Respiratory-related outputs of glutamatergic, hypercapnia-responsive parabrachial neurons in mice

Journal of Comparative Neurology

Volumn 523, Issue 6, 2015, Pages 907-920

  Yokota, Shigefumi ^a,b   Kaur, Satvinder ^a   Vanderhorst, Veronique G ^a   Saper, Clifford B ^a   Chamberlin, Nancy L ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b SHIMANE UNIVERSITY FACULTY OF MEDICINE   (Japan)

Author keywords

AB_2341545; AB_518147; AB_631250; C Fos; Carbon dioxide; Diaphragm; Hypoglossal; Phrenic; Respiratory

Indexed keywords

4 AMINOBUTYRIC ACID; GLUTAMATE DECARBOXYLASE 67; PROTEIN C FOS; VESICULAR GLUTAMATE TRANSPORTER 2; CALCITONIN GENE RELATED PEPTIDE; CHOLERA TOXIN; GLUTAMATE DECARBOXYLASE; GLUTAMATE DECARBOXYLASE 1; GLUTAMIC ACID;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GLUTAMATERGIC NERVE CELL; HYPERCAPNIA; HYPOGLOSSAL NUCLEUS; KOLLIKER FUSE NUCLEUS; MALE; MEDULLA OBLONGATA; MOTONEURON; MOTONEURON NUCLEUS; MOUSE; NERVE CELL; NERVE PROJECTION; NONHUMAN; PARABRACHIAL NERVE CELL; PHRENIC NERVE; PROTEIN EXPRESSION; SPINAL CORD VENTRAL HORN; ANIMAL; BREATHING; C57BL MOUSE; CYTOLOGY; GENETICS; IMMUNOLOGY; METABOLISM; NERVE TRACT; PARABRACHIAL NUCLEUS; PHYSIOLOGY;

ANIMALS; CALCITONIN GENE-RELATED PEPTIDE; CHOLERA TOXIN; GLUTAMATE DECARBOXYLASE; GLUTAMIC ACID; HYPERCAPNIA; MALE; MICE; MICE, INBRED C57BL; MOTOR NEURONS; NEURAL PATHWAYS; PARABRACHIAL NUCLEUS; PROTO-ONCOGENE PROTEINS C-FOS; RESPIRATION; VESICULAR GLUTAMATE TRANSPORT PROTEIN 2;

EID: 84922650717     PISSN: 00219967     EISSN: 10969861     Source Type: Journal    
DOI: 10.1002/cne.23720     Document Type: Article

References (37)

