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Volumn 6, Issue 1, 2015, Pages 3-18

Efficacy and tolerability of glucagon-like peptide-1 receptor agonists in patients with type 2 diabetes mellitus

Author keywords

albiglutide; exenatide; exenatide long acting release; GLP 1 RAs; liraglutide; type 2 diabetes mellitus

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; ALBIGLUTIDE; EXENDIN 4; GLUCAGON LIKE PEPTIDE 1 RECEPTOR AGONIST; GLUCOSE; HEMOGLOBIN A1C; INSULIN; LIRAGLUTIDE; METFORMIN; SULFONYLUREA;

EID: 84922816507     PISSN: 20420188     EISSN: 20420196     Source Type: Journal    
DOI: 10.1177/2042018814558242     Document Type: Review
Times cited : (50)

References (88)
  • 1
    • 84904963065 scopus 로고    scopus 로고
    • HARMONY 3: 104-week randomized, double-blind, placebo- and active- controlled trial assessing the efficacy and safety of albiglutide compared with placebo, sitagliptin, and glimepiride in patients with type 2 diabetes taking metformin
    • Ahren B. Johnson S. Stewart M. Cirkel D. Yang F. Perry C. et al. (2014) HARMONY 3: 104-week randomized, double-blind, placebo- and active- controlled trial assessing the efficacy and safety of albiglutide compared with placebo, sitagliptin, and glimepiride in patients with type 2 diabetes taking metformin. Diabetes Care 37: 2141–2148.
    • (2014) Diabetes Care , vol.37 , pp. 2141-2148
    • Ahren, B.1    Johnson, S.2    Stewart, M.3    Cirkel, D.4    Yang, F.5    Perry, C.6
  • 2
    • 84993811460 scopus 로고    scopus 로고
    • Amylin Pharmaceuticals, Inc
    • Byetta (exenatide) package insert Available at: http://documents.byetta.com/Byetta_PI.pdf > (accessed 12 July 2014).
    • Amylin Pharmaceuticals, Inc. (2011) Byetta (exenatide) package insert. Available at: http://documents.byetta.com/Byetta_PI.pdf> (accessed 12 July 2014).
    • (2011)
  • 3
    • 84905018268 scopus 로고    scopus 로고
    • Amylin Pharmaceuticals, Inc
    • Bydureon (exenatide extended release) package insert Available at: http://documents.bydureon.com/Bydureon_PI.pdf > (accessed 12 July 2014).
    • Amylin Pharmaceuticals, Inc. (2012) Bydureon (exenatide extended release) package insert. Available at: http://documents.bydureon.com/Bydureon_PI.pdf> (accessed 12 July 2014).
    • (2012)
  • 4
    • 77950827693 scopus 로고    scopus 로고
    • Effects of exenatide combined with lifestyle modicfications in patients with type 2 diabetes
    • Apovian C. Bergenstal R. Cuddigy R. Qu Y. Lenox S. Lewis M. et al. (2010) Effects of exenatide combined with lifestyle modicfications in patients with type 2 diabetes. Am J Med 123: e9–17.
    • (2010) Am J Med , vol.123 , pp. e9-17
    • Apovian, C.1    Bergenstal, R.2    Cuddigy, R.3    Qu, Y.4    Lenox, S.5    Lewis, M.6
  • 5
    • 37349008890 scopus 로고    scopus 로고
    • Tolerability and efficacy of exenatide and titrated insulin glargine in adult patients with type 2 diabetes previously uncontrolled with metformin or a sulfonylurea: a multinational, randomized, open-label, two-period, crossover noninferiority trial
    • Barnett A. Burger J. Johns D. Brodows R. Kendall D. Roberts A. et al. (2007) Tolerability and efficacy of exenatide and titrated insulin glargine in adult patients with type 2 diabetes previously uncontrolled with metformin or a sulfonylurea: a multinational, randomized, open-label, two-period, crossover noninferiority trial. Clin Ther 29: 2333–2348.
    • (2007) Clin Ther , vol.29 , pp. 2333-2348
    • Barnett, A.1    Burger, J.2    Johns, D.3    Brodows, R.4    Kendall, D.5    Roberts, A.6
  • 6
    • 79955661908 scopus 로고    scopus 로고
    • DURATION:5 Exenatide once weekly resulted in greater improvements in glycemic control compared with exenatide twice daily in patients with type 2 diabetes
    • Belvins T. Pullman J. Malloy J. Yan P. Taylor K. Schulteis C. (2011) DURATION:5 Exenatide once weekly resulted in greater improvements in glycemic control compared with exenatide twice daily in patients with type 2 diabetes. J Clin Endocrinol Metab 96: 1301–1310.
    • (2011) J Clin Endocrinol Metab , vol.96 , pp. 1301-1310
    • Belvins, T.1    Pullman, J.2    Malloy, J.3    Yan, P.4    Taylor, K.5    Schulteis, C.6
  • 7
    • 84871126011 scopus 로고    scopus 로고
    • Efficacy and safety of taspoglutide versus sitagliptin for type 2 diabetes mellitus (T-Emerge 4 trial)
    • Bergenstal R. Forti A. Chiasson J. Wolochak M. Boldrin M. Balena R. (2012) Efficacy and safety of taspoglutide versus sitagliptin for type 2 diabetes mellitus (T-Emerge 4 trial). Diabetes Ther 3: 13.
    • (2012) Diabetes Ther , vol.3 , pp. 13
    • Bergenstal, R.1    Forti, A.2    Chiasson, J.3    Wolochak, M.4    Boldrin, M.5    Balena, R.6
  • 8
    • 64249143715 scopus 로고    scopus 로고
    • Efficacy and safety of biphasic insulin aspart 70/30 versus exenatide in subjects with type 2 diabetes failing to achieve glycemic control with metformin and a sulfonylurea
    • Bergenstal R. Lewin A. Bailey T. Chang D. Roberts V. (2009) Efficacy and safety of biphasic insulin aspart 70/30 versus exenatide in subjects with type 2 diabetes failing to achieve glycemic control with metformin and a sulfonylurea. Curr Med Res Opin 25:65–75.
    • (2009) Curr Med Res Opin , vol.25 , pp. 65-75
    • Bergenstal, R.1    Lewin, A.2    Bailey, T.3    Chang, D.4    Roberts, V.5
  • 9
    • 77955573674 scopus 로고    scopus 로고
    • Efficacy and safety of exenatide once weekly versus sitaglipitin or pioglitazone as an adjunct to metformin for treatment of type 2 diabetes (DURATION-2): a randomized trial
    • Bergenstal R. Wysham C. MacConell L. Malloy J. Walsh B. Yan P. et al. (2010) Efficacy and safety of exenatide once weekly versus sitaglipitin or pioglitazone as an adjunct to metformin for treatment of type 2 diabetes (DURATION-2): a randomized trial. Lancet 376: 431–439.
    • (2010) Lancet , vol.376 , pp. 431-439
    • Bergenstal, R.1    Wysham, C.2    MacConell, L.3    Malloy, J.4    Walsh, B.5    Yan, P.6
  • 10
    • 33748442464 scopus 로고    scopus 로고
    • Interim analysis of the effects of exenatide treatment on A1c, weight and cardiovascular risk factors over 82 weeks in 314 overweight patients with type 2 diabetes
    • Blonde L. Klein E. Han J. Zhang B. Mac S. Poon T. et al. (2006) Interim analysis of the effects of exenatide treatment on A1c, weight and cardiovascular risk factors over 82 weeks in 314 overweight patients with type 2 diabetes. Diabetes Obes Metab 8: 436–447.
