors 1016, 1242, 1254, and 1260. Toxicol Sci 41:62-76.
24. Meyer HW, Frederiksen M, Göen T, Ebbehøj NE, Gunnarsen L, Brauer C, et al. 2013. Plasma poly chlorinated biphenyls in residents of 91 PCB-contaminated and 108 non-contaminated dwellings—an exposure study. Int J Hyg Environ Health 216:755-762.
25. Pennington JAT. 2000. Total diet studies—experi-ences in the United States. J Food Compos Anal 13:539-544.
26. Persoon C, Peters TM, Kumar N, Hornbuckle KC. 2010. Spatial distribution of airborne polychlorinated biphenyls in Cleveland, Ohio and Chicago, Illinois. Environ Sci Technol 44:2797-2802.
27. Priha E, Hellman S, Sorvari J. 2005. PCB contamination from polysulphide sealants in residential areas— exposure and risk assessment. Chemosphere 59:537-543.
28. Rice D, Barone S. 2000. Critical periods of vulner-ability for the developing nervous system: evidence from humans and animal models. Environ Health Perspect 108(suppl 3):511-533.
29. Rice DC, Hayward S. 1997. Effects of postnatal exposure to a PCB mixture in monkeys on non spatial discrimi-nation reversal and delayed alternation performance. Neurotoxicology 18:479-494.
30. Robertson LW, Ludewig G. 2011. Polychlorinated biphenyl (PCB) carcinogenicity with special emphasis on airborne PCBs. Gefahrst Reinhalt Luft 71:25-32.
31. Schettgen T, Alt A, Preim D, Keller D, Kraus T. 2012. Biological monitoring of indoor-exposure to dioxin-like and non-dioxin-like polychlorinated biphenyls (PCB) in a public building. Toxicol Lett 213:116-121.
32. Seegal RF, Bush B, Brosch KO. 1991. Comparison of effects of Aroclors 1016 and 1260 on non-human primate catecholamine function. Toxicology 66:145-163.
33. Thomas K, Xue J, Williams R, Jones P, Whitaker D. 2012. Polychlorinated Biphenyls (PCBs) in School Buildings: Sources, Environmental Levels, and Exposures. EPA/600/R-12/051. Washington, DC:U.S. EPA. Available: http://www.epa.gov/pcbsincaulk/pdf/pcb_EPA600R12051_final.pdf [accessed 6 January 2015].
34. Treon JF, Cleveland FP, Cappel JW, Atchley RW. 1956. The toxicity of the vapors of Aroclor 1242 and Aroclor 1254. Am Ind Hyg Assoc Q 17:204-213.
35. U.S. EPA (U.S. Environmental Protection Agency). 2002. A Review of the Reference Dose and Reference Concentration Processes. EPA/630/P-02/002F. Washington, DC:U.S. EPA. Available: http://www.epa.gov/raf/publications/pdfs/rfd-final.pdf [accessed 6 January 2015].
36. U.S. EPA (U.S. Environmental Protection Agency). 2011. Exposure Factors Handbook: 2011 Edition (Final). EPA/600/R-09/052F. Washington, DC:U.S. EPA. Available: http://www.epa.gov/ncea/efh/pdfs/efh-complete.pdf[accessed 6 January 2015].
37. U.S. EPA (U.S. Environmental Protection Agency). 2012. Benchmark Dose Technical Guidance. EPA/100/R-12/001. Washington, DC:U.S. EPA. Available: http://www.epa.gov/raf/publications/pdfs/benchmark_dose_guidance.pdf [accessed 6 January 2015].
38. U.S. EPA (U.S. Environmental Protection Agency). 2013. PCB-Containing Fluorescent Light Ballasts (FLBs) in School Buildings. Available: http://www.epa.gov/epawaste/hazard/tsd/pcbs/pubs/ballasts.htm [accessed 31 March 2014].
39. U.S. EPA (U.S. Environmental Protection Agency). 2015. Polychlorinated Biphenyls (PCBs) Manufacturing, Processing, Distribution in Commerce, and Use Prohibitions. Fed Reg 40 CFR 761. Available: http://www.ecfr.gov/cgi-bin/text-idx?tpl=/ecfrbrowse/Title40/40cfr761_main_02.tpl [accessed 6 January 2015].
40. Van den Berg M, Birnbaum LS, Denison M, De Vito M, Farland W, Feeley M, et al. 2006. The 2005 World Health Organization reevaluation of human and mammalian toxic equivalency factors for dioxins and dioxin-like compounds. Toxicol Sci 93:223-241.
41. Williams DT, Lebel GL, Furmanczyk T. 1980. Polychlorinated biphenyl contamination of laboratory air. Chemosphere 9:45-50.
42. Zhao HX, Adamcakova-Dodd A, Hu D, Hornbuckle KC, Just CL, Robertson LW, et al. 2010. Development of a synthetic PCB mixture resembling the average polychlorinated biphenyl profile in Chicago air. Environ Int 36:819-827.