-
1
-
-
84922728091
-
-
SEER stat fact sheets: Thyroid cancer. Available at, Accessed December 31
-
SEER stat fact sheets: Thyroid cancer. Available at http://seer.cancer.gov/statfacts/html/thyro.html. Accessed December 31, 2014.
-
(2014)
-
-
-
2
-
-
64549114616
-
Rising thyroid cancer incidence in the United States by demographic and tumor characteristics, 1980-2005
-
Enewold L, Zhu K, Ron E et al. Rising thyroid cancer incidence in the United States by demographic and tumor characteristics, 1980-2005. Cancer Epidemiol Biomarkers Prev 2009;18: 784-791.
-
(2009)
Cancer Epidemiol Biomarkers Prev
, vol.18
, pp. 784-791
-
-
Enewold, L.1
Zhu, K.2
Ron, E.3
-
4
-
-
84865589843
-
The impact of distant metastases at presentation on prognosis in patients with differentiated carcinoma of the thyroid gland
-
Nixon IJ, Whitcher MM, Palmer FL et al. The impact of distant metastases at presentation on prognosis in patients with differentiated carcinoma of the thyroid gland. Thyroid 2012;22: 884-889.
-
(2012)
Thyroid
, vol.22
, pp. 884-889
-
-
Nixon, I.J.1
Whitcher, M.M.2
Palmer, F.L.3
-
6
-
-
0022547135
-
Long-term results of treatment of 283 patients with lung and bone metastases from differentiated thyroid carcinoma
-
Schlumberger M, Tubiana M, De Vathaire F et al. Long-term results of treatment of 283 patients with lung and bone metastases from differentiated thyroid carcinoma. J Clin Endocrinol Metab 1986; 63:960-967.
-
(1986)
J Clin Endocrinol Metab
, vol.63
, pp. 960-967
-
-
Schlumberger, M.1
Tubiana, M.2
De Vathaire, F.3
-
7
-
-
33747642244
-
Long-term outcome of 444 patients with distant metastases from papillary and follicular thyroid carcinoma: Benefits and limits of radioiodine therapy
-
Durante C, Haddy N, Baudin E et al. Long-term outcome of 444 patients with distant metastases from papillary and follicular thyroid carcinoma: Benefits and limits of radioiodine therapy. J Clin Endocrinol Metab 2006;91:2892-2899.
-
(2006)
J Clin Endocrinol Metab
, vol.91
, pp. 2892-2899
-
-
Durante, C.1
Haddy, N.2
Baudin, E.3
-
8
-
-
0037363923
-
Radioactive iodine and the salivary glands
-
Mandel SJ, Mandel L. Radioactive iodine and the salivary glands. Thyroid 2003;13:265-271.
-
(2003)
Thyroid
, vol.13
, pp. 265-271
-
-
Mandel, S.J.1
Mandel, L.2
-
9
-
-
0036885164
-
Nasolacrimal drainage system obstruction from radioactive iodine therapy for thyroid carcinoma
-
Kloos RT, Duvuuri V, Jhiang SM et al. Nasolacrimal drainage system obstruction from radioactive iodine therapy for thyroid carcinoma. J Clin Endocrinol Metab 2002;87:5817-5820.
-
(2002)
J Clin Endocrinol Metab
, vol.87
, pp. 5817-5820
-
-
Kloos, R.T.1
Duvuuri, V.2
Jhiang, S.M.3
-
10
-
-
77649301564
-
Pulmonary fibrosis following radioiodine therapy of pulmonary metastases from differentiated thyroid carcinoma
-
Chen L, Shen Y, Luo Q et al. Pulmonary fibrosis following radioiodine therapy of pulmonary metastases from differentiated thyroid carcinoma. Thyroid 2010;20:337-340.
-
(2010)
Thyroid
, vol.20
, pp. 337-340
-
-
Chen, L.1
Shen, Y.2
Luo, Q.3
-
11
-
-
0345303967
-
Second primary malignancies in thyroid cancer patients
-
Rubino C, de Vathaire F, Dottorini ME et al. Second primary malignancies in thyroid cancer patients. Br J Cancer 2003;89:1638-1644.
-
(2003)
Br J Cancer
, vol.89
, pp. 1638-1644
-
-
Rubino, C.1
De Vathaire, F.2
Dottorini, M.E.3
-
12
-
-
70449370231
-
RevisedAmerican Thyroid Associationmanagement guidelines for patients with thyroid nodules and differentiated thyroid cancer
-
Cooper DS, Doherty GM, Haugen BR et al. RevisedAmerican Thyroid Associationmanagement guidelines for patients with thyroid nodules and differentiated thyroid cancer. Thyroid 2009;19: 1167-1214.
-
(2009)
Thyroid
, vol.19
, pp. 1167-1214
-
-
Cooper, D.S.1
Doherty, G.M.2
Haugen, B.R.3
-
13
-
-
32544437659
-
Real-time prognosis for metastatic thyroid carcinoma based on 2-[18F]fluoro-2-deoxy-D-glucose-positron emission tomography scanning
-
Robbins RJ, Wan Q, Grewal RK et al. Real-time prognosis for metastatic thyroid carcinoma based on 2-[18F]fluoro-2-deoxy-D-glucose-positron emission tomography scanning. J Clin Endocrinol Metab 2006;91:498-505.
-
(2006)
J Clin Endocrinol Metab
, vol.91
, pp. 498-505
-
-
Robbins, R.J.1
Wan, Q.2
Grewal, R.K.3
-
14
-
-
84875361065
-
Molecular pathogenesis and mechanisms of thyroid cancer
-
Xing M. Molecular pathogenesis and mechanisms of thyroid cancer. Nat Rev Cancer 2013;13: 184-199.
-
(2013)
Nat Rev Cancer
, vol.13
, pp. 184-199
-
-
Xing, M.1
-
15
-
-
0038664387
-
BRAF mutation in papillary thyroid carcinoma
-
Cohen Y, Xing M, Mambo E et al. BRAF mutation in papillary thyroid carcinoma. J Natl Cancer Inst 2003;95:625-627.
-
(2003)
J Natl Cancer Inst
, vol.95
, pp. 625-627
-
-
Cohen, Y.1
Xing, M.2
Mambo, E.3
-
16
-
-
0141453014
-
Clinical implication of hot spot BRAF mutation, V599E, in papillary thyroid cancers
-
Namba H, Nakashima M, Hayashi T et al. Clinical implication of hot spot BRAF mutation, V599E, in papillary thyroid cancers. J Clin Endocrinol Metab 2003;88:4393-4397.
-
(2003)
J Clin Endocrinol Metab
, vol.88
, pp. 4393-4397
-
-
Namba, H.1
Nakashima, M.2
Hayashi, T.3
-
17
-
-
0041589377
-
High prevalence of BRAF gene mutation in papillary thyroid carcinomas and thyroid tumor cell lines
-
Xu X, Quiros RM, Gattuso P et al. High prevalence of BRAF gene mutation in papillary thyroid carcinomas and thyroid tumor cell lines. Cancer Res 2003;63:4561-4567.
-
(2003)
Cancer Res
, vol.63
, pp. 4561-4567
-
-
Xu, X.1
Quiros, R.M.2
Gattuso, P.3
-
18
-
-
0142135475
-
BRAF mutations in papillary carcinomas of the thyroid
-
Fukushima T, Suzuki S, Mashiko M et al. BRAF mutations in papillary carcinomas of the thyroid. Oncogene 2003;22:6455-6457.