    • (2006) Diabetes Obes Metab , vol.8 , pp. 436-447
    • Blonde, L.1    Klein, E.2    Han, J.3    Zhang, B.4    Mac, S.5    Poon, T.6
  • 11
    • 84892556531 scopus 로고    scopus 로고
    • Efficacy and safety of lixisenatide once daily vs. placebo in people with type 2 diabetes insufficiently controlled on metformin (GetGoal-F1)
    • Bolli G. Munteanu M. Dotsenko S. Neimoeller E. Boka G. Wu Y. et al. (2014) Efficacy and safety of lixisenatide once daily vs. placebo in people with type 2 diabetes insufficiently controlled on metformin (GetGoal-F1). Diabetes Med 31: 176–184.
    • (2014) Diabetes Med , vol.31 , pp. 176-184
    • Bolli, G.1    Munteanu, M.2    Dotsenko, S.3    Neimoeller, E.4    Boka, G.5    Wu, Y.6
  • 12
    • 80054090833 scopus 로고    scopus 로고
    • Effects of exenatide on measure of β-cell function after 3 years in metformin-treated patients with type 2 diabetes
    • Bunck M. Cornner A. Eliasson B. Heine R. Shaginian R. Taskinen M. et al. (2011) Effects of exenatide on measure of β-cell function after 3 years in metformin-treated patients with type 2 diabetes. Diabetes Care 34: 2041–2047.
    • (2011) Diabetes Care , vol.34 , pp. 2041-2047
    • Bunck, M.1    Cornner, A.2    Eliasson, B.3    Heine, R.4    Shaginian, R.5    Taskinen, M.6
  • 13
    • 77953828230 scopus 로고    scopus 로고
    • DURATION-1: exenatide once weekly produces sustained glycemic control and weight loss over 52 weeks
    • Buse J. Drucker D. Taylor K. Kim T. Walsh B. Hu H. et al. (2010) DURATION-1: exenatide once weekly produces sustained glycemic control and weight loss over 52 weeks. Diabetes Care 33: 1255–1261.
    • (2010) Diabetes Care , vol.33 , pp. 1255-1261
    • Buse, J.1    Drucker, D.2    Taylor, K.3    Kim, T.4    Walsh, B.5    Hu, H.6
  • 14
    • 79551615182 scopus 로고    scopus 로고
    • Use of twice-daily exenatide in basal insulin-treated patients with type 2 diabetes: a randomized, controlled trial
    • Buse J. Bergenstal R. Glass L. Heilmann C. Lewis M. Kwan A. et al. (2011) Use of twice-daily exenatide in basal insulin-treated patients with type 2 diabetes: a randomized, controlled trial. Ann Intern Med 154: 103–112.
    • (2011) Ann Intern Med , vol.154 , pp. 103-112
    • Buse, J.1    Bergenstal, R.2    Glass, L.3    Heilmann, C.4    Lewis, M.5    Kwan, A.6
  • 15
    • 7444228521 scopus 로고    scopus 로고
    • Effects of exenatide (exendin-4) on glycemic control over 30 weeks in sulfonylurea-treated patients with type 2 diabetes
    • Buse J. Henry R. Han J. Kim D. Fineman M. Baron A. (2004) Effects of exenatide (exendin-4) on glycemic control over 30 weeks in sulfonylurea-treated patients with type 2 diabetes. Diabetes Care 27: 2628–2635.
    • (2004) Diabetes Care , vol.27 , pp. 2628-2635
    • Buse, J.1    Henry, R.2    Han, J.3    Kim, D.4    Fineman, M.5    Baron, A.6
  • 16
    • 33947156808 scopus 로고    scopus 로고
    • Metabolic effects of two years of exenatide treatment on diabetes, obesity, and hepatic biomarkers in patients with type 2 diabetes: an interim analysis of data from the open-label, uncontrolled extension of three double-blind, placebo-controlled trials
    • Buse J. Klonoff D. Nielsen L. Guan X. Bowlus C. Holcombe J. et al. (2007) Metabolic effects of two years of exenatide treatment on diabetes, obesity, and hepatic biomarkers in patients with type 2 diabetes: an interim analysis of data from the open-label, uncontrolled extension of three double-blind, placebo-controlled trials. Clin Ther 29: 139–153.
    • (2007) Clin Ther , vol.29 , pp. 139-153
    • Buse, J.1    Klonoff, D.2    Nielsen, L.3    Guan, X.4    Bowlus, C.5    Holcombe, J.6
  • 17
    • 67649666737 scopus 로고    scopus 로고
    • Liraglutide once a day versus exenatide twice a day for type 2 diabetes: a 26-week randomized, parallel-group, multinational, open-label trial (LEAD-6)
    • Buse J. Rosenstock J. Sesti G. Schmidt W. Montanya E. Brett J. et al. (2009) Liraglutide once a day versus exenatide twice a day for type 2 diabetes: a 26-week randomized, parallel-group, multinational, open-label trial (LEAD-6). Lancet 374: 39–47.
    • (2009) Lancet , vol.374 , pp. 39-47
    • Buse, J.1    Rosenstock, J.2    Sesti, G.3    Schmidt, W.4    Montanya, E.5    Brett, J.6
  • 18
    • 84872084453 scopus 로고    scopus 로고
    • Exenatide once weekly versus liraglutide once daily in patients with type 2 diabetes (DURATION-6): a randomized, open-label study
    • Buse J. Nauck M. Forst T. Sheu W. Shenouda S. Heilmann C. et al. (2013) Exenatide once weekly versus liraglutide once daily in patients with type 2 diabetes (DURATION-6): a randomized, open-label study. Lancet 381: 117–124.
    • (2013) Lancet , vol.381 , pp. 117-124
    • Buse, J.1    Nauck, M.2    Forst, T.3    Sheu, W.4    Shenouda, S.5    Heilmann, C.6
  • 19
    • 84878837962 scopus 로고    scopus 로고
    • Efficacy and safety over 26 weeks of an oral treatment strategy including sitagliptin compared with an injectable treatment strategy with liraglutide in patients with type 2 diabetes mellitus inadequately controlled on metformin: a randomised clinical trial
    • Charbonnel B. Steinberg H. Eymard E. Xu L. Thakkar P. Prabhu V. et al. (2013) Efficacy and safety over 26 weeks of an oral treatment strategy including sitagliptin compared with an injectable treatment strategy with liraglutide in patients with type 2 diabetes mellitus inadequately controlled on metformin: a randomised clinical trial. Diabetologia 56: 1503–1511.
    • (2013) Diabetologia , vol.56 , pp. 1503-1511
    • Charbonnel, B.1    Steinberg, H.2    Eymard, E.3    Xu, L.4    Thakkar, P.5    Prabhu, V.6
  • 20
    • 84875385071 scopus 로고    scopus 로고
    • Treatment with exenatide once weekly or twice daily for 30 weeks is associated with changes in several cardiovascular risk markers
    • Chiquette E. Toth P. Ramirez G. Cobble M. Chilton R. (2012) Treatment with exenatide once weekly or twice daily for 30 weeks is associated with changes in several cardiovascular risk markers. Vasc Health Risk Manag 8: 621–629.
    • (2012) Vasc Health Risk Manag , vol.8 , pp. 621-629
    • Chiquette, E.1    Toth, P.2    Ramirez, G.3    Cobble, M.4    Chilton, R.5
  • 21
    • 70450199755 scopus 로고    scopus 로고
    • Exenatide compared with long-acting insulin to achieve glycaemic control with minimal weight gain in patients with type 2 diabetes: results of the helping evaluate exenatide in patients with diabetes compared with long-acting insulin (HEELA) study
    • Davies M. Donnelly R. Barnett A. Jones S. Nicolay C. Kilcoyne A. (2009) Exenatide compared with long-acting insulin to achieve glycaemic control with minimal weight gain in patients with type 2 diabetes: results of the helping evaluate exenatide in patients with diabetes compared with long-acting insulin (HEELA) study. Diabetes Obes Metab 11: 1153–1162.
