Antidiabetic and antihyperlipidaemic activity of ethanol extract of Melastoma malabathricum Linn. leaf in alloxan induced diabetic rats

Asian Pacific Journal of Tropical Biomedicine

Volumn 4, Issue , 2014, Pages S442-S448

  Balamurugan, Karuppasamy ^a   Nishanthini, Antony ^a   Mohan, Veerabahu Ramasamy ^a  

^a V O CHIDAMBARAM COLLEGE   (India)

Author keywords

Alloxan; Antidiabetic; Antihyperlipidaemic; Glibenclamide; HbA1c; Melastoma malabathricum; SGOT; SGPT

Indexed keywords

ALANINE AMINOTRANSFERASE; ALCOHOL; ALKALINE PHOSPHATASE; ALLOXAN; ASPARTATE AMINOTRANSFERASE; CHOLESTEROL; CREATININE; GLIBENCLAMIDE; GLUCOSE; GLYCOSYLATED HEMOGLOBIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; LIPID; MELASTOMA MALABATHRICUM EXTRACT; PLANT EXTRACT; UNCLASSIFIED DRUG; UREA; VERY LOW DENSITY LIPOPROTEIN CHOLESTEROL;

ACUTE TOXICITY; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALBINO RAT; ALKALINE PHOSPHATASE BLOOD LEVEL; ALLOXAN-INDUCED DIABETES MELLITUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIDIABETIC ACTIVITY; ANTIHYPERLIPIDEMIC ACTIVITY; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CHEMICAL PARAMETERS; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DRUG ACTIVITY; GLUCOSE BLOOD LEVEL; INSULIN BLOOD LEVEL; MALE; NONHUMAN; PHOSPHOLIPID BLOOD LEVEL; PLANT LEAF; RAT;

MELASTOMA MALABATHRICUM; RATTUS;

EID: 84922645745     PISSN: 22211691     EISSN: None     Source Type: Journal    
DOI: 10.12980/APJTB.4.2014C122     Document Type: Article

References (48)

