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Volumn 24, Issue 1, 2015, Pages 199-214

Integrating systemic and surgical approaches to treating metastatic colorectal cancer

Author keywords

Antiangiogenic therapy; Antineoplastic therapy; Colorectal cancer; Liver metastases; Liver directed therapy

Indexed keywords

AFLIBERCEPT; BEVACIZUMAB; CAPECITABINE; CETUXIMAB; EPIDERMAL GROWTH FACTOR RECEPTOR; FLUOROURACIL; FOLINIC ACID; IRINOTECAN; OXALIPLATIN; PANITUMUMAB; REGORAFENIB; VASCULOTROPIN; ANTINEOPLASTIC AGENT;

EID: 84922953076     PISSN: 10553207     EISSN: 15585042     Source Type: Journal    
DOI: 10.1016/j.soc.2014.09.006     Document Type: Review
Times cited : (8)

References (72)
  • 1
    • 84892805731 scopus 로고    scopus 로고
    • Cancer statistics, 2014
    • Siegel R., Ma J., Zou Z., et al. Cancer statistics, 2014. CA Cancer J Clin 2014, 64(1):9-29.
    • (2014) CA Cancer J Clin , vol.64 , Issue.1 , pp. 9-29
    • Siegel, R.1    Ma, J.2    Zou, Z.3
  • 2
    • 84907027361 scopus 로고    scopus 로고
    • CALGB/SWOG 80405: phase III trial of irinotecan/5-FU/leucovorin (FOLFIRI) or oxaliplatin/5-FU/leucovorin (mFOLFOX6) with bevacizumab (BV) or cetuximab (CET) for patients (pts) with KRAS wild-type (wt) untreated metastatic adenocarcinoma of the colon or rectum (MCRC)
    • Venook A.P., Niedzwiecki D., Lenz H.J., et al. CALGB/SWOG 80405: phase III trial of irinotecan/5-FU/leucovorin (FOLFIRI) or oxaliplatin/5-FU/leucovorin (mFOLFOX6) with bevacizumab (BV) or cetuximab (CET) for patients (pts) with KRAS wild-type (wt) untreated metastatic adenocarcinoma of the colon or rectum (MCRC). JClin Oncol 2014, 32:5s.
    • (2014) JClin Oncol , vol.32 , pp. 5s
    • Venook, A.P.1    Niedzwiecki, D.2    Lenz, H.J.3
  • 3
    • 0027461840 scopus 로고
    • Randomised comparison of combination chemotherapy plus supportive care with supportive care alone in patients with metastatic colorectal cancer
    • Scheithauer W., Rosen H., Kornek G.V., et al. Randomised comparison of combination chemotherapy plus supportive care with supportive care alone in patients with metastatic colorectal cancer. BMJ 1993, 306(6880):752-755.
    • (1993) BMJ , vol.306 , Issue.6880 , pp. 752-755
    • Scheithauer, W.1    Rosen, H.2    Kornek, G.V.3
  • 4
    • 33846404530 scopus 로고    scopus 로고
    • The continuum of care: a paradigm for the management of metastatic colorectal cancer
    • Goldberg R.M., Rothenberg M.L., Van Cutsem E., et al. The continuum of care: a paradigm for the management of metastatic colorectal cancer. Oncologist 2007, 12(1):38-50.
    • (2007) Oncologist , vol.12 , Issue.1 , pp. 38-50
    • Goldberg, R.M.1    Rothenberg, M.L.2    Van Cutsem, E.3
  • 5
    • 33644825856 scopus 로고    scopus 로고
    • Overall survival of patients with advanced colorectal cancer correlates with availability of fluorouracil, irinotecan, and oxaliplatin regardless of whether doublet or single-agent therapy is used first line
    • Grothey A., Sargent D. Overall survival of patients with advanced colorectal cancer correlates with availability of fluorouracil, irinotecan, and oxaliplatin regardless of whether doublet or single-agent therapy is used first line. JClin Oncol 2005, 23(36):9441-9442.
    • (2005) JClin Oncol , vol.23 , Issue.36 , pp. 9441-9442
    • Grothey, A.1    Sargent, D.2
  • 6
    • 24644457747 scopus 로고    scopus 로고
    • Phase III randomized trial of FOLFIRI versus FOLFOX4 in the treatment of advanced colorectal cancer: a multicenter study of the Gruppo Oncologico Dell'Italia Meridionale
    • Colucci G., Gebbia V., Paoletti G., et al. Phase III randomized trial of FOLFIRI versus FOLFOX4 in the treatment of advanced colorectal cancer: a multicenter study of the Gruppo Oncologico Dell'Italia Meridionale. JClin Oncol 2005, 23(22):4866-4875.
    • (2005) JClin Oncol , vol.23 , Issue.22 , pp. 4866-4875
    • Colucci, G.1    Gebbia, V.2    Paoletti, G.3
  • 7
    • 34548440297 scopus 로고    scopus 로고
    • Capecitabine plus 3-weekly irinotecan (XELIRI regimen) as first-line chemotherapy for metastatic colorectal cancer: phase II trial results
    • Patt Y.Z., Lee F.C., Liebmann J.E., et al. Capecitabine plus 3-weekly irinotecan (XELIRI regimen) as first-line chemotherapy for metastatic colorectal cancer: phase II trial results. Am J Clin Oncol 2007, 30(4):350-357.
    • (2007) Am J Clin Oncol , vol.30 , Issue.4 , pp. 350-357
    • Patt, Y.Z.1    Lee, F.C.2    Liebmann, J.E.3
  • 8
    • 34948892881 scopus 로고    scopus 로고
    • Phase III study of capecitabine plus oxaliplatin compared with continuous-infusion fluorouracil plus oxaliplatin as first-line therapy in metastatic colorectal cancer: final report of the Spanish Cooperative Group for the treatment of digestive tumors trial
    • Diaz-Rubio E., Tabernero J., Gomez-Espana A., et al. Phase III study of capecitabine plus oxaliplatin compared with continuous-infusion fluorouracil plus oxaliplatin as first-line therapy in metastatic colorectal cancer: final report of the Spanish Cooperative Group for the treatment of digestive tumors trial. JClin Oncol 2007, 25(27):4224-4230.
