Antibacterial drug leads: DNA and enzyme multitargeting

Journal of Medicinal Chemistry

Volumn 58, Issue 3, 2015, Pages 1215-1227

  Zhu, Wei ^a   Wang, Yang ^a   Li, Kai ^a   Gao, Jian ^b   Huang, Chun Hsiang ^b   Chen, Chun Chi ^b   Ko, Tzu Ping ^c   Zhang, Yonghui ^a   Guo, Rey Ting ^b   Oldfield, Eric ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^b INSTITUTE OF GEOLOGY AND GEOPHYSICS   (China)

^c INSTITUTE OF BIOLOGICAL CHEMISTRY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

1,4 BIS[6 (1,4,5,6 TETRAHYDROPYRIMIDIN 2 YL) 1H INDOL 2 YL]BENZENE; 1,4 BIS[6 (4,5 DIHYDRO 1H IMIDAZOL 2 YL) 1H INDOL 2 YL]BENZENE; 2 [3 [[4 [[3 (4,5 DIHYDRO 1H IMIDAZOL 2 YL)PHENYL]ETHYNYL]PHENYL]ETHYNYL]PHENOXY] 6 (HYDROXYMETHYL)TETRAHYDRO 2H PYRAN 3,4,5 TRIOL; 2,2' [5,5' [1,3 PHENYLENEBIS(ETHYNE 2,1 DIYL)]BIS(3 BROMO 5,1 PHENYLENE)]DIETHANAMINE; AMIDINE; ANTIBIOTIC AGENT; DNA; ENZYME; METICILLIN; N 1,N 4 BIS[4 (4,5 DIHYDRO 1H IMIDAZOL 2 YL)PHENYL] 2 NITROTEREPHTHALAMIDE DIHYDROCHLORIDE; N 4 [3 (4,5 DIHYDRO 1H IMIDAZOL 2 YL)PHENYL] N 4' (3 PHENOXYPHENYL)BIPHENYL 4,4 DICARBOXAMIDE; N 4 [3 (4,5 DIHYDRO 1H IMIDAZOL 2 YL)PHENYL] N 4' [3 (HEXYLOXY) PHENYL] [1,1 BIPHENYL] 4,4 DICARBOXAMIDE; N 4 [3 (4,5 DIHYDRO 1H IMIDAZOL 2 YL)PHENYL]N 4' [3 METHOXY PHENYL][1,1 BIPHENYL] 4,4 DICARBOXAMIDE; N 4 [3 (4,5 DIHYDRO 1H IMIDAZOL 2 YL)PHENYL]N 4' [3 [[3,4,5 TRIHYDROXY 6 (HYDROXYMETHYL)TETRAHYDRO 2H PYRAN 2 YL]OXY]PHENYL][1,1 BIPHENYL] 4,4 DICARBOXAMIDE; N4,N4' BIS[3 (1,4,5,6 TETRAHYDROPYRIMIDIN 2 YL)PHENYL]BIPHENYL 4,4' DICARBOXAMIDE; N4,N4' BIS[3 (4,5 DIHYDRO 1H IMIDAZOL 2 YL)PHENYL] [1,1' BIPHENYL] 4,4' BICARBOXAMIDE; N4,N4' BIS[3 (4,5 DIHYDRO 1H IMIDAZOL 2 YL)PHENYL]BIPHENYL 4,4' BIS(CARBOTHIOAMIDE); SYNTHETASE; UNCLASSIFIED DRUG; [1 HYDROXY 2 [3 [3 [3 (2 HYDROXY 2,2 BIS PHOSPHONO ETHYL) BIPHENYL 3 YLSULFAMOYL]BENZENESULFONYLAMINO]BIPHENYL 3 YL] 1 PHOSPHONO ETHYL]PHOSPHONIC ACID; ANTIINFECTIVE AGENT; BACTERIAL DNA; TRANSFERASE; UNDECAPRENYL PYROPHOSPHATE SYNTHETASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL GROWTH; CONTROLLED STUDY; DIFFERENTIAL SCANNING CALORIMETRY; DNA BINDING; DRUG POTENTIATION; DRUG STRUCTURE; DRUG TARGETING; ESCHERICHIA COLI; GROWTH INHIBITION; IC50; MELTING POINT; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS INFECTION; MOUSE; NONHUMAN; ANTAGONISTS AND INHIBITORS; CELL PROLIFERATION; CHEMICAL STRUCTURE; CHEMISTRY; CYTOLOGY; DOSE RESPONSE; DRUG EFFECTS; ENZYMOLOGY; METABOLISM; MICROBIAL SENSITIVITY TEST; STAPHYLOCOCCUS AUREUS; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TEMPERATURE;

ALKYL AND ARYL TRANSFERASES; AMIDINES; ANTI-BACTERIAL AGENTS; CELL PROLIFERATION; DNA, BACTERIAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ESCHERICHIA COLI; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; STAPHYLOCOCCUS AUREUS; STRUCTURE-ACTIVITY RELATIONSHIP; TEMPERATURE;

EID: 84922809449     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm501449u     Document Type: Article

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