    • (2009) Diabetes Obes Metab , vol.11 , pp. 1153-1162
    • Davies, M.1    Donnelly, R.2    Barnett, A.3    Jones, S.4    Nicolay, C.5    Kilcoyne, A.6
  • 23
    • 18144401971 scopus 로고    scopus 로고
    • Effects of exenatide (exendin-4) on glycemic control and weight over 30 weeks in metformin-treated patients with type 2 diabetes
    • de Fronzo R. Ratner R. Han J. Kim D. Fineman M. Baron A. (2005) Effects of exenatide (exendin-4) on glycemic control and weight over 30 weeks in metformin-treated patients with type 2 diabetes. Diabetes Care 28: 1092–1100.
    • (2005) Diabetes Care , vol.28 , pp. 1092-1100
    • de Fronzo, R.1    Ratner, R.2    Han, J.3    Kim, D.4    Fineman, M.5    Baron, A.6
  • 24
    • 84869111529 scopus 로고    scopus 로고
    • Exenatide plus metformin compared with metformin alone on β-cell function in patients with type 2 diabetes
    • Derosa G. Franzetti I. Querci F. Carbone A. Ciccarelli L. Piccinni M. et al. (2012) Exenatide plus metformin compared with metformin alone on β-cell function in patients with type 2 diabetes. Diabet Med 29: 1515–1523.
    • (2012) Diabet Med , vol.29 , pp. 1515-1523
    • Derosa, G.1    Franzetti, I.2    Querci, F.3    Carbone, A.4    Ciccarelli, L.5    Piccinni, M.6
  • 25
    • 84885231257 scopus 로고    scopus 로고
    • Variation in inflammatory markers and glycemic parameters after 12 months of exenatide plus metformin treatment compared with metformin alone: a randomized placebo-controlled trial
    • Derosa G. Franzetti I. Querci F. Carbone A. Ciccarelli L. Piccinni M. et al. (2013) Variation in inflammatory markers and glycemic parameters after 12 months of exenatide plus metformin treatment compared with metformin alone: a randomized placebo-controlled trial. Pharmacotherapy 33: 817–826.
    • (2013) Pharmacotherapy , vol.33 , pp. 817-826
    • Derosa, G.1    Franzetti, I.2    Querci, F.3    Carbone, A.4    Ciccarelli, L.5    Piccinni, M.6
  • 27
    • 79959975635 scopus 로고    scopus 로고
    • Exenatide or glimepiride added to metformin on metabolic control and on insulin resistance in type 2 diabetic patients
    • Derosa G. Putignano P. Bossi A. Bonaventura A. Querci F. Franzetti I. et al. (2011) Exenatide or glimepiride added to metformin on metabolic control and on insulin resistance in type 2 diabetic patients. Eur J Pharmacol 666: 251–256.
    • (2011) Eur J Pharmacol , vol.666 , pp. 251-256
    • Derosa, G.1    Putignano, P.2    Bossi, A.3    Bonaventura, A.4    Querci, F.5    Franzetti, I.6
  • 28
    • 84862903186 scopus 로고    scopus 로고
    • Sequential intensification of metformin treatment in type 2 diabetes with liraglutide followed by randomized addition of basal insulin prompted by A1c targets
    • de Vries J. Bain S. Rodbard H. Seufert J. D'Alessio D. Thomsen A. et al. (2012) Sequential intensification of metformin treatment in type 2 diabetes with liraglutide followed by randomized addition of basal insulin prompted by A1c targets. Diabetes Care 35: 1446–1454.
    • (2012) Diabetes Care , vol.35 , pp. 1446-1454
    • de Vries, J.1    Bain, S.2    Rodbard, H.3    Seufert, J.4    D'Alessio, D.5    Thomsen, A.6
  • 29
    • 84860618430 scopus 로고    scopus 로고
    • Safety and efficacy of once-weekly exenatide compared with insulin glargine titrated to target in patients with type 2 diabetes over 84 weeks
    • Diamant M. Gaal L. Stranks S. Guerci B. MacConell L. Haber H. et al. (2012) Safety and efficacy of once-weekly exenatide compared with insulin glargine titrated to target in patients with type 2 diabetes over 84 weeks. Diabetes Care 35: 683–689.
    • (2012) Diabetes Care , vol.35 , pp. 683-689
    • Diamant, M.1    Gaal, L.2    Stranks, S.3    Guerci, B.4    MacConell, L.5    Haber, H.6
  • 30
    • 77953859640 scopus 로고    scopus 로고
    • Once weekly exenatide compared with insulin glargine titrated to target in patients with type 2 diabetes (Duration-3): an open-label randomized trial
    • Diamant M. Gaal L. Stranks S. Northrup J. Cao D. Taylor K. et al. (2010) Once weekly exenatide compared with insulin glargine titrated to target in patients with type 2 diabetes (Duration-3): an open-label randomized trial. Lancet 375: 2234–2243.
    • (2010) Lancet , vol.375 , pp. 2234-2243
    • Diamant, M.1    Gaal, L.2    Stranks, S.3    Northrup, J.4    Cao, D.5    Taylor, K.6
  • 31
    • 53249142132 scopus 로고    scopus 로고
    • Exenatide once weekly versus twice daily for the treatment of type 2 diabetes: a randomized, open-label, non-inferiority study
    • Drucker D. Buse J. Taylor K. Kendall D. Trautmann M. Zhuang D. et al. (2008) Exenatide once weekly versus twice daily for the treatment of type 2 diabetes: a randomized, open-label, non-inferiority study. Lancet 372: 1240–1250.
    • (2008) Lancet , vol.372 , pp. 1240-1250
    • Drucker, D.1    Buse, J.2    Taylor, K.3    Kendall, D.4    Trautmann, M.5    Zhuang, D.6
  • 32
    • 34447574784 scopus 로고    scopus 로고
    • Incretins and their role in the management of diabetes
    • Frias J. Edelman S. (2007) Incretins and their role in the management of diabetes. Curr Opin Endocrinol Diabetes Obes 14: 269–276.
    • (2007) Curr Opin Endocrinol Diabetes Obes , vol.14 , pp. 269-276
    • Frias, J.1    Edelman, S.2
  • 33
    • 79956151964 scopus 로고    scopus 로고
    • Exenatide twice daily versus premixed insulin aspart 70/30 in metformin-treated patients with type 2 diabetes: a randomized 26-week study on glycemic control and hypoglycemia
    • Gallwitz B. Bohmer M. Segiet T. Molle A. Milek K. Becker B. et al. (2011) Exenatide twice daily versus premixed insulin aspart 70/30 in metformin-treated patients with type 2 diabetes: a randomized 26-week study on glycemic control and hypoglycemia. Diabetes Care 34:604–606.
    • (2011) Diabetes Care , vol.34 , pp. 604-606
    • Gallwitz, B.1    Bohmer, M.2    Segiet, T.3    Molle, A.4    Milek, K.5    Becker, B.6
  • 34
    • 84862302997 scopus 로고    scopus 로고
    • Exenatide twice daily versus glimepiride for prevent of glycaemic deterioration in patients with type 2 diabetes with metformin failure (EUREXA): an open-label, randomized controlled trials
    • Gallwitz B. Guzman F. Dotta F. Guerci B. Simo R. Basson B. et al. (2012) Exenatide twice daily versus glimepiride for prevent of glycaemic deterioration in patients with type 2 diabetes with metformin failure (EUREXA): an open-label, randomized controlled trials. Lancet 379: 2270–2278.
