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Volumn 20, Issue 2, 2015, Pages 113-126

Differentiated thyroid cancer: Focus on emerging treatments for radioactive iodine-refractory patients

Author keywords

BRAF inhibitors; Follicular thyroid cancer; MEK inhibitors; Papillary thyroid cancer; Radioactive iodine refractory differentiated thyroid cancer; Tyrosine kinase inhibitors

Indexed keywords

AXITINIB; BEVACIZUMAB; CABOZANTINIB; CEDIRANIB; DABRAFENIB; EPIDERMAL GROWTH FACTOR RECEPTOR; EVEROLIMUS; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LENVATINIB; MOTESANIB; PASIREOTIDE; PAZOPANIB; PLACEBO; PLATELET DERIVED GROWTH FACTOR RECEPTOR; RADIOACTIVE IODINE; RAPAMYCIN; SELUMETINIB; SORAFENIB; SUNITINIB; TEMSIROLIMUS; VANDETANIB; VASCULOTROPIN RECEPTOR; VEMURAFENIB; B RAF KINASE; BRAF PROTEIN, HUMAN; CARBANILAMIDE DERIVATIVE; IMETELSTAT; INDOLE DERIVATIVE; MITOGEN ACTIVATED PROTEIN KINASE KINASE KINASE 1; NICOTINAMIDE; PROTEIN KINASE INHIBITOR;

EID: 84922713837     PISSN: 10837159     EISSN: 1549490X     Source Type: Journal    
DOI: 10.1634/theoncologist.2014-0313     Document Type: Article
Times cited : (58)

References (123)
  • 1
    • 84922728091 scopus 로고    scopus 로고
    • SEER stat fact sheets: Thyroid cancer. Available at, Accessed December 31
    • SEER stat fact sheets: Thyroid cancer. Available at http://seer.cancer.gov/statfacts/html/thyro.html. Accessed December 31, 2014.
    • (2014)
  • 2
    • 64549114616 scopus 로고    scopus 로고
    • Rising thyroid cancer incidence in the United States by demographic and tumor characteristics, 1980-2005
    • Enewold L, Zhu K, Ron E et al. Rising thyroid cancer incidence in the United States by demographic and tumor characteristics, 1980-2005. Cancer Epidemiol Biomarkers Prev 2009;18: 784-791.
    • (2009) Cancer Epidemiol Biomarkers Prev , vol.18 , pp. 784-791
    • Enewold, L.1    Zhu, K.2    Ron, E.3
  • 3
    • 84857659152 scopus 로고    scopus 로고
    • Well differentiated thyroid carcinoma: Current treatment
    • Byrd JK, Yawn RJ, Wilhoit CS et al. Well differentiated thyroid carcinoma: Current treatment. Curr Treat Options Oncol 2012;13:47-57.
    • (2012) Curr Treat Options Oncol , vol.13 , pp. 47-57
    • Byrd, J.K.1    Yawn, R.J.2    Wilhoit, C.S.3
  • 4
    • 84865589843 scopus 로고    scopus 로고
    • The impact of distant metastases at presentation on prognosis in patients with differentiated carcinoma of the thyroid gland
    • Nixon IJ, Whitcher MM, Palmer FL et al. The impact of distant metastases at presentation on prognosis in patients with differentiated carcinoma of the thyroid gland. Thyroid 2012;22: 884-889.
    • (2012) Thyroid , vol.22 , pp. 884-889
    • Nixon, I.J.1    Whitcher, M.M.2    Palmer, F.L.3
  • 5
  • 6
    • 0022547135 scopus 로고
    • Long-term results of treatment of 283 patients with lung and bone metastases from differentiated thyroid carcinoma
    • Schlumberger M, Tubiana M, De Vathaire F et al. Long-term results of treatment of 283 patients with lung and bone metastases from differentiated thyroid carcinoma. J Clin Endocrinol Metab 1986; 63:960-967.
    • (1986) J Clin Endocrinol Metab , vol.63 , pp. 960-967
    • Schlumberger, M.1    Tubiana, M.2    De Vathaire, F.3
  • 7
    • 33747642244 scopus 로고    scopus 로고
    • Long-term outcome of 444 patients with distant metastases from papillary and follicular thyroid carcinoma: Benefits and limits of radioiodine therapy
    • Durante C, Haddy N, Baudin E et al. Long-term outcome of 444 patients with distant metastases from papillary and follicular thyroid carcinoma: Benefits and limits of radioiodine therapy. J Clin Endocrinol Metab 2006;91:2892-2899.
    • (2006) J Clin Endocrinol Metab , vol.91 , pp. 2892-2899
    • Durante, C.1    Haddy, N.2    Baudin, E.3
  • 8
    • 0037363923 scopus 로고    scopus 로고
    • Radioactive iodine and the salivary glands
    • Mandel SJ, Mandel L. Radioactive iodine and the salivary glands. Thyroid 2003;13:265-271.
    • (2003) Thyroid , vol.13 , pp. 265-271
    • Mandel, S.J.1    Mandel, L.2
  • 9
    • 0036885164 scopus 로고    scopus 로고
    • Nasolacrimal drainage system obstruction from radioactive iodine therapy for thyroid carcinoma
    • Kloos RT, Duvuuri V, Jhiang SM et al. Nasolacrimal drainage system obstruction from radioactive iodine therapy for thyroid carcinoma. J Clin Endocrinol Metab 2002;87:5817-5820.
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 5817-5820
    • Kloos, R.T.1    Duvuuri, V.2    Jhiang, S.M.3
  • 10
    • 77649301564 scopus 로고    scopus 로고
    • Pulmonary fibrosis following radioiodine therapy of pulmonary metastases from differentiated thyroid carcinoma
    • Chen L, Shen Y, Luo Q et al. Pulmonary fibrosis following radioiodine therapy of pulmonary metastases from differentiated thyroid carcinoma. Thyroid 2010;20:337-340.
    • (2010) Thyroid , vol.20 , pp. 337-340
    • Chen, L.1    Shen, Y.2    Luo, Q.3
  • 11
    • 0345303967 scopus 로고    scopus 로고
    • Second primary malignancies in thyroid cancer patients
    • Rubino C, de Vathaire F, Dottorini ME et al. Second primary malignancies in thyroid cancer patients. Br J Cancer 2003;89:1638-1644.
    • (2003) Br J Cancer , vol.89 , pp. 1638-1644
    • Rubino, C.1    De Vathaire, F.2    Dottorini, M.E.3
  • 12
    • 70449370231 scopus 로고    scopus 로고
    • RevisedAmerican Thyroid Associationmanagement guidelines for patients with thyroid nodules and differentiated thyroid cancer
    • Cooper DS, Doherty GM, Haugen BR et al. RevisedAmerican Thyroid Associationmanagement guidelines for patients with thyroid nodules and differentiated thyroid cancer. Thyroid 2009;19: 1167-1214.
    • (2009) Thyroid , vol.19 , pp. 1167-1214
    • Cooper, D.S.1    Doherty, G.M.2    Haugen, B.R.3
  • 13
    • 32544437659 scopus 로고    scopus 로고
    • Real-time prognosis for metastatic thyroid carcinoma based on 2-[18F]fluoro-2-deoxy-D-glucose-positron emission tomography scanning
    • Robbins RJ, Wan Q, Grewal RK et al. Real-time prognosis for metastatic thyroid carcinoma based on 2-[18F]fluoro-2-deoxy-D-glucose-positron emission tomography scanning. J Clin Endocrinol Metab 2006;91:498-505.
    • (2006) J Clin Endocrinol Metab , vol.91 , pp. 498-505
    • Robbins, R.J.1    Wan, Q.2    Grewal, R.K.3
  • 14
    • 84875361065 scopus 로고    scopus 로고
    • Molecular pathogenesis and mechanisms of thyroid cancer
    • Xing M. Molecular pathogenesis and mechanisms of thyroid cancer. Nat Rev Cancer 2013;13: 184-199.
    • (2013) Nat Rev Cancer , vol.13 , pp. 184-199
    • Xing, M.1
  • 15
    • 0038664387 scopus 로고    scopus 로고
    • BRAF mutation in papillary thyroid carcinoma
    • Cohen Y, Xing M, Mambo E et al. BRAF mutation in papillary thyroid carcinoma. J Natl Cancer Inst 2003;95:625-627.
