Blunted neuroendocrine stress reactivity in young women with eating disorders

Journal of Psychosomatic Research

Volumn 78, Issue 3, 2015, Pages 260-267

  Het, Serkan ^a   Vocks, Silja ^b   Wolf, Jutta M ^c   Hammelstein, Philipp ^d   Herpertz, Stephan ^e   Wolf, Oliver T ^a  

^a RUHR UNIVERSITY BOCHUM   (Germany)

^b UNIVERSITY OF OSNABRÜCK   (Germany)

^c BRANDEIS UNIVERSITY   (United States)

^d Christoph Dornier Clinic for Psychotherapy   (Germany)

^e RUHR UNIVERSITY BOCHUM   (Germany)

Author keywords

Anorexia nervosa; Bulimia nervosa; Cortisol; Hypothalamus pituitary adrenal (HPA) axis; Stress; Sympathetic nervous system (SNS)

Indexed keywords

AMYLASE; HYDROCORTISONE;

ADULT; AMYLASE BLOOD LEVEL; ANOREXIA NERVOSA; ARTICLE; BULIMIA; COMORBIDITY; CONTROLLED STUDY; FEMALE; HEART RATE; HEART RATE VARIABILITY; HUMAN; HYDROCORTISONE BLOOD LEVEL; MAJOR CLINICAL STUDY; MENSTRUAL CYCLE; PARASYMPATHETIC TONE; SMOKING; STRESS; ADOLESCENT; ETIOLOGY; HYPOPHYSIS ADRENAL SYSTEM; HYPOTHALAMUS HYPOPHYSIS SYSTEM; MENTAL STRESS; METABOLISM; PATHOPHYSIOLOGY; SALIVA; YOUNG ADULT;

ADOLESCENT; ADULT; ALPHA-AMYLASES; ANOREXIA NERVOSA; BULIMIA NERVOSA; FEMALE; HEART RATE; HUMANS; HYDROCORTISONE; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; PITUITARY-ADRENAL SYSTEM; SALIVA; STRESS, PSYCHOLOGICAL; YOUNG ADULT;

EID: 84922946577     PISSN: 00223999     EISSN: 18791360     Source Type: Journal    
DOI: 10.1016/j.jpsychores.2014.11.001     Document Type: Article

References (90)