    • (2007) JClin Oncol , vol.25 , Issue.27 , pp. 4224-4230
    • Diaz-Rubio, E.1    Tabernero, J.2    Gomez-Espana, A.3
  • 9
    • 34948857445 scopus 로고    scopus 로고
    • Phase III study of capecitabine plus oxaliplatin compared with fluorouracil and leucovorin plus oxaliplatin in metastatic colorectal cancer: a final report of the AIO Colorectal Study Group
    • Porschen R., Arkenau H.T., Kubicka S., et al. Phase III study of capecitabine plus oxaliplatin compared with fluorouracil and leucovorin plus oxaliplatin in metastatic colorectal cancer: a final report of the AIO Colorectal Study Group. JClin Oncol 2007, 25(27):4217-4223.
    • (2007) JClin Oncol , vol.25 , Issue.27 , pp. 4217-4223
    • Porschen, R.1    Arkenau, H.T.2    Kubicka, S.3
  • 10
    • 57449096129 scopus 로고    scopus 로고
    • Five-year data and prognostic factor analysis of oxaliplatin and irinotecan combinations for advanced colorectal cancer: N9741
    • Sanoff H.K., Sargent D.J., Campbell M.E., et al. Five-year data and prognostic factor analysis of oxaliplatin and irinotecan combinations for advanced colorectal cancer: N9741. JClin Oncol 2008, 26(35):5721-5727.
    • (2008) JClin Oncol , vol.26 , Issue.35 , pp. 5721-5727
    • Sanoff, H.K.1    Sargent, D.J.2    Campbell, M.E.3
  • 11
    • 34249000361 scopus 로고    scopus 로고
    • Phase III trial of infusional fluorouracil, leucovorin, oxaliplatin, and irinotecan (FOLFOXIRI) compared with infusional fluorouracil, leucovorin, and irinotecan (FOLFIRI) as first-line treatment for metastatic colorectal cancer: the Gruppo Oncologico Nord Ovest
    • Falcone A., Ricci S., Brunetti I., et al. Phase III trial of infusional fluorouracil, leucovorin, oxaliplatin, and irinotecan (FOLFOXIRI) compared with infusional fluorouracil, leucovorin, and irinotecan (FOLFIRI) as first-line treatment for metastatic colorectal cancer: the Gruppo Oncologico Nord Ovest. JClin Oncol 2007, 25(13):1670-1676.
    • (2007) JClin Oncol , vol.25 , Issue.13 , pp. 1670-1676
    • Falcone, A.1    Ricci, S.2    Brunetti, I.3
  • 12
    • 63449116518 scopus 로고    scopus 로고
    • Long-term outcome of initially unresectable metastatic colorectal cancer patients treated with 5-fluorouracil/leucovorin, oxaliplatin, and irinotecan (FOLFOXIRI) followed by radical surgery of metastases
    • Masi G., Loupakis F., Pollina L., et al. Long-term outcome of initially unresectable metastatic colorectal cancer patients treated with 5-fluorouracil/leucovorin, oxaliplatin, and irinotecan (FOLFOXIRI) followed by radical surgery of metastases. Ann Surg 2009, 249(3):420-425.
    • (2009) Ann Surg , vol.249 , Issue.3 , pp. 420-425
    • Masi, G.1    Loupakis, F.2    Pollina, L.3
  • 13
    • 66149157842 scopus 로고    scopus 로고
    • Efficacy of FOLFIRI-3 (irinotecan D1,D3 combined with LV5-FU) or other irinotecan-based regimens in oxaliplatin-pretreated metastatic colorectal cancer in the GERCOR OPTIMOX1 study
    • Bidard F.C., Tournigand C., Andre T., et al. Efficacy of FOLFIRI-3 (irinotecan D1,D3 combined with LV5-FU) or other irinotecan-based regimens in oxaliplatin-pretreated metastatic colorectal cancer in the GERCOR OPTIMOX1 study. Ann Oncol 2009, 20(6):1042-1047.
    • (2009) Ann Oncol , vol.20 , Issue.6 , pp. 1042-1047
    • Bidard, F.C.1    Tournigand, C.2    Andre, T.3
  • 14
    • 1342290189 scopus 로고    scopus 로고
    • FOLFIRI followed by FOLFOX6 or the reverse sequence in advanced colorectal cancer: a randomized GERCOR study
    • Tournigand C., Andre T., Achille E., et al. FOLFIRI followed by FOLFOX6 or the reverse sequence in advanced colorectal cancer: a randomized GERCOR study. JClin Oncol 2004, 22(2):229-237.
    • (2004) JClin Oncol , vol.22 , Issue.2 , pp. 229-237
    • Tournigand, C.1    Andre, T.2    Achille, E.3
  • 15
    • 0037531121 scopus 로고    scopus 로고
    • Superiority of oxaliplatin and fluorouracil-leucovorin compared with either therapy alone in patients with progressive colorectal cancer after irinotecan and fluorouracil-leucovorin: interim results of a phase III trial
    • Rothenberg M.L., Oza A.M., Bigelow R.H., et al. Superiority of oxaliplatin and fluorouracil-leucovorin compared with either therapy alone in patients with progressive colorectal cancer after irinotecan and fluorouracil-leucovorin: interim results of a phase III trial. JClin Oncol 2003, 21(11):2059-2069.
    • (2003) JClin Oncol , vol.21 , Issue.11 , pp. 2059-2069
    • Rothenberg, M.L.1    Oza, A.M.2    Bigelow, R.H.3
  • 16
    • 34248173883 scopus 로고    scopus 로고
    • Bevacizumab in combination with oxaliplatin, fluorouracil, and leucovorin (FOLFOX4) for previously treated metastatic colorectal cancer: results from the Eastern Cooperative Oncology Group Study E3200
    • Giantonio B.J., Catalano P.J., Meropol N.J., et al. Bevacizumab in combination with oxaliplatin, fluorouracil, and leucovorin (FOLFOX4) for previously treated metastatic colorectal cancer: results from the Eastern Cooperative Oncology Group Study E3200. JClin Oncol 2007, 25(12):1539-1544.