    • (2003) J Natl Cancer Inst , vol.95 , pp. 625-627
    • Cohen, Y.1    Xing, M.2    Mambo, E.3
  • 16
    • 0141453014 scopus 로고    scopus 로고
    • Clinical implication of hot spot BRAF mutation, V599E, in papillary thyroid cancers
    • Namba H, Nakashima M, Hayashi T et al. Clinical implication of hot spot BRAF mutation, V599E, in papillary thyroid cancers. J Clin Endocrinol Metab 2003;88:4393-4397.
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 4393-4397
    • Namba, H.1    Nakashima, M.2    Hayashi, T.3
  • 17
    • 0041589377 scopus 로고    scopus 로고
    • High prevalence of BRAF gene mutation in papillary thyroid carcinomas and thyroid tumor cell lines
    • Xu X, Quiros RM, Gattuso P et al. High prevalence of BRAF gene mutation in papillary thyroid carcinomas and thyroid tumor cell lines. Cancer Res 2003;63:4561-4567.
    • (2003) Cancer Res , vol.63 , pp. 4561-4567
    • Xu, X.1    Quiros, R.M.2    Gattuso, P.3
  • 18
    • 0142135475 scopus 로고    scopus 로고
    • BRAF mutations in papillary carcinomas of the thyroid
    • Fukushima T, Suzuki S, Mashiko M et al. BRAF mutations in papillary carcinomas of the thyroid. Oncogene 2003;22:6455-6457.
    • (2003) Oncogene , vol.22 , pp. 6455-6457
    • Fukushima, T.1    Suzuki, S.2    Mashiko, M.3
  • 19
    • 49249127826 scopus 로고    scopus 로고
    • Highly prevalent genetic alterations in receptor tyrosine kinases and phosphatidylinositol 3-kinase/Akt and mitogenactivated protein kinase pathways in anaplastic and follicular thyroid cancers
    • Liu Z, Hou P, Ji M et al. Highly prevalent genetic alterations in receptor tyrosine kinases and phosphatidylinositol 3-kinase/Akt and mitogenactivated protein kinase pathways in anaplastic and follicular thyroid cancers. J Clin Endocrinol Metab 2008;93:3106-3116.
    • (2008) J Clin Endocrinol Metab , vol.93 , pp. 3106-3116
    • Liu, Z.1    Hou, P.2    Ji, M.3
  • 20
    • 34347251976 scopus 로고    scopus 로고
    • High prevalence and mutual exclusivity of genetic alterations in the phosphatidylinositol-3-kinase/Akt pathway in thyroid tumors
    • Wang Y, Hou P, Yu H et al. High prevalence and mutual exclusivity of genetic alterations in the phosphatidylinositol-3-kinase/Akt pathway in thyroid tumors. J Clin Endocrinol Metab 2007;92: 2387-2390.
    • (2007) J Clin Endocrinol Metab , vol.92 , pp. 2387-2390
    • Wang, Y.1    Hou, P.2    Yu, H.3
  • 21
    • 33947284529 scopus 로고    scopus 로고
    • Genetic alterations and their relationship in the phosphatidylinositol 3-kinase/Akt pathway in thyroid cancer
    • Hou P, Liu D, Shan Y et al. Genetic alterations and their relationship in the phosphatidylinositol 3-kinase/Akt pathway in thyroid cancer. Clin Cancer Res 2007;13:1161-1170.
    • (2007) Clin Cancer Res , vol.13 , pp. 1161-1170
    • Hou, P.1    Liu, D.2    Shan, Y.3
  • 22
    • 66349098309 scopus 로고    scopus 로고
    • Mutational profile of advanced primary and metastatic radioactive iodine-refractory thyroid cancers reveals distinct pathogenetic roles forBRAF, PIK3CA, and AKT1
    • Ricarte-Filho JC, Ryder M, Chitale DA et al. Mutational profile of advanced primary and metastatic radioactive iodine-refractory thyroid cancers reveals distinct pathogenetic roles forBRAF, PIK3CA, and AKT1. Cancer Res 2009;69:4885-4893.
    • (2009) Cancer Res , vol.69 , pp. 4885-4893
    • Ricarte-Filho, J.C.1    Ryder, M.2    Chitale, D.A.3
  • 23
    • 0141465066 scopus 로고    scopus 로고
    • Ras mutations are associated with aggressive tumor phenotypes and poor prognosis in thyroid cancer
    • Garcia-Rostan G, Zhao H, Camp RL et al. ras mutations are associated with aggressive tumor phenotypes and poor prognosis in thyroid cancer. J Clin Oncol 2003;21:3226-3235.
    • (2003) J Clin Oncol , vol.21 , pp. 3226-3235
    • Garcia-Rostan, G.1    Zhao, H.2    Camp, R.L.3
  • 24
    • 0033951970 scopus 로고    scopus 로고
    • N-ras mutation in poorly differentiated thyroid carcinomas: Correlation with bone metastases and inverse correlation to thyroglobulin expression
    • Basolo F, Pisaturo F, Pollina LE et al. N-ras mutation in poorly differentiated thyroid carcinomas: Correlation with bone metastases and inverse correlation to thyroglobulin expression. Thyroid 2000;10:19-23.
    • (2000) Thyroid , vol.10 , pp. 19-23
    • Basolo, F.1    Pisaturo, F.2    Pollina, L.E.3
  • 25
    • 84863500976 scopus 로고    scopus 로고
    • The associations between RAS mutations and clinical characteristics in follicular thyroid tumors: New insights from a single center and a large patient cohort
    • Fukahori M, Yoshida A, Hayashi H et al. The associations between RAS mutations and clinical characteristics in follicular thyroid tumors: New insights from a single center and a large patient cohort. Thyroid 2012;22:683-689.
    • (2012) Thyroid , vol.22 , pp. 683-689
    • Fukahori, M.1    Yoshida, A.2    Hayashi, H.3
  • 26
    • 85047687680 scopus 로고    scopus 로고
    • Molecular profile and clinical-pathologic features of the follicular variant of papillary thyroid carcinoma. An unusually high prevalence of ras mutations
    • Zhu Z, Gandhi M, Nikiforova MN et al. Molecular profile and clinical-pathologic features of the follicular variant of papillary thyroid carcinoma. An unusually high prevalence of ras mutations. Am J Clin Pathol 2003;120:71-77.
    • (2003) Am J Clin Pathol , vol.120 , pp. 71-77
    • Zhu, Z.1    Gandhi, M.2    Nikiforova, M.N.3
  • 27
    • 0028030757 scopus 로고
    • Selective activation of ras oncogenes in follicular and undifferentiated thyroid carcinomas
    • Manenti G, Pilotti S, Re FC et al. Selective activation of ras oncogenes in follicular and undifferentiated thyroid carcinomas. Eur J Cancer 1994;30A:987-993.
    • (1994) Eur J Cancer , vol.30 A , pp. 987-993
    • Manenti, G.1    Pilotti, S.2    Re, F.C.3
  • 28
    • 0034016275 scopus 로고    scopus 로고
    • Pattern of radiation-induced RET and NTRK1 rearrangements in 191 post-chernobyl papillary thyroid carcinomas: Biological, phenotypic, and clinical implications
    • Rabes HM, Demidchik EP, Sidorow JD et al. Pattern of radiation-induced RET and NTRK1 rearrangements in 191 post-chernobyl papillary thyroid carcinomas: Biological, phenotypic, and clinical implications. Clin Cancer Res 2000;6: 1093-1103.
    • (2000) Clin Cancer Res , vol.6 , pp. 1093-1103
    • Rabes, H.M.1    Demidchik, E.P.2    Sidorow, J.D.3
  • 29
    • 0033985035 scopus 로고    scopus 로고
    • Gene rearrangement and Chernobyl related thyroid cancers
    • Santoro M, Thomas GA, Vecchio G et al. Gene rearrangement and Chernobyl related thyroid cancers. Br J Cancer 2000;82:315-322.