-
(2003)
Oncogene
, vol.22
, pp. 6455-6457
-
-
Fukushima, T.1
Suzuki, S.2
Mashiko, M.3
-
19
-
-
49249127826
-
Highly prevalent genetic alterations in receptor tyrosine kinases and phosphatidylinositol 3-kinase/Akt and mitogenactivated protein kinase pathways in anaplastic and follicular thyroid cancers
-
Liu Z, Hou P, Ji M et al. Highly prevalent genetic alterations in receptor tyrosine kinases and phosphatidylinositol 3-kinase/Akt and mitogenactivated protein kinase pathways in anaplastic and follicular thyroid cancers. J Clin Endocrinol Metab 2008;93:3106-3116.
-
(2008)
J Clin Endocrinol Metab
, vol.93
, pp. 3106-3116
-
-
Liu, Z.1
Hou, P.2
Ji, M.3
-
20
-
-
34347251976
-
High prevalence and mutual exclusivity of genetic alterations in the phosphatidylinositol-3-kinase/Akt pathway in thyroid tumors
-
Wang Y, Hou P, Yu H et al. High prevalence and mutual exclusivity of genetic alterations in the phosphatidylinositol-3-kinase/Akt pathway in thyroid tumors. J Clin Endocrinol Metab 2007;92: 2387-2390.
-
(2007)
J Clin Endocrinol Metab
, vol.92
, pp. 2387-2390
-
-
Wang, Y.1
Hou, P.2
Yu, H.3
-
21
-
-
33947284529
-
Genetic alterations and their relationship in the phosphatidylinositol 3-kinase/Akt pathway in thyroid cancer
-
Hou P, Liu D, Shan Y et al. Genetic alterations and their relationship in the phosphatidylinositol 3-kinase/Akt pathway in thyroid cancer. Clin Cancer Res 2007;13:1161-1170.
-
(2007)
Clin Cancer Res
, vol.13
, pp. 1161-1170
-
-
Hou, P.1
Liu, D.2
Shan, Y.3
-
22
-
-
66349098309
-
Mutational profile of advanced primary and metastatic radioactive iodine-refractory thyroid cancers reveals distinct pathogenetic roles forBRAF, PIK3CA, and AKT1
-
Ricarte-Filho JC, Ryder M, Chitale DA et al. Mutational profile of advanced primary and metastatic radioactive iodine-refractory thyroid cancers reveals distinct pathogenetic roles forBRAF, PIK3CA, and AKT1. Cancer Res 2009;69:4885-4893.
-
(2009)
Cancer Res
, vol.69
, pp. 4885-4893
-
-
Ricarte-Filho, J.C.1
Ryder, M.2
Chitale, D.A.3
-
23
-
-
0141465066
-
Ras mutations are associated with aggressive tumor phenotypes and poor prognosis in thyroid cancer
-
Garcia-Rostan G, Zhao H, Camp RL et al. ras mutations are associated with aggressive tumor phenotypes and poor prognosis in thyroid cancer. J Clin Oncol 2003;21:3226-3235.
-
(2003)
J Clin Oncol
, vol.21
, pp. 3226-3235
-
-
Garcia-Rostan, G.1
Zhao, H.2
Camp, R.L.3
-
24
-
-
0033951970
-
N-ras mutation in poorly differentiated thyroid carcinomas: Correlation with bone metastases and inverse correlation to thyroglobulin expression
-
Basolo F, Pisaturo F, Pollina LE et al. N-ras mutation in poorly differentiated thyroid carcinomas: Correlation with bone metastases and inverse correlation to thyroglobulin expression. Thyroid 2000;10:19-23.
-
(2000)
Thyroid
, vol.10
, pp. 19-23
-
-
Basolo, F.1
Pisaturo, F.2
Pollina, L.E.3
-
25
-
-
84863500976
-
The associations between RAS mutations and clinical characteristics in follicular thyroid tumors: New insights from a single center and a large patient cohort
-
Fukahori M, Yoshida A, Hayashi H et al. The associations between RAS mutations and clinical characteristics in follicular thyroid tumors: New insights from a single center and a large patient cohort. Thyroid 2012;22:683-689.
-
(2012)
Thyroid
, vol.22
, pp. 683-689
-
-
Fukahori, M.1
Yoshida, A.2
Hayashi, H.3
-
26
-
-
85047687680
-
Molecular profile and clinical-pathologic features of the follicular variant of papillary thyroid carcinoma. An unusually high prevalence of ras mutations
-
Zhu Z, Gandhi M, Nikiforova MN et al. Molecular profile and clinical-pathologic features of the follicular variant of papillary thyroid carcinoma. An unusually high prevalence of ras mutations. Am J Clin Pathol 2003;120:71-77.
-
(2003)
Am J Clin Pathol
, vol.120
, pp. 71-77
-
-
Zhu, Z.1
Gandhi, M.2
Nikiforova, M.N.3
-
27
-
-
0028030757
-
Selective activation of ras oncogenes in follicular and undifferentiated thyroid carcinomas
-
Manenti G, Pilotti S, Re FC et al. Selective activation of ras oncogenes in follicular and undifferentiated thyroid carcinomas. Eur J Cancer 1994;30A:987-993.
-
(1994)
Eur J Cancer
, vol.30 A
, pp. 987-993
-
-
Manenti, G.1
Pilotti, S.2
Re, F.C.3
-
28
-
-
0034016275
-
Pattern of radiation-induced RET and NTRK1 rearrangements in 191 post-chernobyl papillary thyroid carcinomas: Biological, phenotypic, and clinical implications
-
Rabes HM, Demidchik EP, Sidorow JD et al. Pattern of radiation-induced RET and NTRK1 rearrangements in 191 post-chernobyl papillary thyroid carcinomas: Biological, phenotypic, and clinical implications. Clin Cancer Res 2000;6: 1093-1103.
-
(2000)
Clin Cancer Res
, vol.6
, pp. 1093-1103
-
-
Rabes, H.M.1
Demidchik, E.P.2
Sidorow, J.D.3
-
29
-
-
0033985035
-
Gene rearrangement and Chernobyl related thyroid cancers
-
Santoro M, Thomas GA, Vecchio G et al. Gene rearrangement and Chernobyl related thyroid cancers. Br J Cancer 2000;82:315-322.
-
(2000)
Br J Cancer
, vol.82
, pp. 315-322
-
-
Santoro, M.1
Thomas, G.A.2
Vecchio, G.3
-
30
-
-
0032485045
-
Molecular analysis of new subtypes of ELE/RET rearrangements, their reciprocal transcripts and breakpointsinpapillarythyroidcarcinomasofchildren after Chernobyl
-
Klugbauer S, Demidchik EP, Lengfelder E et al. Molecular analysis of new subtypes of ELE/RET rearrangements, their reciprocal transcripts and breakpointsinpapillarythyroidcarcinomasofchildren after Chernobyl. Oncogene 1998;16:671-675.
-
(1998)
Oncogene
, vol.16
, pp. 671-675
-
-
Klugbauer, S.1
Demidchik, E.P.2
Lengfelder, E.3
-
31
-
-
39049169179
-
Clinicopathological analysis of papillary thyroid cancer with PIK3CA alterations in aMiddle Eastern population
-
Abubaker J, Jehan Z, Bavi P et al. Clinicopathological analysis of papillary thyroid cancer with PIK3CA alterations in aMiddle Eastern population. J Clin Endocrinol Metab 2008;93:611-618.
-
(2008)
J Clin Endocrinol Metab
, vol.93
, pp. 611-618
-
-
Abubaker, J.1
Jehan, Z.2
Bavi, P.3
-
32
-
-
38149115262
-
Phosphatidylinositol 3-kinase/Akt and ras/rafmitogen-activated protein kinase pathway mutations in anaplastic thyroid cancer
-
Santarpia L, El-Naggar AK, Cote GJ et al. Phosphatidylinositol 3-kinase/Akt and ras/rafmitogen-activated protein kinase pathway mutations in anaplastic thyroid cancer. J Clin Endocrinol Metab 2008;93:278-284.