    • (2012) Lancet , vol.379 , pp. 2270-2278
    • Gallwitz, B.1    Guzman, F.2    Dotta, F.3    Guerci, B.4    Simo, R.5    Basson, B.6
  • 35
    • 57949096314 scopus 로고    scopus 로고
    • Efficacy and safety of exenatide in patients of Asian descent with type 2 diabetes inadequately controlled with metformin or metformin and a sulphonylurea
    • Gao Y. Yoon K. Chuan L. Mohan V. Ning G. Shah S. et al. (2009) Efficacy and safety of exenatide in patients of Asian descent with type 2 diabetes inadequately controlled with metformin or metformin and a sulphonylurea. Diabetes Res Clin Pract 83: 69–76.
    • (2009) Diabetes Res Clin Pract , vol.83 , pp. 69-76
    • Gao, Y.1    Yoon, K.2    Chuan, L.3    Mohan, V.4    Ning, G.5    Shah, S.6
  • 36
    • 59449101432 scopus 로고    scopus 로고
    • Liraglutide versus glimepiride monotherapy for type 2 diabetes (LEAD-3 Mono): a randomized, 52 week, phase III, double-blind, parallel-treatment trial
    • Garber A. Henry R. Ratner R. Garcia-Hernandez P. Rodriquez-Pattzi H. Olvera-Alvarez I. et al. (2009) Liraglutide versus glimepiride monotherapy for type 2 diabetes (LEAD-3 Mono): a randomized, 52 week, phase III, double-blind, parallel-treatment trial. Lancet 373: 473–481.
    • (2009) Lancet , vol.373 , pp. 473-481
    • Garber, A.1    Henry, R.2    Ratner, R.3    Garcia-Hernandez, P.4    Rodriquez-Pattzi, H.5    Olvera-Alvarez, I.6
  • 37
    • 79951906623 scopus 로고    scopus 로고
    • Liraglutide, a once-daily human glucagon-like peptide 1 analogue, provide sustained improvements in glycaemic control and weight for 2 years as monotherapy compared with glimepiride in patients with type 2 diabetes
    • Garber A. Henry R. Ratner R. Hale P. Chang C. Bode B. et al. (2011) Liraglutide, a once-daily human glucagon-like peptide 1 analogue, provide sustained improvements in glycaemic control and weight for 2 years as monotherapy compared with glimepiride in patients with type 2 diabetes. Diabetes Obes Metab 13: 348–356.
    • (2011) Diabetes Obes Metab , vol.13 , pp. 348-356
    • Garber, A.1    Henry, R.2    Ratner, R.3    Hale, P.4    Chang, C.5    Bode, B.6
  • 38
    • 76949099016 scopus 로고    scopus 로고
    • Effect of exenatide on heart rate and blood pressure in subjects with type 2 diabetes mellitus: a double-blind, placebo-controlled, randomized pilot study
    • Gill A. Hoogwerf B. Burger J. Bruce S. MacConell L. Yan P. et al. (2010) Effect of exenatide on heart rate and blood pressure in subjects with type 2 diabetes mellitus: a double-blind, placebo-controlled, randomized pilot study. Cardiovasc Diabetol 9: 1–7.
    • (2010) Cardiovasc Diabetol , vol.9 , pp. 1-7
    • Gill, A.1    Hoogwerf, B.2    Burger, J.3    Bruce, S.4    MacConell, L.5    Yan, P.6
  • 39
    • 84993775934 scopus 로고    scopus 로고
    • Tanzeum (albiglutide) package insert
    • Available at: http://www.accessdata.fda.gov/drugsatfda_docs/literabel/2014/125431s000lbl.pdf (accessed 12 July 2014).
    • GlaxoSmithKline L.L.C. (2014) Tanzeum (albiglutide) package insert. Available at: http://www.accessdata.fda.gov/drugsatfda_docs/literabel/2014/125431s000lbl.pdf (accessed 12 July 2014).
    • (2014)
    • GlaxoSmithKline, L.L.C.1
  • 40
    • 26944477362 scopus 로고    scopus 로고
    • Exenatide versus insulin glargine in patients with suboptimally controlled type 2 diabetes; a randomized trial
    • Heine R. van Gaal L. Johns D. Mihm M. Widel M. Brodows R. (2005) Exenatide versus insulin glargine in patients with suboptimally controlled type 2 diabetes; a randomized trial. Ann Intern Med 143: 559–569.
    • (2005) Ann Intern Med , vol.143 , pp. 559-569
    • Heine, R.1    van Gaal, L.2    Johns, D.3    Mihm, M.4    Widel, M.5    Brodows, R.6
  • 41
    • 31844443202 scopus 로고    scopus 로고
    • Glucagon-like peptide-1: from extract to agent. The Claude Bernard Lecture, 2005
    • Holst J. (2006) Glucagon-like peptide-1: from extract to agent. The Claude Bernard Lecture, 2005. Diabetologia 49: 253–260.
    • (2006) Diabetologia , vol.49 , pp. 253-260
    • Holst, J.1
  • 42
    • 35748957503 scopus 로고    scopus 로고
    • The physiology of glucagon-like peptide 1
    • Holst J. (2007) The physiology of glucagon-like peptide 1. Physiol Rev 87: 1409–1439.
    • (2007) Physiol Rev , vol.87 , pp. 1409-1439
    • Holst, J.1
  • 43
    • 84866268783 scopus 로고    scopus 로고
    • Management of hyperglycemia in type 2 diabetes: a patient-centered approach: position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)
    • Inzucchi S. Bergenstal R. Buse J. Diamant M. Ferrannini E. Nauck M. et al. (2012) Management of hyperglycemia in type 2 diabetes: a patient-centered approach: position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Diabetes Care 35: 1364–1379.
    • (2012) Diabetes Care , vol.35 , pp. 1364-1379
    • Inzucchi, S.1    Bergenstal, R.2    Buse, J.3    Diamant, M.4    Ferrannini, E.5    Nauck, M.6
  • 44
    • 84873152483 scopus 로고    scopus 로고
    • Efficacy and safety of exenatide once-weekly vs exenatide twice-daily in Asian patients with type 2 diabetes mellitus
    • Ji L. Onishi Y. Ahn C. Agarwal P. Chou C. Haber H. et al. (2013) Efficacy and safety of exenatide once-weekly vs exenatide twice-daily in Asian patients with type 2 diabetes mellitus. J Diabetes Invest 4: 53–61.
    • (2013) J Diabetes Invest , vol.4 , pp. 53-61
    • Ji, L.1    Onishi, Y.2    Ahn, C.3    Agarwal, P.4    Chou, C.5    Haber, H.6
  • 45
    • 67650490677 scopus 로고    scopus 로고
    • Exenatide exhibits dose-dependent effects on glycemic control over 12 weeks in Japanese patients with suboptimally controlled type 2 diabetes
    • Kadowaki T. Namba M. Yamamura A. Sowa H. Wolka A. Brodows R. (2009) Exenatide exhibits dose-dependent effects on glycemic control over 12 weeks in Japanese patients with suboptimally controlled type 2 diabetes. Endocrine J 56: 415–424.