    • (2000) Br J Cancer , vol.82 , pp. 315-322
    • Santoro, M.1    Thomas, G.A.2    Vecchio, G.3
  • 30
    • 0032485045 scopus 로고    scopus 로고
    • Molecular analysis of new subtypes of ELE/RET rearrangements, their reciprocal transcripts and breakpointsinpapillarythyroidcarcinomasofchildren after Chernobyl
    • Klugbauer S, Demidchik EP, Lengfelder E et al. Molecular analysis of new subtypes of ELE/RET rearrangements, their reciprocal transcripts and breakpointsinpapillarythyroidcarcinomasofchildren after Chernobyl. Oncogene 1998;16:671-675.
    • (1998) Oncogene , vol.16 , pp. 671-675
    • Klugbauer, S.1    Demidchik, E.P.2    Lengfelder, E.3
  • 31
    • 39049169179 scopus 로고    scopus 로고
    • Clinicopathological analysis of papillary thyroid cancer with PIK3CA alterations in aMiddle Eastern population
    • Abubaker J, Jehan Z, Bavi P et al. Clinicopathological analysis of papillary thyroid cancer with PIK3CA alterations in aMiddle Eastern population. J Clin Endocrinol Metab 2008;93:611-618.
    • (2008) J Clin Endocrinol Metab , vol.93 , pp. 611-618
    • Abubaker, J.1    Jehan, Z.2    Bavi, P.3
  • 32
    • 38149115262 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase/Akt and ras/rafmitogen-activated protein kinase pathway mutations in anaplastic thyroid cancer
    • Santarpia L, El-Naggar AK, Cote GJ et al. Phosphatidylinositol 3-kinase/Akt and ras/rafmitogen-activated protein kinase pathway mutations in anaplastic thyroid cancer. J Clin Endocrinol Metab 2008;93:278-284.
    • (2008) J Clin Endocrinol Metab , vol.93 , pp. 278-284
    • Santarpia, L.1    El-Naggar, A.K.2    Cote, G.J.3
  • 33
    • 77949262337 scopus 로고    scopus 로고
    • Identification and functional characterization of isocitrate dehydrogenase 1 (IDH1) mutations in thyroid cancer
    • Murugan AK, Bojdani E, Xing M. Identification and functional characterization of isocitrate dehydrogenase 1 (IDH1) mutations in thyroid cancer. Biochem Biophys Res Commun 2010;393:555-559.
    • (2010) Biochem Biophys Res Commun , vol.393 , pp. 555-559
    • Murugan, A.K.1    Bojdani, E.2    Xing, M.3
  • 34
    • 77957835307 scopus 로고    scopus 로고
    • Identification of several novel non-p.R132 IDH1 variants in thyroid carcinomas
    • Hemerly JP, Bastos AU, Cerutti JM. Identification of several novel non-p.R132 IDH1 variants in thyroid carcinomas. Eur J Endocrinol 2010;163:747-755.
    • (2010) Eur J Endocrinol , vol.163 , pp. 747-755
    • Hemerly, J.P.1    Bastos, A.U.2    Cerutti, J.M.3
  • 35
    • 80051699020 scopus 로고    scopus 로고
    • Uncommon GNAQ, MMP8, AKT3, EGFR, andPIK3R1 mutationsin thyroid cancers
    • Murugan AK, Dong J, Xie J et al. Uncommon GNAQ, MMP8, AKT3, EGFR, andPIK3R1 mutationsin thyroid cancers. Endocr Pathol 2011;22:97-102.
    • (2011) Endocr Pathol , vol.22 , pp. 97-102
    • Murugan, A.K.1    Dong, J.2    Xie, J.3
  • 36
    • 0034714190 scopus 로고    scopus 로고
    • PAX8-PPARgamma1 fusion oncogene in human thyroid carcinoma
    • Kroll TG, Sarraf P, Pecciarini L et al. PAX8-PPARgamma1 fusion oncogene in human thyroid carcinoma. Science 2000;289:1357-1360.
    • (2000) Science , vol.289 , pp. 1357-1360
    • Kroll, T.G.1    Sarraf, P.2    Pecciarini, L.3
  • 37
    • 20344366798 scopus 로고    scopus 로고
    • Somatic and germline mutation in GRIM-19, a dual function gene involved in mitochondrial metabolism and cell death, is linked to mitochondrion-rich (Hurthle cell) tumours of the thyroid
    • Máximo V, Botelho T, Capela J et al. Somatic and germline mutation in GRIM-19, a dual function gene involved in mitochondrial metabolism and cell death, is linked to mitochondrion-rich (Hurthle cell) tumours of the thyroid. Br J Cancer 2005;92: 1892-1898.
    • (2005) Br J Cancer , vol.92 , pp. 1892-1898
    • Máximo, V.1    Botelho, T.2    Capela, J.3
  • 38
    • 3042732518 scopus 로고    scopus 로고
    • Molecular pathology of papillary, follicular and Hürthle cell carcinomas of the thyroid
    • Soares P, Máximo V, Sobrinho-Simöes M. Molecular pathology of papillary, follicular and Hürthle cell carcinomas of the thyroid. Arkh Patol 2003;65:45-47.
    • (2003) Arkh Patol , vol.65 , pp. 45-47
    • Soares, P.1    Máximo, V.2    Sobrinho-Simöes, M.3
  • 39
    • 0037379904 scopus 로고    scopus 로고
    • High prevalence of BRAF mutations in thyroid cancer: Genetic evidence for constitutive activation of the RET/PTC-RAS-BRAF signaling pathway in papillary thyroid carcinoma
    • Kimura ET, Nikiforova MN, Zhu Z et al. High prevalence of BRAF mutations in thyroid cancer: Genetic evidence for constitutive activation of the RET/PTC-RAS-BRAF signaling pathway in papillary thyroid carcinoma. Cancer Res 2003;63:1454-1457.
    • (2003) Cancer Res , vol.63 , pp. 1454-1457
    • Kimura, E.T.1    Nikiforova, M.N.2    Zhu, Z.3
  • 40
    • 33748747215 scopus 로고    scopus 로고
    • Influence of the BRAF V600E mutation on expression of vascular endothelial growth factor in papillary thyroid cancer
    • Jo YS, Li S, Song JH et al. Influence of the BRAF V600E mutation on expression of vascular endothelial growth factor in papillary thyroid cancer. J Clin Endocrinol Metab 2006;91:3667-3670.
    • (2006) J Clin Endocrinol Metab , vol.91 , pp. 3667-3670
    • Jo, Y.S.1    Li, S.2    Song, J.H.3
  • 41
    • 84922701972 scopus 로고    scopus 로고
    • Center for Drug Evaluation and Research, application no. 202324Orig1s000: Pharmacology review(s). Available at, AccessedDecember 31
    • Center for Drug Evaluation and Research, application no. 202324Orig1s000: Pharmacology review(s). Available at http://www.accessdata.fda.gov/drugsatfda_docs/nda/2012/202324Orig1s000PharmR.pdf. AccessedDecember 31, 2014.
    • (2014)
  • 42
    • 58149337448 scopus 로고    scopus 로고
    • Nonclinical antiangiogenesis and antitumor activities of axitinib (AG-013736), an oral, potent, and selective inhibitor of vascular endothelial growth factor receptor tyrosine kinases 1, 2, 3
    • Hu-Lowe DD, Zou HY, Grazzini ML et al. Nonclinical antiangiogenesis and antitumor activities of axitinib (AG-013736), an oral, potent, and selective inhibitor of vascular endothelial growth factor receptor tyrosine kinases 1, 2, 3. Clin Cancer Res 2008;14:7272-7283.
    • (2008) Clin Cancer Res , vol.14 , pp. 7272-7283
    • Hu-Lowe, D.D.1    Zou, H.Y.2    Grazzini, M.L.3
  • 43
    • 84922732545 scopus 로고    scopus 로고
    • Center for Drug Evaluation and Research, application no. 203756Orig1s000: Pharmacology review(s). Available at, Accessed December 31
    • Center for Drug Evaluation and Research, application no. 203756Orig1s000: Pharmacology review(s). Available at http://www.accessdata.fda.gov/drugsatfda_docs/nda/2012/203756Orig1s000PharmR.pdf. Accessed December 31, 2014.
