High prevalence of prediabetes in a Swedish cohort of severely obese children

Pediatric Diabetes

Volumn 16, Issue 2, 2015, Pages 117-128

  Ek, Anna E ^a   Rössner, Sophia M ^a   Hagman, Emilia ^a   Marcus, Claude ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Child; Fasting glucose; Impaired glucose tolerance; Insulin resistance; Obese

Indexed keywords

C PEPTIDE; GLUCOSE; INSULIN; NEUTRAL INSULIN;

ADOLESCENT; ANTHROPOMETRIC PARAMETERS; ARTICLE; BICYCLE ERGOMETER; BLOOD SAMPLING; BODY COMPOSITION; BODY MASS; CARDIORESPIRATORY FITNESS; CHILD; CHILDHOOD OBESITY; COHORT ANALYSIS; DIET RESTRICTION; DISEASE SEVERITY; DUAL ENERGY X RAY ABSORPTIOMETRY; FEMALE; GLUCOSE BLOOD LEVEL; HOMEOSTATIC MODEL OF INSULIN RESISTANCE; HUMAN; IMPAIRED GLUCOSE TOLERANCE; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; INTRAVENOUS GLUCOSE TOLERANCE TEST; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; ORAL GLUCOSE TOLERANCE TEST; PREVALENCE; PRIORITY JOURNAL; SWEDEN; SWEDISH CITIZEN; WHOLE BODY SCANNER; CROSS-SECTIONAL STUDY; GLUCOSE INTOLERANCE; HYPERGLYCEMIA; INCIDENCE; METABOLISM; PATHOPHYSIOLOGY; PATIENT REFERRAL; PREDIABETIC STATE; REGISTER; RISK FACTOR; SEVERITY OF ILLNESS INDEX; SEX DIFFERENCE; UNIVERSITY HOSPITAL;

ADOLESCENT; BODY MASS INDEX; CHILD; COHORT STUDIES; CROSS-SECTIONAL STUDIES; FEMALE; GLUCOSE INTOLERANCE; HOSPITALS, UNIVERSITY; HUMANS; HYPERGLYCEMIA; INCIDENCE; INSULIN RESISTANCE; MALE; PEDIATRIC OBESITY; PREDIABETIC STATE; PREVALENCE; REFERRAL AND CONSULTATION; REGISTRIES; RISK FACTORS; SEVERITY OF ILLNESS INDEX; SEX FACTORS; SWEDEN;

EID: 84922889267     PISSN: 1399543X     EISSN: 13995448     Source Type: Journal    
DOI: 10.1111/pedi.12136     Document Type: Article

References (48)