1. Eseyin O, Ebong P, Eyong E, Awofisayo O, Agboke A. Effect of Telfairia occidentalis on oral glucose tolerance in rats. Afr J Pharm Pharmacol 2010; 4: 368-372.
2. Patel DK, Prasad SK, Kumar R, Hemalatha S. An overview on antidiabetic medicinal plants having insulin mimetic property. Asian Pac J Trop Biomed 2012; 2: 320-330.
3. Rajan M, Kumar VK, Kumar PS, Swathi KR, Haritha S. Antidiabetic, antihyperlipidaemic and hepatoprotective activity of methanolic extract of Ruellia tuberose Linn. leaves in normal and alloxan induced diabetes. J Chem Pharm Res 2012; 4: 2860-2868.
4. Rajasekar V, Kirbanandan S, Lakshmi BS. Assessment of antidiabetic activity of Syzygium jambolanum using in vitro model. Am J Infect Dis 2010; 5: 99-105.
5. Malviya N, Jain S, Malviya S. Antidiabetic potential of medicinal plants. Acta Pol Pharm 2010; 67: 113-118.
6. Dangi KS, Mishra SN. Antihyperglycemic, antioxidant and hypolipidemic effect of Capparis aphylla stem extracts in streptozotocin induced diabetic rats. Biol Med 2010; 2: 35-44.
7. Sunilson JA, Anandarajagopal K, Kumari AV, Mohan S. Antidiarrhoeal activity of leaves of Melastoma malabathricum. Indian J Pharm Sci 2009; 71: 691-695.
8. Brinda P, Sasikala P, Purushothaman KK. Pharmacognostic studies on merugan kizhangu. Bull Med Ethnobot Res 1981; 3: 84-96.
9. Lala PK. Lab manuals of pharmacognosy. Kolkata: CSI Publishers and Distributers; 1993.
10. Organisation for Economic cooperation and Development. OECD guidelines for the testing of chemicals: acute oral toxicity-acute toxic class method. Paris: OECD; 2002. [Online] Available from: http://www.oecd-ilibrary.org/docserver/download/9742301e.pdf?expires=1394073831&id=id&accname=guest&checksum=7DD1F36B2AD3F83470793BFD79E060AF [Accessed on 20th January, 2014]
11. Nagappa AN, Thakurdesai PA, Venkat Rao N, Sing J. Antidiabetic activity of Terminalia catappa Linn. fruits. J Ethnopharmacol 2003; 88: 45-50.
12. Sasaki T, Masty S, Sonae A. Effect of acetic acid concentration on the colour reaction in the o-toluidine boric acid method for blood glucose estimation. Rinsho Kagaku 1972; 1: 346-353.
13. Anderson L, Dinesen B, Jørgonsen PN, Poulsen F, Røder ME. Enzyme immune assay for intact human insulin in serum or plasma. Clin Chem 1993; 39: 578-582.
14. Varley H. Practical clinical biochemistry. Chennai: Arnold Heinemann Publication Pvt. Ltd.; 1976, p. 452.
15. Owen JA, Iggo JB, Scangrett FJ, Steward IP. The determination of creatinine in plasma or serum, and in urine-a critical examination. Biochem J 1954; 58: 426-437.
16. Karunanayake EH, Chandrasekharan NV. An evaluation of a colorimetric procedure for the estimation of glycosylated haemoglobin and establishment of reference values for Sri Lanka. J Natl Sci Counc Sri Lanka 1985; 13: 235-258.
17. Lowry OH, Rosenbrough NJ, Farr AL, Randall RJ. Protein measurement with the Folin's phenol reagent. J Biol Chem 1951; 193: 265-275.
18. Reitman S, Frankel SA. A colorimetric method for the determination of serum glutamic oxaloacetic and glutamic pyruvic transaminases. Am J Clin Pathol 1957; 28: 56-63.
19. King EJ, Armstrong AR. A convenient method for determining serum and bile phosphatase activity. Can Med Assoc J 1934; 31: 376-381.
20. Parekh AC, Jung DH. Cholesterol determination with ferric acetate, uranium acetate and sulphuric acid, ferrous sulphate reagent. Anal Chem1970; 42: 1423-1427.
21. Rice EW. Triglycerides in serum. In: Roderick MP, editor. Standard methods of clinical chemistry. 9th ed. New York: Academic Press; 1970, p. 215-222.
22. Friedwald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low density lipoprotein cholesterol in plasma, without use of the preparative ultra centrifuge. Clin Chem 1972; 18: 499-502.
23. Warnick GR, Nguyan T, Albers AA. Comparison of improved precipitation methods for quantification of high density lipoprotein cholesterol. Clin Chem 1985; 31: 217-222.
24. Takayama M, Itoh S, Nagasaki T, Tanimizu I. A new enzymatic method for determination of serum phospholipids. Clin Chem Acta 1977; 79: 93-98.
25. Tripathi AK, Bhoyar PK, Baheti JR, Biyaani DM, Khalique M, Kothmire MS, et al. Herbal antidiabetics: a review. Int J Res Pharm Sci 2011; 2: 30-37.
26. Kavishankar GB, Lakshmidevi N, Muthy SM, Prakash HS, Niranjana SR. Diabetes and medicinal plants-a review. Int J Pharm Biomed Sci 2011; 2: 65-80.