    • (2007) JClin Oncol , vol.25 , Issue.12 , pp. 1539-1544
    • Giantonio, B.J.1    Catalano, P.J.2    Meropol, N.J.3
  • 17
    • 20644432867 scopus 로고    scopus 로고
    • Bevacizumab in combination with fluorouracil and leucovorin: an active regimen for first-line metastatic colorectal cancer
    • Hurwitz H.I., Fehrenbacher L., Hainsworth J.D., et al. Bevacizumab in combination with fluorouracil and leucovorin: an active regimen for first-line metastatic colorectal cancer. JClin Oncol 2005, 23(15):3502-3508.
    • (2005) JClin Oncol , vol.23 , Issue.15 , pp. 3502-3508
    • Hurwitz, H.I.1    Fehrenbacher, L.2    Hainsworth, J.D.3
  • 18
    • 20544471876 scopus 로고    scopus 로고
    • Combined analysis of efficacy: the addition of bevacizumab to fluorouracil/leucovorin improves survival for patients with metastatic colorectal cancer
    • Kabbinavar F.F., Hambleton J., Mass R.D., et al. Combined analysis of efficacy: the addition of bevacizumab to fluorouracil/leucovorin improves survival for patients with metastatic colorectal cancer. JClin Oncol 2005, 23(16):3706-3712.
    • (2005) JClin Oncol , vol.23 , Issue.16 , pp. 3706-3712
    • Kabbinavar, F.F.1    Hambleton, J.2    Mass, R.D.3
  • 19
    • 70350103864 scopus 로고    scopus 로고
    • Bevacizumab in association with de Gramont 5-fluorouracil/folinic acid in patients with oxaliplatin-, irinotecan-, and cetuximab-refractory colorectal cancer: a single-center phase 2 trial
    • Vincenzi B., Santini D., Russo A., et al. Bevacizumab in association with de Gramont 5-fluorouracil/folinic acid in patients with oxaliplatin-, irinotecan-, and cetuximab-refractory colorectal cancer: a single-center phase 2 trial. Cancer 2009, 115(20):4849-4856.
    • (2009) Cancer , vol.115 , Issue.20 , pp. 4849-4856
    • Vincenzi, B.1    Santini, D.2    Russo, A.3
  • 20
    • 49049105525 scopus 로고    scopus 로고
    • Safety and efficacy of oxaliplatin and fluoropyrimidine regimens with or without bevacizumab as first-line treatment of metastatic colorectal cancer: results of the TREE Study
    • Hochster H.S., Hart L.L., Ramanathan R.K., et al. Safety and efficacy of oxaliplatin and fluoropyrimidine regimens with or without bevacizumab as first-line treatment of metastatic colorectal cancer: results of the TREE Study. JClin Oncol 2008, 26(21):3523-3529.
    • (2008) JClin Oncol , vol.26 , Issue.21 , pp. 3523-3529
    • Hochster, H.S.1    Hart, L.L.2    Ramanathan, R.K.3
  • 21
    • 34548141828 scopus 로고    scopus 로고
    • Arterial thromboembolic events in patients with metastatic carcinoma treated with chemotherapy and bevacizumab
    • Scappaticci F.A., Skillings J.R., Holden S.N., et al. Arterial thromboembolic events in patients with metastatic carcinoma treated with chemotherapy and bevacizumab. JNatl Cancer Inst 2007, 99(16):1232-1239.
    • (2007) JNatl Cancer Inst , vol.99 , Issue.16 , pp. 1232-1239
    • Scappaticci, F.A.1    Skillings, J.R.2    Holden, S.N.3
  • 22
    • 84871720057 scopus 로고    scopus 로고
    • Continuation of bevacizumab after first progression in metastatic colorectal cancer (ML18147): a randomised phase 3 trial
    • Bennouna J., Sastre J., Arnold D., et al. Continuation of bevacizumab after first progression in metastatic colorectal cancer (ML18147): a randomised phase 3 trial. Lancet Oncol 2013, 14(1):29-37.
    • (2013) Lancet Oncol , vol.14 , Issue.1 , pp. 29-37
    • Bennouna, J.1    Sastre, J.2    Arnold, D.3
  • 23
    • 0037143764 scopus 로고    scopus 로고
    • VEGF-Trap: a VEGF blocker with potent antitumor effects
    • Holash J., Davis S., Papadopoulos N., et al. VEGF-Trap: a VEGF blocker with potent antitumor effects. Proc Natl Acad Sci USA 2002, 99(17):11393-11398.
    • (2002) Proc Natl Acad Sci USA , vol.99 , Issue.17 , pp. 11393-11398
    • Holash, J.1    Davis, S.2    Papadopoulos, N.3
  • 24
    • 84871650598 scopus 로고    scopus 로고
    • Aflibercept versus placebo in combination with FOLFIRI in previously treated metastatic colorectal cancer (mCRC): mean overall survival (OS) estimation from a phase III trial (VELOUR)
    • Abstract: 3602
    • Joulain F., Van Cutsem E., Iqbal S.U., et al. Aflibercept versus placebo in combination with FOLFIRI in previously treated metastatic colorectal cancer (mCRC): mean overall survival (OS) estimation from a phase III trial (VELOUR). JClin Oncol 2012, 30(15). Abstract: 3602.
    • (2012) JClin Oncol , vol.30 , Issue.15
    • Joulain, F.1    Van Cutsem, E.2    Iqbal, S.U.3
  • 25
    • 84868526153 scopus 로고    scopus 로고
    • Effects of prior bevacizumab (B) use on outcomes from the VELOUR study: a phase III study of aflibercept (Afl) and FOLFIRI in patients (pts) with metastatic colorectal cancer (mCRC) after failure of an oxaliplatin regimen
    • Abstract: 3505
    • Allegra C.J., Lakomy R., Tabernero J., et al. Effects of prior bevacizumab (B) use on outcomes from the VELOUR study: a phase III study of aflibercept (Afl) and FOLFIRI in patients (pts) with metastatic colorectal cancer (mCRC) after failure of an oxaliplatin regimen. JClin Oncol 2012, 30(15). Abstract: 3505.
    • (2012) JClin Oncol , vol.30 , Issue.15
    • Allegra, C.J.1    Lakomy, R.2    Tabernero, J.3
  • 26
    • 79551580551 scopus 로고    scopus 로고
    • Systematic review: anti-epidermal growth factor receptor treatment effect modification by KRAS mutations in advanced colorectal cancer
    • Dahabreh I.J., Terasawa T., Castaldi P.J., et al. Systematic review: anti-epidermal growth factor receptor treatment effect modification by KRAS mutations in advanced colorectal cancer. Ann Intern Med 2011, 154(1):37-49.
