A small-molecule inhibitor of the aberrant transcription factor CBFβ-SMMHC delays leukemia in mice

Science

Volumn 347, Issue 6223, 2015, Pages 779-784

  Illendula, Anuradha ^a   Pulikkan, John A ^b   Zong, Hongliang ^c   Grembecka, Jolanta ^d   Xue, Liting ^b   Sen, Siddhartha ^c   Zhou, Yunpeng ^a   Boulton, Adam ^a   Kuntimaddi, Aravinda ^a   Gao, Yan ^a   Rajewski, Roger A ^e   Guzman, Monica L ^c   Castilla, Lucio H ^b   Bushweller, John H ^a  

^a UNIVERSITY OF VIRGINIA   (United States)

^b UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^c WEILL CORNELL MEDICAL COLLEGE   (United States)

^d UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^e UNIVERSITY OF KANSAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AI 10 49; ANTINEOPLASTIC AGENT; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR CORE BINDING FACTOR BETA; TRANSCRIPTION FACTOR RUNX1; TRANSCRIPTION FACTOR SMOOTH MUSCLE MYOSIN HEAVY CHAIN; UNCLASSIFIED DRUG; 2,2'-(5,5'-((OXYBIS(ETHANE-2,1-DIYL))BIS(OXY))BIS(PYRIDINE-5,2-DIYL))BIS(6-(TRIFLUOROMETHOXY)-1H-BENZO(D)IMIDAZOLE); BENZIMIDAZOLE DERIVATIVE; CBFBETA-MYH11 FUSION PROTEIN; MOLECULAR LIBRARY; ONCOPROTEIN; RUNX1 PROTEIN, HUMAN;

BLOOD; CANCER; CELL ORGANELLE; DATA SET; GENE EXPRESSION; INHIBITION; INHIBITOR; MOLECULAR ANALYSIS; RODENT;

ACUTE GRANULOCYTIC LEUKEMIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER INHIBITION; CELL DEATH; CONTROLLED STUDY; DRUG HALF LIFE; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SYNTHESIS; FLUORESCENCE RESONANCE ENERGY TRANSFER; HUMAN; HUMAN CELL; IC50; ISOTHERMAL TITRATION CALORIMETRY; LEUKEMIA CELL LINE; LIVER MICROSOME; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; TRANSCRIPTION INITIATION; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; CHEMISTRY; FEMALE; LEUKEMIA, MYELOID, ACUTE; METABOLISM; MOLECULAR LIBRARY; TUMOR CELL LINE;

MUS;

ANIMALS; ANTINEOPLASTIC AGENTS; BENZIMIDAZOLES; CELL LINE, TUMOR; CORE BINDING FACTOR ALPHA 2 SUBUNIT; FEMALE; HUMANS; LEUKEMIA, MYELOID, ACUTE; MICE; MICE, INBRED C57BL; ONCOGENE PROTEINS, FUSION; PROTEIN INTERACTION MAPS; SMALL MOLECULE LIBRARIES;

EID: 84922949970     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aaa0314     Document Type: Article

References (30)

1. C. C. Kumar, Genes Cancer 2, 95-107 (2011).
2. P. Liu et al., Science 261, 1041-1044 (1993).
3. L. H. Castilla et al., Nat. Genet. 23, 144-146 (1999).
4. L. H. Castilla et al., Proc. Natl. Acad. Sci. U.S.A. 101, 4924-4929 (2004).
5. F. Ravandi, A. K. Burnett, E. D. Agura, H. M. Kantarjian, Cancer 110, 1900-1910 (2007).
6. N. Adya, L. H. Castilla, P. P. Liu, Semin. Cell Dev. Biol. 11, 361-368 (2000).
7. M. F. de Bruijn, N. A. Speck, Oncogene 23, 4238-4248 (2004).
8. S. M. Lukasik et al., Nat. Struct. Biol. 9, 674-679 (2002).
9. Y. H. Kuo et al., Cancer Cell 9, 57-68 (2006).
10. P. D. Kottaridis et al., Blood 100, 2393-2398 (2002).
11. L. Y. Shih et al., Leukemia 22, 303-307 (2008).
12. Y. Nakano et al., Br. J. Haematol. 104, 659-664 (1999).
13. M. J. Gorczynski et al., Chem. Biol. 14, 1186-1197 (2007).
14. S. A. Heilman, Y. H. Kuo, C. S. Goudswaard, P. J. Valk, L. H. Castilla, Cancer Res. 66, 11214-11218 (2006).
15. X. Huang, J. W. Peng, N. A. Speck, J. H. Bushweller, Nat. Struct. Biol. 6, 624-627 (1999).
16. M. Mammen, S. K. Choi, G. M. Whitesides, Angew. Chem. Int. Ed. 37, 2754-2794 (1998).
17. L. L. Kiessling, J. E. Gestwicki, L. E. Strong, Angew. Chem. Int. Ed. Engl. 45, 2348-2368 (2006).
18. F. R. Leroux, B. Manteau, J. P. Vors, S. Pazenok, Beilstein J. Org. Chem. 4, 13 (2008).
19. B. Manteau, S. Pazenok, J. P. Vors, F. R. Leroux, J. Fluor. Chem. 131, 140-158 (2010).
20. C. K. Cheng et al., Blood 112, 3391-3402 (2008).
21. H. Guo, O. Ma, N. A. Speck, A. D. Friedman, Blood 119, 4408-4418 (2012).
22. D. E. Zhang et al., Mol. Cell. Biol. 14, 8085-8095 (1994).
23. W. Cao et al., Oncogene 15, 1315-1327 (1997).
24. J. Markus et al., Cancer Res. 67, 992-1000 (2007).
25. C. Haferlach et al., Leukemia 24, 1065-1069 (2010).
26. L. Xue, J. A. Pulikkan, P. J. Valk, L. H. Castilla, Blood 124, 426-436 (2014).
27. A. T. Look, Science 278, 1059-1064 (1997).
28. M. Ladanyi, Diagn. Mol. Pathol. 4, 162-173 (1995).
29. D. Hessels, J. A. Schalken, Curr. Urol. Rep. 14, 214-222 (2013).
30. S. V. Frye, Nat. Chem. Biol. 6, 159-161 (2010).