-
(2008)
J Clin Endocrinol Metab
, vol.93
, pp. 278-284
-
-
Santarpia, L.1
El-Naggar, A.K.2
Cote, G.J.3
-
33
-
-
77949262337
-
Identification and functional characterization of isocitrate dehydrogenase 1 (IDH1) mutations in thyroid cancer
-
Murugan AK, Bojdani E, Xing M. Identification and functional characterization of isocitrate dehydrogenase 1 (IDH1) mutations in thyroid cancer. Biochem Biophys Res Commun 2010;393:555-559.
-
(2010)
Biochem Biophys Res Commun
, vol.393
, pp. 555-559
-
-
Murugan, A.K.1
Bojdani, E.2
Xing, M.3
-
34
-
-
77957835307
-
Identification of several novel non-p.R132 IDH1 variants in thyroid carcinomas
-
Hemerly JP, Bastos AU, Cerutti JM. Identification of several novel non-p.R132 IDH1 variants in thyroid carcinomas. Eur J Endocrinol 2010;163:747-755.
-
(2010)
Eur J Endocrinol
, vol.163
, pp. 747-755
-
-
Hemerly, J.P.1
Bastos, A.U.2
Cerutti, J.M.3
-
35
-
-
80051699020
-
Uncommon GNAQ, MMP8, AKT3, EGFR, andPIK3R1 mutationsin thyroid cancers
-
Murugan AK, Dong J, Xie J et al. Uncommon GNAQ, MMP8, AKT3, EGFR, andPIK3R1 mutationsin thyroid cancers. Endocr Pathol 2011;22:97-102.
-
(2011)
Endocr Pathol
, vol.22
, pp. 97-102
-
-
Murugan, A.K.1
Dong, J.2
Xie, J.3
-
36
-
-
0034714190
-
PAX8-PPARgamma1 fusion oncogene in human thyroid carcinoma
-
Kroll TG, Sarraf P, Pecciarini L et al. PAX8-PPARgamma1 fusion oncogene in human thyroid carcinoma. Science 2000;289:1357-1360.
-
(2000)
Science
, vol.289
, pp. 1357-1360
-
-
Kroll, T.G.1
Sarraf, P.2
Pecciarini, L.3
-
37
-
-
20344366798
-
Somatic and germline mutation in GRIM-19, a dual function gene involved in mitochondrial metabolism and cell death, is linked to mitochondrion-rich (Hurthle cell) tumours of the thyroid
-
Máximo V, Botelho T, Capela J et al. Somatic and germline mutation in GRIM-19, a dual function gene involved in mitochondrial metabolism and cell death, is linked to mitochondrion-rich (Hurthle cell) tumours of the thyroid. Br J Cancer 2005;92: 1892-1898.
-
(2005)
Br J Cancer
, vol.92
, pp. 1892-1898
-
-
Máximo, V.1
Botelho, T.2
Capela, J.3
-
38
-
-
3042732518
-
Molecular pathology of papillary, follicular and Hürthle cell carcinomas of the thyroid
-
Soares P, Máximo V, Sobrinho-Simöes M. Molecular pathology of papillary, follicular and Hürthle cell carcinomas of the thyroid. Arkh Patol 2003;65:45-47.
-
(2003)
Arkh Patol
, vol.65
, pp. 45-47
-
-
Soares, P.1
Máximo, V.2
Sobrinho-Simöes, M.3
-
39
-
-
0037379904
-
High prevalence of BRAF mutations in thyroid cancer: Genetic evidence for constitutive activation of the RET/PTC-RAS-BRAF signaling pathway in papillary thyroid carcinoma
-
Kimura ET, Nikiforova MN, Zhu Z et al. High prevalence of BRAF mutations in thyroid cancer: Genetic evidence for constitutive activation of the RET/PTC-RAS-BRAF signaling pathway in papillary thyroid carcinoma. Cancer Res 2003;63:1454-1457.
-
(2003)
Cancer Res
, vol.63
, pp. 1454-1457
-
-
Kimura, E.T.1
Nikiforova, M.N.2
Zhu, Z.3
-
40
-
-
33748747215
-
Influence of the BRAF V600E mutation on expression of vascular endothelial growth factor in papillary thyroid cancer
-
Jo YS, Li S, Song JH et al. Influence of the BRAF V600E mutation on expression of vascular endothelial growth factor in papillary thyroid cancer. J Clin Endocrinol Metab 2006;91:3667-3670.
-
(2006)
J Clin Endocrinol Metab
, vol.91
, pp. 3667-3670
-
-
Jo, Y.S.1
Li, S.2
Song, J.H.3
-
41
-
-
84922701972
-
-
Center for Drug Evaluation and Research, application no. 202324Orig1s000: Pharmacology review(s). Available at, AccessedDecember 31
-
Center for Drug Evaluation and Research, application no. 202324Orig1s000: Pharmacology review(s). Available at http://www.accessdata.fda.gov/drugsatfda_docs/nda/2012/202324Orig1s000PharmR.pdf. AccessedDecember 31, 2014.
-
(2014)
-
-
-
42
-
-
58149337448
-
Nonclinical antiangiogenesis and antitumor activities of axitinib (AG-013736), an oral, potent, and selective inhibitor of vascular endothelial growth factor receptor tyrosine kinases 1, 2, 3
-
Hu-Lowe DD, Zou HY, Grazzini ML et al. Nonclinical antiangiogenesis and antitumor activities of axitinib (AG-013736), an oral, potent, and selective inhibitor of vascular endothelial growth factor receptor tyrosine kinases 1, 2, 3. Clin Cancer Res 2008;14:7272-7283.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 7272-7283
-
-
Hu-Lowe, D.D.1
Zou, H.Y.2
Grazzini, M.L.3
-
43
-
-
84922732545
-
-
Center for Drug Evaluation and Research, application no. 203756Orig1s000: Pharmacology review(s). Available at, Accessed December 31
-
Center for Drug Evaluation and Research, application no. 203756Orig1s000: Pharmacology review(s). Available at http://www.accessdata.fda.gov/drugsatfda_docs/nda/2012/203756Orig1s000PharmR.pdf. Accessed December 31, 2014.
-
(2014)
-
-
-
44
-
-
84922760355
-
-
Center for Drug Evaluation and Research, application no. 202806Orig1s000: Pharmacology review(s). Available at, Accessed December 31
-
Center for Drug Evaluation and Research, application no. 202806Orig1s000: Pharmacology review(s). Available at http://www.accessdata.fda.gov/drugsatfda_docs/nda/2013/202806Orig1s000PharmR.pdf. Accessed December 31, 2014.
-
(2014)
-
-
-
45
-
-
20144370978
-
AZD2171: A highly potent, orally bioavailable, vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor for the treatment of cancer
-
Wedge SR, Kendrew J, Hennequin LF et al. AZD2171: A highly potent, orally bioavailable, vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor for the treatment of cancer. Cancer Res 2005;65:4389-4400.
-
(2005)
Cancer Res
, vol.65
, pp. 4389-4400
-
-
Wedge, S.R.1
Kendrew, J.2
Hennequin, L.F.3
-
46
-
-
37349105704
-
E7080, a novel inhibitor that targets multiple kinases, has potent antitumor activities against stem cell factor producinghumansmall cell lung cancer H146, based on angiogenesis inhibition
-
Matsui J, Yamamoto Y, Funahashi Y et al. E7080, a novel inhibitor that targets multiple kinases, has potent antitumor activities against stem cell factor producinghumansmall cell lung cancer H146, based on angiogenesis inhibition. Int J Cancer 2008;122: 664-671.