    • (2014)
  • 44
    • 84922760355 scopus 로고    scopus 로고
    • Center for Drug Evaluation and Research, application no. 202806Orig1s000: Pharmacology review(s). Available at, Accessed December 31
    • Center for Drug Evaluation and Research, application no. 202806Orig1s000: Pharmacology review(s). Available at http://www.accessdata.fda.gov/drugsatfda_docs/nda/2013/202806Orig1s000PharmR.pdf. Accessed December 31, 2014.
    • (2014)
  • 45
    • 20144370978 scopus 로고    scopus 로고
    • AZD2171: A highly potent, orally bioavailable, vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor for the treatment of cancer
    • Wedge SR, Kendrew J, Hennequin LF et al. AZD2171: A highly potent, orally bioavailable, vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor for the treatment of cancer. Cancer Res 2005;65:4389-4400.
    • (2005) Cancer Res , vol.65 , pp. 4389-4400
    • Wedge, S.R.1    Kendrew, J.2    Hennequin, L.F.3
  • 46
    • 37349105704 scopus 로고    scopus 로고
    • E7080, a novel inhibitor that targets multiple kinases, has potent antitumor activities against stem cell factor producinghumansmall cell lung cancer H146, based on angiogenesis inhibition
    • Matsui J, Yamamoto Y, Funahashi Y et al. E7080, a novel inhibitor that targets multiple kinases, has potent antitumor activities against stem cell factor producinghumansmall cell lung cancer H146, based on angiogenesis inhibition. Int J Cancer 2008;122: 664-671.
    • (2008) Int J Cancer , vol.122 , pp. 664-671
    • Matsui, J.1    Yamamoto, Y.2    Funahashi, Y.3
  • 47
    • 33749000911 scopus 로고    scopus 로고
    • AMG706, an oral, multikinase inhibitor that selectively targets vascular endothelial growth factor, platelet-derived growth factor, and kit receptors, potently inhibits angiogenesis and induces regression in tumor xenografts
    • Polverino A, Coxon A, Starnes C et al.AMG706, an oral, multikinase inhibitor that selectively targets vascular endothelial growth factor, platelet-derived growth factor, and kit receptors, potently inhibits angiogenesis and induces regression in tumor xenografts. Cancer Res 2006;66:8715-8721.
    • (2006) Cancer Res , vol.66 , pp. 8715-8721
    • Polverino, A.1    Coxon, A.2    Starnes, C.3
  • 48
    • 70449523183 scopus 로고    scopus 로고
    • Myelosuppression and kinase selectivity of multikinase angiogenesis inhibitors
    • Kumar R, Crouthamel MC, Rominger DH et al. Myelosuppression and kinase selectivity of multikinase angiogenesis inhibitors. Br J Cancer 2009;101:1717-1723.
    • (2009) Br J Cancer , vol.101 , pp. 1717-1723
    • Kumar, R.1    Crouthamel, M.C.2    Rominger, D.H.3
  • 49
    • 84922742467 scopus 로고    scopus 로고
    • Center for Drug Evaluation and Research, application no. 22-465: Pharmacology review(s). Available at, Accessed December 31
    • Center for Drug Evaluation and Research, application no. 22-465: Pharmacology review(s). Available at http://www.accessdata.fda.gov/drugsatfda_docs/nda/2009/022465s000_PharmR.pdf. Accessed December 31, 2014.
    • (2014)
  • 50
    • 34447322566 scopus 로고    scopus 로고
    • Pharmacokinetic-pharmacodynamic correlation frommousetohumanwithpazopanib, amultikinase angiogenesis inhibitor with potent antitumor and antiangiogenic activity
    • Kumar R, Knick VB, Rudolph SK et al. Pharmacokinetic-pharmacodynamic correlation frommousetohumanwithpazopanib, amultikinase angiogenesis inhibitor with potent antitumor and antiangiogenic activity. Mol Cancer Ther 2007;6: 2012-2021.
    • (2007) Mol Cancer Ther , vol.6 , pp. 2012-2021
    • Kumar, R.1    Knick, V.B.2    Rudolph, S.K.3
  • 51
    • 84922757586 scopus 로고    scopus 로고
    • Center for Drug Evaluation and Research, approval package for application no. NDA 21-923: Pharmacology review(s). Available at, Accessed December 31
    • Center for Drug Evaluation and Research, approval package for application no. NDA 21-923: Pharmacology review(s). Available at http://www.accessdata.fda.gov/drugsatfda_docs/nda/2005/021923_s000_Nexavar_PharmR.pdf. Accessed December 31, 2014.
    • (2014)
  • 52
    • 4944249117 scopus 로고    scopus 로고
    • BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis
    • Wilhelm SM, Carter C, Tang L et al.BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. Cancer Res 2004;64:7099-7109.
    • (2004) Cancer Res , vol.64 , pp. 7099-7109
    • Wilhelm, S.M.1    Carter, C.2    Tang, L.3
  • 53
    • 84873056956 scopus 로고    scopus 로고
    • Activitybased kinase profiling of approved tyrosine kinase inhibitors
    • Kitagawa D, Yokota K, Gouda M et al. Activitybased kinase profiling of approved tyrosine kinase inhibitors. Genes Cells 2013;18:110-122.
    • (2013) Genes Cells , vol.18 , pp. 110-122
    • Kitagawa, D.1    Yokota, K.2    Gouda, M.3
  • 54
    • 84922703448 scopus 로고    scopus 로고
    • Center for Drug Evaluation and Research, approval package for application no. NDA 21-938 (GIST), NDA 21-968 (MRCC): Pharmacology review (s). Available at, Accessed December 31
    • Center for Drug Evaluation and Research, approval package for application no. NDA 21-938 (GIST), NDA 21-968 (MRCC): Pharmacology review (s). Available at http://www.accessdata.fda.gov/drugsatfda_docs/nda/2006/021938_S000_Sutent_PharmR.pdf. Accessed December 31, 2014.
    • (2014)
  • 55
    • 33947401129 scopus 로고    scopus 로고
    • Biological characterization of ARRY-142886 (AZD6244), a potent, highly selective mitogen-activated protein kinase kinase 1/2 inhibitor
    • Yeh TC, Marsh V, Bernat BA et al. Biological characterization of ARRY-142886 (AZD6244), a potent, highly selective mitogen-activated protein kinase kinase 1/2 inhibitor. Clin Cancer Res 2007; 13:1576-1583.
    • (2007) Clin Cancer Res , vol.13 , pp. 1576-1583
    • Yeh, T.C.1    Marsh, V.2    Bernat, B.A.3
  • 56
    • 84922755664 scopus 로고    scopus 로고
    • Center for Drug Evaluation and Research, application no. 022405Orig1s000: Clinical pharmacology and biopharmaceutics review(s). Available at, AccessedDecember 31
    • Center for Drug Evaluation and Research, application no. 022405Orig1s000: Clinical pharmacology and biopharmaceutics review(s). Available at http://www.accessdata.fda.gov/drugsatfda_docs/nda/2011/022405Orig1s000ClinPharmR.pdf. AccessedDecember 31, 2014.
    • (2014)
  • 57
    • 0037102369 scopus 로고    scopus 로고
    • ZD6474 inhibits vascular endothelial growth factor signaling, angiogenesis, and tumor growth following oral administration
    • Wedge SR, Ogilvie DJ, Dukes M et al. ZD6474 inhibits vascular endothelial growth factor signaling, angiogenesis, and tumor growth following oral administration. Cancer Res 2002;62:4645-4655.
    • (2002) Cancer Res , vol.62 , pp. 4645-4655
    • Wedge, S.R.1    Ogilvie, D.J.2    Dukes, M.3
  • 58
    • 84922742119 scopus 로고    scopus 로고
    • Center for Drug Evaluation and Research, application no. 22-334: Pharmacology review(s). Available at, Accessed December 31
    • Center for Drug Evaluation and Research, application no. 22-334: Pharmacology review(s). Available at http://www.accessdata.fda.gov/drugsatfda_docs/nda/2009/022334s000_PharmR.pdf. Accessed December 31, 2014.
    • (2014)
  • 59
    • 42349113247 scopus 로고    scopus 로고
    • A new pharmacologic action of CCI-779 involves FKBP12-independent inhibition of mTOR kinase activity and profound repression of global protein synthesis
    • Shor B, Zhang WG, Toral-Barza L et al. A new pharmacologic action of CCI-779 involves FKBP12-independent inhibition of mTOR kinase activity and profound repression of global protein synthesis. Cancer Res 2008;68:2934-2943.
