Boar spermatozoa successfully predict mitochondrial modes of toxicity: Implications for drug toxicity testing and the 3R principles

Toxicology in Vitro

Volumn 29, Issue 3, 2015, Pages 582-591

  Vicente Carrillo, A ^a   Edebert, I ^b   Garside, H ^d   Cotgreave, I ^c   Rigler, R ^c   Loitto, V ^a   Magnusson, K E ^a   Rodriguez Martinez H ^a  

^a LINKÖPING UNIVERSITY   (Sweden)

^b Medical Microbiology Department of Clinical and Experimental Medicine Linköping University ^*  (Sweden)

^c KAROLINSKA INSTITUTE   (Sweden)

^d ASTRAZENECA   (United Kingdom)

Author keywords

Boar; Drug; Mitochondria; Motility; Sperm; Toxicity

Indexed keywords

2,4 DINITROPHENOL; ADENOSINE TRIPHOSPHATE; AGENTS AFFECTING NUCLEIC ACID METABOLISM; AGENTS INTERACTING WITH TRANSMITTER, HORMONE OR DRUG RECEPTORS; ANTIBIOTIC AGENT; ANTIFUNGAL AGENT; ANTIMYCIN A1; ANTIPARASITIC AGENT; ARSENIC TRIOXIDE; ATRACTYLOSIDE; CARBONYL CYANIDE 4 (TRIFLUOROMETHOXY)PHENYLHYDRAZONE; CHEMICALS AND DRUGS; CYCLOOXYGENASE 1 INHIBITOR; CYCLOOXYGENASE 2 INHIBITOR; DNA SYNTHESIS INHIBITOR; ION CHANNEL INHIBITOR; ION TRANSPORT AFFECTING AGENT; MEMBRANE TRANSPORTER INHIBITOR; NEURONAL RECEPTOR AGONIST; NEURONAL RECEPTOR ANTAGONIST; NEURONAL RECEPTOR MODULATOR; NUCLEAR RECEPTOR AND COFACTOR INHIBITOR; OLIGOMYCIN; PHOSPHOTRANSFERASE INHIBITOR; POTASSIUM CYANIDE; RNA SYNTHESIS INHIBITOR; ROTENONE; UNCLASSIFIED DRUG;

ADVERSE OUTCOME PATHWAY; ANIMAL CELL; ARTICLE; BIOLOGICAL MODEL; CELL ASSAY; CELL KINETICS; CELL SUSPENSION; CELL VIABILITY; CELLULAR, SUBCELLULAR AND MOLECULAR BIOLOGICAL PHENOMENA AND FUNCTIONS; CLINICAL PROTOCOL; COMPARATIVE STUDY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG TOXICITY; FLUORESCENCE ANALYSIS; HEPG2 CELL LINE; HUMAN; HUMAN CELL; IC50; MALE; MALE GENITAL TRACT PARAMETERS; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL TOXICITY; MOLECULAR DYNAMICS; NONHUMAN; PREDICTIVE VALUE; REDUCTION REPLACEMENT AND REFINEMENT OF EXPERIMENTATION WITH ANIMAL PRONCIPLE; RELIABILITY; SOMATIC CELL; SPERM SPEED; SPERMATOZOON; SPERMATOZOON MOTILITY; SWINE; TOXICITY TESTING; ANIMAL; ANIMAL TESTING ALTERNATIVE; CELL LINE; DOSE RESPONSE; DRUG EFFECTS; IN VITRO STUDY; METABOLISM; MITOCHONDRION; PIG; SOFTWARE;

ANIMALIA; VASCONCELLEA CANDICANS;

ADENOSINE TRIPHOSPHATE; ANIMAL TESTING ALTERNATIVES; ANIMALS; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; IN VITRO TECHNIQUES; MALE; MITOCHONDRIA; SOFTWARE; SPERM MOTILITY; SPERMATOZOA; SWINE; TOXICITY TESTS;

EID: 84922638401     PISSN: 08872333     EISSN: 18793177     Source Type: Journal    
DOI: 10.1016/j.tiv.2015.01.004     Document Type: Article

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