CD8+ T cell profiles in patients with rheumatoid arthritis and their relationship to disease activity

Arthritis and Rheumatology

Volumn 67, Issue 2, 2015, Pages 363-371

  Carvalheiro, Helena ^a   Duarte, Cátia ^b   Silva Cardoso, Sandra ^a   Da Silva, José A P ^b   Souto Carneiro, M Margarida ^a  

^a UNIVERSITY OF COIMBRA   (Portugal)

^b CENTRO HOSPITALAR E UNIVERSITÁRIO DE COIMBRA   (Portugal)

Author keywords

[No Author keywords available]

Indexed keywords

C REACTIVE PROTEIN; CD27 ANTIGEN; CD69 ANTIGEN; CD8 ANTIGEN; CELL SURFACE MARKER; CHEMOKINE RECEPTOR CXCR4; CYTOKINE; GAMMA INTERFERON; GRANZYME B; INTERLEUKIN 10; INTERLEUKIN 17; INTERLEUKIN 6; L SELECTIN; PERFORIN; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR INHIBITOR; CXCR4 PROTEIN, HUMAN;

ARTICLE; BLOOD SAMPLING; CD8+ T LYMPHOCYTE; CLINICAL EVALUATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOTOXIC T LYMPHOCYTE; DAS28; DISEASE ACTIVITY; ERYTHROCYTE SEDIMENTATION RATE; FEMALE; FLOW CYTOMETRY; HLA SYSTEM; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; REMISSION; RHEUMATOID ARTHRITIS; SYNOVIAL FLUID LEVEL; T LYMPHOCYTE SUBPOPULATION; BLOOD; CASE CONTROL STUDY; CYTOLOGY; METABOLISM; PATHOLOGY; PHENOTYPE; SEVERITY OF ILLNESS INDEX; SYNOVIAL FLUID;

ARTHRITIS, RHEUMATOID; CASE-CONTROL STUDIES; CD8-POSITIVE T-LYMPHOCYTES; CYTOKINES; FEMALE; FLOW CYTOMETRY; HUMANS; MALE; PHENOTYPE; RECEPTORS, CXCR4; SEVERITY OF ILLNESS INDEX; SYNOVIAL FLUID;

EID: 84922796854     PISSN: 23265191     EISSN: 23265205     Source Type: Journal    
DOI: 10.1002/art.38941     Document Type: Article

References (28)