    • (2011) Ann Intern Med , vol.154 , Issue.1 , pp. 37-49
    • Dahabreh, I.J.1    Terasawa, T.2    Castaldi, P.J.3
  • 27
    • 65349189958 scopus 로고    scopus 로고
    • American Society of Clinical Oncology provisional clinical opinion: testing for KRAS gene mutations in patients with metastatic colorectal carcinoma to predict response to anti-epidermal growth factor receptor monoclonal antibody therapy
    • Allegra C.J., Jessup J.M., Somerfield M.R., et al. American Society of Clinical Oncology provisional clinical opinion: testing for KRAS gene mutations in patients with metastatic colorectal carcinoma to predict response to anti-epidermal growth factor receptor monoclonal antibody therapy. JClin Oncol 2009, 27(12):2091-2096.
    • (2009) JClin Oncol , vol.27 , Issue.12 , pp. 2091-2096
    • Allegra, C.J.1    Jessup, J.M.2    Somerfield, M.R.3
  • 28
    • 84883680951 scopus 로고    scopus 로고
    • Panitumumab-FOLFOX4 treatment and RAS mutations in colorectal cancer
    • Douillard J.Y., Oliner K.S., Siena S., et al. Panitumumab-FOLFOX4 treatment and RAS mutations in colorectal cancer. NEngl J Med 2013, 369(11):1023-1034.
    • (2013) NEngl J Med , vol.369 , Issue.11 , pp. 1023-1034
    • Douillard, J.Y.1    Oliner, K.S.2    Siena, S.3
  • 29
    • 68749119351 scopus 로고    scopus 로고
    • KRAS codon 61, 146 and BRAF mutations predict resistance to cetuximab plus irinotecan in KRAS codon 12 and 13 wild-type metastatic colorectal cancer
    • Loupakis F., Ruzzo A., Cremolini C., et al. KRAS codon 61, 146 and BRAF mutations predict resistance to cetuximab plus irinotecan in KRAS codon 12 and 13 wild-type metastatic colorectal cancer. Br J Cancer 2009, 101(4):715-721.
    • (2009) Br J Cancer , vol.101 , Issue.4 , pp. 715-721
    • Loupakis, F.1    Ruzzo, A.2    Cremolini, C.3
  • 30
    • 84885060097 scopus 로고    scopus 로고
    • Analysis of KRAS/NRAS mutations in PEAK: A randomized phase II study of FOLFOX6 plus panitumumab (pmab) or bevacizumab (bev) as first-line treatment (tx) for wild-type (WT) KRAS (exon 2) metastatic colorectal cancer (mCRC)
    • Abstract: 3631
    • Schwartzberg L.S., Rivera F., Karthaus M., et al. Analysis of KRAS/NRAS mutations in PEAK: A randomized phase II study of FOLFOX6 plus panitumumab (pmab) or bevacizumab (bev) as first-line treatment (tx) for wild-type (WT) KRAS (exon 2) metastatic colorectal cancer (mCRC). JClin Oncol 2013, 31(15). Abstract: 3631.
    • (2013) JClin Oncol , vol.31 , Issue.15
    • Schwartzberg, L.S.1    Rivera, F.2    Karthaus, M.3
  • 31
    • 84896121177 scopus 로고    scopus 로고
    • Analysis of KRAS/NRAS and BRAF mutations in FIRE-3: a randomized phase III study of FOLFIRI plus cetuximab or bevacizumab as first-line treatment for wild-type (WT) KRAS (exon 2) metastatic colorectal cancer (mCRC) patients
    • Data presented at the 13th annual European Cancer Congress (ECC), Amsterdam, The Netherlands. September 28
    • Stintzing S, Jung A, Rossius L, etal. Analysis of KRAS/NRAS and BRAF mutations in FIRE-3: a randomized phase III study of FOLFIRI plus cetuximab or bevacizumab as first-line treatment for wild-type (WT) KRAS (exon 2) metastatic colorectal cancer (mCRC) patients. Data presented at the 13th annual European Cancer Congress (ECC), Amsterdam, The Netherlands. September 28, 2013.
    • (2013)
    • Stintzing, S.1    Jung, A.2    Rossius, L.3
  • 32
    • 79956298812 scopus 로고    scopus 로고
    • Cetuximab plus irinotecan, fluorouracil, and leucovorin as first-line treatment for metastatic colorectal cancer: updated analysis of overall survival according to tumor KRAS and BRAF mutation status
    • Van Cutsem E., Kohne C.H., Lang I., et al. Cetuximab plus irinotecan, fluorouracil, and leucovorin as first-line treatment for metastatic colorectal cancer: updated analysis of overall survival according to tumor KRAS and BRAF mutation status. JClin Oncol 2011, 29(15):2011-2019.
    • (2011) JClin Oncol , vol.29 , Issue.15 , pp. 2011-2019
    • Van Cutsem, E.1    Kohne, C.H.2    Lang, I.3
  • 33
    • 44249111440 scopus 로고    scopus 로고
    • EPIC: phase III trial of cetuximab plus irinotecan after fluoropyrimidine and oxaliplatin failure in patients with metastatic colorectal cancer
    • Sobrero A.F., Maurel J., Fehrenbacher L., et al. EPIC: phase III trial of cetuximab plus irinotecan after fluoropyrimidine and oxaliplatin failure in patients with metastatic colorectal cancer. JClin Oncol 2008, 26(14):2311-2319.
    • (2008) JClin Oncol , vol.26 , Issue.14 , pp. 2311-2319
    • Sobrero, A.F.1    Maurel, J.2    Fehrenbacher, L.3
  • 34
    • 84873817509 scopus 로고    scopus 로고
    • Panitumumab combined with irinotecan for patients with KRAS wild-type metastatic colorectal cancer refractory to standard chemotherapy: a GERCOR efficacy, tolerance, and translational molecular study
    • Andre T., Blons H., Mabro M., et al. Panitumumab combined with irinotecan for patients with KRAS wild-type metastatic colorectal cancer refractory to standard chemotherapy: a GERCOR efficacy, tolerance, and translational molecular study. Ann Oncol 2013, 24(2):412-419.