    • (2008) Cancer Res , vol.68 , pp. 2934-2943
    • Shor, B.1    Zhang, W.G.2    Toral-Barza, L.3
  • 60
    • 84922708558 scopus 로고    scopus 로고
    • Tafinlar (dabrafenib) [prescribing information]. Research Triangle Park, SC: GlaxoSmithKline
    • Tafinlar (dabrafenib) [prescribing information]. Research Triangle Park, SC: GlaxoSmithKline; 2014.
    • (2014)
  • 61
    • 84922699746 scopus 로고    scopus 로고
    • Center for Drug Evaluation and Research, application no. 202429Orig1s000: Clinical pharmacology and biopharmaceutics review(s). Available at, Accessed December 31
    • Center for Drug Evaluation and Research, application no. 202429Orig1s000: Clinical pharmacology and biopharmaceutics review(s). Available at http://www.accessdata.fda.gov/drugsatfda_docs/nda/2011/202429Orig1s000ClinPharmR.pdf. Accessed December 31, 2014.
    • (2014)
  • 62
    • 77956513286 scopus 로고    scopus 로고
    • Clinical efficacy of aRAFinhibitor needs broadtarget blockade inBRAFmutant melanoma
    • Bollag G, Hirth P, Tsai J et al. Clinical efficacy of aRAFinhibitor needs broadtarget blockade inBRAFmutant melanoma. Nature 2010;467:596-599.
    • (2010) Nature , vol.467 , pp. 596-599
    • Bollag, G.1    Hirth, P.2    Tsai, J.3
  • 63
    • 50649095801 scopus 로고    scopus 로고
    • Axitinib is an active treatment for all histologic subtypes of advanced thyroid cancer: Results from a phase II study
    • Cohen EE, Rosen LS, Vokes EE et al. Axitinib is an active treatment for all histologic subtypes of advanced thyroid cancer: Results from a phase II study. J Clin Oncol 2008;26:4708-4713.
    • (2008) J Clin Oncol , vol.26 , pp. 4708-4713
    • Cohen, E.E.1    Rosen, L.S.2    Vokes, E.E.3
  • 64
    • 84922730925 scopus 로고    scopus 로고
    • Phase 2 trial of axitinib for advanced thyroid cancer: Preliminary activity results [abstract PP17]
    • Locati L, Licitra L, Ou S-HI et al. Phase 2 trial of axitinib for advanced thyroid cancer: Preliminary activity results [abstract PP17]. Eur Arch Otorhinolaryngol 2012;269:1345.
    • (2012) Eur Arch Otorhinolaryngol , vol.269 , pp. 1345
    • Locati, L.1    Licitra, L.2    Ou, S.-H.3
  • 65
    • 40949130884 scopus 로고    scopus 로고
    • A phase II study of gefitinib in patients with advanced thyroid cancer
    • Pennell NA, Daniels GH, Haddad RI et al. A phase II study of gefitinib in patients with advanced thyroid cancer. Thyroid 2008;18:317-323.
    • (2008) Thyroid , vol.18 , pp. 317-323
    • Pennell, N.A.1    Daniels, G.H.2    Haddad, R.I.3
  • 66
    • 80053160399 scopus 로고    scopus 로고
    • A phase II trial of the multitargeted kinase inhibitor E7080 in advanced radioiodine (RAI)-refractory differentiated thyroid cancer (DTC)
    • Sherman SI, Jarzab B, Cabanillas ME et al. A phase II trial of the multitargeted kinase inhibitor E7080 in advanced radioiodine (RAI)-refractory differentiated thyroid cancer (DTC). J Clin Oncol 2011;29(suppl):5503a.
    • (2011) J Clin Oncol , vol.29 , pp. 5503a
    • Sherman, S.I.1    Jarzab, B.2    Cabanillas, M.E.3
  • 67
    • 46449117698 scopus 로고    scopus 로고
    • Motesanib diphosphate in progressive differentiated thyroid cancer
    • Sherman SI, Wirth LJ, Droz JP et al. Motesanib diphosphate in progressive differentiated thyroid cancer. N Engl J Med 2008;359:31-42.
    • (2008) N Engl J Med , vol.359 , pp. 31-42
    • Sherman, S.I.1    Wirth, L.J.2    Droz, J.P.3
  • 68
    • 77957359933 scopus 로고    scopus 로고
    • Efficacy of pazopanib in progressive, radioiodine-refractory, metastatic differentiated thyroid cancers: Results of a phase 2 consortium study
    • Bible KC, Suman VJ, Molina JR et al. Efficacy of pazopanib in progressive, radioiodine-refractory, metastatic differentiated thyroid cancers: Results of a phase 2 consortium study. Lancet Oncol 2010;11: 962-972.
    • (2010) Lancet Oncol , vol.11 , pp. 962-972
    • Bible, K.C.1    Suman, V.J.2    Molina, J.R.3
  • 69
    • 84873681262 scopus 로고    scopus 로고
    • Selumetinibenhanced radioiodine uptake in advanced thyroid cancer
    • Ho AL, Grewal RK, Leboeuf R et al. Selumetinibenhanced radioiodine uptake in advanced thyroid cancer. N Engl J Med 2013;368:623-632.
    • (2013) N Engl J Med , vol.368 , pp. 623-632
    • Ho, A.L.1    Grewal, R.K.2    Leboeuf, R.3
  • 70
    • 84859410770 scopus 로고    scopus 로고
    • Phase II efficacy and pharmacogenomic study of Selumetinib (AZD6244; ARRY-142886) in iodine-131 refractory papillary thyroid carcinomawith or without follicular elements
    • Hayes DN, Lucas AS, Tanvetyanon T et al. Phase II efficacy and pharmacogenomic study of Selumetinib (AZD6244; ARRY-142886) in iodine-131 refractory papillary thyroid carcinomawith or without follicular elements. Clin Cancer Res 2012;18: 2056-2065.
    • (2012) Clin Cancer Res , vol.18 , pp. 2056-2065
    • Hayes, D.N.1    Lucas, A.S.2    Tanvetyanon, T.3
  • 71
    • 63849265332 scopus 로고    scopus 로고
    • Phase II trial of sorafenib in metastatic thyroid cancer
    • Kloos RT, Ringel MD, Knopp MV et al. Phase II trial of sorafenib in metastatic thyroid cancer. J Clin Oncol 2009;27:1675-1684.
    • (2009) J Clin Oncol , vol.27 , pp. 1675-1684
    • Kloos, R.T.1    Ringel, M.D.2    Knopp, M.V.3
  • 72
    • 79953249278 scopus 로고    scopus 로고
    • Response to sorafenib at a low dose in patients with radioiodinerefractory pulmonary metastases from papillary thyroid carcinoma
    • Chen L, Shen Y, Luo Q et al. Response to sorafenib at a low dose in patients with radioiodinerefractory pulmonary metastases from papillary thyroid carcinoma. Thyroid 2011;21:119-124.
    • (2011) Thyroid , vol.21 , pp. 119-124
    • Chen, L.1    Shen, Y.2    Luo, Q.3
  • 73
    • 84887111477 scopus 로고    scopus 로고
    • Sorafenib in locally advanced or metastatic patients with radioactive iodine-refractory differentiated thyroid cancer: The phase III DECISION trial
    • Brose MS, Nutting CM, Jarzab B et al. Sorafenib in locally advanced or metastatic patients with radioactive iodine-refractory differentiated thyroid cancer: The phase III DECISION trial. J Clin Oncol 2013;31(suppl):04a.
    • (2013) J Clin Oncol , vol.31 , pp. 04a
    • Brose, M.S.1    Nutting, C.M.2    Jarzab, B.3
  • 74
    • 50649095250 scopus 로고    scopus 로고
    • Phase II trial of sorafenib in advanced thyroid cancer
    • Gupta-Abramson V, Troxel AB, Nellore A et al. Phase II trial of sorafenib in advanced thyroid cancer. J Clin Oncol 2008;26:4714-4719.