1. McInnes IB,. Leukotrienes, mast cells, and T cells. Arthritis Res Ther 2003; 5: 288-9.
2. De Hair MJ, van de Sande MG, Ramwadhdoebe TH, Hansson M, Landewe R, van der Leij C, et al. Features of the synovium of individuals at risk of developing rheumatoid arthritis: implications for understanding preclinical rheumatoid arthritis. Arthritis Rheumatol 2014; 66: 513-22.
3. + T cells in rheumatoid arthritis. Autoimmun Rev 2013; 12: 401-9.
4. Gupta S, Gollapudi S,. Effector memory CD8+ T cells are resistant to apoptosis. Ann N Y Acad Sci 2007; 1109: 145-50.
5. Marzo AL, Yagita H, Lefrancois L,. Migration to nonlymphoid tissues results in functional conversion of central to effector memory CD8 T cells. J Immunol 2007; 179: 36-40.
6. + T cells in peripheral blood of rheumatoid arthritis patients. Arthritis Res Ther 2003; 5: R91-6.
7. + T cells in the synovial fluid of rheumatoid arthritis. J Clin Immunol 2012; 32: 709-20.
8. Fitzgerald JE, Ricalton NS, Meyer AC, West SG, Kaplan H, Behrendt C, et al. Analysis of clonal CD8+ T cell expansions in normal individuals and patients with rheumatoid arthritis. J Immunol 1995; 154: 3538-47.
9. Morley JK, Batliwalla FM, Hingorani R, Gregersen PK,. Oligoclonal CD8+ T cells are preferentially expanded in the CD57+ subset. J Immunol 1995; 154: 6182-90.
10. Behar SM, Roy C, Brenner MB,. Expansions of Vα12 CD8+ T-cells in rheumatoid arthritis. Ann N Y Acad Sci 1995; 756: 130-7.
11. Sottini A, Imberti L, Bettinardi A, Mazza C, Gorla R, Primi D,. Selection of T lymphocytes in two rheumatoid arthritis patients defines different T-cell receptor Vβ repertoires in CD4+ and CD8+ T-cell subsets. J Autoimmun 1993; 6: 621-37.
12. Al-Azem I, Fernandez-Madrid F, Long PM, Wooley PH,. The immunoregulation of rheumatoid factor by the CD8 T lymphocyte subset in rheumatoid arthritis. J Rheumatol 1992; 19: 1337-41.
13. Henriques A, Ines L, Couto M, Pedreiro S, Santos C, Magalhaes M, et al. Frequency and functional activity of Th17, Tc17 and other T-cell subsets in systemic lupus erythematosus. Cell Immunol 2010; 264: 97-103.
14. Wagner UG, Kurtin PJ, Wahner A, Brackertz M, Berry DJ, Goronzy JJ, et al. The role of CD8+ CD40L+ T cells in the formation of germinal centers in rheumatoid synovitis. J Immunol 1998; 161: 6390-7.
15. Kang YM, Zhang X, Wagner UG, Yang H, Beckenbaugh RD, Kurtin PJ, et al. CD8 T cells are required for the formation of ectopic germinal centers in rheumatoid synovitis. J Exp Med 2002; 195: 1325-36.
16. Croia C, Serafini B, Bombardieri M, Kelly S, Humby F, Severa M, et al. Epstein-Barr virus persistence and infection of autoreactive plasma cells in synovial lymphoid structures in rheumatoid arthritis. Ann Rheum Dis 2013; 72: 1559-68.
17. Suzuki M, Konya C, Goronzy JJ, Weyand CM,. Inhibitory CD8+ T cells in autoimmune disease. Hum Immunol 2008; 69: 781-9.
18. Davila E, Kang YM, Park YW, Sawai H, He X, Pryshchep S, et al. Cell-based immunotherapy with suppressor CD8+ T cells in rheumatoid arthritis. J Immunol 2005; 174: 7292-301.
19. Shammas RM, Ranganath VK, Paulus HE,. Remission in rheumatoid arthritis. Curr Rheumatol Rep 2010; 12: 355-62.
20. Raposo BR, Rodrigues-Santos P, Carvalheiro H, Agua-Doce AM, Carvalho L, da Silva JA Pereira, et al. Monoclonal anti-CD8 therapy induces disease amelioration in the K/BxN mouse model of spontaneous chronic polyarthritis. Arthritis Rheum 2010; 62: 2953-62.
21. Afeltra A, Galeazzi M, Ferri GM, Amoroso A, De Pita O, Porzio F, et al. Expression of CD69 antigen on synovial fluid T cells in patients with rheumatoid arthritis and other chronic synovitis. Ann Rheum Dis 1993; 52: 457-60.
22. Afeltra A, Galeazzi M, Sebastiani GD, Ferri GM, Caccavo D, Addessi MA, et al. Coexpression of CD69 and HLADR activation markers on synovial fluid T lymphocytes of patients affected by rheumatoid arthritis: a three-colour cytometric analysis. Int J Exp Pathol 1997; 78: 331-6.
23. Iannone F, Corrigal VM, Panayi GS,. CD69 on synovial T cells in rheumatoid arthritis correlates with disease activity. Br J Rheumatol 1996; 35: 397.
24. Fernandez-Gutierrez B, Hernandez-Garcia C, Banares AA, Jover JA,. Characterization and regulation of CD69 expression on rheumatoid arthritis synovial fluid T cells. J Rheumatol 1995; 22: 413-20.
25. Laffon A, Garcia-Vicuna R, Humbria A, Postigo AA, Corbi AL, de Landazuri MO, et al. Upregulated expression and function of VLA-4 fibronectin receptors on human activated T cells in rheumatoid arthritis. J Clin Invest 1991; 88: 546-52.
26. Kummer JA, Tak PP, Brinkman BM, van Tilborg AA, Kamp AM, Verweij CL, et al. Expression of granzymes A and B in synovial tissue from patients with rheumatoid arthritis and osteoarthritis. Clin Immunol Immunopathol 1994; 73: 88-95.
27. Berner B, Akca D, Jung T, Muller GA, Reuss-Borst MA,. Analysis of Th1 and Th2 cytokines expressing CD4+ and CD8+ T cells in rheumatoid arthritis by flow cytometry. J Rheumatol 2000; 27: 1128-35.
28. Van der Graaff WL, Prins AP, Niers TM, Dijkmans BA, van Lier RA,. Quantitation of interferon γ- and interleukin-4-producing T cells in synovial fluid and peripheral blood of arthritis patients. Rheumatology (Oxford) 1999; 38: 214-20.