Comparison of standardized uptake values with volume of distribution for quantitation of [11C]PBR28 brain uptake

Nuclear Medicine and Biology

Volumn 42, Issue 3, 2015, Pages 305-308

  Yoder, Karmen K ^a   Territo, Paul R ^a   Hutchins, Gary D ^a   Hannestad, Jonas ^b   Morris, Evan D ^b   Gallezot, Jean Dominique ^b   Normandin, Marc D ^c   Cosgrove, Kelly P ^b  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Inflammation; PBR28; PET; SUV; TSPO; Validity

Indexed keywords

PBR 28 C 11; RADIOPHARMACEUTICAL AGENT; UNCLASSIFIED DRUG; (METHYL-(11)C)N-ACETYL-N-(2-METHOXYBENZYL)-2-PHENOXY-5-PYRIDINAMINE; 4 AMINOBUTYRIC ACID RECEPTOR; LIPOPOLYSACCHARIDE; PROTEIN BINDING; PYRIMIDINE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BABOON; BRAIN REGION; BRAIN STEM; CAUDATE NUCLEUS; CENTRUM SEMIOVALE; CEREBELLUM; CINGULATE GYRUS; FRONTAL CORTEX; GLOBUS PALLIDUS; INSULA; NERVOUS SYSTEM INFLAMMATION; NONHUMAN; NUCLEUS ACCUMBENS; OCCIPITAL CORTEX; PET SCANNER; PONS; POSITRON EMISSION TOMOGRAPHY; PUTAMEN; RADIOLOGICAL PARAMETERS; STANDARDIZED UPTAKE VALUE; THALAMUS; VOLUME OF DISTRIBUTION; ANIMAL; BRAIN; COMPARATIVE STUDY; DRUG EFFECTS; METABOLISM; SCINTISCANNING; STANDARD;

ANIMALS; BRAIN; LIPOPOLYSACCHARIDES; PAPIO; POSITRON-EMISSION TOMOGRAPHY; PROTEIN BINDING; PYRIMIDINES; RECEPTORS, GABA; REFERENCE STANDARDS;

EID: 84922855865     PISSN: 09698051     EISSN: 18729614     Source Type: Journal    
DOI: 10.1016/j.nucmedbio.2014.11.003     Document Type: Article

References (23)

