Overexpression of N-terminal kinase like gene promotes tumorigenicity of hepatocellular carcinoma by regulating cell cycle progression and cell motility

Oncotarget

Volumn 6, Issue 3, 2015, Pages 1618-1630

  Wang, Jian ^a,b   Liu, Ming ^a,b   Chen, Leilei ^a,b   Chan, Tim Hon Man ^a,b   Jiang, Lingxi ^a,b   Yuan, Yun Fei ^c   Guan, Xin Yuan ^a,b,c  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

^b THE UNIVERSITY OF HONG KONG   (Hong Kong)

^c SUN YAT SEN UNIVERSITY CANCER CENTER   (China)

Author keywords

CHD1L; Dynamin2; HCC; Metastasis; NTKL

Indexed keywords

AGAR; CYCLIN D1; DYNAMIN II; F ACTIN; GUANOSINE TRIPHOSPHATASE; N TERMINAL KINASE LIKE PROTEIN; PROTEIN; PROTEIN CDC42; PROTEIN P53; RAC1 PROTEIN; UNCLASSIFIED DRUG; CHD1L PROTEIN, HUMAN; DNA BINDING PROTEIN; DNA HELICASE; DNM2 PROTEIN, HUMAN; DYNAMIN; SCYL1 PROTEIN, HUMAN; TRANSCRIPTION FACTOR;

ADULT; AMINO TERMINAL KINASE LIKE GENE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CANCER PROGNOSIS; CARCINOGENESIS; CARCINOGENICITY; CELL CYCLE PROGRESSION; CELL DIVISION; CELL GROWTH; CELL MOTILITY; CHD1L ONCOGENE; CHROMATIN IMMUNOPRECIPITATION; CHROMOSOME SEGREGATION; COLONY FORMATION; CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOKINESIS; ENZYME PHOSPHORYLATION; FEMALE; G1 PHASE CELL CYCLE CHECKPOINT; GENE; GENE EXPRESSION; GENE OVEREXPRESSION; HUMAN; HUMAN TISSUE; LAMELLIPODIUM; LIVER CELL CARCINOMA; MAJOR CLINICAL STUDY; MALE; MASS SPECTROMETRY; MITOSIS; MOUSE; MUTATION; NONHUMAN; NUDE MOUSE; ONCOGENE; PHENOTYPE; PROMOTER REGION; REAL TIME POLYMERASE CHAIN REACTION; ANIMAL; BIOSYNTHESIS; CELL CYCLE; CELL MOTION; CELL PROLIFERATION; ENZYMOLOGY; GENETICS; LIVER TUMOR; METABOLISM; MIDDLE AGED; PATHOLOGY; PHYSIOLOGY; TUMOR CELL LINE; XENOGRAFT;

ANIMALS; APOPTOSIS; CARCINOMA, HEPATOCELLULAR; CELL CYCLE; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; DNA HELICASES; DNA-BINDING PROTEINS; DYNAMINS; FEMALE; GENE EXPRESSION; HETEROGRAFTS; HUMANS; LIVER NEOPLASMS; MALE; MICE; MIDDLE AGED; TRANSCRIPTION FACTORS;

EID: 84922729372     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.2730     Document Type: Article

References (32)

1. Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer. 2010; 127:2893-2917.
2. Marchio A, Meddeb M, Pineau P, Danglot G, Tiollais P, Bernheim A, Dejean A. Recurrent chromosomal abnormalities in hepatocellular carcinoma detected by comparative genomic hybridization. Genes Chromosomes Cancer. 1997; 18:59-65.
3. Kusano N, Shiraishi K, Kubo K, Oga A, Okita K, Sasaki K. Genetic aberrations detected by comparative genomic hybridization in hepatocellular carcinomas: their relationship to clinicopathological features. Hepatology. 1999; 29:1858-1862.
4. Wong N, Lai P, Lee SW, Fan S, Pang E, Liew CT, Sheng Z, Lau JW, Johnson PJ. Assessment of genetic changes in hepatocellular carcinoma by comparative genomic hybridization analysis: relationship to disease stage, tumor size, and cirrhosis. Am J Pathol. 1999; 154:37-43.
5. Guan XY, Fang Y, Sham JS, Kwong DL, Zhang Y, Liang Q, Li H, Zhou H, Trent JM. Recurrent chromosome alterations in hepatocellular carcinoma detected by comparative genomic hybridization. Genes Chromosomes Cancer. 2000; 29:110-116.
6. Ma NF, Hu L, Fung JM, Xie D, Zheng BJ, Chen L, Tang DJ, Fu L, Wu Z, Chen M, Fang Y, Guan XY. Isolation and characterization of a novel oncogene, amplified in liver cancer 1, within a commonly amplified region at 1q21 in hepatocellular carcinoma. Hepatology. 2008; 47:503-510.
7. Chen L, Hu L, Chan TH, Tsao GS, Xie D, Huo KK, Fu L, Ma S, Zheng BJ, Guan XY. Chromodomain helicase/adenosine triphosphatase DNA binding protein 1-like (CHD1L) gene suppresses the nucleus-to-mitochondria translocation of nur77 to sustain hepatocellular carcinoma cell survival. Hepatology. 2009; 50:122-129.
8. Chen L, Chan TH, Yuan YF, Hu L, Huang J, Ma S, Wang J, Dong SS, Tang KH, Xie D, Li Y, Guan XY. CHD1L promotes hepatocellular carcinoma progression and metastasis in mice and is associated with these processes in human patients. J Clin Invest. 2010; 120:1178-1191.
9. Chen L, Yuan YF, Li Y, Chan TH, Zheng BJ, Huang J, Guan XY. Clinical significance of CHD1L in hepatocellular carcinoma and therapeutic potentials of virus-mediated CHD1L depletion. Gut. 2011; 60:534-43.
10. Chen M, Huang JD, Hu L, Zheng BJ, Chen L, Tsang SL, Guan XY. Transgenic CHD1L expression in mouse induces spontaneous tumors. PLoS ONE. 2009; 4:e6727.
11. Ahel D, Horejsí Z, Wiechens N, Polo SE, Garcia-Wilson E, Ahel I, Flynn H, Skehel M, West SC, Jackson SP, Owen-Hughes T, Boulton SJ. Poly(ADP-ribose)-dependent regulation of DNA repair by the chromatin remodeling enzyme ALC1. Science. 2009; 325:1240-1243.
12. Kato M, Yano K, Morotomi-Yano K, Saito H, Miki Y. Identification and characterization of the human protein kinase-like gene NTKL: mitosis-specific centrosomal localization of an alternatively spliced isoform. Genomics. 2002; 79:760-767.
13. Burman JL, Bourbonniere L, Philie J, Stroh T, Dejgaard SY, Presley JF, McPherson PS. Scyl1, mutated in a recessive form of spinocerebellar neurodegeneration, regulates COPI-mediated retrograde traffic. J Biol Chem. 2008; 15:22774-22786.
14. Chafe SC, Mangroo D. Scyl1 facilitates nuclear tRNA export in mammalian cells by acting at the nuclear pore complex. Mol Biol Cell. 2010; 15:2483-2499.
