Platelet-derived growth factor-D modulates extracellular matrix homeostasis and remodeling through TIMP-1 induction and attenuation of MMP-2 and MMP-9 gelatinase activities

Biochemical and Biophysical Research Communications

Volumn 457, Issue 3, 2015, Pages 307-313

  Borkham Kamphorst, Erawan ^a   Alexi, Pascal ^a   Tihaa, Lidia ^a   Haas, Ute ^a   Weiskirchen, Ralf ^a  

^a UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

Author keywords

Extracellular matrix; MMP; PDGF; Receptors; Signaling; TIMP 1

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; GELATINASE A; GELATINASE B; PLATELET DERIVED GROWTH FACTOR B; PLATELET DERIVED GROWTH FACTOR D; TISSUE INHIBITOR OF METALLOPROTEINASE 1; COLLAGEN TYPE 1; LYMPHOKINE; MMP2 PROTEIN, MOUSE; MMP9 PROTEIN, MOUSE; NEUTRALIZING ANTIBODY; PDGFD PROTEIN, MOUSE; PLATELET DERIVED GROWTH FACTOR; PLATELET DERIVED GROWTH FACTOR ALPHA RECEPTOR; PLATELET DERIVED GROWTH FACTOR BETA RECEPTOR; PLATELET-DERIVED GROWTH FACTOR BB; TIMP1 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INDUCTION; EXTRACELLULAR MATRIX; FIBROGENESIS; HOMEOSTASIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; UPREGULATION; ZYMOGRAPHY; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; CELL LINE; DOWN REGULATION; FIBRINOLYSIS; GENETICS; IMMUNOLOGY; LIVER CIRRHOSIS; METABOLISM;

ANIMALS; ANTIBODIES, NEUTRALIZING; CELL LINE; COLLAGEN TYPE I; DOWN-REGULATION; EXTRACELLULAR MATRIX; FIBRINOLYSIS; HOMEOSTASIS; LIVER CIRRHOSIS; LYMPHOKINES; MAP KINASE SIGNALING SYSTEM; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; MICE; PLATELET-DERIVED GROWTH FACTOR; PROTO-ONCOGENE PROTEINS C-SIS; RECEPTOR, PLATELET-DERIVED GROWTH FACTOR ALPHA; RECEPTOR, PLATELET-DERIVED GROWTH FACTOR BETA; SIGNAL TRANSDUCTION; TISSUE INHIBITOR OF METALLOPROTEINASE-1;

EID: 84922723637     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2014.12.106     Document Type: Article

References (28)