1. Hay PJ, Mond J, Buttner P, Darby A Eating disorder behaviors are increasing: findings from two sequential community surveys in South Australia. PLoS One 2008, 3:e1541.
2. Hilbert A, de Zwaan M, Braehler E How frequent are eating disturbances in the population? Norms of the eating disorder examination-questionnaire. PLoS One 2012, 7:e29125.
3. Murray K, Rieger E, Byrne D The relationship between stress and body satisfaction in female and male adolescents. Stress Health : J Int Soc Invest Stress 2013.
4. American Psychiatric Association (APA) Diagnostic and statistical manual of mental disorders - fifth edition (DSM-5) 2013, American Psychiatric Publishing, Arlington, VA.
5. Kaye WH, Fudge JL, Paulus M New insights into symptoms and neurocircuit function of anorexia nervosa. Nat Rev Neurosci 2009, 10:573-584.
6. Jacobi C, Hayward C, de Zwaan M, Kraemer HC, Agras WS Coming to terms with risk factors for eating disorders: application of risk terminology and suggestions for a general taxonomy. Psychol Bull 2004, 130:19-65.
7. Rojo L, Conesa L, Bermudez O, Livianos L Influence of stress in the onset of eating disorders: data from a two-stage epidemiologic controlled study. Psychosom Med 2006, 68:628-635.
8. de Kloet ER About stress hormones and resilience to psychopathology. J Neuroendocrinol 2008, 20:885-892.
9. McEwen BS Mood disorders and allostatic load. Biol Psychiatry 2003, 54:200-207.
10. Chida Y, Hamer M Chronic psychosocial factors and acute physiological responses to laboratory-induced stress in healthy populations: a quantitative review of 30years of investigations. Psychol Bull 2008, 134:829-885.
11. McEwen BS Protection and damage from acute and chronic stress: allostasis and allostatic overload and relevance to the pathophysiology of psychiatric disorders. Ann N Y Acad Sci 2004, 1032:1-7.
12. Sapolsky RM, Romero LM, Munck AU How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions. Endocr Rev 2000, 21:55-89.
13. Ulrich-Lai YM, Herman JP Neural regulation of endocrine and autonomic stress responses. Nat Rev Neurosci 2009, 10:397-409.
14. Joels M, Karst H, DeRijk R, de Kloet ER The coming out of the brain mineralocorticoid receptor. Trends Neurosci 2008, 31:1-7.
15. Krieger DT Rhythms of ACTH and corticosteroid secretion in health and disease, and their experimental modification. J Steroid Biochem 1975, 6:785-791.
16. Pruessner JC, Wolf OT, Hellhammer DH, Buske-Kirschbaum A, von Auer K, Jobst S, et al. Free cortisol levels after awakening: a reliable biological marker for the assessment of adrenocortical activity. Life Sci 1997, 61:2539-2549.
17. Chida Y, Steptoe A Cortisol awakening response and psychosocial factors: a systematic review and meta-analysis. Biol Psychol 2009, 80:265-278.
18. Clow A, Hucklebridge F, Stalder T, Evans P, Thorn L The cortisol awakening response: more than a measure of HPA axis function. Neurosci Biobehav Rev 2010, 35:97-103.
19. Fries E, Dettenborn L, Kirschbaum C The cortisol awakening response (CAR): facts and future directions. Int J Psychophysiol 2009, 72:67-73.
20. Kudielka BM, Kirschbaum C Awakening cortisol responses are influenced by health status and awakening time but not by menstrual cycle phase. Psychoneuroendocrinology 2003, 28:35-47.
21. Pirke KM, Platte P, Laessle R, Seidl M, Fichter MM The effect of a mental challenge test of plasma norepinephrine and cortisol in bulimia nervosa and in controls. Biol Psychiatry 1992, 32:202-206.
22. Koo-Loeb JH, Pedersen C, Girdler SS Blunted cardiovascular and catecholamine stress reactivity in women with bulimia nervosa. Psychiatry Res 1998, 80:13-27.
23. Girdler SS, Koo-Loeb J, Pedersen CA, Brown HJ, Maixner W Blood pressure-related hypoalgesia in bulimia nervosa. Psychosom Med 1998, 60:736-743.
24. Koo-Loeb JH, Costello N, Light KC, Girdler SS Women with eating disorder tendencies display altered cardiovascular, neuroendocrine, and psychosocial profiles. Psychosom Med 2000, 62:539-548.