-
(2008)
Int J Cancer
, vol.122
, pp. 664-671
-
-
Matsui, J.1
Yamamoto, Y.2
Funahashi, Y.3
-
47
-
-
33749000911
-
AMG706, an oral, multikinase inhibitor that selectively targets vascular endothelial growth factor, platelet-derived growth factor, and kit receptors, potently inhibits angiogenesis and induces regression in tumor xenografts
-
Polverino A, Coxon A, Starnes C et al.AMG706, an oral, multikinase inhibitor that selectively targets vascular endothelial growth factor, platelet-derived growth factor, and kit receptors, potently inhibits angiogenesis and induces regression in tumor xenografts. Cancer Res 2006;66:8715-8721.
-
(2006)
Cancer Res
, vol.66
, pp. 8715-8721
-
-
Polverino, A.1
Coxon, A.2
Starnes, C.3
-
48
-
-
70449523183
-
Myelosuppression and kinase selectivity of multikinase angiogenesis inhibitors
-
Kumar R, Crouthamel MC, Rominger DH et al. Myelosuppression and kinase selectivity of multikinase angiogenesis inhibitors. Br J Cancer 2009;101:1717-1723.
-
(2009)
Br J Cancer
, vol.101
, pp. 1717-1723
-
-
Kumar, R.1
Crouthamel, M.C.2
Rominger, D.H.3
-
49
-
-
84922742467
-
-
Center for Drug Evaluation and Research, application no. 22-465: Pharmacology review(s). Available at, Accessed December 31
-
Center for Drug Evaluation and Research, application no. 22-465: Pharmacology review(s). Available at http://www.accessdata.fda.gov/drugsatfda_docs/nda/2009/022465s000_PharmR.pdf. Accessed December 31, 2014.
-
(2014)
-
-
-
50
-
-
34447322566
-
Pharmacokinetic-pharmacodynamic correlation frommousetohumanwithpazopanib, amultikinase angiogenesis inhibitor with potent antitumor and antiangiogenic activity
-
Kumar R, Knick VB, Rudolph SK et al. Pharmacokinetic-pharmacodynamic correlation frommousetohumanwithpazopanib, amultikinase angiogenesis inhibitor with potent antitumor and antiangiogenic activity. Mol Cancer Ther 2007;6: 2012-2021.
-
(2007)
Mol Cancer Ther
, vol.6
, pp. 2012-2021
-
-
Kumar, R.1
Knick, V.B.2
Rudolph, S.K.3
-
51
-
-
84922757586
-
-
Center for Drug Evaluation and Research, approval package for application no. NDA 21-923: Pharmacology review(s). Available at, Accessed December 31
-
Center for Drug Evaluation and Research, approval package for application no. NDA 21-923: Pharmacology review(s). Available at http://www.accessdata.fda.gov/drugsatfda_docs/nda/2005/021923_s000_Nexavar_PharmR.pdf. Accessed December 31, 2014.
-
(2014)
-
-
-
52
-
-
4944249117
-
BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis
-
Wilhelm SM, Carter C, Tang L et al.BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. Cancer Res 2004;64:7099-7109.
-
(2004)
Cancer Res
, vol.64
, pp. 7099-7109
-
-
Wilhelm, S.M.1
Carter, C.2
Tang, L.3
-
53
-
-
84873056956
-
Activitybased kinase profiling of approved tyrosine kinase inhibitors
-
Kitagawa D, Yokota K, Gouda M et al. Activitybased kinase profiling of approved tyrosine kinase inhibitors. Genes Cells 2013;18:110-122.
-
(2013)
Genes Cells
, vol.18
, pp. 110-122
-
-
Kitagawa, D.1
Yokota, K.2
Gouda, M.3
-
54
-
-
84922703448
-
-
Center for Drug Evaluation and Research, approval package for application no. NDA 21-938 (GIST), NDA 21-968 (MRCC): Pharmacology review (s). Available at, Accessed December 31
-
Center for Drug Evaluation and Research, approval package for application no. NDA 21-938 (GIST), NDA 21-968 (MRCC): Pharmacology review (s). Available at http://www.accessdata.fda.gov/drugsatfda_docs/nda/2006/021938_S000_Sutent_PharmR.pdf. Accessed December 31, 2014.
-
(2014)
-
-
-
55
-
-
33947401129
-
Biological characterization of ARRY-142886 (AZD6244), a potent, highly selective mitogen-activated protein kinase kinase 1/2 inhibitor
-
Yeh TC, Marsh V, Bernat BA et al. Biological characterization of ARRY-142886 (AZD6244), a potent, highly selective mitogen-activated protein kinase kinase 1/2 inhibitor. Clin Cancer Res 2007; 13:1576-1583.
-
(2007)
Clin Cancer Res
, vol.13
, pp. 1576-1583
-
-
Yeh, T.C.1
Marsh, V.2
Bernat, B.A.3
-
56
-
-
84922755664
-
-
Center for Drug Evaluation and Research, application no. 022405Orig1s000: Clinical pharmacology and biopharmaceutics review(s). Available at, AccessedDecember 31
-
Center for Drug Evaluation and Research, application no. 022405Orig1s000: Clinical pharmacology and biopharmaceutics review(s). Available at http://www.accessdata.fda.gov/drugsatfda_docs/nda/2011/022405Orig1s000ClinPharmR.pdf. AccessedDecember 31, 2014.
-
(2014)
-
-
-
57
-
-
0037102369
-
ZD6474 inhibits vascular endothelial growth factor signaling, angiogenesis, and tumor growth following oral administration
-
Wedge SR, Ogilvie DJ, Dukes M et al. ZD6474 inhibits vascular endothelial growth factor signaling, angiogenesis, and tumor growth following oral administration. Cancer Res 2002;62:4645-4655.
-
(2002)
Cancer Res
, vol.62
, pp. 4645-4655
-
-
Wedge, S.R.1
Ogilvie, D.J.2
Dukes, M.3
-
58
-
-
84922742119
-
-
Center for Drug Evaluation and Research, application no. 22-334: Pharmacology review(s). Available at, Accessed December 31
-
Center for Drug Evaluation and Research, application no. 22-334: Pharmacology review(s). Available at http://www.accessdata.fda.gov/drugsatfda_docs/nda/2009/022334s000_PharmR.pdf. Accessed December 31, 2014.
-
(2014)
-
-
-
59
-
-
42349113247
-
A new pharmacologic action of CCI-779 involves FKBP12-independent inhibition of mTOR kinase activity and profound repression of global protein synthesis
-
Shor B, Zhang WG, Toral-Barza L et al. A new pharmacologic action of CCI-779 involves FKBP12-independent inhibition of mTOR kinase activity and profound repression of global protein synthesis. Cancer Res 2008;68:2934-2943.
-
(2008)
Cancer Res
, vol.68
, pp. 2934-2943
-
-
Shor, B.1
Zhang, W.G.2
Toral-Barza, L.3
-
60
-
-
84922708558
-
-
Tafinlar (dabrafenib) [prescribing information]. Research Triangle Park, SC: GlaxoSmithKline
-
Tafinlar (dabrafenib) [prescribing information]. Research Triangle Park, SC: GlaxoSmithKline; 2014.
-
(2014)
-
-
-
61
-
-
84922699746
-
-
Center for Drug Evaluation and Research, application no. 202429Orig1s000: Clinical pharmacology and biopharmaceutics review(s). Available at, Accessed December 31
-
Center for Drug Evaluation and Research, application no. 202429Orig1s000: Clinical pharmacology and biopharmaceutics review(s). Available at http://www.accessdata.fda.gov/drugsatfda_docs/nda/2011/202429Orig1s000ClinPharmR.pdf. Accessed December 31, 2014.