    • (2008) J Clin Oncol , vol.26 , pp. 4714-4719
    • Gupta-Abramson, V.1    Troxel, A.B.2    Nellore, A.3
  • 75
    • 79960179069 scopus 로고    scopus 로고
    • Analysis of the efficacy and toxicity of sorafenib in thyroid cancer: A phase II study in a UK based population
    • Ahmed M, Barbachano Y, Riddell A et al. Analysis of the efficacy and toxicity of sorafenib in thyroid cancer: A phase II study in a UK based population. Eur J Endocrinol 2011;165:315-322.
    • (2011) Eur J Endocrinol , vol.165 , pp. 315-322
    • Ahmed, M.1    Barbachano, Y.2    Riddell, A.3
  • 76
    • 72949106263 scopus 로고    scopus 로고
    • Beneficial effects of sorafenibontumor progression, but not on radioiodine uptake, in patients with differentiated thyroid carcinoma
    • Hoftijzer H, Heemstra KA, Morreau H et al. Beneficial effects of sorafenibontumor progression, but not on radioiodine uptake, in patients with differentiated thyroid carcinoma. Eur J Endocrinol 2009;161:923-931.
    • (2009) Eur J Endocrinol , vol.161 , pp. 923-931
    • Hoftijzer, H.1    Heemstra, K.A.2    Morreau, H.3
  • 77
    • 78049462514 scopus 로고    scopus 로고
    • Phase II study of daily sunitinib in FDG-PET-positive, iodinerefractory differentiated thyroid cancer and metastatic medullary carcinoma of the thyroid with functional imaging correlation
    • Carr LL, Mankoff DA, Goulart BH et al. Phase II study of daily sunitinib in FDG-PET-positive, iodinerefractory differentiated thyroid cancer and metastatic medullary carcinoma of the thyroid with functional imaging correlation. Clin Cancer Res 2010;16:5260-5268.
    • (2010) Clin Cancer Res , vol.16 , pp. 5260-5268
    • Carr, L.L.1    Mankoff, D.A.2    Goulart, B.H.3
  • 78
    • 65749087602 scopus 로고    scopus 로고
    • Phase 2 study of sunitinib in refractory thyroid cancer
    • Cohen EE, Needles BM, Cullen KJ et al. Phase 2 study of sunitinib in refractory thyroid cancer. J Clin Oncol 2008;26(suppl):6025a.
    • (2008) J Clin Oncol , vol.26 , pp. 6025a
    • Cohen, E.E.1    Needles, B.M.2    Cullen, K.J.3
  • 79
    • 84865552505 scopus 로고    scopus 로고
    • Vandetanib in locally advanced or metastatic differentiated thyroid cancer: A randomised, double-blind, phase 2 trial
    • Leboulleux S, Bastholt L, Krause T et al. Vandetanib in locally advanced or metastatic differentiated thyroid cancer: A randomised, double-blind, phase 2 trial. Lancet Oncol 2012;13: 897-905.
    • (2012) Lancet Oncol , vol.13 , pp. 897-905
    • Leboulleux, S.1    Bastholt, L.2    Krause, T.3
  • 80
    • 84912067480 scopus 로고    scopus 로고
    • An open-label, multi-center phase 2 study of the BRAF inhibitor vemurafenib in patients with metastatic or unresectable papillary thyroid cancer (Ptc) positive for the BRAF V600 mutation and resistant to radioactive iodine
    • Brose MS, Cabanillas ME, Cohen EEW et al. An open-label, multi-center phase 2 study of the BRAF inhibitor vemurafenib in patients with metastatic or unresectable papillary thyroid cancer (ptc) positive for the BRAF V600 mutation and resistant to radioactive iodine. Eur J Cancer 2013; 49(suppl 3):LBA28.
    • (2013) Eur J Cancer , vol.49
    • Brose, M.S.1    Cabanillas, M.E.2    Cohen, E.3
  • 81
    • 84904855170 scopus 로고    scopus 로고
    • Sorafenib in radioactive iodine-refractory, locally advanced or metastatic differentiated thyroid cancer: A randomised, double-blind, phase 3 trial
    • Brose MS, Nutting CM, Jarzab B et al. Sorafenib in radioactive iodine-refractory, locally advanced or metastatic differentiated thyroid cancer: A randomised, double-blind, phase 3 trial. Lancet 2014;384: 319-328.
    • (2014) Lancet , vol.384 , pp. 319-328
    • Brose, M.S.1    Nutting, C.M.2    Jarzab, B.3
  • 82
    • 84910633715 scopus 로고    scopus 로고
    • Aphase 3, multicenter, double-blind, placebo-controlled trial of lenvatinib (E7080) in patients with 131I-refractory differentiated thyroid cancer (SELECT)
    • Schlumberger M, Makoto T, Wirth L et al.Aphase 3, multicenter, double-blind, placebo-controlled trial of lenvatinib (E7080) in patients with 131I-refractory differentiated thyroid cancer (SELECT). J Clin Oncol 2014;32(suppl 5):LBA6008.
    • (2014) J Clin Oncol , vol.32
    • Schlumberger, M.1    Makoto, T.2    Wirth, L.3
  • 83
    • 84975871765 scopus 로고    scopus 로고
    • Phase III randomized, double-blinded, placebo-controlled trial of sorafenib in locally advanced or metastatic patients with radioactive iodine (RAI)-refractory differentiated thyroid cancer (DTC)-exploratory analyses of patient-reported outcomes
    • Schlumberger M, Jarzab B, Elisei R et al. Phase III randomized, double-blinded, placebo-controlled trial of sorafenib in locally advanced or metastatic patients with radioactive iodine (RAI)-refractory differentiated thyroid cancer (DTC)-exploratory analyses of patient-reported outcomes. Thyroid 2013;23:A-49-A-50.
    • (2013) Thyroid , vol.23 , pp. A-49
    • Schlumberger, M.1    Jarzab, B.2    Elisei, R.3
  • 84
    • 84911888284 scopus 로고    scopus 로고
    • A phase I study of cabozantinib (XL184) in patients with differentiated thyroid cancer
    • Cabanillas ME, Brose MS, Holland J et al. A phase I study of cabozantinib (XL184) in patients with differentiated thyroid cancer.Thyroid 2014;24: 1508-1514.
    • (2014) Thyroid , vol.24 , pp. 1508-1514
    • Cabanillas, M.E.1    Brose, M.S.2    Holland, J.3
  • 85
    • 84879177690 scopus 로고    scopus 로고
    • Clinical responses to vemurafenib in patients with metastatic papillary thyroid cancer harboring BRAF (V600E) mutation
    • Kim KB, Cabanillas ME, Lazar AJ et al. Clinical responses to vemurafenib in patients with metastatic papillary thyroid cancer harboring BRAF (V600E) mutation. Thyroid 2013;23:1277-1283.
    • (2013) Thyroid , vol.23 , pp. 1277-1283
    • Kim, K.B.1    Cabanillas, M.E.2    Lazar, A.J.3
  • 86
    • 84922718779 scopus 로고    scopus 로고
    • Efficacy and tolerability of vemurafenib in BRAFV600E positive papillary thyroid cancer (PTC)
    • Dadu R, Shah K, Waguespack SG et al. Efficacy and tolerability of vemurafenib in BRAFV600E positive papillary thyroid cancer (PTC). Thyroid 2013;23:A-95-A-96.
    • (2013) Thyroid , vol.23 , pp. A-95
    • Dadu, R.1    Shah, K.2    Waguespack, S.G.3
  • 87
    • 84922707859 scopus 로고    scopus 로고
    • BRAF inhibitor dabrafenib in patients with metastatic BRAF-mutant thyroid cancer
    • Epub ahead of print]
    • Falchook GS, Millward M, Hong D et al. BRAF inhibitor dabrafenib in patients with metastatic BRAF-mutant thyroid cancer. Thyroid 2014 [Epub ahead of print].
    • (2014) Thyroid
    • Falchook, G.S.1    Millward, M.2    Hong, D.3
  • 88
    • 84888811206 scopus 로고    scopus 로고
    • A multicenter, phase II trial of everolimus in locally advanced or metastatic thyroid cancer of all histologic subtypes
    • Lim SM, Chang H, Yoon MJ et al. A multicenter, phase II trial of everolimus in locally advanced or metastatic thyroid cancer of all histologic subtypes. Ann Oncol 2013;24:3089-3094.