25. Mazurak N, Enck P, Muth E, Teufel M, Zipfel S Heart rate variability as a measure of cardiac autonomic function in anorexia nervosa: a review of the literature. Eur Eat Disord Rev 2011, 19(2):87-99.
26. Monteleone P, Scognamiglio P, Monteleone AM, Mastromo D, Steardo L, Serino I, et al. Abnormal diurnal patterns of salivary alpha-amylase and cortisol secretion in acute patients with anorexia nervosa. World J Biol Psychiatry 2011, 12:455-461.
27. Kaye WH, Rubinow D, Gwirtsman HE, George DT, Jimerson DC, Gold PW CSF somatostatin in anorexia nervosa and bulimia: relationship to the hypothalamic pituitary-adrenal cortical axis. Psychoneuroendocrinology 1988, 13:265-272.
28. dos Santos E, dos Santos JE, Ribeiro RP, Rosa ESAC, Moreira AC, Silva de Sa MF Absence of circadian salivary cortisol rhythm in women with anorexia nervosa. J Pediatr Adolesc Gynecol 2007, 20:13-18.
29. Diaz-Marsa M, Carrasco JL, Basurte E, Saiz J, Lopez-Ibor JJ, Hollander E Enhanced cortisol suppression in eating disorders with impulsive personality features. Psychiatry Res 2008, 158:93-97.
30. Monteleone P, Scognamiglio P, Canestrelli B, Serino I, Monteleone AM, Maj M Asymmetry of salivary cortisol and alpha-amylase responses to psychosocial stress in anorexia nervosa but not in bulimia nervosa. Psychol Med 2011, 41:1963-1969.
31. Vocks S, Legenbauer T, Wachter A, Wucherer M, Kosfelder J What happens in the course of body exposure? Emotional, cognitive, and physiological reactions to mirror confrontation in eating disorders. J Psychosom Res 2007, 62:231-239.
32. Lo Sauro C, Ravaldi C, Cabras PL, Faravelli C, Ricca V Stress, hypothalamic-pituitary-adrenal axis and eating disorders. Neuropsychobiology 2008, 57:95-115.
33. Licinio J, Wong ML, Gold PW The hypothalamic-pituitary-adrenal axis in anorexia nervosa. Psychiatry Res 1996, 62:75-83.
34. Zonnevylle-Bender MJ, van Goozen SH, Cohen-Kettenis PT, Jansen LM, van Elburg A, Engeland H Adolescent anorexia nervosa patients have a discrepancy between neurophysiological responses and self-reported emotional arousal to psychosocial stress. Psychiatry Res 2005, 135:45-52.
35. Ginty AT, Phillips AC, Higgs S, Heaney JL, Carroll D Disordered eating behaviour is associated with blunted cortisol and cardiovascular reactions to acute psychological stress. Psychoneuroendocrinology 2012, 37:715-724.
36. Kirschbaum C, Pirke KM, Hellhammer DH The 'Trier Social Stress Test'-a tool for investigating psychobiological stress responses in a laboratory setting. Neuropsychobiology 1993, 28:76-81.
37. Dickerson SS, Kemeny ME Acute stressors and cortisol responses: a theoretical integration and synthesis of laboratory research. Psychol Bull 2004, 130:355-391.
38. Brunner RL, Maloney MJ, Daniels S, Mays W, Farrell M A controlled study of type A behavior and psychophysiologic responses to stress in anorexia nervosa. Psychiatry Res 1989, 30:223-230.
39. Lattimore PJ Stress-induced eating: an alternative method for inducing ego-threatening stress. Appetite 2001, 36:187-188.
40. Tuschen-Caffier B, Vogele C Psychological and physiological reactivity to stress: an experimental study on bulimic patients, restrained eaters and controls. Psychother Psychosom 1999, 68:333-340.
41. Is the desire to binge triggered by interpersonal stress and achievement challenge? An experimental study on bulimics 1995, Verlag für Psychotherapie, Münster. B. Tuschen, C. Vögele, K. Kuhnhardt (Eds.).
42. Gross MJ, Kahn JP, Laxenaire M, Nicolas JP, Burlet C Corticotropin-releasing factor and anorexia nervosa: reactions of the hypothalamus-pituitary-adrenal axis to neurotropic stress. Ann Endocrinol (Paris) 1994, 55:221-228.
43. Miller SP, Erickson SJ, Branom C, Steiner H Habitual response to stress in recovering adolescent anorexic patients. Child Psychiatry Hum Dev 2009, 40:43-54.
44. Miller SP, Redlich AD, Steiner H The stress response in anorexia nervosa. Child Psychiatry Hum Dev 2003, 33:295-306.
45. Hilbert A, Vogele C, Tuschen-Caffier B, Hartmann AS Psychophysiological responses to idiosyncratic stress in bulimia nervosa and binge eating disorder. Physiol Behav 2011, 104:770-777.