    • (2013) Ann Oncol , vol.24 , Issue.2 , pp. 412-419
    • Andre, T.1    Blons, H.2    Mabro, M.3
  • 35
    • 80052435936 scopus 로고    scopus 로고
    • An open-label, single-arm, phase 2 trial of panitumumab plus FOLFIRI as second-line therapy in patients with metastatic colorectal cancer
    • Cohn A.L., Shumaker G.C., Khandelwal P., et al. An open-label, single-arm, phase 2 trial of panitumumab plus FOLFIRI as second-line therapy in patients with metastatic colorectal cancer. Clin Colorectal Cancer 2011, 10(3):171-177.
    • (2011) Clin Colorectal Cancer , vol.10 , Issue.3 , pp. 171-177
    • Cohn, A.L.1    Shumaker, G.C.2    Khandelwal, P.3
  • 36
    • 78149250536 scopus 로고    scopus 로고
    • Randomized, phase III trial of panitumumab with infusional fluorouracil, leucovorin, and oxaliplatin (FOLFOX4) versus FOLFOX4 alone as first-line treatment in patients with previously untreated metastatic colorectal cancer: the PRIME study
    • Douillard J.Y., Siena S., Cassidy J., et al. Randomized, phase III trial of panitumumab with infusional fluorouracil, leucovorin, and oxaliplatin (FOLFOX4) versus FOLFOX4 alone as first-line treatment in patients with previously untreated metastatic colorectal cancer: the PRIME study. JClin Oncol 2010, 28(31):4697-4705.
    • (2010) JClin Oncol , vol.28 , Issue.31 , pp. 4697-4705
    • Douillard, J.Y.1    Siena, S.2    Cassidy, J.3
  • 37
    • 84857050570 scopus 로고    scopus 로고
    • First-line panitumumab plus irinotecan/5-fluorouracil/leucovorin treatment in patients with metastatic colorectal cancer
    • Kohne C.H., Hofheinz R., Mineur L., et al. First-line panitumumab plus irinotecan/5-fluorouracil/leucovorin treatment in patients with metastatic colorectal cancer. JCancer Res Clin Oncol 2012, 138(1):65-72.
    • (2012) JCancer Res Clin Oncol , vol.138 , Issue.1 , pp. 65-72
    • Kohne, C.H.1    Hofheinz, R.2    Mineur, L.3
  • 38
    • 84899940235 scopus 로고    scopus 로고
    • Final results from a randomized phase 3 study of FOLFIRI {+/-} panitumumab for second-line treatment of metastatic colorectal cancer
    • Peeters M., Price T.J., Cervantes A., et al. Final results from a randomized phase 3 study of FOLFIRI {+/-} panitumumab for second-line treatment of metastatic colorectal cancer. Ann Oncol 2014, 25(1):107-116.
    • (2014) Ann Oncol , vol.25 , Issue.1 , pp. 107-116
    • Peeters, M.1    Price, T.J.2    Cervantes, A.3
  • 39
    • 84879786289 scopus 로고    scopus 로고
    • Panitumumab and irinotecan versus irinotecan alone for patients with KRAS wild-type, fluorouracil-resistant advanced colorectal cancer (PICCOLO): a prospectively stratified randomised trial
    • Seymour M.T., Brown S.R., Middleton G., et al. Panitumumab and irinotecan versus irinotecan alone for patients with KRAS wild-type, fluorouracil-resistant advanced colorectal cancer (PICCOLO): a prospectively stratified randomised trial. Lancet Oncol 2013, 14(8):749-759.
    • (2013) Lancet Oncol , vol.14 , Issue.8 , pp. 749-759
    • Seymour, M.T.1    Brown, S.R.2    Middleton, G.3
  • 40
    • 84958670477 scopus 로고    scopus 로고
    • ASPECCT: a randomized, multicenter, open-label, phase 3 study of panitumumab (pmab) vs cetuximab (cmab) for previously treated wild-type (WT) KRAS metastatic colorectal cancer (mCRC)
    • Data presented at the 2013 annual European Cancer Congress (ECC), Amsterdam, The Netherlands. September 29.
    • Price T, Peeters M, Kim TW, etal. ASPECCT: a randomized, multicenter, open-label, phase 3 study of panitumumab (pmab) vs cetuximab (cmab) for previously treated wild-type (WT) KRAS metastatic colorectal cancer (mCRC). Data presented at the 2013 annual European Cancer Congress (ECC), Amsterdam, The Netherlands. September 29, 2013.
    • (2013)
    • Price, T.1    Peeters, M.2    Kim, T.W.3
  • 41
    • 34147103678 scopus 로고    scopus 로고
    • Open-label phase III trial of panitumumab plus best supportive care compared with best supportive care alone in patients with chemotherapy-refractory metastatic colorectal cancer
    • Van Cutsem E., Peeters M., Siena S., et al. Open-label phase III trial of panitumumab plus best supportive care compared with best supportive care alone in patients with chemotherapy-refractory metastatic colorectal cancer. JClin Oncol 2007, 25(13):1658-1664.
    • (2007) JClin Oncol , vol.25 , Issue.13 , pp. 1658-1664
    • Van Cutsem, E.1    Peeters, M.2    Siena, S.3
  • 42
    • 59949102930 scopus 로고    scopus 로고
    • Arandomized phase IIIB trial of chemotherapy, bevacizumab, and panitumumab compared with chemotherapy and bevacizumab alone for metastatic colorectal cancer
    • Hecht J.R., Mitchell E., Chidiac T., et al. Arandomized phase IIIB trial of chemotherapy, bevacizumab, and panitumumab compared with chemotherapy and bevacizumab alone for metastatic colorectal cancer. JClin Oncol 2009, 27(5):672-680.
    • (2009) JClin Oncol , vol.27 , Issue.5 , pp. 672-680
    • Hecht, J.R.1    Mitchell, E.2    Chidiac, T.3
  • 43
    • 59749091477 scopus 로고    scopus 로고
    • Chemotherapy, bevacizumab, and cetuximab in metastatic colorectal cancer
    • Tol J., Koopman M., Cats A., et al. Chemotherapy, bevacizumab, and cetuximab in metastatic colorectal cancer. NEngl J Med 2009, 360(6):563-572.