1. Papadopoulos V., Baraldi M., Guilarte T.R., Knudsen T.B., Lacapere J.J., Lindemann P., et al. Translocator protein (18kDa): new nomenclature for the peripheral-type benzodiazepine receptor based on its structure and molecular function. Trends Pharmacol Sci 2006, 27:402-409.
2. Papadopoulos V., Lecanu L. Translocator protein (18kDa) TSPO: an emerging therapeutic target in neurotrauma. Exp Neurol 2009, 219:53-57.
3. Imaizumi M., Kim H.J., Zoghbi S.S., Briard E., Hong J., Musachio J.L., et al. PET imaging with [11C]PBR28 can localize and quantify upregulated peripheral benzodiazepine receptors associated with cerebral ischemia in rat. Neurosci Lett 2007, 411:200-205.
4. Brown A.K., Fujita M., Fujimura Y., Liow J.S., Stabin M., Ryu Y.H., et al. Radiation dosimetry and biodistribution in monkey and man of 11C-PBR28: a PET radioligand to image inflammation. J Nucl Med 2007, 48:2072-2079.
5. Cosenza-Nashat M., Zhao M.L., Suh H.S., Morgan J., Natividad R., Morgello S., et al. Expression of the translocator protein of 18kDa by microglia, macrophages and astrocytes based on immunohistochemical localization in abnormal human brain. Neuropathol Appl Neurobiol 2009, 35:306-328.
6. Hannestad J., Gallezot J.D., Schafbauer T., Lim K., Kloczynski T., Morris E.D., et al. Endotoxin-induced systemic inflammation activates microglia: [(1)(1)C]PBR28 positron emission tomography in nonhuman primates. Neuroimage 2012, 63:232-239.
7. Zanotti-Fregonara P., Liow J.S., Fujita M., Dusch E., Zoghbi S.S., Luong E., et al. Image-derived input function for human brain using high resolution PET imaging with [C](R)-rolipram and [C]PBR28. PLoS One 2011, 6:e17056.
8. Rizzo G., Veronese M., Tonietto M., Zanotti-Fregonara P., Turkheimer F.E., Bertoldo A. Kinetic modeling without accounting for the vascular component impairs the quantification of [(11)C]PBR28 brain PET data. J Cereb Blood Flow Metab 2014, 34:1060-1069.
9. Kropholler M.A., Boellaard R., Schuitemaker A., Folkersma H., van Berckel B.N., Lammertsma A.A. Evaluation of reference tissue models for the analysis of [11C](R)-PK11195 studies. J Cereb Blood Flow Metab 2006, 26:1431-1441.
10. Kropholler M.A., Boellaard R., van Berckel B.N., Schuitemaker A., Kloet R.W., Lubberink M.J., et al. Evaluation of reference regions for (R)-[(11)C]PK11195 studies in Alzheimer's disease and mild cognitive impairment. J Cereb Blood Flow Metab 2007, 27:1965-1974.
11. Tomasi G., Edison P., Bertoldo A., Roncaroli F., Singh P., Gerhard A., et al. Novel reference region model reveals increased microglial and reduced vascular binding of 11C-(R)-PK11195 in patients with Alzheimer's disease. J Nucl Med 2008, 49:1249-1256.
12. Turkheimer F.E., Edison P., Pavese N., Roncaroli F., Anderson A.N., Hammers A., et al. Reference and target region modeling of [11C]-(R)-PK11195 brain studies. J Nucl Med 2007, 48:158-167.
13. N.R.Council Guide for the care and use of laboratory animals 1996, The National Academies Press, Washington, D.C.
14. Logan J., Fowler J., Volkow N., Wolf A., Dewey S., Schlyer D., et al. Graphical analysis of reversible radioligand binding from time-activity measurements applied to [N-11C-methyl]-(-)-cocaine PET studies in human subjects. J Cereb Blood Flow Metab 1990, 10:740-747.
15. Fujita M., Imaizumi M., Zoghbi S.S., Fujimura Y., Farris A.G., Suhara T., et al. Kinetic analysis in healthy humans of a novel positron emission tomography radioligand to image the peripheral benzodiazepine receptor, a potential biomarker for inflammation. Neuroimage 2008, 40:43-52.
16. Hannestad J., DellaGioia N., Gallezot J.D., Lim K., Nabulsi N., Esterlis I., et al. The neuroinflammation marker translocator protein is not elevated in individuals with mild-to-moderate depression: a [(1)(1)C]PBR28 PET study. Brain Behav Immun 2013, 33:131-138.
17. Hines C.S., Fujita M., Zoghbi S.S., Kim J.S., Quezado Z., Herscovitch P., et al. Propofol decreases in vivo binding of 11C-PBR28 to translocator protein (18kDa) in the human brain. J Nucl Med 2013, 54:64-69.
18. Kreisl W.C., Lyoo C.H., McGwier M., Snow J., Jenko K.J., Kimura N., et al. In vivo radioligand binding to translocator protein correlates with severity of Alzheimer's disease. Brain 2013, 136:2228-2238.
19. Cohen J. Statistical power analyses for the behavioral sciences 1988, Lawrence Erlbaum Associates, Inc., Mahwah, NJ. Second ed.
20. Yoder K.K., Nho K., Risacher S.L., Kim S., Shen L., Saykin A.J. Influence of TSPO genotype on 11C-PBR28 standardized uptake values. J Nucl Med 2013, 54:1320-1322.
21. Briard E., Zoghbi S.S., Imaizumi M., Gourley J.P., Shetty H.U., Hong J., et al. Synthesis and evaluation in monkey of two sensitive 11C-labeled aryloxyanilide ligands for imaging brain peripheral benzodiazepine receptors in vivo. J Med Chem 2008, 51:17-30.
22. Kim J.A., Li L., Zuo Z. Delayed treatment with isoflurane attenuates lipopolysaccharide and interferon gamma-induced activation and injury of mouse microglial cells. Anesthesiology 2009, 111:566-573.
23. Xu X., Kim J.A., Zuo Z. Isoflurane preconditioning reduces mouse microglial activation and injury induced by lipopolysaccharide and interferon-gamma. Neuroscience 2008, 154:1002-1008.