    • (2009) Endocrine J , vol.56 , pp. 415-424
    • Kadowaki, T.1    Namba, M.2    Yamamura, A.3    Sowa, H.4    Wolka, A.5    Brodows, R.6
  • 46
    • 17144371646 scopus 로고    scopus 로고
    • Effects of exenatide (exendin-4) on glycemic control over 30 weeks in patients with type 2 diabetes treated with metformin and a sulfonylurea
    • Kendall D. Riddle M. Rosenstock J. Zhuang D. Kim D. Fineman M. et al. (2005) Effects of exenatide (exendin-4) on glycemic control over 30 weeks in patients with type 2 diabetes treated with metformin and a sulfonylurea. Diabetes Care 28: 1083–1091.
    • (2005) Diabetes Care , vol.28 , pp. 1083-1091
    • Kendall, D.1    Riddle, M.2    Rosenstock, J.3    Zhuang, D.4    Kim, D.5    Fineman, M.6
  • 47
    • 38549162147 scopus 로고    scopus 로고
    • Exenatide effects on diabetes, obesity, cardiovascular risk factors and hepatic biomarkers in patients with type diabetes treated for at least 3 years
    • Klonoff D. Buse J. Nielsen L. Guan X. Bowlus C. Holcombe J. et al. (2008) Exenatide effects on diabetes, obesity, cardiovascular risk factors and hepatic biomarkers in patients with type diabetes treated for at least 3 years. Curr Med Res Opin 24: 275–286.
    • (2008) Curr Med Res Opin , vol.24 , pp. 275-286
    • Klonoff, D.1    Buse, J.2    Nielsen, L.3    Guan, X.4    Bowlus, C.5    Holcombe, J.6
  • 48
    • 0023638829 scopus 로고
    • Glucagon-like peptide-1 7–36: a physiological incretin in man
    • Kreymann B. Ghatei M. Williams G. Bloom S. (1987) Glucagon-like peptide-1 7–36: a physiological incretin in man. Lancet 2: 1300–1304.
    • (1987) Lancet , vol.2 , pp. 1300-1304
    • Kreymann, B.1    Ghatei, M.2    Williams, G.3    Bloom, S.4
  • 49
    • 84857531976 scopus 로고    scopus 로고
    • Clinical outcomes using long-term combination therapy with insulin glargine and exenatide in patients with type 2 diabetes mellitus
    • Levin P. Mersey J. Zhou S. Bromberger L. (2012) Clinical outcomes using long-term combination therapy with insulin glargine and exenatide in patients with type 2 diabetes mellitus. Endocr Pract 18: 17–25.
    • (2012) Endocr Pract , vol.18 , pp. 17-25
    • Levin, P.1    Mersey, J.2    Zhou, S.3    Bromberger, L.4
  • 50
    • 84993731064 scopus 로고    scopus 로고
    • Lilly's investigational GLP-1 receptor agonist, dulaglutide, showed superior glycemic control versus comparators in patients with type 2 diabetes: safety and efficacy results from three phase III registration clinical trials presented at the 73td American diabetes association scientific sessions
    • Available at: http://lilly.mediaroom.com/index.php?s=9042&item=137218%20 (accessed 15 July 2014).
    • Lilly (2013) Lilly's investigational GLP-1 receptor agonist, dulaglutide, showed superior glycemic control versus comparators in patients with type 2 diabetes: safety and efficacy results from three phase III registration clinical trials presented at the 73td American diabetes association scientific sessions. Available at: http://lilly.mediaroom.com/index.php?s=9042&item=137218%20 (accessed 15 July 2014).
    • (2013)
    • Lilly1
  • 51
    • 77958540163 scopus 로고    scopus 로고
    • A placebo-controlled trial of exenatide twice-daily added to thiazolidinediones alone or in combination with metformin
    • Liutkus J. Rosas Guzman J. Norwood P. Pop L. Northrup J. Cao D. et al. (2010) A placebo-controlled trial of exenatide twice-daily added to thiazolidinediones alone or in combination with metformin. Diabetes Obes Metab 12: 1058–1065.
    • (2010) Diabetes Obes Metab , vol.12 , pp. 1058-1065
    • Liutkus, J.1    Rosas Guzman, J.2    Norwood, P.3    Pop, L.4    Northrup, J.5    Cao, D.6
  • 52
    • 84875385687 scopus 로고    scopus 로고
    • Safety and efficacy of twice-daily exenatide in Taiwanese patients with inadequately controlled type 2 diabetes mellitus
    • Lu C. Wu T. Shih K. Ni E. Reed V. Yu M. et al. (2013) Safety and efficacy of twice-daily exenatide in Taiwanese patients with inadequately controlled type 2 diabetes mellitus. J Formos Med Assoc 112: 144–150.
    • (2013) J Formos Med Assoc , vol.112 , pp. 144-150
    • Lu, C.1    Wu, T.2    Shih, K.3    Ni, E.4    Reed, V.5    Yu, M.6
  • 53
    • 84872944068 scopus 로고    scopus 로고
    • Exenatide once weekly: sustained improvement in glycemic control and cardiometabolic measures through 3 years
    • MacConell L. Pencek R. Li Y. Maggs D. Porter L. (2013) Exenatide once weekly: sustained improvement in glycemic control and cardiometabolic measures through 3 years. Diabetes Metab Syndr Obes 6: 31–41.
    • (2013) Diabetes Metab Syndr Obes , vol.6 , pp. 31-41
    • MacConell, L.1    Pencek, R.2    Li, Y.3    Maggs, D.4    Porter, L.5
  • 54
    • 84993683178 scopus 로고    scopus 로고
    • Poster 1010 presented at
    • 74th American Diabetes Association Scientific Sessions San Francisco, CA
    • Marbury T. Flint A. Segel S. Lindegaard M. Lasseter K. (2014) Poster 1010 presented at: 74th American Diabetes Association Scientific Sessions; 13–17 June 2014; San Francisco, CA.
    • (2014)
    • Marbury, T.1    Flint, A.2    Segel, S.3    Lindegaard, M.4    Lasseter, K.5
  • 55
    • 62449129181 scopus 로고    scopus 로고
    • Liraglutide, a once-daily human GLP-1 analogue, added to a sulphonylurea over 26 weeks produces greater improvements in glycaemic and weight control compared with adding rosiglitazone or placebo in subjects with type 2 diabetes (LEAD-1 SU)
    • Marre M. Shaw J. Brandle M. Bebakar W. Kamaruddin N. Strand J. et al. (2009) Liraglutide, a once-daily human GLP-1 analogue, added to a sulphonylurea over 26 weeks produces greater improvements in glycaemic and weight control compared with adding rosiglitazone or placebo in subjects with type 2 diabetes (LEAD-1 SU). Diabet Med 26: 268–278.
    • (2009) Diabet Med , vol.26 , pp. 268-278
    • Marre, M.1    Shaw, J.2    Brandle, M.3    Bebakar, W.4    Kamaruddin, N.5    Strand, J.6
  • 56
    • 51549095571 scopus 로고    scopus 로고
    • Efficacy and tolerability of exenatide monotherapy over 24 weeks in antidiabetic drug-naïve patients with type 2 diabetes: a randomized, double-blind, placebo-controlled, parallel-group study
    • Moretto T. Milton D. Ridge T. MacConell L. Okerson T. Wolka A. et al. (2008) Efficacy and tolerability of exenatide monotherapy over 24 weeks in antidiabetic drug-naïve patients with type 2 diabetes: a randomized, double-blind, placebo-controlled, parallel-group study. Clin Ther 230: 1448–1460.