    • (2009) NEngl J Med , vol.360 , Issue.6 , pp. 563-572
    • Tol, J.1    Koopman, M.2    Cats, A.3
  • 44
    • 84872921660 scopus 로고    scopus 로고
    • Regorafenib monotherapy for previously treated metastatic colorectal cancer (CORRECT): an international, multicentre, randomised, placebo-controlled, phase 3 trial
    • Grothey A., Van Cutsem E., Sobrero A., et al. Regorafenib monotherapy for previously treated metastatic colorectal cancer (CORRECT): an international, multicentre, randomised, placebo-controlled, phase 3 trial. Lancet 2013, 381(9863):303-312.
    • (2013) Lancet , vol.381 , Issue.9863 , pp. 303-312
    • Grothey, A.1    Van Cutsem, E.2    Sobrero, A.3
  • 45
    • 73349089651 scopus 로고    scopus 로고
    • Can chemotherapy be discontinued in unresectable metastatic colorectal cancer? The GERCOR OPTIMOX2 Study
    • Chibaudel B., Maindrault-Goebel F., Lledo G., et al. Can chemotherapy be discontinued in unresectable metastatic colorectal cancer? The GERCOR OPTIMOX2 Study. JClin Oncol 2009, 27(34):5727-5733.
    • (2009) JClin Oncol , vol.27 , Issue.34 , pp. 5727-5733
    • Chibaudel, B.1    Maindrault-Goebel, F.2    Lledo, G.3
  • 46
    • 33644843853 scopus 로고    scopus 로고
    • OPTIMOX1: a randomized study of FOLFOX4 or FOLFOX7 with oxaliplatin in a stop-and-go fashion in advanced colorectal cancer-a GERCOR study
    • Tournigand C., Cervantes A., Figer A., et al. OPTIMOX1: a randomized study of FOLFOX4 or FOLFOX7 with oxaliplatin in a stop-and-go fashion in advanced colorectal cancer-a GERCOR study. JClin Oncol 2006, 24(3):394-400.
    • (2006) JClin Oncol , vol.24 , Issue.3 , pp. 394-400
    • Tournigand, C.1    Cervantes, A.2    Figer, A.3
  • 47
    • 84902247358 scopus 로고    scopus 로고
    • Final results and subgroup analyses of the phase 3 CAIRO3 study: maintenance treatment with capecitabine and bevacizumab versus observation after induction treatment with chemotherapy and bevacizumab in metastatic colorectal cancer (mCRC)
    • Abstract: LBA388
    • Koopman M., Simkens L., May A., et al. Final results and subgroup analyses of the phase 3 CAIRO3 study: maintenance treatment with capecitabine and bevacizumab versus observation after induction treatment with chemotherapy and bevacizumab in metastatic colorectal cancer (mCRC). JClin Oncol 2014, 32(3). Abstract: LBA388.
    • (2014) JClin Oncol , vol.32 , Issue.3
    • Koopman, M.1    Simkens, L.2    May, A.3
  • 48
    • 80052511917 scopus 로고    scopus 로고
    • Durable complete responses in metastatic colorectal cancer treated with chemotherapy alone
    • Ferrarotto R., Pathak P., Maru D., et al. Durable complete responses in metastatic colorectal cancer treated with chemotherapy alone. Clin Colorectal Cancer 2011, 10(3):178-182.
    • (2011) Clin Colorectal Cancer , vol.10 , Issue.3 , pp. 178-182
    • Ferrarotto, R.1    Pathak, P.2    Maru, D.3
  • 49
    • 37549016003 scopus 로고    scopus 로고
    • Evaluation of long-term survival after hepatic resection for metastatic colorectal cancer: a multifactorial model of 929 patients
    • Rees M., Tekkis P.P., Welsh F.K., et al. Evaluation of long-term survival after hepatic resection for metastatic colorectal cancer: a multifactorial model of 929 patients. Ann Surg 2008, 247(1):125-135.
    • (2008) Ann Surg , vol.247 , Issue.1 , pp. 125-135
    • Rees, M.1    Tekkis, P.P.2    Welsh, F.K.3
  • 50
    • 0033504042 scopus 로고    scopus 로고
    • Clinical score for predicting recurrence after hepatic resection for metastatic colorectal cancer: analysis of 1001 consecutive cases
    • [discussion: 318-21]
    • Fong Y., Fortner J., Sun R.L., et al. Clinical score for predicting recurrence after hepatic resection for metastatic colorectal cancer: analysis of 1001 consecutive cases. Ann Surg 1999, 230(3):309-318. [discussion: 318-21].
    • (1999) Ann Surg , vol.230 , Issue.3 , pp. 309-318
    • Fong, Y.1    Fortner, J.2    Sun, R.L.3
  • 51
    • 35648981122 scopus 로고    scopus 로고
    • Actual 10-year survival after resection of colorectal liver metastases defines cure
    • Tomlinson J.S., Jarnagin W.R., DeMatteo R.P., et al. Actual 10-year survival after resection of colorectal liver metastases defines cure. JClin Oncol 2007, 25(29):4575-4580.
    • (2007) JClin Oncol , vol.25 , Issue.29 , pp. 4575-4580
    • Tomlinson, J.S.1    Jarnagin, W.R.2    DeMatteo, R.P.3
  • 52
    • 34250335967 scopus 로고    scopus 로고
    • Surgical resection of pulmonary metastases from colorectal cancer: a systematic review of published series
    • Pfannschmidt J., Dienemann H., Hoffmann H. Surgical resection of pulmonary metastases from colorectal cancer: a systematic review of published series. Ann Thorac Surg 2007, 84(1):324-338.
    • (2007) Ann Thorac Surg , vol.84 , Issue.1 , pp. 324-338
    • Pfannschmidt, J.1    Dienemann, H.2    Hoffmann, H.3
  • 53
    • 64649092523 scopus 로고    scopus 로고
    • Patients with initially unresectable colorectal liver metastases: is there a possibility of cure?
    • Adam R., Wicherts D.A., de Haas R.J., et al. Patients with initially unresectable colorectal liver metastases: is there a possibility of cure?. JClin Oncol 2009, 27(11):1829-1835.