46. Wade TD, Bergin JL, Martin NG, Gillespie NA, Fairburn CG A transdiagnostic approach to understanding eating disorders. J Nerv Ment Dis 2006, 194:510-517.
47. Fairburn CG, Cooper Z, Shafran R Cognitive behaviour therapy for eating disorders: a "transdiagnostic" theory and treatment. Behav Res Ther 2003, 41:509-528.
48. Agras WS, Walsh T, Fairburn CG, Wilson GT, Kraemer HC A multicenter comparison of cognitive-behavioral therapy and interpersonal psychotherapy for bulimia nervosa. Arch Gen Psychiatry 2000, 57:459-466.
49. Sullivan PF, Bulik CM, Fear JL, Pickering A Outcome of anorexia nervosa: a case-control study. Am J Psychiatry 1998, 155:939-946.
50. Hilbert A, Pike KM, Goldschmidt AB, Wilfley DE, Fairburn CG, Dohm FA, et al. Risk factors across the eating disorders. Psychiatry Res 2014, [E-pub]. 10.1016/j.psychres.2014.05.054.
51. Fairburn CG, Harrison PJ Eating disorders. Lancet 2003, 361:407-416.
52. Fairburn CG, Cooper Z Eating disorders, DSM-5 and clinical reality. Br J Psychiatry 2011, 198:8-10.
53. Kaye W Neurobiology of anorexia and bulimia nervosa. Physiol Behav 2008, 94:121-135.
54. Wittchen H-U, Zaudig M, Fydrich T SKID - Strukturiertes Klinisches Interview für DSM-IV (Achse I und II) 1997, Hogrefe, Göttingen.
55. Hautzinger M, Bailer M, Worall H, Keller F Beck-Depressions-Inventar (BDI) 1995, Hans Huber, Bern.
56. Franke GH SCL-90-R - Die Symptomcheckliste von L.R. Derogatis 2002, Göttingen, Beltz.
57. Hilbert A, Tuschen-Caffier B Eating disorder examination - questionnaire 2006, Deutschsprachige Übersetzung, Verlag für Psychotherapie, Münster.
58. APA Diagnostic and statistical manual of mental disorders. Text Revision (DSM-IV-TR) 2000, American Psychiatric Association (APA), Washington, DC, [Deutsche Übersetzung nach Saß, H., Wittchen, H.-U., Zaudig, M., Houben, I. (2003): Diagnostsiches und Statistisches Manual Psychischer Störungen - Textrevision (DSM-IV-TR). Göttingen: Hogrefe]. 4th ed.
59. Holtzman CW, Shapiro DI, Trotman HD, Walker EF Stress and the prodromal phase of psychosis. Curr Pharm Des 2012, 18:527-533.
60. Wingenfeld K, Wolf OT HPA axis alterations in mental disorders: impact on memory and its relevance for therapeutic interventions. CNS Neurosci Ther 2011, 17:714-722.
61. Kudielka BM, Hellhammer DH, Wust S Why do we respond so differently? Reviewing determinants of human salivary cortisol responses to challenge. Psychoneuroendocrinology 2009, 34:2-18.
62. Het S, Rohleder N, Schoofs D, Kirschbaum C, Wolf OT Neuroendocrine and psychometric evaluation of a placebo version of the 'Trier Social Stress Test'. Psychoneuroendocrinology 2009, 34:1075-1086.
63. Rohleder N, Nater UM Determinants of salivary alpha-amylase in humans and methodological considerations. Psychoneuroendocrinology 2009, 34:469-485.
64. Kirschbaum C, Hellhammer DH Salivary cortisol in psychoneuroendocrine research: recent developments and applications. Psychoneuroendocrinology 1994, 19:313-333.
65. Hellhammer J, Fries E, Schweisthal OW, Schlotz W, Stone AA, Hagemann D Several daily measurements are necessary to reliably assess the cortisol rise after awakening: state- and trait components. Psychoneuroendocrinology 2007, 32:80-86.
66. Clow A, Thorn L, Evans P, Hucklebridge F The awakening cortisol response: methodological issues and significance. Stress 2004, 7:29-37.
67. Radespiel-Troger M, Rauh R, Mahlke C, Gottschalk T, Muck-Weymann M Agreement of two different methods for measurement of heart rate variability. Clin Auton Res 2003, 13:99-102.
68. Nater UM, La Marca R, Florin L, Moses A, Langhans W, Koller MM, et al. Stress-induced changes in human salivary alpha-amylase activity - associations with adrenergic activity. Psychoneuroendocrinology 2006, 31:49-58.
69. Smeets T, Giesbrecht T, Jelicic M, Merckelbach H Context-dependent enhancement of declarative memory performance following acute psychosocial stress. Biol Psychol 2007, 76:116-123.