15. Zhang SX, Garcia-Gras E, Wycuff DR, Marriot SJ, Kadeer N, Yu W, Olson EN, Garry DJ, Parmacek MS, Schwartz RJ. Identification of direct serum-response factor gene targets during Me2SO-induced P19 cardiac cell differentiation. J Biol Chem. 2005; 13:19115-19126.
16. Vinciguerra P, Godinho SA, Parmar K, Pellman D, D'Andrea AD. Cytokinesis failure occurs in Fanconi anemia pathway-deficient murine and human bone marrow hematopoietic cells. J Clin Invest. 2010; 120:3834-3842.
17. Altieri DC. Cytokinesis, apoptosis and survivin: three for tango? Cell Death Differ. 2001; 8:4-5.
18. Schafer DA. Regulating actin dynamics at membranes: a focus on dynamin. Traffic. 2004; 5:463-469.
19. Sinha S, Mondal G, Hwang EJ, Han da W, Dutta SK, Iyer S, Karumanchi SA, Kim KI, Couch FJ, Mukhopadhyay D. Von Hippel-Lindau gene product directs cytokinesis: a new tumor suppressor function. J Cell Sci. 2011; 124:2132-2142.
20. Bijman MN, van Nieuw Amerongen GP, Laurens N, van Hinsbergh VW, Boven E. Microtubule-targeting agents inhibit angiogenesis at subtoxic concentrations, a process associated with inhibition of Rac1 and Cdc42 activity and changes in the endothelial cytoskeleton. Mol Cancer Ther!. 2006; 5:2348-2357.
21. Chan TH, Chen L, Liu M, Hu L, Zheng BJ, Poon VK, Huang P, Yuan YF, Huang JD, Yang J, Tsao GS, Guan XY. Translationally controlled tumor protein induces mitotic defects and chromosome missegregation in hepatocellular carcinoma development. Hepatology. 2012; 55:491-505.
22. Li Y, Chen L, Chan TH, Liu M, Kong KL, Qiu JL, Li Y, Yuan YF, Guan XY. SPOCK1 is regulated by CHD1L and blocks apoptosis and promotes HCC cell invasiveness and metastasis in mice. Gastroenterology. 2013; 144:179-191.
23. Hu L, Liu M, Chen L, Chan TH, Wang J, Huo KK, Zheng BJ, Xie D, Guan XY. SCYL1 binding protein 1 promotes the ubiquitin-dependent degradation of Pirh2 and has tumor suppressive function in the development of hepatocellular carcinoma. Carcinogenesis. 2012; 33:1581-1588.
24. Chang DC, Xu N, Luo KQ. Degradation of cyclin B is required for the onset of anaphase in Mammalian cells. J Biol Chem. 2003; 278:37865-73.
25. Vassilev LT, Tovar C, Chen S, Knezevic D, Zhao X, Sun H, Heimbrook DC, Chen L. Selective small-molecule inhibitor reveals critical mitotic functions of human CDK1. Proc Natl Acad Sci U S A. 2006; 103:10660-5.
26. Wong C, Stearns T. Mammalian cells lack checkpoints for tetraploidy, aberrant centrosome number, and cytokinesis failure. BMC Cell Biol. 2005; 6:6.
27. Ishida N, Nakamura Y, Tanabe K, Li SA, Takei K. Dynamin 2 associatess with microtubules at mitosis and regulates cell cycle progression. Cell Struct Funct. 2011; 36:145-154.
28. Mooren OL, Kotova TI, Moore AJ, Schafer DA. Dynamin2 GTPase and cortactin remodel actin filaments. J Biol Chem. 2009; 284:23995-24005.
29. Welch MD, Mullins RD. Cellular control of actin nucleation. Annu Rev Cell Dev Biol. 2002; 18:247-288.
30. Machesky LM. Lamellipodia and filopodia in metastasis and invasion. FEBS Lett. 2008; 582:2102-2111.
31. Sossey-Alaoui K, Li X, Ranalli TA, Cowell JK. WAVE3-mediated cell migration and lamellipodia formation are regulated downstream of phosphatidylinositol 3-Kinase. J Biol Chem. 2005; 280:21748-21755.
32. Baldassarre M, Pompeo A, Beznoussenko G, Castaldi C, Cortellino S, McNiven MA, Luini A, Buccione R. Dynamin participates in focal extracellular matrix degradation by invasive cells. Mol Biol Cell. 2003; 14:1074-1084.