Preservation of autophagy should not direct nutritional therapy

Current Opinion in Clinical Nutrition and Metabolic Care

Volumn 18, Issue 2, 2015, Pages 155-161

  McClave, Stephen A ^a   Weijs, Peter J M ^b  

^a University of Louisville School of Medicine   (United States)

^b VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Autophagy; Cell death pathways; Enteral nutrition; Mammalian target of rapamycin signaling

Indexed keywords

ARTICLE; AUTOPHAGY; CRITICAL ILLNESS; CRITICALLY ILL PATIENT; DIET THERAPY; ENTERIC FEEDING; FEEDING; HOSPITAL ADMISSION; HUMAN; INTENSIVE CARE UNIT; MACROAUTOPHAGY; NONHUMAN; OXIDATIVE STRESS; PARENTERAL NUTRITION; PRESERVATION; TREATMENT WITHDRAWAL; XENOPHAGY; CONTRAINDICATIONS; ENERGY METABOLISM; IMMUNOLOGY; INTENSIVE CARE; PHYSIOLOGY; PROCEDURES; TIME;

MAMMALIA;

MTOR PROTEIN, HUMAN; TARGET OF RAPAMYCIN KINASE;

AUTOPHAGY; CRITICAL CARE; CRITICAL ILLNESS; ENERGY METABOLISM; ENTERAL NUTRITION; HUMANS; TIME FACTORS; TOR SERINE-THREONINE KINASES;

EID: 84922684509     PISSN: 13631950     EISSN: 14736519     Source Type: Journal    
DOI: 10.1097/MCO.0000000000000144     Document Type: Article

References (22)

1. Schetz M, Casaer MP, Van den Berghe G. Does artificial nutrition improve outcome of critical illness? Crit Care 2013; 17:302. This study spells out the argument that forced mandatory feeding should be avoided to preserve autophgy in critical illness.
2. Cuervo AM, Macian F. Autophagy, nutrition and immunology. Mol Aspects Med 2012; 33:2-13.
3. Choi AM, Ryter SW, Levine B. Autophagy in human health and disease. N Engl J Med 2013; 368:651-662.
4. Levine B, Mizushima N, Virgin HW. Autophagy in immunity and inflammation. Nature 2011; 469:323-335.
5. Boya P, Reggiori F, Codogno P. Emerging regulation and functions of autophagy. Nat Cell Biol 2013; 15:713-720. This study shows how autophagy can recycle amino acids from old protein and even external organisms (bacteria, viruses) to generate ATP and perform protein synthesis.
6. Casaer MP, Mesotten D, Hermans G, et al. Early versus late parenteral nutrition in critically ill adults. N Engl J Med 2011; 365:506-517.
7. Casaer MP, Wilmer A, Hermans G, et al. Role of disease and macronutrient dose in the randomized controlled EPaNIC trial: a post hoc analysis. Am J Respir Crit Care Med 2013; 187:247-255.
8. Derde S, Vanhorebeek I, Güiza F, et al. Early parenteral nutrition evokes a phenotype of autophagy deficiency in liver and skeletal muscle of critically ill rabbits. Endocrinology 2012; 153:2267-2276.
9. Morimoto RI. Cells in stress: transcriptional activation of heat shock genes. Science 1993; 259:1409-1410.
10. Ozcan U, Cao Q, Yilmaz E, et al. Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes. Science 2004; 306:457-461.
11. Hsieh YC, Athar M, Chaudry IH. When apoptosis meets autophagy: deciding cell fate after trauma and sepsis. Trends Mol Med 2009; 15:129-138.
12. Pandol SJ, Saluja AK, Imrie CW, Banks PA. Acute pancreatitis: bench to the bedside. Gastroenterology 2007; 132:1127-1151.
13. Appenzeller-Herzog C, HallMN. Bidirectional crosstalk between endoplasmic reticulum stress and mTOR signaling. Trends Cell Biol 2012; 22:274-282.
14. McClave SA. Drivers of oxidative stress in acute pancreatitis: the role of nutrition therapy. JPEN J Parenter Enteral Nutr 2012; 36:24-35.
15. Mizock BA. Immunonutrition and critical illness: an update. Nutrition 2010; 26:701-707.
16. Crouser ED. Autophagy, the first step towards recovery from critical illness. Crit Care Med 2013; 41:358-359.
17. Sakiyama T, Musch MW, Ropeleski MJ, et al. Glutamine increases autophagy under basal and stressed conditions in intestinal epithelial cells. Gastroent 2009; 136:924-932.
18. Heyland D, Muscedere J, Wischmeyer PE, et al., Canadian Critical Care Trials Group. A randomized trial of glutamine and antioxidants in critically ill patients. N Engl J Med 2013; 368:1489-1497.
19. Andrews PJ, Avenell A, Noble DW, et al., Scottish Intensive care Glutamine or seleNium Evaluative Trial Trials Group. Randomised trial of glutamine, selenium, or both, to supplement parenteral nutrition for critically ill patients. Br Med J 2011; 342:d1542.
20. Wernerman J, Kirketeig T, Andersson B, et al., Scandinavian Critical Care Trials Group. Scandinavian glutamine trial. A pragmatic multicentre randomised clinical trial of intensive care unit patients. Acta Anaesthesiol Scand 2011; 55:812-818.
21. Ziegler T: Efficacy and mechanisms of GLN dipeptide in the SICU (GLND). (www.clinicaltrials.gov/show/NCT00248638).
22. Berg A, Rooyackers O, Bellander BM, Wernerman J. Whole body protein kinetics during hypocaloric and normocaloric feeding in critically ill patients. Crit Care 2013; 17:R158.