Adipocyte fatty acid-binding protein is released from adipocytes by a non-conventional mechanism

International Journal of Obesity

Volumn 38, Issue 9, 2014, Pages 1251-1254

  Kralisch, S ^a   Ebert, T ^a   Lossner, U ^a   Jessnitzer, B ^a   Stumvoll, M ^a   Fasshauer, M ^a  

^a UNIVERSITY OF LEIPZIG   (Germany)

Author keywords

adipocyte fatty acid binding protein; adipocyte derived microvesicles; calcium; insulin; secretory mechanism

Indexed keywords

CALCIUM; CALCIUM IONOPHORE; FATTY ACID BINDING PROTEIN 4; INSULIN; IONOMYCIN; LIPOPOLYSACCHARIDE; 2-(2'-(5-ETHYL-3,4-DIPHENYL-1H-PYRAZOL-1-YL)BIPHENYL-3-YLOXY)ACETIC ACID; BIPHENYL DERIVATIVE; FATTY ACID BINDING PROTEIN; PYRAZOLE DERIVATIVE;

ADIPOCYTE; ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CELL DIFFERENTIATION; CELL FRACTIONATION; DOWN REGULATION; ENDOPLASMIC RETICULUM; ENZYME LINKED IMMUNOSORBENT ASSAY; GOLGI COMPLEX; HORMONAL REGULATION; IMMUNOBLOTTING; IN VITRO STUDY; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN SECRETION; TRAFFIC; UPREGULATION; 3T3 CELL LINE; ANIMAL; INSULIN RESISTANCE; METABOLISM; SECRETION (PROCESS); TRANSPORT AT THE CELLULAR LEVEL;

MURINAE;

3T3-L1 CELLS; ADIPOCYTES; ANIMALS; BIOLOGICAL TRANSPORT; BIPHENYL COMPOUNDS; FATTY ACID-BINDING PROTEINS; INSULIN; INSULIN RESISTANCE; MICE; PYRAZOLES;

EID: 84922688994     PISSN: 03070565     EISSN: 14765497     Source Type: Journal    
DOI: 10.1038/ijo.2013.232     Document Type: Article

References (18)

1. Kralisch S, Fasshauer M. Adipocyte fatty acid binding protein: a novel adipokine involved in the pathogenesis of metabolic and vascular disease? Diabetologia 2013; 56: 10-21.
2. Bernlohr DA, Angus CW, Lane MD, Bolanowski MA, Kelly TJ. Expression of specific messenger-Rnas during adipose differentiation-identification of an messenger-Rna encoding a homolog of myelin-P2 protein. Proc Natl Acad Sci USA Biol Sci 1984; 81: 5468-5472.
3. Hotamisligil GS, Johanson RS, Distel RJ, Ellis R, Papaioannou VE, Spiegelman BM. Uncoupling of obesity from insulin resistance through a targeted mutation in aP2, the adipocyte fatty acid binding protein. Science 1996; 274: 1377-1379.
4. Makowski L, Boord JB, Maeda K, Babaev VR, Uysal KT, Morgan MA et al. Lack of macrophage fatty-acid-binding protein aP2 protects mice deficient in apolipoprotein E against atherosclerosis. Nat Med 2001; 7: 699-705.
5. Furuhashi M, Tuncman G, Gö rgün CZ, Makowski L, Atsumi G, Vaillancourt E et al. Treatment of diabetes and atherosclerosis by inhibiting fatty-acid-binding protein aP2. Nature 2007; 447: 959-965.
6. Cao H, Sekiya M, Ertunc ME, Burak MF, Mayers JR, White A et al. Adipocyte lipid chaperone aP2 is a Secreted adipokine regulating hepatic glucose production. Cell Metab 2013; 17: 768-778.
7. Aoki N, Jin-no S, Nakagawa Y, Asai N, Arakawa E, Tamura N et al. Identification and characterization of microvesicles secreted by 3T3-L1 adipocytes: redox-and hormone-dependent induction of milk fat globule-epidermal growth factor 8-associated microvesicles. Endocrinology 2007; 148: 3850-3862.
8. Kralisch S, Sommer G, Weise S, Lipfert J, Lossner U, Kamprad M et al. Interleukin-1beta is a positive regulator of TIARP/STAMP2 gene and protein expression in adipocytes in vitro. FEBS Lett 2009; 583: 1196-1200.
9. Xie L, O'Reilly CP, Chapes SK, Mora S. Adiponectin and leptin are secreted through distinct trafficking pathways in adipocytes. Biochim Biophys Acta BBA Mol Basis Dis 2008; 1782: 99-108.
10. Xie L, Boyle D, Sanford D, Scherer PE, Pessin JE, Mora S. Intracellular trafficking and secretion of adiponectin is dependent on GGA-coated vesicles. J Biol Chem 2006; 281: 7253-7259.
11. Scherer PE, Williams S, Fogliano M, Baldini G, Lodish HF. A novel serum protein similar to C1q, produced exclusively in adipocytes. J Biol Chem 1995; 270: 26746-26749.
12. Hughes RC. Secretion of the galectin family of mammalian carbohydrate-binding proteins. Biochim Biophys Acta BBA Gen Subj 1999; 1473: 172-185.
13. Hamon Y, Luciani M-F, Becq F, Verrier B, Rubartelli A, Chimini G. Interleukin-1b secretion is impaired by inhibitors of the ATP binding cassette transporter, ABC1. Blood 1997; 90: 2911-2915.
14. Lamounier-Zepter V, Look C, Alvarez J, Christ T, Ravens U, Schnuck WH et al. Adipocyte fatty acid-binding protein suppresses cardiomyocyte contraction: a new link between obesity and heart disease. Circ Res 2009; 105: 326-334.
15. Aoki N, Yokoyama R, Asai N, Ohki M, Ohki Y, Kusubata K et al. Adipocyte-derived microvesicles are associated with multiple angiogenic factors and induce angiogenesis in vivo and in vitro. Endocrinology 2010; 151: 2567-2576.
16. Ogawa R, Tanaka C, Sato M, Nagasaki H, Sugimura K, Okumura K et al. Adipocytederived microvesicles contain RNA that is transported into macrophages and might be secreted into blood circulation. Biochem Biophys Res Commun 2010; 398: 723-729.
17. Ye F, Than A, Zhao Y, Goh KH, Chen P. Vesicular storage, vesicle trafficking, and secretion of leptin and resistin: the similarities, differences, and interplays. J Endocrinol 2010; 206: 27-36.
18. Schlottmann I, Erhart-Bornstein M, Wabitsch M, Bornstein SR, Lamounier-Zepter V. Calcium-dependent release of adipocyte fatty acid binding protein from human adipocytes. Int J Obes (Lond) 2014; doi:10.1038/ijo.2013.241.