    • (2008) Clin Ther , vol.230 , pp. 1448-1460
    • Moretto, T.1    Milton, D.2    Ridge, T.3    MacConell, L.4    Okerson, T.5    Wolka, A.6
  • 57
    • 9444244529 scopus 로고    scopus 로고
    • Gastric inhibitory polypeptide and glucagon-like peptide-1 in the pathogenesis of type 2 diabetes
    • Nauck M. Baller B. Meier J. (2004) Gastric inhibitory polypeptide and glucagon-like peptide-1 in the pathogenesis of type 2 diabetes. Diabetes 53: S190–S196.
    • (2004) Diabetes , vol.53 , pp. S190-S196
    • Nauck, M.1    Baller, B.2    Meier, J.3
  • 58
    • 34247195226 scopus 로고    scopus 로고
    • A comparison of twice-daily exenatide and biphasic insulin aspart in patients with type 2 diabetes who were suboptimally controlled with sulfonylurea and metformin: a non-inferiority study
    • Nauck M. Duran S. Kim D. Johns D. Northup J. Festa A. et al. (2007) A comparison of twice-daily exenatide and biphasic insulin aspart in patients with type 2 diabetes who were suboptimally controlled with sulfonylurea and metformin: a non-inferiority study. Diabetologia 50: 529–267.
    • (2007) Diabetologia , vol.50 , pp. 267-529
    • Nauck, M.1    Duran, S.2    Kim, D.3    Johns, D.4    Northup, J.5    Festa, A.6
  • 59
    • 62449169287 scopus 로고    scopus 로고
    • Efficacy and safety comparison of liraglutide, glimepiride, and placebo, all in combination with metformin, in type 2 diabetes
    • Nauck M. Frid A. Hermansen K. Shah N. Tankova T. Mitha I. et al. (2009) Efficacy and safety comparison of liraglutide, glimepiride, and placebo, all in combination with metformin, in type 2 diabetes. Diabetes Care 32: 84–90.
    • (2009) Diabetes Care , vol.32 , pp. 84-90
    • Nauck, M.1    Frid, A.2    Hermansen, K.3    Shah, N.4    Tankova, T.5    Mitha, I.6
  • 60
    • 84871093044 scopus 로고    scopus 로고
    • Taspoglutide, a once-weekly glucagon-like peptide 1 analogue, vs. insulin glargine titrated to target in patients with type 2 diabetes: an open-label randomized trial
    • Nauck M. Horton E. Andjelkovic M. Ampudia-Blasco F. Parusel C. Boldrin M. et al. (2013) Taspoglutide, a once-weekly glucagon-like peptide 1 analogue, vs. insulin glargine titrated to target in patients with type 2 diabetes: an open-label randomized trial. Diabet Med 30: 109–113.
    • (2013) Diabet Med , vol.30 , pp. 109-113
    • Nauck, M.1    Horton, E.2    Andjelkovic, M.3    Ampudia-Blasco, F.4    Parusel, C.5    Boldrin, M.6
  • 61
    • 0027248866 scopus 로고
    • Normalization of fasting hyperglycemia by exogenous glucagon-like peptide 1 (7–36 amide) in type 2 (non-insulin-dependent) diabetic patients
    • Nauck M. Kleine N. Orskov C. Holst J. Willms B. Creutzfeldt W. (1993) Normalization of fasting hyperglycemia by exogenous glucagon-like peptide 1 (7–36 amide) in type 2 (non-insulin-dependent) diabetic patients. Diabetologia 36: 741–744.
    • (1993) Diabetologia , vol.36 , pp. 741-744
    • Nauck, M.1    Kleine, N.2    Orskov, C.3    Holst, J.4    Willms, B.5    Creutzfeldt, W.6
  • 62
    • 84874949437 scopus 로고    scopus 로고
    • The once-weekly human GLP-1 analogue semaglutide provides significant reductions in HbA1c and body weight in patients with type 2 diabetes
    • Suppl. 1 abstract 2-OR.
    • Nauck M. Petrie J. Sesti G. Mannucci E. Courreges J. Atkin S. et al. (2012) The once-weekly human GLP-1 analogue semaglutide provides significant reductions in HbA1c and body weight in patients with type 2 diabetes. Diabetologia 55(Suppl. 1): abstract 2-OR.
    • (2012) Diabetologia , vol.55
    • Nauck, M.1    Petrie, J.2    Sesti, G.3    Mannucci, E.4    Courreges, J.5    Atkin, S.6
  • 63
    • 0022617246 scopus 로고
    • Reduced incretin effect in type 2 (non-insulin-dependent) diabetes
    • Nauck M. Stockmann F. Ebert R. Creutzfeldt W. (1986) Reduced incretin effect in type 2 (non-insulin-dependent) diabetes. Diabetologia 29: 46–52.
    • (1986) Diabetologia , vol.29 , pp. 46-52
    • Nauck, M.1    Stockmann, F.2    Ebert, R.3    Creutzfeldt, W.4
  • 64
    • 84993683161 scopus 로고    scopus 로고
    • Novo Nordisk A/S
    • Victoza (liraglutide) package insert Available at: http://www.novo-pi.com/victoza.pdf (accessed 12 July 2014).
    • Novo Nordisk A/S (2013) Victoza (liraglutide) package insert. Available at: http://www.novo-pi.com/victoza.pdf (accessed 12 July 2014).
    • (2013)
  • 65
    • 84878361342 scopus 로고    scopus 로고
    • Safety of exenatide once weekly for 52 weeks in Japanese patients with type 2 diabetes mellitus
    • Onishi Y. Koshiyama H. Imaoka T. Haber H. Scism-Bacon J. Boardman M. (2013) Safety of exenatide once weekly for 52 weeks in Japanese patients with type 2 diabetes mellitus. J Diabetes Invest 4: 182–189.
    • (2013) J Diabetes Invest , vol.4 , pp. 182-189
    • Onishi, Y.1    Koshiyama, H.2    Imaoka, T.3    Haber, H.4    Scism-Bacon, J.5    Boardman, M.6
  • 66
    • 77952309372 scopus 로고    scopus 로고
    • Liraglutide versus sitagliptin for patients with type 2 diabetes who did not have adequate glycaemic control with metformin: a 26-week, randomized, parallel-group, open-label trial
    • Pratley R. Nauck M. Bailey T. Montanya E. Cuddihy R. Filetti S. et al. (2010) Liraglutide versus sitagliptin for patients with type 2 diabetes who did not have adequate glycaemic control with metformin: a 26-week, randomized, parallel-group, open-label trial. Lancet 375: 1447–1456.
    • (2010) Lancet , vol.375 , pp. 1447-1456
    • Pratley, R.1    Nauck, M.2    Bailey, T.3    Montanya, E.4    Cuddihy, R.5    Filetti, S.6
  • 67
    • 79952755181 scopus 로고    scopus 로고
    • One year of liraglutide treatment offers sustained and more effective glycaemic control and weight reduction compared with sitagliptin, both in combination with metformin, in patients with type 2 diabetes: a randomised, parallel-group, open-label trial
    • Pratley R. Nauck M. Bailey T. Montanya E. Cuddihy R. Filetti S. et al. (2011) One year of liraglutide treatment offers sustained and more effective glycaemic control and weight reduction compared with sitagliptin, both in combination with metformin, in patients with type 2 diabetes: a randomised, parallel-group, open-label trial. Int J Clin Pract 65: 397–407.
    • (2011) Int J Clin Pract , vol.65 , pp. 397-407
    • Pratley, R.1    Nauck, M.2    Bailey, T.3    Montanya, E.4    Cuddihy, R.5    Filetti, S.6
  • 68
    • 84866650686 scopus 로고    scopus 로고
    • Efficacy and safety of switching from the DPP-4 inhibitor sitagliptin to the human GLP-1 analog liraglutide after 52 weeks in metformin-treated patients with type 2 diabetes
    • Pratley R. Nauck M. Bailey T. Montanya E. Filetti S. Garber A. et al. (2012) Efficacy and safety of switching from the DPP-4 inhibitor sitagliptin to the human GLP-1 analog liraglutide after 52 weeks in metformin-treated patients with type 2 diabetes. Diabetes Care 35: 1986–1993.