-
(2014)
-
-
-
62
-
-
77956513286
-
Clinical efficacy of aRAFinhibitor needs broadtarget blockade inBRAFmutant melanoma
-
Bollag G, Hirth P, Tsai J et al. Clinical efficacy of aRAFinhibitor needs broadtarget blockade inBRAFmutant melanoma. Nature 2010;467:596-599.
-
(2010)
Nature
, vol.467
, pp. 596-599
-
-
Bollag, G.1
Hirth, P.2
Tsai, J.3
-
63
-
-
50649095801
-
Axitinib is an active treatment for all histologic subtypes of advanced thyroid cancer: Results from a phase II study
-
Cohen EE, Rosen LS, Vokes EE et al. Axitinib is an active treatment for all histologic subtypes of advanced thyroid cancer: Results from a phase II study. J Clin Oncol 2008;26:4708-4713.
-
(2008)
J Clin Oncol
, vol.26
, pp. 4708-4713
-
-
Cohen, E.E.1
Rosen, L.S.2
Vokes, E.E.3
-
64
-
-
84922730925
-
Phase 2 trial of axitinib for advanced thyroid cancer: Preliminary activity results [abstract PP17]
-
Locati L, Licitra L, Ou S-HI et al. Phase 2 trial of axitinib for advanced thyroid cancer: Preliminary activity results [abstract PP17]. Eur Arch Otorhinolaryngol 2012;269:1345.
-
(2012)
Eur Arch Otorhinolaryngol
, vol.269
, pp. 1345
-
-
Locati, L.1
Licitra, L.2
Ou, S.-H.3
-
65
-
-
40949130884
-
A phase II study of gefitinib in patients with advanced thyroid cancer
-
Pennell NA, Daniels GH, Haddad RI et al. A phase II study of gefitinib in patients with advanced thyroid cancer. Thyroid 2008;18:317-323.
-
(2008)
Thyroid
, vol.18
, pp. 317-323
-
-
Pennell, N.A.1
Daniels, G.H.2
Haddad, R.I.3
-
66
-
-
80053160399
-
A phase II trial of the multitargeted kinase inhibitor E7080 in advanced radioiodine (RAI)-refractory differentiated thyroid cancer (DTC)
-
Sherman SI, Jarzab B, Cabanillas ME et al. A phase II trial of the multitargeted kinase inhibitor E7080 in advanced radioiodine (RAI)-refractory differentiated thyroid cancer (DTC). J Clin Oncol 2011;29(suppl):5503a.
-
(2011)
J Clin Oncol
, vol.29
, pp. 5503a
-
-
Sherman, S.I.1
Jarzab, B.2
Cabanillas, M.E.3
-
67
-
-
46449117698
-
Motesanib diphosphate in progressive differentiated thyroid cancer
-
Sherman SI, Wirth LJ, Droz JP et al. Motesanib diphosphate in progressive differentiated thyroid cancer. N Engl J Med 2008;359:31-42.
-
(2008)
N Engl J Med
, vol.359
, pp. 31-42
-
-
Sherman, S.I.1
Wirth, L.J.2
Droz, J.P.3
-
68
-
-
77957359933
-
Efficacy of pazopanib in progressive, radioiodine-refractory, metastatic differentiated thyroid cancers: Results of a phase 2 consortium study
-
Bible KC, Suman VJ, Molina JR et al. Efficacy of pazopanib in progressive, radioiodine-refractory, metastatic differentiated thyroid cancers: Results of a phase 2 consortium study. Lancet Oncol 2010;11: 962-972.
-
(2010)
Lancet Oncol
, vol.11
, pp. 962-972
-
-
Bible, K.C.1
Suman, V.J.2
Molina, J.R.3
-
69
-
-
84873681262
-
Selumetinibenhanced radioiodine uptake in advanced thyroid cancer
-
Ho AL, Grewal RK, Leboeuf R et al. Selumetinibenhanced radioiodine uptake in advanced thyroid cancer. N Engl J Med 2013;368:623-632.
-
(2013)
N Engl J Med
, vol.368
, pp. 623-632
-
-
Ho, A.L.1
Grewal, R.K.2
Leboeuf, R.3
-
70
-
-
84859410770
-
Phase II efficacy and pharmacogenomic study of Selumetinib (AZD6244; ARRY-142886) in iodine-131 refractory papillary thyroid carcinomawith or without follicular elements
-
Hayes DN, Lucas AS, Tanvetyanon T et al. Phase II efficacy and pharmacogenomic study of Selumetinib (AZD6244; ARRY-142886) in iodine-131 refractory papillary thyroid carcinomawith or without follicular elements. Clin Cancer Res 2012;18: 2056-2065.
-
(2012)
Clin Cancer Res
, vol.18
, pp. 2056-2065
-
-
Hayes, D.N.1
Lucas, A.S.2
Tanvetyanon, T.3
-
71
-
-
63849265332
-
Phase II trial of sorafenib in metastatic thyroid cancer
-
Kloos RT, Ringel MD, Knopp MV et al. Phase II trial of sorafenib in metastatic thyroid cancer. J Clin Oncol 2009;27:1675-1684.
-
(2009)
J Clin Oncol
, vol.27
, pp. 1675-1684
-
-
Kloos, R.T.1
Ringel, M.D.2
Knopp, M.V.3
-
72
-
-
79953249278
-
Response to sorafenib at a low dose in patients with radioiodinerefractory pulmonary metastases from papillary thyroid carcinoma
-
Chen L, Shen Y, Luo Q et al. Response to sorafenib at a low dose in patients with radioiodinerefractory pulmonary metastases from papillary thyroid carcinoma. Thyroid 2011;21:119-124.
-
(2011)
Thyroid
, vol.21
, pp. 119-124
-
-
Chen, L.1
Shen, Y.2
Luo, Q.3
-
73
-
-
84887111477
-
Sorafenib in locally advanced or metastatic patients with radioactive iodine-refractory differentiated thyroid cancer: The phase III DECISION trial
-
Brose MS, Nutting CM, Jarzab B et al. Sorafenib in locally advanced or metastatic patients with radioactive iodine-refractory differentiated thyroid cancer: The phase III DECISION trial. J Clin Oncol 2013;31(suppl):04a.
-
(2013)
J Clin Oncol
, vol.31
, pp. 04a
-
-
Brose, M.S.1
Nutting, C.M.2
Jarzab, B.3
-
74
-
-
50649095250
-
Phase II trial of sorafenib in advanced thyroid cancer
-
Gupta-Abramson V, Troxel AB, Nellore A et al. Phase II trial of sorafenib in advanced thyroid cancer. J Clin Oncol 2008;26:4714-4719.
-
(2008)
J Clin Oncol
, vol.26
, pp. 4714-4719
-
-
Gupta-Abramson, V.1
Troxel, A.B.2
Nellore, A.3
-
75
-
-
79960179069
-
Analysis of the efficacy and toxicity of sorafenib in thyroid cancer: A phase II study in a UK based population
-
Ahmed M, Barbachano Y, Riddell A et al. Analysis of the efficacy and toxicity of sorafenib in thyroid cancer: A phase II study in a UK based population. Eur J Endocrinol 2011;165:315-322.
-
(2011)
Eur J Endocrinol
, vol.165
, pp. 315-322
-
-
Ahmed, M.1
Barbachano, Y.2
Riddell, A.3
-
76
-
-
72949106263
-
Beneficial effects of sorafenibontumor progression, but not on radioiodine uptake, in patients with differentiated thyroid carcinoma
-
Hoftijzer H, Heemstra KA, Morreau H et al. Beneficial effects of sorafenibontumor progression, but not on radioiodine uptake, in patients with differentiated thyroid carcinoma. Eur J Endocrinol 2009;161:923-931.