1. Bernard JF, Alden M, Besson JM. 1993. The organization of the efferent projections from the pontine parabrachial area to the amygdaloid complex: a Phaseolus vulgaris leucoagglutinin (PHA-L) study in the rat. J Comp Neurol 329:201-229.
2. Berquin P, Bodineau L, Gros F, Larnicol N. 2000. Brainstem and hypothalamic areas involved in respiratory chemoreflexes: a Fos study in adult rats. Brain Res 857:30-40.
3. Bochorishvili G, Stornetta RL, Coates MB, Guyenet PG. 2012. Pre-Botzinger complex receives glutamatergic innervation from galaninergic and other retrotrapezoid nucleus neurons. J Comp Neurol 520:1047-1061.
4. Chamberlin NL. 2004. Functional organization of the parabrachial complex and intertrigeminal region in the control of breathing. Respir Physiol Neurobiol 143:115-125.
5. Chamberlin NL, Saper CB. 1992. Topographic organization of cardiovascular responses to electrical and glutamate microstimulation of the parabrachial nucleus in the rat. J Comp Neurol 326:245-262.
6. Chamberlin NL, Eikermann M, Fassbender P, White DP, Malhotra A. 2007. Genioglossus premotoneurons and the negative pressure reflex in rats. J Physiol 579(Part 2):515-526.
7. Dutschmann M, Dick TE. 2012. Pontine mechanisms of respiratory control. Compr Physiol 2:2443-2469.
8. Erlander MG, Tillakaratne NJ, Feldblum S, Patel N, Tobin AJ. 1991. Two genes encode distinct glutamate decarboxylases. Neuron 7:91-100.
9. Ezure K, Tanaka I. 2006. Distribution and medullary projection of respiratory neurons in the dorsolateral pons of the rat. Neuroscience 141:1011-1023.
10. Finley JCW, Katz DM. 1992. The central organization of carotid body afferent projections to the brainstem of the rat. Brain Res 572:108-116.
11. Fulwiler CE, Saper CB. 1984. Subnuclear organization of the efferent connections of the parabrachial nucleus in the rat. Brain Res Rev 7:229-259.
12. Herbert H, Moga MM, Saper CB. 1990. Connections of the parabrachial nucleus with the nucleus of the solitary tract and the medullary reticular formation in the rat. J Comp Neurol 293:540-580.
13. Kaur S, Pedersen NP, Yokota S, Hur EE, Fuller PM, Lazarus M, Chamberlin NL, Saper CB. 2013. Glutamatergic signaling from the parabrachial nucleus plays a critical role in hypercapnic arousal. J Neurosci 33:7627-7640.
14. Lu J, Greco MA, Shiromani P, Saper CB. 2000. Effect of lesions of the ventrolateral preoptic nucleus on NREM and REM sleep. J Neurosci 20:3830-3842.
15. McCrimmon DR, Feldman JL, Speck DF. 1986. Respiratory motoneuronal activity is altered by injections of picomoles of glutamate into cat brain stem. J Neurosci 6:2384-2392.
16. Miller RL, Knuepfer MM, Wang MH, Denny GO, Gray PA, Loewy AD. 2012. Fos-activation of FoxP2 and Lmx1b neurons in the parabrachial nucleus evoked by hypotension and hypertension in conscious rats. Neuroscience 218:110-125.
17. Mizusawa A, Ogawa H, Kikuchi Y, Hida W, Shirato K. 1995. Role of parabrachial nucleus in ventilatory responses of awake rats. J Physiol 489:877-884.
18. Panneton WM, Loewy AD. 1980. Projections of the carotid sinus nerve to the nucleus of the solitary tract in the cat. Brain Res 191:239-244.
19. Qiu K, Lane MA, Lee KZ, Reier PJ, Fuller DD. 2010. The phrenic motor nucleus in the adult mouse. Exp Neurol 226:254-258.
20. Ricardo JA, Koh ET. 1978. Anatomical evidence of direct projections from the nucleus of the solitary tract to the hypothalamus, amygdala, and other forebrain structures in the rat. Brain Res 1553:1-26.
21. Rosin DL, Chang DA, Guyenet PG. 2006. Afferent and efferent connections of the rat retrotrapezoid nucleus. J Comp Neurol 499:64-89.
22. Sagar SM, Sharp FR. 1993. Early response genes as markers of neuronal activity and growth factor action. Adv Neurol 59:273-284.
23. Scammell TE, Estabrooke IV, McCarthy MT, Chemelli RM, Yanagisawa M, Miller MS, Saper CB. 2000. Hypothalamic arousal regions are activated during modafinil-induced wakefulness. J Neurosci 20:8620-8628.
24. Schwaber JS, Sternini C, Brecha NC, Rogers WT, Card JP. 1988. Neurons containing calcitonin gene-related peptide in the parabrachial nucleus project to the central nucleus of the amygdala. J Comp Neurol 270:416-426, 398-419.
25. Song G, Poon CS. 2009. Lateral parabrachial nucleus mediates shortening of expiration and increase of inspiratory drive during hypercapnia. Respir Physiol Neurobiol 165:9-12.
26. 2-sensitive neurons in rats. J Physiol 572(Part 2):503-523.
27. Teppema LJ, Veening JG, Kranenburg A, Dahan A, Berkenbosch A, Olievier C. 1997. Expression of c-Fos in the rat brainstem after exposure to hypoxia and to normoxic and hyperoxic hypercapnia. J Comp Neurol 388:169-190.
28. Tong Q, Ye C, McCrimmon RJ, Dhillon H, Choi B, Kramer MD, Yu J, Yang Z, Christiansen LM, Lee CE, Choi CS, Zigman JM, Shulman GI, Sherwin RS, Elmquist JK, Lowell BB. 2007. Synaptic glutamate release by ventromedial hypothalamic neurons is part of the neurocircuitry that prevents hypoglycemia. Cell Metab 5:383-393.
29. VanderHorst VG, Ulfhake B. 2006. The organization of the brainstem and spinal cord of the mouse: relationships between monoaminergic, cholinergic, and spinal projection systems. J Chem Neuroanat 31:2-36.
30. Wang H, Wei F, Dubner R, Ren K. 2006. Selective distribution and function of primary afferent nociceptive inputs from deep muscle tissue to the brainstem trigeminal transition zone. J Comp Neurol 498:390-402.
31. Wang W, Tiwari JK, Bradley SR, Zaykin RV, Richerson GB. 2001. Acidosis-stimulated neurons of the medullary raphe are serotonergic. J Neurophysiol 85:2224-2235.
32. 2. Proc Natl Acad Sci 104:10685-10690.
33. Yasui Y, Saper CB, Cechetto DF. 1989. Calcitonin gene-related peptide immunoreactivity in the visceral sensory cortex, thalamus, and related pathways in the rat. J Comp Neurol 290:487-501.
34. Yokota S, Tsumori T, Ono K, Yasui Y. 2001. Phrenic motoneurons receive monosynaptic inputs from the Kolliker-Fuse nucleus: a light- and electron-microscopic study in the rat. Brain Res 888:330-335.
35. Yokota S, Tsumori T, Ono K, Yasui Y. 2004. Glutamatergic pathways from the Kölliker-Fuse nucleus to the phrenic nucleus in the rat. Brain Res 995:118-130.
36. Yokota S, Oka T, Tsumori T, Nakamura S, Yasui Y. 2007. Glutamatergic neurons in the Kolliker-Fuse nucleus project to the rostral ventral respiratory group and phrenic nucleus: a combined retrograde tracing and in situ hybridization study in the rat. Neurosci Res 59:341-346.
37. Yokota S, Niu JG, Tsumori T, Oka T, Yasui Y. 2011. Glutamatergic Kolliker-Fuse nucleus neurons innervate hypoglossal motoneurons whose axons form the medial (protruder) branch of the hypoglossal nerve in the rat. Brain Res 1404:10-20.