    • (2012) Diabetes Care , vol.35 , pp. 1986-1993
    • Pratley, R.1    Nauck, M.2    Bailey, T.3    Montanya, E.4    Filetti, S.5    Garber, A.6
  • 69
    • 84899585635 scopus 로고    scopus 로고
    • Once-weekly albiglutide versus once-daily liraglutide in patients with type 2 diabetes inadequately controlled on oral drugs (HARMONY 7): a randomized, open-label, multicenter, non-inferiority phase 3 study
    • Pratley R. Nauck M. Barnett A. Feinglos M. Ovalle F. Harman-Boehm I. et al. (2014) Once-weekly albiglutide versus once-daily liraglutide in patients with type 2 diabetes inadequately controlled on oral drugs (HARMONY 7): a randomized, open-label, multicenter, non-inferiority phase 3 study. Lancet Diabetes Endocrinol 2: 289–297.
    • (2014) Lancet Diabetes Endocrinol , vol.2 , pp. 289-297
    • Pratley, R.1    Nauck, M.2    Barnett, A.3    Feinglos, M.4    Ovalle, F.5    Harman-Boehm, I.6
  • 70
    • 84873087943 scopus 로고    scopus 로고
    • Efficacy and tolerability of taspoglutide versus pioglitazone in subjects with type 2 diabetes uncontrolled with sulphonylurea or sulphonylurea-metformin therapy: a randomized, double-blind study (T-emerge 6)
    • Pratley R. Urosevic D. Boldrin M. Balena R. (2013) Efficacy and tolerability of taspoglutide versus pioglitazone in subjects with type 2 diabetes uncontrolled with sulphonylurea or sulphonylurea-metformin therapy: a randomized, double-blind study (T-emerge 6). Diabetes Obesity Metabolism 15: 234–240.
    • (2013) Diabetes Obesity Metabolism , vol.15 , pp. 234-240
    • Pratley, R.1    Urosevic, D.2    Boldrin, M.3    Balena, R.4
  • 71
    • 33748471110 scopus 로고    scopus 로고
    • Long-term effects of exenatide therapy over 82 weeks on glycaemic control and weight in over-weight metformin-treated patients with type 2 diabetes mellitus
    • Ratner R. Maggs D. Nielsen L. Stonehouse H. Poon T. Zhang B. et al. (2006) Long-term effects of exenatide therapy over 82 weeks on glycaemic control and weight in over-weight metformin-treated patients with type 2 diabetes mellitus. Diabetes Obes Metab 8: 419–428.
    • (2006) Diabetes Obes Metab , vol.8 , pp. 419-428
    • Ratner, R.1    Maggs, D.2    Nielsen, L.3    Stonehouse, H.4    Poon, T.5    Zhang, B.6
  • 72
    • 33749364478 scopus 로고    scopus 로고
    • Exenatide elicits sustained glycaemic control and progressive reduction of body weight in patients with type 2 diabetes inadequately controlled by sulphonylureas with or without metformin
    • Riddle M. Henry R. Poon T. Zhang B. Mac S. Holcombe J. et al. (2006) Exenatide elicits sustained glycaemic control and progressive reduction of body weight in patients with type 2 diabetes inadequately controlled by sulphonylureas with or without metformin. Diabetes Metab Res Rev 22: 483–491.
    • (2006) Diabetes Metab Res Rev , vol.22 , pp. 483-491
    • Riddle, M.1    Henry, R.2    Poon, T.3    Zhang, B.4    Mac, S.5    Holcombe, J.6
  • 73
    • 84874434023 scopus 로고    scopus 로고
    • The fate of taspoglutide, a weekly GLP-1 receptor agonist, versus twice-daily exenatide for type 2 diabetes
    • Rosenstock J. Balas B. Charbonnel B. Bolli G. Boldrin M. Ratner R. et al. (2013 a) The fate of taspoglutide, a weekly GLP-1 receptor agonist, versus twice-daily exenatide for type 2 diabetes. Diabetes Care 36: 498–504.
    • (2013) Diabetes Care , vol.36 , pp. 498-504
    • Rosenstock, J.1    Balas, B.2    Charbonnel, B.3    Bolli, G.4    Boldrin, M.5    Ratner, R.6
  • 74
    • 84899545131 scopus 로고    scopus 로고
    • Beneficial effects of once-daily lixisenatide on overall and postprandial glycemic levels without significant excess of hypoglycemia in type 2 diabetes inadequately controlled on a sulfonylurea with or without metformin (GetGoal-S)
    • Rosenstock J. Hanefeld M. Shamanna P. Min K. Boka G. Miossec P. et al. (2014) Beneficial effects of once-daily lixisenatide on overall and postprandial glycemic levels without significant excess of hypoglycemia in type 2 diabetes inadequately controlled on a sulfonylurea with or without metformin (GetGoal-S). J Diabetes Complications 28: 386–392.
    • (2014) J Diabetes Complications , vol.28 , pp. 386-392
    • Rosenstock, J.1    Hanefeld, M.2    Shamanna, P.3    Min, K.4    Boka, G.5    Miossec, P.6
  • 75
    • 84883778164 scopus 로고    scopus 로고
    • One-year sustained glycemic control and weight reduction in type 2 diabetes after addition of liraglutide to metformin followed by insulin detemir according to HbA1c target
    • Rosenstock J. Rodbard H. Bain S. D'Alessio D. Seufert J. Thomsen A. et al. (2013 b) One-year sustained glycemic control and weight reduction in type 2 diabetes after addition of liraglutide to metformin followed by insulin detemir according to HbA1c target. J Diabetes Complications 27: 492–500.
    • (2013) J Diabetes Complications , vol.27 , pp. 492-500
    • Rosenstock, J.1    Rodbard, H.2    Bain, S.3    D'Alessio, D.4    Seufert, J.5    Thomsen, A.6
  • 76
    • 84859013614 scopus 로고    scopus 로고
    • Efficacy and safety of exenatide once weekly versus metformin, pioglitazone, and sitagliptin used as monotherapy in drug-naïve patients with type 2 diabetes (DURATION-4)
    • Russell-Jones D. Cuddihy R. Hanefeld M. Kumar A. Gonzalez J. Chan M. et al. (2012) Efficacy and safety of exenatide once weekly versus metformin, pioglitazone, and sitagliptin used as monotherapy in drug-naïve patients with type 2 diabetes (DURATION-4). Diabetes Care 35: 252–258.
    • (2012) Diabetes Care , vol.35 , pp. 252-258
    • Russell-Jones, D.1    Cuddihy, R.2    Hanefeld, M.3    Kumar, A.4    Gonzalez, J.5    Chan, M.6
  • 77
    • 69949117621 scopus 로고    scopus 로고
    • Liraglutide vs insulin glargine and placebo in combination with metformin and sulfonylurea therapy in type 2 diabetes mellitus (LEAD-5 met+SU): a randomised controlled trial
    • Russell-Jones D. Vaag A. Schmitz O. Sethi B. Lalic N. Antic S. et al. (2009) Liraglutide vs insulin glargine and placebo in combination with metformin and sulfonylurea therapy in type 2 diabetes mellitus (LEAD-5 met+SU): a randomised controlled trial. Diabetologia 52: 2046–2055.