-
(2009)
Eur J Endocrinol
, vol.161
, pp. 923-931
-
-
Hoftijzer, H.1
Heemstra, K.A.2
Morreau, H.3
-
77
-
-
78049462514
-
Phase II study of daily sunitinib in FDG-PET-positive, iodinerefractory differentiated thyroid cancer and metastatic medullary carcinoma of the thyroid with functional imaging correlation
-
Carr LL, Mankoff DA, Goulart BH et al. Phase II study of daily sunitinib in FDG-PET-positive, iodinerefractory differentiated thyroid cancer and metastatic medullary carcinoma of the thyroid with functional imaging correlation. Clin Cancer Res 2010;16:5260-5268.
-
(2010)
Clin Cancer Res
, vol.16
, pp. 5260-5268
-
-
Carr, L.L.1
Mankoff, D.A.2
Goulart, B.H.3
-
78
-
-
65749087602
-
Phase 2 study of sunitinib in refractory thyroid cancer
-
Cohen EE, Needles BM, Cullen KJ et al. Phase 2 study of sunitinib in refractory thyroid cancer. J Clin Oncol 2008;26(suppl):6025a.
-
(2008)
J Clin Oncol
, vol.26
, pp. 6025a
-
-
Cohen, E.E.1
Needles, B.M.2
Cullen, K.J.3
-
79
-
-
84865552505
-
Vandetanib in locally advanced or metastatic differentiated thyroid cancer: A randomised, double-blind, phase 2 trial
-
Leboulleux S, Bastholt L, Krause T et al. Vandetanib in locally advanced or metastatic differentiated thyroid cancer: A randomised, double-blind, phase 2 trial. Lancet Oncol 2012;13: 897-905.
-
(2012)
Lancet Oncol
, vol.13
, pp. 897-905
-
-
Leboulleux, S.1
Bastholt, L.2
Krause, T.3
-
80
-
-
84912067480
-
An open-label, multi-center phase 2 study of the BRAF inhibitor vemurafenib in patients with metastatic or unresectable papillary thyroid cancer (Ptc) positive for the BRAF V600 mutation and resistant to radioactive iodine
-
Brose MS, Cabanillas ME, Cohen EEW et al. An open-label, multi-center phase 2 study of the BRAF inhibitor vemurafenib in patients with metastatic or unresectable papillary thyroid cancer (ptc) positive for the BRAF V600 mutation and resistant to radioactive iodine. Eur J Cancer 2013; 49(suppl 3):LBA28.
-
(2013)
Eur J Cancer
, vol.49
-
-
Brose, M.S.1
Cabanillas, M.E.2
Cohen, E.3
-
81
-
-
84904855170
-
Sorafenib in radioactive iodine-refractory, locally advanced or metastatic differentiated thyroid cancer: A randomised, double-blind, phase 3 trial
-
Brose MS, Nutting CM, Jarzab B et al. Sorafenib in radioactive iodine-refractory, locally advanced or metastatic differentiated thyroid cancer: A randomised, double-blind, phase 3 trial. Lancet 2014;384: 319-328.
-
(2014)
Lancet
, vol.384
, pp. 319-328
-
-
Brose, M.S.1
Nutting, C.M.2
Jarzab, B.3
-
82
-
-
84910633715
-
Aphase 3, multicenter, double-blind, placebo-controlled trial of lenvatinib (E7080) in patients with 131I-refractory differentiated thyroid cancer (SELECT)
-
Schlumberger M, Makoto T, Wirth L et al.Aphase 3, multicenter, double-blind, placebo-controlled trial of lenvatinib (E7080) in patients with 131I-refractory differentiated thyroid cancer (SELECT). J Clin Oncol 2014;32(suppl 5):LBA6008.
-
(2014)
J Clin Oncol
, vol.32
-
-
Schlumberger, M.1
Makoto, T.2
Wirth, L.3
-
83
-
-
84975871765
-
Phase III randomized, double-blinded, placebo-controlled trial of sorafenib in locally advanced or metastatic patients with radioactive iodine (RAI)-refractory differentiated thyroid cancer (DTC)-exploratory analyses of patient-reported outcomes
-
Schlumberger M, Jarzab B, Elisei R et al. Phase III randomized, double-blinded, placebo-controlled trial of sorafenib in locally advanced or metastatic patients with radioactive iodine (RAI)-refractory differentiated thyroid cancer (DTC)-exploratory analyses of patient-reported outcomes. Thyroid 2013;23:A-49-A-50.
-
(2013)
Thyroid
, vol.23
, pp. A-49
-
-
Schlumberger, M.1
Jarzab, B.2
Elisei, R.3
-
84
-
-
84911888284
-
A phase I study of cabozantinib (XL184) in patients with differentiated thyroid cancer
-
Cabanillas ME, Brose MS, Holland J et al. A phase I study of cabozantinib (XL184) in patients with differentiated thyroid cancer.Thyroid 2014;24: 1508-1514.
-
(2014)
Thyroid
, vol.24
, pp. 1508-1514
-
-
Cabanillas, M.E.1
Brose, M.S.2
Holland, J.3
-
85
-
-
84879177690
-
Clinical responses to vemurafenib in patients with metastatic papillary thyroid cancer harboring BRAF (V600E) mutation
-
Kim KB, Cabanillas ME, Lazar AJ et al. Clinical responses to vemurafenib in patients with metastatic papillary thyroid cancer harboring BRAF (V600E) mutation. Thyroid 2013;23:1277-1283.
-
(2013)
Thyroid
, vol.23
, pp. 1277-1283
-
-
Kim, K.B.1
Cabanillas, M.E.2
Lazar, A.J.3
-
86
-
-
84922718779
-
Efficacy and tolerability of vemurafenib in BRAFV600E positive papillary thyroid cancer (PTC)
-
Dadu R, Shah K, Waguespack SG et al. Efficacy and tolerability of vemurafenib in BRAFV600E positive papillary thyroid cancer (PTC). Thyroid 2013;23:A-95-A-96.
-
(2013)
Thyroid
, vol.23
, pp. A-95
-
-
Dadu, R.1
Shah, K.2
Waguespack, S.G.3
-
87
-
-
84922707859
-
BRAF inhibitor dabrafenib in patients with metastatic BRAF-mutant thyroid cancer
-
Epub ahead of print]
-
Falchook GS, Millward M, Hong D et al. BRAF inhibitor dabrafenib in patients with metastatic BRAF-mutant thyroid cancer. Thyroid 2014 [Epub ahead of print].
-
(2014)
Thyroid
-
-
Falchook, G.S.1
Millward, M.2
Hong, D.3
-
88
-
-
84888811206
-
A multicenter, phase II trial of everolimus in locally advanced or metastatic thyroid cancer of all histologic subtypes
-
Lim SM, Chang H, Yoon MJ et al. A multicenter, phase II trial of everolimus in locally advanced or metastatic thyroid cancer of all histologic subtypes. Ann Oncol 2013;24:3089-3094.
-
(2013)
Ann Oncol
, vol.24
, pp. 3089-3094
-
-
Lim, S.M.1
Chang, H.2
Yoon, M.J.3
-
89
-
-
84922753752
-
-
Cediranib maleate with or without lenalidomide in treating patients with thyroid cancer. Available at, Accessed December 31
-
Cediranib maleate with or without lenalidomide in treating patients with thyroid cancer. Available at https://clinicaltrials.gov/ct2/show/NCT01208051. Accessed December 31, 2014.