1. Nguyen QM, Srinivasan SR, Xu JH, Chen W, Berenson GS. Fasting plasma glucose levels within the normoglycemic range in childhood as a predictor of prediabetes and type 2 diabetes in adulthood: the Bogalusa Heart Study. Arch Pediatr Adolesc Med 2010: 164: 124-128.
2. O'Malley G, Santoro N, Northrup V et al. High normal fasting glucose level in obese youth: a marker for insulin resistance and beta cell dysregulation. Diabetologia 2010: 53: 1199-1209.
3. Bacha F, Gungor N, Lee S, Arslanian SA. In vivo insulin sensitivity and secretion in obese youth: what are the differences between normal glucose tolerance, impaired glucose tolerance, and type 2 diabetes? Diabetes Care 2009: 32: 100-105.
4. Faerch K, Vaag A, Holst JJ, Hansen T, Jorgensen T, Borch-Johnsen K. Natural history of insulin sensitivity and insulin secretion in the progression from normal glucose tolerance to impaired fasting glycemia and impaired glucose tolerance: the Inter99 study. Diabetes Care 2009: 32: 439-444.
5. Cali AM, Bonadonna RC, Trombetta M, Weiss R, Caprio S. Metabolic abnormalities underlying the different prediabetic phenotypes in obese adolescents. J Clin Endocrinol Metab 2008: 93: 1767-1773.
6. Meyer C, Pimenta W, Woerle HJ et al. Different mechanisms for impaired fasting glucose and impaired postprandial glucose tolerance in humans. Diabetes Care 2006: 29: 1909-1914.
7. Faerch K, Borch-Johnsen K, Holst JJ, Vaag A. Pathophysiology and aetiology of impaired fasting glycaemia and impaired glucose tolerance: does it matter for prevention and treatment of type 2 diabetes? Diabetologia 2009: 52: 1714-1723.
8. Invitti C, Guzzaloni G, Gilardini L, Morabito F, Viberti G. Prevalence and concomitants of glucose intolerance in European obese children and adolescents. Diabetes Care 2003: 26: 118-124.
9. Wabitsch M, Hauner H, Hertrampf M et al. Type II diabetes mellitus and impaired glucose regulation in Caucasian children and adolescents with obesity living in Germany. Int J Obes Relat Metab Disord 2004: 28: 307-313.
10. Reinehr T, Andler W, Denzer C, Siegried W, Mayer H, Wabitsch M. Cardiovascular risk factors in overweight German children and adolescents: relation to gender, age and degree of overweight. Nutr Metab Cardiovasc Dis 2005: 15: 181-187.
11. Cambuli VM, Incani M, Pilia S et al. Oral glucose tolerance test in Italian overweight/obese children and adolescents results in a very high prevalence of impaired fasting glycaemia, but not of diabetes. Diabetes Metab Res Rev 2009: 25: 528-534.
12. Hagman E, Reinehr T, Kowalski J, Ekbom A, Marcus C, Holl RW. Impaired fasting glucose prevalence in two nationwide cohorts of obese children and adolescents. Int J Obes (Lond) 2014: 38: 40-45.
13. Neovius M, Janson A, Rossner S. Prevalence of obesity in Sweden. Obes Rev 2006: 7: 1-3.
14. Thunander M, Petersson C, Jonzon K et al. Incidence of type 1 and type 2 diabetes in adults and children in Kronoberg, Sweden. Diabetes Res Clin Pract 2008: 82: 247-255.
15. Sinha R, Fisch G, Teague B et al. Prevalence of impaired glucose tolerance among children and adolescents with marked obesity. N Engl J Med 2002: 346: 802-810.
16. Morinder G, Larsson UE, Norgren S, Marcus C. Insulin sensitivity, VO2max and body composition in severely obese Swedish children and adolescents. Acta Paediatr 2009: 98: 132-138.
17. Janssen I, Cramp WC. Cardiorespiratory fitness is strongly related to the metabolic syndrome in adolescents. Diabetes Care 2007: 30: 2143-2144.
18. Cole TJ, Bellizzi MC, Flegal KM, Dietz WH. Establishing a standard definition for child overweight and obesity worldwide: international survey. BMJ 2000: 320: 1240-1243.
19. Karlberg J, Kwan CW, Albertsson-Wikland K. Reference values for change in body mass index from birth to 18 years of age. Acta Paediatr 2003: 92: 648-652.
20. Tanner JM, Whitehouse RH. Clinical longitudinal standards for height, weight, height velocity, weight velocity, and stages of puberty. Arch Dis Child 1976: 51: 170-179.
21. Kamel A, Norgren S, Elimam A, Danielsson P, Marcus C. Effects of growth hormone treatment in obese prepubertal boys. J Clin Endocrinol Metab 2000: 85: 1412-1419.
22. Boston RC, Moate PJ, Stefanovski D, Sumner AE, Bergman RN. AKA-Glucose: a program for kinetic and epidemiological analysis of frequently sampled intravenous glucose tolerance test data using database technology. Diabetes Technol Ther 2005: 7: 298-307.
23. Bergman RN. Lilly lecture 1989. Toward physiological understanding of glucose tolerance. Minimal-model approach. Diabetes 1989: 38: 1512-1527.
