Identification of protective linear B-cell epitopes on the subolesin/akirin orthologues of Ornithodoros spp. soft ticks

Vaccine

Volumn 33, Issue 8, 2015, Pages 1046-1055

  Manzano Román, Raúl ^a   Díaz Martín, Verónica ^a   Oleaga, Ana ^a   Pérez Sánchez, Ricardo ^a  

^a INSTITUTO DE RECURSOS NATURALES Y AGROBIOLOGÍA DE SALAMANCA   (Spain)

Author keywords

Akirin; B cell epitopes; Epitope mapping; Ornithodoros; Soft ticks; Subolesin; Synthetic peptide

Indexed keywords

EPITOPE; KEYHOLE LIMPET HEMOCYANIN; PROTEIN OE1; PROTEIN OE2; PROTEIN OM1; PROTEIN OM2; RECOMBINANT ANTIGEN; RECOMBINANT SUBOLESIN; SYNTHETIC PEPTIDE; UNCLASSIFIED DRUG; ANTIBODY; ANTIGEN; ARTHROPOD PROTEIN; PEPTIDE; SUBOLESIN, TICK;

AMINO ACID SEQUENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY PRODUCTION; ANTIGEN RECOGNITION; ARTICLE; B LYMPHOCYTE; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; EGG LAYING; FEMALE; FERTILITY; GENE SILENCING; HUMORAL IMMUNITY; MALE; NEW ZEALAND WHITE (RABBIT); NONHUMAN; ORNITHODOROS ERRATICUS; ORNITHODOROS MOUBATA; PRIORITY JOURNAL; RNA INTERFERENCE; STRUCTURE ACTIVITY RELATION; TICK; VACCINATION; VECTOR CONTROL; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; EPITOPE MAPPING; IMMUNOLOGY; MOLECULAR GENETICS; ORNITHODOROS; PROTEIN CONFORMATION; RABBIT; TICK INFESTATIONS;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES; ANTIGENS; ARTHROPOD PROTEINS; EPITOPE MAPPING; EPITOPES, B-LYMPHOCYTE; FEMALE; IMMUNITY, HUMORAL; MALE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; ORNITHODOROS; PEPTIDES; PROTEIN CONFORMATION; RABBITS; TICK INFESTATIONS; VACCINATION;

EID: 84922925271     PISSN: 0264410X     EISSN: 18732518     Source Type: Journal    
DOI: 10.1016/j.vaccine.2015.01.015     Document Type: Article

References (44)