70. Strahler J, Mueller A, Rosenloecher F, Kirschbaum C, Rohleder N Salivary alpha-amylase stress reactivity across different age groups. Psychophysiology 2010, 47:587-595.
71. Heart rate variability. Standards of measurement, physiological interpretation, and clinical use. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. Eur Heart J 1996, 17:354-381.
72. Watson D, Clark LA, Tellegen A Development and validation of brief measures of positive and negative affect: the PANAS scales. J Pers Soc Psychol 1988, 54:1063-1070.
73. Crawford JR, Henry JD The positive and negative affect schedule (PANAS): construct validity, measurement properties and normative data in a large non-clinical sample. Br J Clin Psychol 2004, 43:245-265.
74. Pruessner JC, Kirschbaum C, Meinlschmid G, Hellhammer DH Two formulas for computation of the area under the curve represent measures of total hormone concentration versus time-dependent change. Psychoneuroendocrinology 2003, 28:916-931.
75. Miller R, Plessow F, Kirschbaum C, Stalder T Classification criteria for distinguishing cortisol responders from nonresponders to psychosocial stress: evaluation of salivary cortisol pulse detection in panel designs. Psychosom Med 2013, 75:832-840.
76. Lawson EA, Holsen LM, Desanti R, Santin M, Meenaghan E, Herzog DB, et al. Increased hypothalamic-pituitary-adrenal drive is associated with decreased appetite and hypoactivation of food-motivation neurocircuitry in anorexia nervosa. Eur J Endocrinol 2013, 169:639-647.
77. Fichter MM, Pirke KM Effect of experimental and pathological weight loss upon the hypothalamo-pituitary-adrenal axis. Psychoneuroendocrinology 1986, 11:295-305.
78. McEwen BS Stress, adaptation, and disease. Allostasis and allostatic load. Ann N Y Acad Sci 1998, 840:33-44.
79. Heim C, Ehlert U, Hellhammer DH The potential role of hypocortisolism in the pathophysiology of stress-related bodily disorders. Psychoneuroendocrinology 2000, 25:1-35.
80. Carrasco JL, Diaz-Marsa M, Pastrana JI, Molina R, Brotons L, Lopez-Ibor MI, et al. Hypothalamic-pituitary-adrenal axis response in borderline personality disorder without post-traumatic features. Br J Psychiatry 2007, 190:357-358.
81. Lange W, Wulff H, Berea C, Beblo T, Saavedra AS, Mensebach C, et al. Dexamethasone suppression test in borderline personality disorder-effects of posttraumatic stress disorder. Psychoneuroendocrinology 2005, 30:919-923.
82. Furlan PM, DeMartinis N, Schweizer E, Rickels K, Lucki I Abnormal salivary cortisol levels in social phobic patients in response to acute psychological but not physical stress. Biol Psychiatry 2001, 50:254-259.
83. Petrowski K, Wintermann GB, Schaarschmidt M, Bornstein SR, Kirschbaum C Blunted salivary and plasma cortisol response in patients with panic disorder under psychosocial stress. Int J Psychophysiol 2013, 88:35-39.
84. Rosenberg N, Bloch M, Ben Avi I, Rouach V, Schreiber S, Stern N, et al. Cortisol response and desire to binge following psychological stress: comparison between obese subjects with and without binge eating disorder. Psychiatry Res 2013, 208:156-161.
85. Borges S, Gayer-Anderson C, Mondelli V A systematic review of the activity of the hypothalamic-pituitary-adrenal axis in first episode psychosis. Psychoneuroendocrinology 2013, 38:603-611.
86. Renoir T, Hasebe K, Gray L Mind and body: how the health of the body impacts on neuropsychiatry. Front Pharmacol 2013, 4:158.
87. Murray K, Rieger E, Byrne D A longitudinal investigation of the mediating role of self-esteem and body importance in the relationship between stress and body dissatisfaction in adolescent females and males. Body Image 2013, 10:544-551.
88. Vogele C, Hilbert A, Tuschen-Caffier B Dietary restriction, cardiac autonomic regulation and stress reactivity in bulimic women. Physiol Behav 2009, 98:229-234.
89. Pirke KM Central and peripheral noradrenalin regulation in eating disorders. Psychiatry Res 1996, 62:43-49.
90. Cattanach L, Malley R, Rodin J Psychologic and physiologic reactivity to stressors in eating disordered individuals. Psychosom Med 1988, 50:591-599.