-
(2014)
-
-
-
90
-
-
84922738508
-
-
Cabozantinib-S-malate in treating patients with refractory thyroid cancer. Available at, Accessed December 31
-
Cabozantinib-S-malate in treating patients with refractory thyroid cancer. Available at https:// clinicaltrials.gov/ct2/show/NCT01811212. Accessed December 31, 2014.
-
(2014)
-
-
-
91
-
-
84922712000
-
-
A phase II trial of cabozantinib for the treatment of radioiodine (RAI)-refractory differentiated thyroid carcinoma (DTC) in the first-line setting. Available at, Accessed December 31
-
A phase II trial of cabozantinib for the treatment of radioiodine (RAI)-refractory differentiated thyroid carcinoma (DTC) in the first-line setting. Available at https://clinicaltrials.gov/ct2/show/NCT02041260. Accessed December 31, 2014.
-
(2014)
-
-
-
92
-
-
84922728391
-
-
Dabrafenib with or without trametinib in treating patients with recurrent thyroid cancer. Available at, Accessed December 31
-
Dabrafenib with or without trametinib in treating patients with recurrent thyroid cancer. Available at https://clinicaltrials.gov/ct2/show/NCT01723202. Accessed December 31, 2014.
-
(2014)
-
-
-
93
-
-
84922698742
-
-
RAD001 for patients with radioiodine refractory thyroid cancer.Available at, Accessed December 31
-
RAD001 for patients with radioiodine refractory thyroid cancer.Available at https://clinicaltrials.gov/ct2/show/NCT00936858. Accessed December 31, 2014.
-
(2014)
-
-
-
94
-
-
84922739717
-
-
Everolimus in treating patients with locally advanced or metastatic thyroid cancer. Available at, Accessed December 31
-
Everolimus in treating patients with locally advanced or metastatic thyroid cancer. Available at https://clinicaltrials.gov/ct2/show/NCT01164176. Accessed December 31, 2014.
-
(2014)
-
-
-
95
-
-
84922712745
-
-
Everolimus in treating patients with progressive or recurrent, unresectable, or metastatic thyroid cancer. Available at, Accessed December 31
-
Everolimus in treating patients with progressive or recurrent, unresectable, or metastatic thyroid cancer. Available at https://clinicaltrials.gov/ct2/show/NCT01118065. Accessed December 31, 2014.
-
(2014)
-
-
-
96
-
-
84922705698
-
-
Study of everolimus and sorafenib in patients with advanced thyroid cancer who progressed on sorafenib alone. Available at, Accessed December 31
-
Study of everolimus and sorafenib in patients with advanced thyroid cancer who progressed on sorafenib alone. Available at https://clinicaltrials.gov/ct2/show/NCT01263951. Accessed December 31, 2014.
-
(2014)
-
-
-
97
-
-
84922737116
-
-
Evaluating the combination of everolimus and sorafenib in the treatment of thyroid cancer. Available at, Accessed December 31
-
Evaluating the combination of everolimus and sorafenib in the treatment of thyroid cancer. Available at https://clinicaltrials.gov/ct2/show/NCT01141309. Accessed December 31, 2014.
-
(2014)
-
-
-
98
-
-
84922717526
-
-
A trial of pasireotide and everolimus in adult patients with radioiodine-refractory differentiated and medullary thyroid cancer. Available at, Accessed December 31
-
A trial of pasireotide and everolimus in adult patients with radioiodine-refractory differentiated and medullary thyroid cancer. Available at https://clinicaltrials.gov/ct2/show/NCT01270321. Accessed December 31, 2014.
-
(2014)
-
-
-
99
-
-
84922741285
-
-
A multicenter, randomized, double-blind, placebo-controlled, phase 3 trial of lenvatinib (E7080) in 131I-refractory differentiated thyroid cancer. Available at, Accessed December 31
-
A multicenter, randomized, double-blind, placebo-controlled, phase 3 trial of lenvatinib (E7080) in 131I-refractory differentiated thyroid cancer. Available at https://clinicaltrials.gov/ct2/show/NCT01321554. Accessed December 31, 2014.
-
(2014)
-
-
-
100
-
-
84922709527
-
-
Pazopanib hydrochloride in treating patients with advanced thyroid cancer. Available at, Accessed December 31
-
Pazopanib hydrochloride in treating patients with advanced thyroid cancer. Available at https://clinicaltrials.gov/ct2/show/NCT00625846. Accessed December 31, 2014.
-
(2014)
-
-
-
101
-
-
84922733516
-
-
Phase II study of the optimal scheme of administration of pazopanib in thyroid carcinoma. Available at, Accessed December 31
-
Phase II study of the optimal scheme of administration of pazopanib in thyroid carcinoma. Available at https://clinicaltrials.gov/ct2/show/NCT01813136. Accessed December 31, 2014.
-
(2014)
-
-
-
102
-
-
84922731802
-
-
AZD6244 in treating patients with papillary thyroid cancer that did not respond to radioactive iodine. Available at, Accessed December 31
-
AZD6244 in treating patients with papillary thyroid cancer that did not respond to radioactive iodine. Available at https://clinicaltrials.gov/ct2/show/NCT00559949. Accessed December 31, 2014.
-
(2014)
-
-
-
103
-
-
84922752879
-
-
Sunitinib in treating patients with thyroid cancer that did not respond to iodine I 131 and cannot be removed by surgery. Available at, Accessed December 31
-
Sunitinib in treating patients with thyroid cancer that did not respond to iodine I 131 and cannot be removed by surgery. Available at https://clinicaltrials.gov/ct2/show/NCT00381641. Accessed December 31, 2014.
-
(2014)
-
-
-
104
-
-
84922694951
-
-
Sutentadjunctive treatment of differentiated thyroid cancer (IIT Sutent). Available at, Accessed December 31
-
Sutentadjunctive treatment of differentiated thyroid cancer (IIT Sutent). Available at https:// clinicaltrials.gov/ct2/show/NCT00668811. Accessed December 31, 2014.
-
(2014)
-
-
-
105
-
-
84922732910
-
-
Sunitinib malate in treating patients with iodine-refractory recurrent or metastatic thyroid cancer. Available at, Accessed December 31
-
Sunitinib malate in treating patients with iodine-refractory recurrent or metastatic thyroid cancer. Available at https://clinicaltrials.gov/ct2/show/NCT00519896. Accessed December 31, 2014.
-
(2014)
-
-
-
106
-
-
84922738058
-
-
Combination of temsirolimus and sorafenib in the treatment of radioactive iodine refractory thyroid cancer. Available at, Accessed December 31
-
Combination of temsirolimus and sorafenib in the treatment of radioactive iodine refractory thyroid cancer. Available at https://clinicaltrials.gov/ct2/show/NCT01025453. Accessed December 31, 2014.
-
(2014)
-
-
-
107
-
-
84922709059
-
-
Evaluation of efficacy, safety of vandetanib in patients with differentiatedthyroidcancer (VERIFY). Available at, Accessed December 31
-
Evaluation of efficacy, safety of vandetanib in patients with differentiatedthyroidcancer (VERIFY). Available at https://clinicaltrials.gov/ct2/show/NCT01876784. Accessed December 31, 2014.
-
(2014)
-
-
-
108
-
-
84922711646
-
-
A study of RO5185426 (vemurafenib) in patients with metastatic or unresectable papillary thyroid cancer positive for the BRAF V600 mutation. Available at, Accessed December 31
-
A study of RO5185426 (vemurafenib) in patients with metastatic or unresectable papillary thyroid cancer positive for the BRAF V600 mutation. Available at https://clinicaltrials.gov/ct2/show/NCT01286753. Accessed December 31, 2014.