    • (2009) Diabetologia , vol.52 , pp. 2046-2055
    • Russell-Jones, D.1    Vaag, A.2    Schmitz, O.3    Sethi, B.4    Lalic, N.5    Antic, S.6
  • 78
    • 84991377058 scopus 로고    scopus 로고
    • Sanofi provides update on lixisenatide new drug application in US
    • Available at: http://m-en.sanofi.com/Images/33756_20130912_lixisenatide_en.pdf (accessed 8 July 2014).
    • Sanofi (2013) Sanofi provides update on lixisenatide new drug application in US Available at: http://m-en.sanofi.com/Images/33756_20130912_lixisenatide_en.pdf (accessed 8 July 2014).
    • (2013)
    • Sanofi1
  • 79
    • 81855193976 scopus 로고    scopus 로고
    • Effects of combined exenatide and pioglitazone therapy on hepatic fat content in type 2 diabetes
    • Sathyanarayana P. Jogi M. Muthupillai R. Krishnamurthy R. Samson S. Bajaj M. (2011) Effects of combined exenatide and pioglitazone therapy on hepatic fat content in type 2 diabetes. Obesity 19: 2310–2315.
    • (2011) Obesity , vol.19 , pp. 2310-2315
    • Sathyanarayana, P.1    Jogi, M.2    Muthupillai, R.3    Krishnamurthy, R.4    Samson, S.5    Bajaj, M.6
  • 80
    • 79958268386 scopus 로고    scopus 로고
    • Exenatide once weekly treatment maintained improvements in glycemic control and weight loss over 2 years
    • Taylor K. Gurney K. Han J. Pencek R. Walsh B. Trautmann M. (2011) Exenatide once weekly treatment maintained improvements in glycemic control and weight loss over 2 years. BMC Endocrine Disord 11: 1–9.
    • (2011) BMC Endocrine Disord , vol.11 , pp. 1-9
    • Taylor, K.1    Gurney, K.2    Han, J.3    Pencek, R.4    Walsh, B.5    Trautmann, M.6
  • 81
    • 79959428521 scopus 로고    scopus 로고
    • Safety, efficacy and tolerability of exenatide in combination with insulin in the association of British clinical diabetologists nationwide exenatide audit
    • Thong K. Jose B. Sukumar N. Cull M. Mills A. Sathyapalan T. et al. (2011) Safety, efficacy and tolerability of exenatide in combination with insulin in the association of British clinical diabetologists nationwide exenatide audit. Diabetes Obes Metab 13: 703–710.
    • (2011) Diabetes Obes Metab , vol.13 , pp. 703-710
    • Thong, K.1    Jose, B.2    Sukumar, N.3    Cull, M.4    Mills, A.5    Sathyapalan, T.6
  • 82
    • 0032976939 scopus 로고    scopus 로고
    • Continuous subcutaneous infusion of glucagon-like peptide 1 lowers plasma glucose and reduces appetite in type 2 diabetic patients
    • Toft-Nielsen M. Madsbad S. Holst J. (1999) Continuous subcutaneous infusion of glucagon-like peptide 1 lowers plasma glucose and reduces appetite in type 2 diabetic patients. Diabetes Care 22: 1137–1143.
    • (1999) Diabetes Care , vol.22 , pp. 1137-1143
    • Toft-Nielsen, M.1    Madsbad, S.2    Holst, J.3
  • 83
    • 79551607371 scopus 로고    scopus 로고
    • Effect of exenatide on inflammatory and oxidative stress markers in patients with type 2 diabetes mellitus
    • Wu J. Xu X. Zhu J. Ding B. Du T. Gao G. et al. (2011) Effect of exenatide on inflammatory and oxidative stress markers in patients with type 2 diabetes mellitus. Diabetes Technol Ther 13: 143–148.
    • (2011) Diabetes Technol Ther , vol.13 , pp. 143-148
    • Wu, J.1    Xu, X.2    Zhu, J.3    Ding, B.4    Du, T.5    Gao, G.6
  • 84
    • 79955960213 scopus 로고    scopus 로고
    • DURATION-2: efficacy and safety of switching from maximum daily sitagliptin or pioglitazone to once-weekly exenatide
    • Wysham C. Bergenstal R. Malloy J. Yan P. Walsh B. Malone J. et al. (2011) DURATION-2: efficacy and safety of switching from maximum daily sitagliptin or pioglitazone to once-weekly exenatide. Diabet Med 28: 705–714.
    • (2011) Diabet Med , vol.28 , pp. 705-714
    • Wysham, C.1    Bergenstal, R.2    Malloy, J.3    Yan, P.4    Walsh, B.5    Malone, J.6
  • 85
    • 78649709557 scopus 로고    scopus 로고
    • Liraglutide provides similar glycaemic control as glimepiride (both in combination with metformin) and reduces body weight and systolic blood pressure in Asian population with type 2 diabetes from China, South Korea, and India: a 16-week, randomized, double-blind, active control trial
    • Yang W. Chen L. Ji Q. Liu X. Ma J. Tandon N. et al. (2011) Liraglutide provides similar glycaemic control as glimepiride (both in combination with metformin) and reduces body weight and systolic blood pressure in Asian population with type 2 diabetes from China, South Korea, and India: a 16-week, randomized, double-blind, active control trial. Diabetes Obes Metab 13: 81–88.
    • (2011) Diabetes Obes Metab , vol.13 , pp. 81-88
    • Yang, W.1    Chen, L.2    Ji, Q.3    Liu, X.4    Ma, J.5    Tandon, N.6
  • 86
    • 84865636331 scopus 로고    scopus 로고
    • Efficacy and tolerability of exenatide monotherapy in obese patients with newly diagnosed type 2 diabetes: a randomized, 26 weeks metformin-controlled, parallel-group study
    • Yuan G. Song W. Huang Y. Guo X. Gao Y. (2012) Efficacy and tolerability of exenatide monotherapy in obese patients with newly diagnosed type 2 diabetes: a randomized, 26 weeks metformin-controlled, parallel-group study. Chin Med J 125: 2677–2681.
    • (2012) Chin Med J , vol.125 , pp. 2677-2681
    • Yuan, G.1    Song, W.2    Huang, Y.3    Guo, X.4    Gao, Y.5
  • 87
    • 34247259577 scopus 로고    scopus 로고
    • The effect of adding exenatide to a thiazolidinedione in suboptimally controlled type 2 diabetes
    • Zinman B. Hoogwerf B. Garcia S. Milton D. Gioconia J. Kim D. et al. (2007) The effect of adding exenatide to a thiazolidinedione in suboptimally controlled type 2 diabetes. Ann Intern Med 146: 477–485.
    • (2007) Ann Intern Med , vol.146 , pp. 477-485
    • Zinman, B.1    Hoogwerf, B.2    Garcia, S.3    Milton, D.4    Gioconia, J.5    Kim, D.6
  • 88
    • 67650066860 scopus 로고    scopus 로고
    • Efficacy and safety of the human glucagon-like peptide-1 analog liraglutide in combination with metformin and thiazolidinedione in patients with type 2 diabetes (LEAD-4 Met+TZD)
    • Zinman B. Gerich J. Buse J. Lewin A. Schwartz S. Raskin P. et al. (2009) Efficacy and safety of the human glucagon-like peptide-1 analog liraglutide in combination with metformin and thiazolidinedione in patients with type 2 diabetes (LEAD-4 Met+TZD). Diabetes Care 32:1224–1230.
    • (2009) Diabetes Care , vol.32 , pp. 1224-1230
    • Zinman, B.1    Gerich, J.2    Buse, J.3    Lewin, A.4    Schwartz, S.5    Raskin, P.6


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