24. Burnett RW, D'Orazio P, Fogh-Andersen N et al. IFCC recommendation on reporting results for blood glucose. Clin Chim Acta 2001: 307 (1-2): 205-209.
25. Jeppsson JO, Kobold U, Barr J et al. Approved IFCC reference method for the measurement of HbA1c in human blood. Clin Chem Lab Med 2002: 40: 78-89.
26. Hanas R, John G. 2010 consensus statement on the worldwide standardization of the hemoglobin A1C measurement. Diabetes Care 2010: 33: 1903-1904.
27. Astrand PO, Ryhming I. A nomogram for calculation of aerobic capacity (physical fitness) from pulse rate during sub-maximal work. J Appl Physiol 1954: 7: 218-221.
28. American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care 2010: 33 (Suppl. 1): S62-S69.
29. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985: 28: 412-419.
30. Wiegand S, Maikowski U, Blankenstein O, Biebermann H, Tarnow P, Gruters A. Type 2 diabetes and impaired glucose tolerance in European children and adolescents with obesity -- a problem that is no longer restricted to minority groups. Eur J Endocrinol 2004: 151: 199-206.
31. Ball GD, Shaibi GQ, Cruz ML, Watkins MP, Weigensberg MJ, Goran MI. Insulin sensitivity, cardiorespiratory fitness, and physical activity in overweight Hispanic youth. Obes Res 2004: 12: 77-85.
32. Goran MI, Bergman RN, Avila Q et al. Impaired glucose tolerance and reduced beta-cell function in overweight Latino children with a positive family history for type 2 diabetes. J Clin Endocrinol Metab 2004: 89: 207-212.
33. Bacha F, Lee S, Gungor N, Arslanian SA. From pre-diabetes to type 2 diabetes in obese youth: pathophysiological characteristics along the spectrum of glucose dysregulation. Diabetes Care 2010: 33: 2225-2231.
34. Henderson M, Rabasa-Lhoret R, Bastard JP et al. Measuring insulin sensitivity in youth: How do the different indices compare with the gold-standard method? Diabetes Metab 2011: 37: 72-78.
35. Bergman RN, Prager R, Volund A, Olefsky JM. Equivalence of the insulin sensitivity index in man derived by the minimal model method and the euglycemic glucose clamp. J Clin Invest 1987: 79: 790-800.
36. Goran MI, Gower BA. Longitudinal study on pubertal insulin resistance. Diabetes 2001: 50: 2444-2450.
37. Moran A, Jacobs DR Jr, Steinberger J et al. Insulin resistance during puberty: results from clamp studies in 357 children. Diabetes 1999: 48: 2039-2044.
38. Allard P, Delvin EE, Paradis G et al. Distribution of fasting plasma insulin, free fatty acids, and glucose concentrations and of homeostasis model assessment of insulin resistance in a representative sample of Quebec children and adolescents. Clin Chem 2003: 49: 644-649.
39. Williams DE, Cadwell BL, Cheng YJ et al. Prevalence of impaired fasting glucose and its relationship with cardiovascular disease risk factors in US adolescents, 1999-2000. Pediatrics 2005: 116: 1122-1126.
40. Santaguida PL, Balion C, Hunt D et al. Diagnosis, prognosis, and treatment of impaired glucose tolerance and impaired fasting glucose. Evid Rep Technol Assess (Summ) 2005: 128: 1-11.
41. Wang G, Arguelles L, Liu R et al. Tracking blood glucose and predicting prediabetes in Chinese children and adolescents: a prospective twin study. PLoS One 2011: 6: e28573.
42. Santoro N. Childhood obesity and type 2 diabetes: the frightening epidemic. World J Pediatr 2013: 9: 101-102.
43. Gungor N, Arslanian S. Progressive beta cell failure in type 2 diabetes mellitus of youth. J Pediatr 2004: 144: 656-659.
44. Weiss R, Taksali SE, Tamborlane WV, Burgert TS, Savoye M, Caprio S. Predictors of changes in glucose tolerance status in obese youth. Diabetes Care 2005: 28: 902-909.
45. Sjoberg A, Moraeus L, Yngve A, Poortvliet E, Al-Ansari U, Lissner L. Overweight and obesity in a representative sample of schoolchildren - exploring the urban-rural gradient in Sweden. Obes Rev 2011: 12: 305-314.
46. Carlsson A, Kockum I, Lindblad B et al. Low risk HLA-DQ and increased body mass index in newly diagnosed type 1 diabetes children in the Better Diabetes Diagnosis study in Sweden. Int J Obes (Lond) 2012: 36: 718-724.
47. The Swedish National Diabetes Register (NDR). The annual report 2012 from the Swedish children diabetes register (Swediabkids) 2012 (available from http://www.ndr.nu/).
48. Cruz ML, Weigensberg MJ, Huang TT, Ball G, Shaibi GQ, Goran MI. The metabolic syndrome in overweight Hispanic youth and the role of insulin sensitivity. J Clin Endocrinol Metab 2004: 89: 108-113.