    • (2013) Ann Oncol , vol.24 , pp. 3089-3094
    • Lim, S.M.1    Chang, H.2    Yoon, M.J.3
  • 89
    • 84922753752 scopus 로고    scopus 로고
    • Cediranib maleate with or without lenalidomide in treating patients with thyroid cancer. Available at, Accessed December 31
    • Cediranib maleate with or without lenalidomide in treating patients with thyroid cancer. Available at https://clinicaltrials.gov/ct2/show/NCT01208051. Accessed December 31, 2014.
    • (2014)
  • 90
    • 84922738508 scopus 로고    scopus 로고
    • Cabozantinib-S-malate in treating patients with refractory thyroid cancer. Available at, Accessed December 31
    • Cabozantinib-S-malate in treating patients with refractory thyroid cancer. Available at https:// clinicaltrials.gov/ct2/show/NCT01811212. Accessed December 31, 2014.
    • (2014)
  • 91
    • 84922712000 scopus 로고    scopus 로고
    • A phase II trial of cabozantinib for the treatment of radioiodine (RAI)-refractory differentiated thyroid carcinoma (DTC) in the first-line setting. Available at, Accessed December 31
    • A phase II trial of cabozantinib for the treatment of radioiodine (RAI)-refractory differentiated thyroid carcinoma (DTC) in the first-line setting. Available at https://clinicaltrials.gov/ct2/show/NCT02041260. Accessed December 31, 2014.
    • (2014)
  • 92
    • 84922728391 scopus 로고    scopus 로고
    • Dabrafenib with or without trametinib in treating patients with recurrent thyroid cancer. Available at, Accessed December 31
    • Dabrafenib with or without trametinib in treating patients with recurrent thyroid cancer. Available at https://clinicaltrials.gov/ct2/show/NCT01723202. Accessed December 31, 2014.
    • (2014)
  • 93
    • 84922698742 scopus 로고    scopus 로고
    • RAD001 for patients with radioiodine refractory thyroid cancer.Available at, Accessed December 31
    • RAD001 for patients with radioiodine refractory thyroid cancer.Available at https://clinicaltrials.gov/ct2/show/NCT00936858. Accessed December 31, 2014.
    • (2014)
  • 94
    • 84922739717 scopus 로고    scopus 로고
    • Everolimus in treating patients with locally advanced or metastatic thyroid cancer. Available at, Accessed December 31
    • Everolimus in treating patients with locally advanced or metastatic thyroid cancer. Available at https://clinicaltrials.gov/ct2/show/NCT01164176. Accessed December 31, 2014.
    • (2014)
  • 95
    • 84922712745 scopus 로고    scopus 로고
    • Everolimus in treating patients with progressive or recurrent, unresectable, or metastatic thyroid cancer. Available at, Accessed December 31
    • Everolimus in treating patients with progressive or recurrent, unresectable, or metastatic thyroid cancer. Available at https://clinicaltrials.gov/ct2/show/NCT01118065. Accessed December 31, 2014.
    • (2014)
  • 96
    • 84922705698 scopus 로고    scopus 로고
    • Study of everolimus and sorafenib in patients with advanced thyroid cancer who progressed on sorafenib alone. Available at, Accessed December 31
    • Study of everolimus and sorafenib in patients with advanced thyroid cancer who progressed on sorafenib alone. Available at https://clinicaltrials.gov/ct2/show/NCT01263951. Accessed December 31, 2014.
    • (2014)
  • 97
    • 84922737116 scopus 로고    scopus 로고
    • Evaluating the combination of everolimus and sorafenib in the treatment of thyroid cancer. Available at, Accessed December 31
    • Evaluating the combination of everolimus and sorafenib in the treatment of thyroid cancer. Available at https://clinicaltrials.gov/ct2/show/NCT01141309. Accessed December 31, 2014.
    • (2014)
  • 98
    • 84922717526 scopus 로고    scopus 로고
    • A trial of pasireotide and everolimus in adult patients with radioiodine-refractory differentiated and medullary thyroid cancer. Available at, Accessed December 31
    • A trial of pasireotide and everolimus in adult patients with radioiodine-refractory differentiated and medullary thyroid cancer. Available at https://clinicaltrials.gov/ct2/show/NCT01270321. Accessed December 31, 2014.
    • (2014)
  • 99
    • 84922741285 scopus 로고    scopus 로고
    • A multicenter, randomized, double-blind, placebo-controlled, phase 3 trial of lenvatinib (E7080) in 131I-refractory differentiated thyroid cancer. Available at, Accessed December 31
    • A multicenter, randomized, double-blind, placebo-controlled, phase 3 trial of lenvatinib (E7080) in 131I-refractory differentiated thyroid cancer. Available at https://clinicaltrials.gov/ct2/show/NCT01321554. Accessed December 31, 2014.
    • (2014)
  • 100
    • 84922709527 scopus 로고    scopus 로고
    • Pazopanib hydrochloride in treating patients with advanced thyroid cancer. Available at, Accessed December 31
    • Pazopanib hydrochloride in treating patients with advanced thyroid cancer. Available at https://clinicaltrials.gov/ct2/show/NCT00625846. Accessed December 31, 2014.
    • (2014)
  • 101
    • 84922733516 scopus 로고    scopus 로고
    • Phase II study of the optimal scheme of administration of pazopanib in thyroid carcinoma. Available at, Accessed December 31
    • Phase II study of the optimal scheme of administration of pazopanib in thyroid carcinoma. Available at https://clinicaltrials.gov/ct2/show/NCT01813136. Accessed December 31, 2014.
    • (2014)
  • 102
    • 84922731802 scopus 로고    scopus 로고
    • AZD6244 in treating patients with papillary thyroid cancer that did not respond to radioactive iodine. Available at, Accessed December 31
    • AZD6244 in treating patients with papillary thyroid cancer that did not respond to radioactive iodine. Available at https://clinicaltrials.gov/ct2/show/NCT00559949. Accessed December 31, 2014.
    • (2014)
  • 103
    • 84922752879 scopus 로고    scopus 로고
    • Sunitinib in treating patients with thyroid cancer that did not respond to iodine I 131 and cannot be removed by surgery. Available at, Accessed December 31
    • Sunitinib in treating patients with thyroid cancer that did not respond to iodine I 131 and cannot be removed by surgery. Available at https://clinicaltrials.gov/ct2/show/NCT00381641. Accessed December 31, 2014.
    • (2014)
  • 104
    • 84922694951 scopus 로고    scopus 로고
    • Sutentadjunctive treatment of differentiated thyroid cancer (IIT Sutent). Available at, Accessed December 31
    • Sutentadjunctive treatment of differentiated thyroid cancer (IIT Sutent). Available at https:// clinicaltrials.gov/ct2/show/NCT00668811. Accessed December 31, 2014.
    • (2014)
  • 105
    • 84922732910 scopus 로고    scopus 로고
    • Sunitinib malate in treating patients with iodine-refractory recurrent or metastatic thyroid cancer. Available at, Accessed December 31
    • Sunitinib malate in treating patients with iodine-refractory recurrent or metastatic thyroid cancer. Available at https://clinicaltrials.gov/ct2/show/NCT00519896. Accessed December 31, 2014.
    • (2014)
  • 106
    • 84922738058 scopus 로고    scopus 로고
    • Combination of temsirolimus and sorafenib in the treatment of radioactive iodine refractory thyroid cancer. Available at, Accessed December 31
    • Combination of temsirolimus and sorafenib in the treatment of radioactive iodine refractory thyroid cancer. Available at https://clinicaltrials.gov/ct2/show/NCT01025453. Accessed December 31, 2014.
    • (2014)
  • 107
    • 84922709059 scopus 로고    scopus 로고
    • Evaluation of efficacy, safety of vandetanib in patients with differentiatedthyroidcancer (VERIFY). Available at, Accessed December 31
    • Evaluation of efficacy, safety of vandetanib in patients with differentiatedthyroidcancer (VERIFY). Available at https://clinicaltrials.gov/ct2/show/NCT01876784. Accessed December 31, 2014.