    • (2009) JClin Oncol , vol.27 , Issue.11 , pp. 1829-1835
    • Adam, R.1    Wicherts, D.A.2    de Haas, R.J.3
  • 54
    • 84884674438 scopus 로고    scopus 로고
    • FOLFOXIRI/bevacizumab (bev) versus FOLFIRI/bev as first-line treatment in unresectable metastatic colorectal cancer (mCRC) patients (pts): results of the phase III TRIBE trial by GONO group
    • Abstract: 3505
    • Falcone A., Cremolini C., Masi G., et al. FOLFOXIRI/bevacizumab (bev) versus FOLFIRI/bev as first-line treatment in unresectable metastatic colorectal cancer (mCRC) patients (pts): results of the phase III TRIBE trial by GONO group. JClin Oncol 2013, 31(15). Abstract: 3505.
    • (2013) JClin Oncol , vol.31 , Issue.15
    • Falcone, A.1    Cremolini, C.2    Masi, G.3
  • 55
    • 84904904651 scopus 로고    scopus 로고
    • Survival of patients with initially unresectable colorectal liver metastases treated with FOLFOX/cetuximab or FOLFIRI/cetuximab in a multidisciplinary concept (CELIM study)
    • Folprecht G., Gruenberger T., Bechstein W., et al. Survival of patients with initially unresectable colorectal liver metastases treated with FOLFOX/cetuximab or FOLFIRI/cetuximab in a multidisciplinary concept (CELIM study). Ann Oncol 2014, 25(5):1018-1025.
    • (2014) Ann Oncol , vol.25 , Issue.5 , pp. 1018-1025
    • Folprecht, G.1    Gruenberger, T.2    Bechstein, W.3
  • 56
    • 84880736194 scopus 로고    scopus 로고
    • Randomized controlled trial of cetuximab plus chemotherapy for patients with KRAS wild-type unresectable colorectal liver-limited metastases
    • Ye L.C., Liu T.S., Ren L., et al. Randomized controlled trial of cetuximab plus chemotherapy for patients with KRAS wild-type unresectable colorectal liver-limited metastases. JClin Oncol 2013, 31(16):1931-1938.
    • (2013) JClin Oncol , vol.31 , Issue.16 , pp. 1931-1938
    • Ye, L.C.1    Liu, T.S.2    Ren, L.3
  • 57
    • 84922901433 scopus 로고    scopus 로고
    • NSABP FC-6: phase II study to determine surgical conversion rate in patients (pts) receiving neoadjuvant (NA) mFOLFOX7 plus dose-escalating cetuximab (C) for unresectable K-RAS wild-type (WT) colorectal cancer with metastases (mCRC) confined to the liver
    • Wagman L.D., Geller D.A., Jacobs S.A., et al. NSABP FC-6: phase II study to determine surgical conversion rate in patients (pts) receiving neoadjuvant (NA) mFOLFOX7 plus dose-escalating cetuximab (C) for unresectable K-RAS wild-type (WT) colorectal cancer with metastases (mCRC) confined to the liver. Ann Surg Oncol 2014, 21:S13.
    • (2014) Ann Surg Oncol , vol.21 , pp. S13
    • Wagman, L.D.1    Geller, D.A.2    Jacobs, S.A.3
  • 58
    • 77950864892 scopus 로고    scopus 로고
    • Prolonged survival of initially unresectable hepatic colorectal cancer patients treated with hepatic arterial infusion of oxaliplatin followed by radical surgery of metastases
    • Goere D., Deshaies I., de Baere T., et al. Prolonged survival of initially unresectable hepatic colorectal cancer patients treated with hepatic arterial infusion of oxaliplatin followed by radical surgery of metastases. Ann Surg 2010, 251(4):686-691.
    • (2010) Ann Surg , vol.251 , Issue.4 , pp. 686-691
    • Goere, D.1    Deshaies, I.2    de Baere, T.3
  • 59
    • 70249149719 scopus 로고    scopus 로고
    • Conversion to resectability using hepatic artery infusion plus systemic chemotherapy for the treatment of unresectable liver metastases from colorectal carcinoma
    • Kemeny N.E., Melendez F.D., Capanu M., et al. Conversion to resectability using hepatic artery infusion plus systemic chemotherapy for the treatment of unresectable liver metastases from colorectal carcinoma. JClin Oncol 2009, 27(21):3465-3471.
    • (2009) JClin Oncol , vol.27 , Issue.21 , pp. 3465-3471
    • Kemeny, N.E.1    Melendez, F.D.2    Capanu, M.3
  • 60
    • 40749149728 scopus 로고    scopus 로고
    • Perioperative chemotherapy with FOLFOX4 and surgery versus surgery alone for resectable liver metastases from colorectal cancer (EORTC Intergroup trial 40983): a randomised controlled trial
    • Nordlinger B., Sorbye H., Glimelius B., et al. Perioperative chemotherapy with FOLFOX4 and surgery versus surgery alone for resectable liver metastases from colorectal cancer (EORTC Intergroup trial 40983): a randomised controlled trial. Lancet 2008, 371(9617):1007-1016.
    • (2008) Lancet , vol.371 , Issue.9617 , pp. 1007-1016
    • Nordlinger, B.1    Sorbye, H.2    Glimelius, B.3
  • 61
    • 84886719568 scopus 로고    scopus 로고
    • Perioperative FOLFOX4 chemotherapy and surgery versus surgery alone for resectable liver metastases from colorectal cancer (EORTC 40983): long-term results of a randomised, controlled, phase 3 trial
    • Nordlinger B., Sorbye H., Glimelius B., et al. Perioperative FOLFOX4 chemotherapy and surgery versus surgery alone for resectable liver metastases from colorectal cancer (EORTC 40983): long-term results of a randomised, controlled, phase 3 trial. Lancet Oncol 2013, 14(12):1208-1215.
    • (2013) Lancet Oncol , vol.14 , Issue.12 , pp. 1208-1215
    • Nordlinger, B.1    Sorbye, H.2    Glimelius, B.3
  • 62
    • 84907020985 scopus 로고    scopus 로고
    • Effect of neoadjuvant chemotherapy in patients with resectable colorectal liver metastases
    • Zhu D., Zhong Y., Wei Y., et al. Effect of neoadjuvant chemotherapy in patients with resectable colorectal liver metastases. PLoS One 2014, 9(1):e86543.