-
(2014)
-
-
-
109
-
-
84922757684
-
-
Vemurafenib neoadjuvant trial in locally advanced thyroid cancer. Available at, Accessed December 31
-
Vemurafenib neoadjuvant trial in locally advanced thyroid cancer. Available at https://clinicaltrials.gov/ct2/show/NCT01709292. Accessed December 31, 2014.
-
(2014)
-
-
-
110
-
-
84922713105
-
Genetic profiling of advanced RAI-resistant differentiated thyroid cancer and correlation with axitinib response
-
Schechter RB, Nagilla M, Joseph L et al. Genetic profiling of advanced RAI-resistant differentiated thyroid cancer and correlation with axitinib response. J Clin Oncol 2013;31(suppl):6066a.
-
(2013)
J Clin Oncol
, vol.31
, pp. 6066a
-
-
Schechter, R.B.1
Nagilla, M.2
Joseph, L.3
-
111
-
-
84922711537
-
Association between tumor BRAF andRASmutation status and clinical outcomes in patients with radioactive iodine (RAI)-refractory differentiated thyroid cancer (DTC) randomized to sorafenib or placebo: Subanalysis of the phase III DECISION trial
-
Brose MS, Nutting C, Shong YK et al. Association between tumor BRAF andRASmutation status and clinical outcomes in patients with radioactive iodine (RAI)-refractory differentiated thyroid cancer (DTC) randomized to sorafenib or placebo: Subanalysis of the phase III DECISION trial. Eur J Cancer 2013;49(suppl 2):O3155.
-
(2013)
Eur J Cancer
, vol.49
, pp. O3155
-
-
Brose, M.S.1
Nutting, C.2
Shong, Y.K.3
-
112
-
-
84922689721
-
Pazopanib resistance induced by in vitro selection of BHP2-7 papillary thyroid cancer cells is associated with acquired KRAS mutation and more aggressive in vivo phenotype
-
A-78
-
Isham CR, Netzel BC, Bossou AR et al. Pazopanib resistance induced by in vitro selection of BHP2-7 papillary thyroid cancer cells is associated with acquired KRAS mutation and more aggressive in vivo phenotype. Thyroid 2013;23:A-78.
-
(2013)
Thyroid
, vol.23
-
-
Isham, C.R.1
Netzel, B.C.2
Bossou, A.R.3
-
113
-
-
84877581959
-
Lenvatinib treatment of advanced RAI-refractory differentiated thyroid cancer (DTC): Cytokine and angiogenic factor (CAF) profiling in combination with tumor genetic analysis to identify markers associated with response
-
Ball DW, Sherman SI, Jarzab B et al. Lenvatinib treatment of advanced RAI-refractory differentiated thyroid cancer (DTC): Cytokine and angiogenic factor (CAF) profiling in combination with tumor genetic analysis to identify markers associated with response. J Clin Oncol 2012;30(suppl):5518a.
-
(2012)
J Clin Oncol
, vol.30
, pp. 5518a
-
-
Ball, D.W.1
Sherman, S.I.2
Jarzab, B.3
-
114
-
-
84922760285
-
-
Study of AG-013736 in patients with 131Irefractory thyroid cancer. Available at, Accessed December 31
-
Study of AG-013736 in patients with 131Irefractory thyroid cancer. Available at https://clinicaltrials.gov/ct2/show/NCT00389441. Accessed December 31, 2014.
-
(2014)
-
-
-
115
-
-
84922708781
-
-
Nexavar (sorafenib) [prescribing information]. Wayne, NJ: Bayer HealthCare Pharmaceuticals Inc
-
Nexavar (sorafenib) [prescribing information]. Wayne, NJ: Bayer HealthCare Pharmaceuticals Inc; 2013.
-
(2013)
-
-
-
116
-
-
84901265163
-
Aerodigestive fistula formation as a rare side effect of antiangiogenic tyrosine kinase inhibitor therapy for thyroid cancer
-
Blevins DP, Dadu R, Hu M et al. Aerodigestive fistula formation as a rare side effect of antiangiogenic tyrosine kinase inhibitor therapy for thyroid cancer. Thyroid 2014;24:918-922.
-
(2014)
Thyroid
, vol.24
, pp. 918-922
-
-
Blevins, D.P.1
Dadu, R.2
Hu, M.3
-
117
-
-
84867770488
-
Sunitiniband sorafenib-induced nephrotic syndrome in a patient with gastrointestinal stromal tumor
-
Turan N, Benekli M, Ozturk SC et al. Sunitiniband sorafenib-induced nephrotic syndrome in a patient with gastrointestinal stromal tumor. Ann Pharmacother 2012;46:e27.
-
(2012)
Ann Pharmacother
, vol.46
-
-
Turan, N.1
Benekli, M.2
Ozturk, S.C.3
-
118
-
-
84899076200
-
Images in clinical medicine. Sunitinib-associated hair depigmentation
-
Brzezniak C, Szabo E. Images in clinical medicine. Sunitinib-associated hair depigmentation. N Engl J Med 2014;370:e27.
-
(2014)
N Engl J Med
, vol.370
-
-
Brzezniak, C.1
Szabo, E.2
-
119
-
-
84902334839
-
Role of salvage targeted therapy in differentiated thyroid cancer patients who failed first-line sorafenib
-
Dadu R, Devine C, Hernandez M et al. Role of salvage targeted therapy in differentiated thyroid cancer patients who failed first-line sorafenib. J Clin Endocrinol Metab 2014;99: 2086-2094.
-
(2014)
J Clin Endocrinol Metab
, vol.99
, pp. 2086-2094
-
-
Dadu, R.1
Devine, C.2
Hernandez, M.3
-
120
-
-
84899477812
-
Tyrosine kinase inhibitor treatments in patients with metastatic thyroid carcinomas: A retrospective study of the TUTHYREF network
-
Massicotte MH, Brassard M, Claude-Desroches M et al. Tyrosine kinase inhibitor treatments in patients with metastatic thyroid carcinomas: A retrospective study of the TUTHYREF network. Eur J Endocrinol 2014;170:575-582.
-
(2014)
Eur J Endocrinol
, vol.170
, pp. 575-582
-
-
Massicotte, M.H.1
Brassard, M.2
Claude-Desroches, M.3
-
121
-
-
84897874155
-
Re-differentiation of radioiodine-refractory BRAF V600E-mutant thyroid carcinoma with dabrafenib: A pilot study
-
Rothenberg SM, McFadden DG, Palmer E et al. Re-differentiation of radioiodine-refractory BRAF V600E-mutant thyroid carcinoma with dabrafenib: A pilot study. J Clin Oncol 2013;31(suppl): 6025a.
-
(2013)
J Clin Oncol
, vol.31
, pp. 6025a
-
-
Rothenberg, S.M.1
McFadden, D.G.2
Palmer, E.3
-
122
-
-
84868224906
-
Combined BRAF and MEK inhibition in melanoma with BRAF V600 mutations
-
Flaherty KT, Infante JR, Daud A et al. Combined BRAF and MEK inhibition in melanoma with BRAF V600 mutations. N Engl J Med 2012;367: 1694-1703.
-
(2012)
N Engl J Med
, vol.367
, pp. 1694-1703
-
-
Flaherty, K.T.1
Infante, J.R.2
Daud, A.3
-
123
-
-
84884597338
-
MEK inhibition in the treatment of advanced melanoma
-
Salama AK, Kim KB. MEK inhibition in the treatment of advanced melanoma. Curr Oncol Rep 2013;15:473-482.
-
(2013)
Curr Oncol Rep
, vol.15
, pp. 473-482
-
-
Salama, A.K.1
Kim, K.B.2
|