1. Oleaga A., Escudero-Población A., Camafeita E., Pérez-Sánchez R. A proteomic approach to the identification of salivary proteins from the argasid ticks Ornithodoros moubata and Ornithodoros erraticus. Insect Biochem Mol Biol 2007, 37:1149-1159.
2. Cutler S.J. Relapsing fever - a forgotten disease revealed. J Appl Microbiol 2010, 108:1115-1122.
3. Costard S., Mur L., Lubrothc J., Sanchez-Vizcaino J.M., Pfeiffer D.U. Epidemiology of African swine fever virus. Virus Res 2013, 173:191-197.
4. Oleaga-Pérez A., Pérez-Sánchez R., Encinas-Grandes A. Distribution and biology of Ornithodoros erraticus in the African Swine Fever Enzootic Area of Spain. Vet Rec 1990, 126:32-37.
5. Oleaga-Pérez A., Pérez-Sánchez R., Astigarraga A., Encinas-Grandes A. Detection of pig farms with Ornithodoros erraticus by pig serology. Elimination of non-specific reactions by carbohydrate epitopes of salivary antigens. Vet Parasitol 1994, 52:97-111.
6. Manzano-Román R., García-Varas S., Encinas-Grandes A., Pérez-Sánchez R. Purification and characterization of Oe45, a kDa concealed antigen from the midgut membranes of Ornithodoros erraticus that induces lethal anti-tick immune responses in pigs. Vet Parasitol 2007, 145:314-325.
7. Vial L. Biological and ecological characteristics of soft ticks (Ixodida:Argasidae) and their impact for predicting tick and associated disease distribution. Parasite 2009, 16:191-202.
8. Boinas F.S., Wilson A.J., Hutchings G.H., Martins C., Dixon L.J. The persistence of African swine fever virus in field-infected Ornithodoros erraticus during the ASF endemic period in Portugal. PLoS ONE 2011, 6:e20383.
9. Sánchez-Vizcaíno J.M., Mur L., Matínez-Lopez B. African swine fever: an epidemiological update. Transb Emer Dis 2012, 59(Suppl. 1):1-9.
10. Wilson A.J., Ribeir R., Boinas F., et al. Use of a Bayesian network model to identify factors associated with the presence of the tick Ornithodoros erraticus on pig farms in southern Portugal. Prev Vet Med 2013, 2013(110):45-53.
11. European Food Safety Authority (EFSA) Scientific opinion on African swine fever. EFSA J. 2014, 12:3628-3705.
12. Willadsen P. Anti-tick vaccines. Ticks: biology, disease and control 2008, 2008:424-446. Cambridge University Press, Cambridge.
13. de la Fuente J., Moreno-Cid J.A., Canales M., Villar M., Pérez de la Lastra J.M., Kocan K.M., et al. Targeting arthropod subolesin/akirin for the development of a universal vaccine for control of vector infestations and pathogen transmission. Vet Parasitol 2011, 181:17-22.
14. Guerrero F., Miller R.J., Pérez de León A. Cattle tick vaccines: many candidates antigens, but will a commertial product emerge?. Int J Parasitol 2012, 42:421-424.
15. Moreno-Cid J.A., Pérez de la Lastra J.M., Villar M., Jiménez M., Pinal R., Estrada-Peña A., et al. Control of multiple arthropod vector infestations with subolesin/akirin vaccines. Vaccine 2013, 31:1187-1196.
16. Almazan C., Kocan K.M., Bergman D.K., Garcia-Garcia J.C., Blouin E.F., de la Fuente J. Identification of protective antigens for the control of Ixodes scapularis infestations using cDNA expression library immunization. Vaccine 2003, 21:1492-1501.
17. de la Fuente J., Moreno-Cid J.A., Galindo R.C., Almazan C., Kocan K.M., Merino O., Perez de la Lastra J.M., Estrada-Peña A., Blouin E.F. Subolesin/akirin vaccines for the control of arthropod vectors and vectorborne pathogens. Transbound Emerg Dis 2013, 60 S:172-178.
18. Merino O., Antunes S., Mosqueda J., Moreno-Cid J.A., Pérez de la Lastra JM, Rosario-Cruz R., Rodríguez S., Domingos A., de la Fuente J. Vaccination with proteins involved in tick-pathogen interactions reduces vector infestations and pathogen infection. Vaccine 2013, 31:5889-5896.
19. Naranjo V., Ayllon N., Perez de la Lastra J.M., Galindo R.C., Kocan K.M., et al. Reciprocal Regulation of NF-kB (Relish) and Subolesin in the Tick Vector, Ixodes scapularis. PLoS ONE 2013 2013, 8:e65915.
20. Torina A., Moreno-Cid J.M., Blanda V., Fernández de Mera I.G., Pérez de la Lastra J.M., Scimeca S., et al. Control of tick infestations and pathogen prevalence in cattle and sheep farms vaccinated with the recombinant Subolesin-Major Surface Protein 1a chimeric antigen. Parasites & Vectors 2014, 7:10-25.
21. Prudencio C.R., Pérez de la Lastra J.M., Canales M., Villar M., de la Fuente J. Mapping protective epitopes in the tick and mosquitosubolesin ortholog proteins. Vaccine 2010, 28:5398-5406.