    • (2014) PLoS One , vol.9 , Issue.1 , pp. e86543
    • Zhu, D.1    Zhong, Y.2    Wei, Y.3
  • 63
    • 0031021798 scopus 로고    scopus 로고
    • Repeat hepatectomy for colorectal liver metastases
    • [discussion: 60-2]
    • Adam R., Bismuth H., Castaing D., et al. Repeat hepatectomy for colorectal liver metastases. Ann Surg 1997, 225(1):51-60. [discussion: 60-2].
    • (1997) Ann Surg , vol.225 , Issue.1 , pp. 51-60
    • Adam, R.1    Bismuth, H.2    Castaing, D.3
  • 64
    • 84879286177 scopus 로고    scopus 로고
    • Repeat liver resection for colorectal metastases
    • Kulik U., Bektas H., Klempnauer J., et al. Repeat liver resection for colorectal metastases. Br J Surg 2013, 100(7):926-932.
    • (2013) Br J Surg , vol.100 , Issue.7 , pp. 926-932
    • Kulik, U.1    Bektas, H.2    Klempnauer, J.3
  • 65
    • 84862785085 scopus 로고    scopus 로고
    • Systematic review and meta-analysis of follow-up after hepatectomy for colorectal liver metastases
    • Jones R.P., Jackson R., Dunne D.F., et al. Systematic review and meta-analysis of follow-up after hepatectomy for colorectal liver metastases. Br J Surg 2012, 99(4):477-486.
    • (2012) Br J Surg , vol.99 , Issue.4 , pp. 477-486
    • Jones, R.P.1    Jackson, R.2    Dunne, D.F.3
  • 66
    • 84878876142 scopus 로고    scopus 로고
    • Detection of recurrences during follow-up after liver surgery for colorectal metastases: both carcinoembryonic antigen (CEA) and imaging are important
    • Verberne C.J., Wiggers T., Vermeulen K.M., et al. Detection of recurrences during follow-up after liver surgery for colorectal metastases: both carcinoembryonic antigen (CEA) and imaging are important. Ann Surg Oncol 2013, 20(2):457-463.
    • (2013) Ann Surg Oncol , vol.20 , Issue.2 , pp. 457-463
    • Verberne, C.J.1    Wiggers, T.2    Vermeulen, K.M.3
  • 67
    • 84859971752 scopus 로고    scopus 로고
    • Intra-arterial infusion of irinotecan-loaded drug-eluting beads (DEBIRI) versus intravenous therapy (FOLFIRI) for hepatic metastases from colorectal cancer: final results of a phase III study
    • Fiorentini G., Aliberti C., Tilli M., et al. Intra-arterial infusion of irinotecan-loaded drug-eluting beads (DEBIRI) versus intravenous therapy (FOLFIRI) for hepatic metastases from colorectal cancer: final results of a phase III study. Anticancer Res 2012, 32(4):1387-1395.
    • (2012) Anticancer Res , vol.32 , Issue.4 , pp. 1387-1395
    • Fiorentini, G.1    Aliberti, C.2    Tilli, M.3
  • 68
    • 75749100265 scopus 로고    scopus 로고
    • American Society of Clinical Oncology 2009 clinical evidence review on radiofrequency ablation of hepatic metastases from colorectal cancer
    • Wong S.L., Mangu P.B., Choti M.A., et al. American Society of Clinical Oncology 2009 clinical evidence review on radiofrequency ablation of hepatic metastases from colorectal cancer. JClin Oncol 2010, 28(3):493-508.
    • (2010) JClin Oncol , vol.28 , Issue.3 , pp. 493-508
    • Wong, S.L.1    Mangu, P.B.2    Choti, M.A.3
  • 69
    • 84866537992 scopus 로고    scopus 로고
    • Primary mFOLFOX6 plus bevacizumab without resection of the primary tumor for patients presenting with surgically unresectable metastatic colon cancer and an intact asymptomatic colon cancer: definitive analysis of NSABP trial C-10
    • McCahill L.E., Yothers G., Sharif S., et al. Primary mFOLFOX6 plus bevacizumab without resection of the primary tumor for patients presenting with surgically unresectable metastatic colon cancer and an intact asymptomatic colon cancer: definitive analysis of NSABP trial C-10. JClin Oncol 2012, 30(26):3223-3228.
    • (2012) JClin Oncol , vol.30 , Issue.26 , pp. 3223-3228
    • McCahill, L.E.1    Yothers, G.2    Sharif, S.3
  • 70
    • 84922885049 scopus 로고    scopus 로고
    • Primary tumor resection in colorectal cancer with unresectable synchronous metastases: a review
    • de Mestier L., Manceau G., Neuzillet C., et al. Primary tumor resection in colorectal cancer with unresectable synchronous metastases: a review. World J Gastrointest Oncol 2014, 6(6):156-169.
    • (2014) World J Gastrointest Oncol , vol.6 , Issue.6 , pp. 156-169
    • de Mestier, L.1    Manceau, G.2    Neuzillet, C.3
  • 71
    • 84876792373 scopus 로고    scopus 로고
    • The liver-first approach to the management of colorectal cancer with synchronous hepatic metastases: a systematic review
    • Jegatheeswaran S., Mason J.M., Hancock H.C., et al. The liver-first approach to the management of colorectal cancer with synchronous hepatic metastases: a systematic review. JAMA Surg 2013, 148(4):385-391.
    • (2013) JAMA Surg , vol.148 , Issue.4 , pp. 385-391
    • Jegatheeswaran, S.1    Mason, J.M.2    Hancock, H.C.3
  • 72
    • 84877619075 scopus 로고    scopus 로고
    • Acolorectal cancer classification system that associates cellular phenotype and responses to therapy
    • Sadanandam A., Lyssiotis C.A., Homicsko K., et al. Acolorectal cancer classification system that associates cellular phenotype and responses to therapy. Nat Med 2013, 19(5):619-625.
    • (2013) Nat Med , vol.19 , Issue.5 , pp. 619-625
    • Sadanandam, A.1    Lyssiotis, C.A.2    Homicsko, K.3


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