27. Sharma VK, Kumar S, Patel HJ, Hugar S. Hypoglycemic activity of Ficus glomerata in alloxan induced diabetic rats. Int J Pharm Sci Rev Res 2010; 1: 18-22.
28. Bhatt NM, Barua S, Gupta S. Protective effect of Enicostemma littorale Blume on rat model of diabetic neuropathy. Am J Infect Dis 2009; 5: 106-112.
29. Veeramani C, Pushpavalli G, Pugalendi KV. Antihyperglycaemic effect of Cardiospermum halicacabum Linn. leaf extract on streptozotocin induced diabetic rats. J Appl Biomed 2008; 6: 19-26.
30. Sezik E, Aslan M, Yesilada E, Ito S. Hypoglycaemic activity of Gentiana olivieri and isolation of the active constituent through bioassay-directed fractionation techniques. Life Sci 2005; 76: 1223-1238.
31. Pattabiraman K, Muthukumaran P. Antidiabetic and antioxidant activity of Morinda tinctoria Roxb. fruits extract in streptozotocin-induced diabetic rats. Asian J Pharm Tech 2011; 1: 34-39.
32. Maruthupandian A, Mohan VR. Antidiabetic, antihyperlipidaemic and antioxidant activity of Pterocarpus marsupian Roxb. in alloxan induced diabetic rats. Int J PharmTech 2011; 3: 1681-1687.
33. Shanmugasundaram R, Devi VK, Soris PT, Maruthupandian A, Mohan VR. Antidiabetic, antihyperlipidaemic and antioxidant activity of Senna auriculata (L.) Roxb. leaves in alloxan induced diabetic rats. Int J PharmTech Res 2011; 3: 747-756.
34. Kala SM, Tresina PS, Mohan VR. Antioxidant, antihyperlipidaemic and antidiabetic activity of Eugenia floccosa Bedd. leaves in alloxan induced diabetic rats. J Basic Clin Pharmacy. 2012; 3: 235-240.
35. Kala SM, Tresina PS, Mohan VR. Antioxidant, antihyperlipidaemic and antidiabetic activity of Eugenia singamattina Bedd. leaves in alloxan induced diabetic rats. Int J Pharm Pharm Sci. 2012; 4: 412-416.
36. Shajeela PS, Kalpanadevi V, Mohan VR. Potential antidiabetic, hypolipidaemic and antioxidant effects of Nymphaea pubercens extract in alloxan induced diabetic rats. J Appl Pharm Sci 2012; 2: 83-88.
37. Lal SS, Sukla Y, Singh A, Andriyas EA, Lall AM. Hyperuricemia, high serum urea and hypoproteinemia are are the risk factor for diabetes. Asian J Med Sci 2009; 1: 33-34.
38. Deguchi Y, Miyazaki K. Anti-hyperglycemic and antihyperlipidemic effects of guava leaf extract. Nutr Metab 2010; 7: 9.
39. Lanjhiyana S, Garabadu D, Ahirwar D, Bigoniya P, Chandrana A, Chandrapatra K, et al. Antidiabetic activity of methanolic extract of stem bark of Elaeodendron glaucum Pers. in alloxanized rat model. Adv Appl Sci Res 2011; 2: 47-62.
40. Alagammal M, Nishanthini A, Mohan VR. Antihyperglycemic and antihyperlipidaemic effect of Polygala rosmarinifolia Wright & Arn on alloxan induced diabetic rats. J Appl Pharm Sci 2012; 2: 143-148.
41. Kaleem M, Medha P, Ahmed QU, Asif M, Bano B. Beneficial effects of Annona squamosa extract in streptozotocin-induced diabetic rats. Singapore Med J 2008; 49: 800-804.
42. Ramachandran S, Naveen KR, Rajinikanth B, Akbar M, Rajasekaran A. Antidiabetic, antihyperlipidemic and in vivo antioxidant potential of aqueous extract of Anogeissus latifolia bark in type 2 diabetic rats. Asian J Pac Trop Dis 2012; 2(Suppl 2): S596-S602.
43. Rao GM, Morghom LO, Kabur MN, Ben Mohmud BM, Ashibani K. Serum glutamic oxaloacetic transaminase (GOT) and glutamate pyruvate transaminase (GPT) levels in diabetes mellitus. Indian J Med Sci 1989; 43: 118-121.
44. Al-Shamaony L, Al-Khazraji SM, Twaij HA. Hypoglycaemic effect of Artemisia herba alba II. Effect of a valuable extract on some blood parameters in diabetic animals. J Ethnopharmacol 1994; 43: 167-171.
45. Al-Logmani AS, Zari TA. Effects of Nigella sativa L. and Cinnamomum zeylanicum Blume oils on some physiological parameters in streptozotocin-induced diabetic rats. Bol Latinoam Caribe Plant Med Aromat 2009; 8: 86-96.
46. Anitha M, Rajalakshmi K, Muthukumarasamy S, Mohan VR. Antihyperglycemic, antihyperlipidaemic and antioxidant ativity of Cynoglossum zeylanicum (Vahl Ex Hornem) Thurnb Ex lehrn in alloxan induced diabetic rats. Int J Pharm Pharm Sci 2012: 4: 490-495.
47. Alagammal M, Rajalakshmi K, Mohan VR. Antidiabetic and antihyperlipidaemic activity of Polygala chinensis L. whole plant in alloxan induced diabetic rats. Int J Chem Pharm Sci 2012; 3: 37-44.
48. Alagammal M, Agnel RA, Mohan VR. Antidiabetic and antihyperlipidaemic effect of Polygala javana DC on alloxan induced diabetic rats. Int Res J Pharm 2012; 3: 231-234.