22. Manzano-Román R., Díaz-Martín V., Oleaga A., Siles-Lucas M., Pérez-Sánchez R. Subolesin/akirin orthologs from Ornithodoros spp. soft ticks: cloning, RNAi gene silencing and protective effect of the recombinant proteins. Vet Parasitol 2012, 185:248-259.
23. Díaz-Martín V., Manzano-Román R., Valero L., Oleaga A., Encinas-Grandes A., Pérez-Sánchez R. An insight into the proteome of the saliva of the argasid tick Ornithodoros moubata reveals important differences in saliva protein composition between the sexes. J Proteomics 2013, 80:216-235.
24. Manzano-Roman R., Encinas-Grandes A., Perez-Sanchez R. Antigens from the midgut membranes of Ornithodoros erraticus induce lethal anti-tick immune responses in pig and mice. Vet Parasitol 2006, 135:65-79.
25. Rodríguez-Crespo I., Yélamos B., Roncal F., Albar J.P., Ortiz de Montellano P.R., Gavilanes F. Identification of novel cellular proteins that bind to the LC8 dynein light chain using a pepscan technique. FEBS Lett 2001, 503:135-141.
26. Kelley L.A., Sternberg M.J.E. Protein structure prediction on the web: a case study using the phyre server. Nat Protoc 2009, 4:363-371.
27. Ward J.J., Sodhi J.S., McGuffin L.J., Buxton B.F., Jones D.T. Prediction and functional analysis of native disorder in proteins from the three kingdoms of life. J Mol Biol 2004, 337:635-645.
28. Zhang Y. I-TASSER server for protein 3D structure prediction. BMC Bioinform 2008, 9:40.
29. Roy A., Kucukural A., Zhang Y. I-TASSER: a unified platform for automated protein structure and function prediction. Nat Protoc 2010, 5:725-738.
30. DeLano W.L. The PyMOL Molecular Graphics System 2002, DeLano Scientific, Palo Alto, CA, USA.
31. Saha S., Raghava G.P.S. BcePred:prediction of continuous B-cell epitopes in antigenic sequences using physico-chemical properties. ICARIS 2004, LNCS 3239 2004, 197-204. Springer. G. Nicosia, V. Cutello, P.J. Bentley, J. Timis (Eds.).
32. Saha S., Raghava G.P.S. Prediction of continuous B-cell epitopes in an antigen using recurrent neural network. Proteins 2006, 65:40-48.
33. García-Varas S., Manzano-Román R., Fernández-Soto P., Encinas-Grandes A., Oleaga A., Pérez-Sánchez R. Purification and characterization of a P-selectin binding molecule from the salivary glands of Ornithodoros moubata that induces protective anti-tick immune responses in pigs. Int J Parasitol 2010, 40:313-326.
34. Sugase K., Dyson H.J., Wright P.E. Mechanism of coupled folding and binding of an intrinsically disordered protein. Nature 2007, 447:1021-1025.
35. Feng Z.P., Zhang X., Han P., Arora N., Anders R.F., Norton R.S. Abundance of intrinsically unstructured proteins in P. falciparum and other apicomplexan parasite proteomes. Mol Biochem Parasitol 2006, 150:256-267.
36. Pavlović M.D., Jandrlić D.R., Mitić N.S. Epitope distribution in ordered and disordered protein regions. Part B - ordered regions and disordered binding sites are targets of T- and B-cell immunity. J Immunol Methods 2014, 407:90-107.
37. de la Fuente J., Blouin E.F., Manzano-Roman R., Naranjo V., Almazan C., Perez de la Lastra J.M., et al. Differential expression of the tick protective antigen subolesin in Anaplasma marginale- and A. phagocytophilum-infected host cells. Ann N Y Acad Sci 2008, 1149:27-35.
38. Kulkarni P., Rajagopalan K., Yeater D., Getzenberg R.H. Protein folding and the order/disorder paradox. J Cell Biochem 2011, 112:1949-1952.
39. Caoili S.E. On the meaning of affinity limits in B-cell epitope prediction for antipeptide antibody-mediated immunity. Adv Bioinform 2012, 2012:346765. 10.1155/2012/346765.
40. Stavrakoudis A. Conformational flexibility in designing peptides for immunology: the molecular dynamics approach. Curr Comput Aided Drug Des 2010, 6:207-222.
41. Camacho C.J., Katsumata Y., Ascherman D.P. Structural and thermodynamic approach to peptide immunogenicity. PLoS Comput Biol 2008, 4:e1000231.
42. Fassolari M., Chemes L.B., Gallo M., Smal C., Sánchez I.E., de Prat-Gay G. Minute time scale prolyl isomerization governs antibody recognition of an intrinsically disordered immunodominant epitope. J Biol Chem 2013, 288:13110-13123.
43. Uversky V.N. A decade and a half of protein intrinsic disorder: biology still waits for physics. Protein Sci 2013, 22:693-724.
44. Uversky V.N. Unusual biophysics of intrinsically disordered proteins. Biochim Biophys Acta 2013, 1834:932-951.