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Volumn 12, Issue 5, 2010, Pages 355-362

Remission in rheumatoid arthritis

Author keywords

Remission; Rheumatoid arthritis

Indexed keywords

ADALIMUMAB; DISEASE MODIFYING ANTIRHEUMATIC DRUG; METHOTREXATE;

EID: 78149465865     PISSN: 15233774     EISSN: 15346307     Source Type: Journal    
DOI: 10.1007/s11926-010-0121-2     Document Type: Review
Times cited : (38)

References (39)
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    • This article describes the ACR and EULAR collaboration to define remission in rheumatoid arthritis. It outlines the current questions regarding remission and the research agenda set out to reach a consensus definition, concluding that a strict definition needs to be used
    • •• Van Tuyl LHD, Vlad SC, Felson DT, et al.: Defining remission in rheumatoid arthritis: results of an initial American College of Rheumatology/European League Against Rheumatism consensus conference. Arthritis Rheum 2009, 61:704-710. This article describes the ACR and EULAR collaboration to define remission in rheumatoid arthritis. It outlines the current questions regarding remission and the research agenda set out to reach a consensus definition, concluding that a strict definition needs to be used.
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    • • Van der Leeden M, Steultjens MP, van Schaardenburg D, Dekker J: Forefoot disease activity in rheumatoid arthritis patients in remission: results of a cohort study. Arthritis Res Ther 2010, 12: R3. This study highlights one of the limitations of the DAS28 criteria, showing that there can be significant forefoot disease activity in patients who meet DAS28 remission criteria.
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    • •• Tippana-Kinnunen T, Paimela T, Kautanian H, et al.: Can disease modifying anti-rheumatic drugs be discontinued in longstanding rheumatoid arthritis? A 15 year follow-up. Scand J Rheumatol 2010, 39:12-18. Of the drug-free remission papers, the follow-up period of 15 years used here is the longest. DMARDS were discontinued in RA patients meeting ACR criteria, 45% of whom had to be restarted on treatment due to disease flares. None of the patients who had to restart DMARDs were in remission by the end of 15 years.
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    • An explanation of the apparent dissociation between clinical remission and continued structural deterioration in rheumatoid arthritis
    • This is an important paper showing that RA patients in remission by ACR and DAS criteria can continue to have subclinical inflammation by ultrasound and MRI Inflammatory scores on ultrasound, especially power Doppler signals, and MRI synovitis scores at baseline were significantly associated with development of radiographic damage over 1 year, offering an explanation as to why RA patients in remission have continued structural damage over time.
    • •• Brown AK, Conaghan PG, Karim Z, et al.: An explanation of the apparent dissociation between clinical remission and continued structural deterioration in rheumatoid arthritis. Arthritis Rheum 2008, 58:2958-2967. This is an important paper showing that RA patients in remission by ACR and DAS criteria can continue to have subclinical inflammation by ultrasound and MRI. Inflammatory scores on ultrasound, especially power Doppler signals, and MRI synovitis scores at baseline were significantly associated with development of radiographic damage over 1 year, offering an explanation as to why RA patients in remission have continued structural damage over time.
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    • Ultrasonographic evaluation of joint involvement in early rheumatoid arthritis in clinical remission: Power Doppler signal predicts short-term relapse
    • This study illustrates that subclinical inflammation in patients who are thought to be in remission may be a tool to help predict short-term relapse of disease activity
    • • Scire CA, Montecucco C, Codullo V, et al.: Ultrasonographic evaluation of joint involvement in early rheumatoid arthritis in clinical remission: power Doppler signal predicts short-term relapse. Rheumatology 2009, 48:1092-1097. This study illustrates that subclinical inflammation in patients who are thought to be in remission may be a tool to help predict short-term relapse of disease activity.
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    • Scire, C.A.1    Montecucco, C.2    Codullo, V.3
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    • Pregnancy in patients with rheumatoid arthritis and inflammatory spondyloarthropathies
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    • Women with inflammatory polyarthritis have babies of lower birth weight
    • Bowden AP, Barrett JH, Fallow W, Silman J: Women with inflammatory polyarthritis have babies of lower birth weight. J Rheumatol 2001, 28:355-359.
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    • Disease activity of rheumatoid arthritis during pregnancy: Results from a nationwide prospective study
    • This paper looks at the disease activity of RA patients during and after pregnancy. It demonstrates the increased rate of remission as defined by DAS28 during pregnancy and the increase flare rate postpartum. It also shows that RA remission in pregnancy is not achieved as frequently as previously reported
    • •• De Man YA, Dolhain RJ, van de Geijn FE, et al.: Disease activity of rheumatoid arthritis during pregnancy: results from a nationwide prospective study. Arthritis Rheum 2008, 59:1241-1248. This paper looks at the disease activity of RA patients during and after pregnancy. It demonstrates the increased rate of remission as defined by DAS28 during pregnancy and the increase flare rate postpartum. It also shows that RA remission in pregnancy is not achieved as frequently as previously reported.
    • (2008) Arthritis Rheum , vol.59 , pp. 1241-1248
    • De Man, Y.A.1    Dolhain, R.J.2    Van De Geijn, F.E.3
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    • Accuracy of Wallace criteria for clinical remission in juvenile idiopathic arthritis: A cohort study of 761 consecutive cases
    • Lurati A, Salmaso A, Gerloni V, et al.: Accuracy of Wallace criteria for clinical remission in juvenile idiopathic arthritis: a cohort study of 761 consecutive cases. J Rheumatol 2009, 36:1532-1535.
    • (2009) J Rheumatol , vol.36 , pp. 1532-1535
    • Lurati, A.1    Salmaso, A.2    Gerloni, V.3
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    • Patterns of clinical remission in select categories of juvenile idiopathic arthritis
    • Wallace CA, Huang B, Bandeira M, et al.: Patterns of clinical remission in select categories of juvenile idiopathic arthritis. Arthritis Rheum 2005, 52:3554-3562.]
    • (2005) Arthritis Rheum , vol.52 , pp. 3554-3562
    • Wallace, C.A.1    Huang, B.2    Bandeira, M.3


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