1. L. Fredriksson, H. Li, U. Eriksson, The PDGF family: four gene products form five dimeric isoforms, Cytokine Growth Factor Rev. 15 (2004) 197-204.
2. J. Andrae, R. Gallini, C. Betsholtz, Role of platelet-derived growth factors in physiology and medicine, Genes. Dev. 22 (2008) 1276-1312.
3. C.H. Heldin, B. Westermark, Mechanism of action and in vivo role of platelet-derived growth factor, Physiol. Rev. 79 (1999) 1283-1316.
4. J.C. Bonner, Regulation of PDGF and its receptors in fibrotic diseases, Cytokine Growth Factor Rev. 15 (2004) 255-273.
5. L. Wong, G. Yamasaki, R.J. Johnson, S.L. Friedman, Induction of β-platelet-derived growth factor receptor in rat hepatic lipocytes during cellular activation in vivo and in culture, J. Clin. Invest. 94 (1994) 1563-1569.
6. S.L. Friedman, M.J. Arthur, Activation of cultured rat hepatic lipocytes by Kupffer cell conditioned medium, direct enhancement of matrix synthesis and stimulation of cell proliferation via induction of platelet-derived growth factor receptors, J. Clin. Invest 84 (1989) 1780-1785.
7. M. Pinzani, L. Gesualdo, G.M. Sabbah, H.E. Abboud, Effects of platelet-derived growth factor and other polypeptide mitogens on DNA synthesis and growth of cultured rat liver fat-storing cells, J. Clin. Invest 84 (1989) 1786-1793.
8. M. Pinzani, S. Milani, H. Herbst, R. DeFranco, C. Grappone, A. Gentilini, A. Caligiuri, G. Pellegrini, D.V. Ngo, R.G. Romanelli, P. Gentilini, Expression of platelet-derived growth factor and its receptors in normal human liver and during active hepatic fibrogenesis, Am. J. Pathol. 148 (1996) 785-800.
9. E. Borkham-Kamphorst, J. Herrmann, D. Stoll, J. Treptau, A.M. Gressner, R. Weiskirchen, Dominant-negative soluble PDGF-β receptor inhibits hepatic stellate cell activation and attenuates liver fibrosis, Lab. Invest 84 (2004) 766-777.
10. P. Czochra, B. Klopcic, E. Meyer, J. Herkel, J.F. Garcia-Lazaro, F. Thieringer, P. Schirmacher, S. Biesterfeld, P.R. Galle, A.W. Lohse, S. Kanzler, Liver fibrosis induced by hepatic overexpression of PDGF-B in transgenic mice, J. Hepatol. 45 (2006) 419-428.
11. E. Borkham-Kamphorst, C.R. van Roeyen, T. Ostendorf, J. Floege, A.M. Gressner, R. Weiskirchen, Pro-fibrogenic potential of PDGF-D in liver fibrosis, J. Hepatol. 46 (2007) 1064-1074.
12. W.J. LaRochelle, M. Jeffers, W.F. McDonald, R.A. Chillakuru, N.A. Giese, N.A. Lokker, C. Sullivan, F.L. Boldog, M. Yang, C. Vernet, C.E. Burgess, E. Fernandes, L.L. Deegler, B. Rittman, J. Shimkets, R.A. Shimkets, J.M. Rothberg, H.S. Lichenstein, PDGF-D, a new protease-activated growth factor, Nat. Cell Biol. 3 (2001) 517-521.
13. E. Bergsten, M. Uutela, X. Li, K. Pietras, A. Ostman, C.H. Heldin, K. Alitalo, U. Eriksson, PDGF-D is a specific, protease-activated ligand for the PDGF β-receptor, Nat. Cell Biol. 3 (2001) 512-516.
14. A. Pontén, E.B. Folestad, K. Pietras, U. Eriksson, Platelet-derived growth factor D induces cardiac fibrosis and proliferation of vascular smooth muscle cells in heart-specific transgenic mice, Circ. Res. 97 (2005) 1036-1045.
15. S. Taneda, K.L. Hudkins, S. Topouzis, D.G. Gilbertson, V. Ophascharoensuk, L. Truong, R.J. Johnson, C.E. Alpers, Obstructive uropathy in mice and humans: potential role for PDGF-D in the progression of tubulointerstitial injury, J. Am. Soc. Nephrol. 14 (2003) 2544-2555.
16. K.L. Hudkins, D.G. Gilbertson, M. Carling, S. Taneda, S.D. Hughes, M.S. Holdren, T.E. Palmer, S. Topouzis, A.C. Haran, A.L. Feldhaus, C.E. Alpers, Exogenous PDGF-D is a potent mesangial cell mitogen and causes a severe mesangial proliferative glomerulopathy, J. Am. Soc. Nephrol. 15 (2004) 286-298.
17. C.R. van Roeyen, F. Eitner, P. Boor, M.J. Moeller, U. Raffetseder, L. Hanssen, E. Bücher, L. Villa, M.C. Banas, K.L. Hudkins, C.E. Alpers, T. Ostendorf, J. Floege, Induction of progressive glomerulonephritis by podocyte-specific overexpression of platelet-derived growth factor-D, Kidney Int. 80 (2011) 1292-1305.
18. R. Borojevic, A.N. Monteiro, S.A. Vinhas, G.B. Domont, P.A. Mourão, H. Emonard, G. Grimaldi Jr., J.A. Grimaud, Establishment of a continuous cell line from fibrotic schistosomal granulomas in mice livers, Vitro Cell Dev. Biol. 21 (1985) 382-390.
19. E. Borkham-Kamphorst, D. Stoll, A.M. Gressner, R. Weiskirchen, Inhibitory effect of soluble PDGF-β receptor in culture-activated hepatic stellate cells, Biochem. Biophys. Res. Commun. 317 (2004) 451-462.
20. C.H. Heldin, A. Ostman, L. Rönnstrand, Signal transduction via platelet-derived growth factor receptors, Biochim. Biophys. Acta 1378 (1998) F79-F113.
21. C.H. Heldin, A. Wasteson, B. Westermark, Interaction of platelet-derived growth factor with its fibroblast receptor, demonstration of ligand degradation and receptor modulation, J. Biol. Chem. 257 (1982) 4216-4221.
22. A. Sorkin, B. Westermark, C.H. Heldin, L. Claesson-Welsh, Effect of receptor kinase inactivation on the rate of internalization and degradation of PDGF and the PDGF β-receptor, J. Cell Biol. 112 (1991) 469-478.
23. S. Mori, K. Tanaka, S. Omura, Y. Saito, Degradation process of ligand-stimulated platelet-derived growth factor β-receptor involves ubiquitin-proteasome proteolytic pathway, J. Biol. Chem. 270 (1995) 29447-29452.
24. M. Pinheiro-Margis, R. Margis, R. Borojevic, Collagen synthesis in an established liver connective tissue cell line (GRX) during induction of the fatstoring phenotype, Exp. Mol. Pathol. 56 (1992) 108-118.
25. K. Yokote, U. Hellman, S. Ekman, Y. Saito, L. Rönnstrand, Y. Saito, C.H. Heldin, S. Mori, Identification of Tyr-762 in the platelet-derived growth factor α-receptor as the binding site for Crk proteins, Oncogene 16 (1998) 1229-1239.
26. T. Matsumoto, K. Yokote, A. Take, M. Takemoto, S. Asaumi, Y. Hashimoto, M. Matsuda, Y. Saito, S. Mori, Differential interaction of CrkII adaptor protein with platelet-derived growth factor α- and β-receptors is determined by its internal tyrosine phosphorylation, Biochem. Biophys. Res. Commun. 270 (2000) 28-33.
27. M. Kretzschmar, J. Doody, I. Timokhina, J. Massagui, A mechanism of repression of TGFβ/Smad signaling by oncogenic Ras, Genes. Dev. 13 (1999) 804-816.
28. J. Massague, Integration of Smad and MAPK pathways: a link and a linker revisited, Genes. Dev. 17 (2003) 2993-2997.