    • (2014)
  • 108
    • 84922711646 scopus 로고    scopus 로고
    • A study of RO5185426 (vemurafenib) in patients with metastatic or unresectable papillary thyroid cancer positive for the BRAF V600 mutation. Available at, Accessed December 31
    • A study of RO5185426 (vemurafenib) in patients with metastatic or unresectable papillary thyroid cancer positive for the BRAF V600 mutation. Available at https://clinicaltrials.gov/ct2/show/NCT01286753. Accessed December 31, 2014.
    • (2014)
  • 109
    • 84922757684 scopus 로고    scopus 로고
    • Vemurafenib neoadjuvant trial in locally advanced thyroid cancer. Available at, Accessed December 31
    • Vemurafenib neoadjuvant trial in locally advanced thyroid cancer. Available at https://clinicaltrials.gov/ct2/show/NCT01709292. Accessed December 31, 2014.
    • (2014)
  • 110
    • 84922713105 scopus 로고    scopus 로고
    • Genetic profiling of advanced RAI-resistant differentiated thyroid cancer and correlation with axitinib response
    • Schechter RB, Nagilla M, Joseph L et al. Genetic profiling of advanced RAI-resistant differentiated thyroid cancer and correlation with axitinib response. J Clin Oncol 2013;31(suppl):6066a.
    • (2013) J Clin Oncol , vol.31 , pp. 6066a
    • Schechter, R.B.1    Nagilla, M.2    Joseph, L.3
  • 111
    • 84922711537 scopus 로고    scopus 로고
    • Association between tumor BRAF andRASmutation status and clinical outcomes in patients with radioactive iodine (RAI)-refractory differentiated thyroid cancer (DTC) randomized to sorafenib or placebo: Subanalysis of the phase III DECISION trial
    • Brose MS, Nutting C, Shong YK et al. Association between tumor BRAF andRASmutation status and clinical outcomes in patients with radioactive iodine (RAI)-refractory differentiated thyroid cancer (DTC) randomized to sorafenib or placebo: Subanalysis of the phase III DECISION trial. Eur J Cancer 2013;49(suppl 2):O3155.
    • (2013) Eur J Cancer , vol.49 , pp. O3155
    • Brose, M.S.1    Nutting, C.2    Shong, Y.K.3
  • 112
    • 84922689721 scopus 로고    scopus 로고
    • Pazopanib resistance induced by in vitro selection of BHP2-7 papillary thyroid cancer cells is associated with acquired KRAS mutation and more aggressive in vivo phenotype
    • A-78
    • Isham CR, Netzel BC, Bossou AR et al. Pazopanib resistance induced by in vitro selection of BHP2-7 papillary thyroid cancer cells is associated with acquired KRAS mutation and more aggressive in vivo phenotype. Thyroid 2013;23:A-78.
    • (2013) Thyroid , vol.23
    • Isham, C.R.1    Netzel, B.C.2    Bossou, A.R.3
  • 113
    • 84877581959 scopus 로고    scopus 로고
    • Lenvatinib treatment of advanced RAI-refractory differentiated thyroid cancer (DTC): Cytokine and angiogenic factor (CAF) profiling in combination with tumor genetic analysis to identify markers associated with response
    • Ball DW, Sherman SI, Jarzab B et al. Lenvatinib treatment of advanced RAI-refractory differentiated thyroid cancer (DTC): Cytokine and angiogenic factor (CAF) profiling in combination with tumor genetic analysis to identify markers associated with response. J Clin Oncol 2012;30(suppl):5518a.
    • (2012) J Clin Oncol , vol.30 , pp. 5518a
    • Ball, D.W.1    Sherman, S.I.2    Jarzab, B.3
  • 114
    • 84922760285 scopus 로고    scopus 로고
    • Study of AG-013736 in patients with 131Irefractory thyroid cancer. Available at, Accessed December 31
    • Study of AG-013736 in patients with 131Irefractory thyroid cancer. Available at https://clinicaltrials.gov/ct2/show/NCT00389441. Accessed December 31, 2014.
    • (2014)
  • 115
    • 84922708781 scopus 로고    scopus 로고
    • Nexavar (sorafenib) [prescribing information]. Wayne, NJ: Bayer HealthCare Pharmaceuticals Inc
    • Nexavar (sorafenib) [prescribing information]. Wayne, NJ: Bayer HealthCare Pharmaceuticals Inc; 2013.
    • (2013)
  • 116
    • 84901265163 scopus 로고    scopus 로고
    • Aerodigestive fistula formation as a rare side effect of antiangiogenic tyrosine kinase inhibitor therapy for thyroid cancer
    • Blevins DP, Dadu R, Hu M et al. Aerodigestive fistula formation as a rare side effect of antiangiogenic tyrosine kinase inhibitor therapy for thyroid cancer. Thyroid 2014;24:918-922.
    • (2014) Thyroid , vol.24 , pp. 918-922
    • Blevins, D.P.1    Dadu, R.2    Hu, M.3
  • 117
    • 84867770488 scopus 로고    scopus 로고
    • Sunitiniband sorafenib-induced nephrotic syndrome in a patient with gastrointestinal stromal tumor
    • Turan N, Benekli M, Ozturk SC et al. Sunitiniband sorafenib-induced nephrotic syndrome in a patient with gastrointestinal stromal tumor. Ann Pharmacother 2012;46:e27.
    • (2012) Ann Pharmacother , vol.46
    • Turan, N.1    Benekli, M.2    Ozturk, S.C.3
  • 118
    • 84899076200 scopus 로고    scopus 로고
    • Images in clinical medicine. Sunitinib-associated hair depigmentation
    • Brzezniak C, Szabo E. Images in clinical medicine. Sunitinib-associated hair depigmentation. N Engl J Med 2014;370:e27.
    • (2014) N Engl J Med , vol.370
    • Brzezniak, C.1    Szabo, E.2
  • 119
    • 84902334839 scopus 로고    scopus 로고
    • Role of salvage targeted therapy in differentiated thyroid cancer patients who failed first-line sorafenib
    • Dadu R, Devine C, Hernandez M et al. Role of salvage targeted therapy in differentiated thyroid cancer patients who failed first-line sorafenib. J Clin Endocrinol Metab 2014;99: 2086-2094.
    • (2014) J Clin Endocrinol Metab , vol.99 , pp. 2086-2094
    • Dadu, R.1    Devine, C.2    Hernandez, M.3
  • 120
    • 84899477812 scopus 로고    scopus 로고
    • Tyrosine kinase inhibitor treatments in patients with metastatic thyroid carcinomas: A retrospective study of the TUTHYREF network
    • Massicotte MH, Brassard M, Claude-Desroches M et al. Tyrosine kinase inhibitor treatments in patients with metastatic thyroid carcinomas: A retrospective study of the TUTHYREF network. Eur J Endocrinol 2014;170:575-582.
    • (2014) Eur J Endocrinol , vol.170 , pp. 575-582
    • Massicotte, M.H.1    Brassard, M.2    Claude-Desroches, M.3
  • 121
    • 84897874155 scopus 로고    scopus 로고
    • Re-differentiation of radioiodine-refractory BRAF V600E-mutant thyroid carcinoma with dabrafenib: A pilot study
    • Rothenberg SM, McFadden DG, Palmer E et al. Re-differentiation of radioiodine-refractory BRAF V600E-mutant thyroid carcinoma with dabrafenib: A pilot study. J Clin Oncol 2013;31(suppl): 6025a.
    • (2013) J Clin Oncol , vol.31 , pp. 6025a
    • Rothenberg, S.M.1    McFadden, D.G.2    Palmer, E.3
  • 122
    • 84868224906 scopus 로고    scopus 로고
    • Combined BRAF and MEK inhibition in melanoma with BRAF V600 mutations
    • Flaherty KT, Infante JR, Daud A et al. Combined BRAF and MEK inhibition in melanoma with BRAF V600 mutations. N Engl J Med 2012;367: 1694-1703.
    • (2012) N Engl J Med , vol.367 , pp. 1694-1703
    • Flaherty, K.T.1    Infante, J.R.2    Daud, A.3
  • 123
    • 84884597338 scopus 로고    scopus 로고
    • MEK inhibition in the treatment of advanced melanoma
    • Salama AK, Kim KB. MEK inhibition in the treatment of advanced melanoma. Curr Oncol Rep 2013;15:473-482.
    • (2013) Curr Oncol Rep , vol.15 , pp. 473-482
    • Salama, A.K.1    Kim, K.B.2


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