Prognostic value of preoperative neutrophils to lymphocytes ratio in patients resected for gastric cancer

American Journal of Surgery

Volumn 209, Issue 2, 2015, Pages 333-337

  Graziosi, Luigina ^a   Marino, Elisabetta ^a   De Angelis, Verena ^b   Rebonato, Alberto ^a   Cavazzoni, Emanuel ^a   Donini, Annibale ^a  

^a Nuova Facoltà di Medicina e Chirurgia   (Italy)

^b SANTA MARIA DELLA MISERICORDIA HOSPITAL   (Italy)

Author keywords

Keywords Gastric cancer; Neutrophils to lymphocytes ratio

Indexed keywords

ANTINEOPLASTIC AGENT;

ADULT; AGED; ARTICLE; CANCER ADJUVANT THERAPY; CANCER PATIENT; CANCER PROGNOSIS; CANCER STAGING; CANCER SURGERY; CANCER SURVIVAL; DEATH; DISEASE FREE SURVIVAL; FEMALE; FOLLOW UP; GASTRECTOMY; HUMAN; LYMPH NODE DISSECTION; LYMPHOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; MULTIMODALITY CANCER THERAPY; NEUTROPHIL COUNT; NEUTROPHIL LYMPHOCYTE RATIO; NUTRITIONAL STATUS; OUTCOME ASSESSMENT; OVERALL SURVIVAL; PERIPHERAL LYMPHOCYTE; PERITONEUM METASTASIS; POSTOPERATIVE CARE; PREDICTIVE VALUE; PREOPERATIVE EVALUATION; PRIORITY JOURNAL; PROSPECTIVE STUDY; RECURRENT DISEASE; STOMACH ADENOCARCINOMA; STOMACH CANCER; SURVIVAL RATE; ADENOCARCINOMA; LYMPHOCYTE; MIDDLE AGED; MORTALITY; NEUTROPHIL; PATHOLOGY; PROCEDURES; PROGNOSIS; STOMACH NEOPLASMS; TREATMENT OUTCOME; VERY ELDERLY;

ADENOCARCINOMA; ADULT; AGED; AGED, 80 AND OVER; FEMALE; GASTRECTOMY; HUMANS; LYMPHOCYTES; MALE; MIDDLE AGED; NEOPLASM STAGING; NEUTROPHILS; PREDICTIVE VALUE OF TESTS; PROGNOSIS; PROSPECTIVE STUDIES; STOMACH NEOPLASMS; SURVIVAL RATE; TREATMENT OUTCOME;

EID: 84922637055     PISSN: 00029610     EISSN: 18791883     Source Type: Journal    
DOI: 10.1016/j.amjsurg.2014.06.014     Document Type: Article

References (29)

1. W. Wang, Y.F. Li, and X.W. Sun Prognosis of 980 patients with gastric cancer after surgical resection Chin J Cancer 29 2010 923 930
2. J.R. Siewert, K. Böttcher, and H.J. Stein Relevant prognostic factors in gastric cancer: ten-year results of the German Gastric Cancer Study Ann Surg 228 1998 449 461
3. L.P. Setälä, V.M. Kosma, and S. Marin Prognostic factors in gastric cancer: the value of vascular invasion, mitotic rate and lymphoplasmacytic infiltration Br J Cancer 74 1996 766 772
4. S.Y. Wang, C.N. Yeh, and H.L. Lee Clinical impact of positive surgical margin status on gastric cancer patients undergoing gastrectomy Ann Surg Oncol 16 2009 2738 2743
5. D.C. McMillan Systemic inflammation, nutritional status and survival in patients with cancer Curr Opin Clin Nutr Metab Care 12 2009 223 226
6. C.S. Roxburgh, and D.C. McMillan Role of systemic inflammatory response in predicting survival in patients with primary operable cancer Future Oncol 6 2010 149 163
7. Y. Mohri, K. Tanaka, and M. Ohi Prognostic significance of host- and tumor-related factors in patients with gastric cancer World J Surg 34 2010 285 290
8. C.S. Wang, and C.F. Sun C-reactive protein and malignancy: clinico-pathological association and therapeutic implication Chang Gung Med J 32 2009 471 482
9. K. Ietomi [A study on the role of granulocytes in carcinoma-bearing hosts - G/L ratio as a new host indicator (in Japanese) Nihon Gan Chiryo Gakkai Shi 25 1990 662 671
10. A. Satomi, S. Murakami, and K. Ishida Significance of increased neutrophils in patients with advanced colorectal cancer Acta Oncol 34 1995 69 73
11. S.R. Walsh, E.J. Cook, and F. Goulder Neutrophil-lymphocyte ratio as a prognostic factor in colorectal cancer J Surg Oncol 91 2005 181 184
12. K.M. Sarraf, E. Belcher, and E. Raevsky Neutrophil/lymphocyte ratio and its association with survival after complete resection in non-small cell lung cancer J Thorac Cardiovasc Surg 137 2009 425 428
13. K.J. Halazun, A. Aldoori, and H.Z. Malik Elevated preoperative neutrophil to lymphocyte ratio predicts survival following hepatic resection for colorectal liver metastases Eur J Surg Oncol 34 2008 55 60
14. D. Gomez, S. Farid, and H.Z. Malik Preoperative neutrophil-to-lymphocyte ratio as a prognostic predictor after curative resection for hepatocellular carcinoma World J Surg 32 2008 1757 1762
15. H.Y. Shau, and A. Kim Suppression of lymphokine-activated killer induction by neutrophils J Immunol 141 1988 4395 4402
16. T. Yamanaka, S. Matsumoto, and S. Teramukai The baseline ratio of neutrophils to lymphocytes is associated with patient prognosis in advanced gastric cancer Oncology 73 2007 215 220
17. Japanese Gastric Cancer Association Japanese classification of gastric carcinoma - 2nd English edition Gastric Cancer 1 1998 10 24
18. E.J. Clark, S. Connor, and M.A. Taylor Preoperative lymphocyte count as a prognostic factor in resected pancreatic ductal adenocarcinoma HPB (Oxford) 9 2007 456 460
19. H.E. Ownby, L.D. Roi, and R.R. Isenberg Peripheral lymphocyte and eosinophil counts as indicators of prognosis in primary breast cancer Cancer 52 1983 126 130
20. J. Zhang, S.H. Huang, and H. Li Preoperative lymphocyte count is a favorable prognostic factor of disease-free survival in non-small-cell lung cancer Med Oncol 30 2013 352
21. L.M. Coussens, and Z. Werb Inflammation and cancer Nature 420 2002 860 867
22. I.D. Nagtegaal, C.A. Marijnen, and E.K. Kranenberg Local and distant recurrences in rectal cancer patients are predicted by the nonspecific immune response; specific response as only a systemic effect - A histopathological and immunohistochemical study BMC Cancer 1 2001 7
23. P. Shamamian, J.D. Schwartz, and B.J. Pocock Activation of progelatinase A (MMP-2) by neutrophil elastase, cathepsin G, and proteinase-3: a role for inflammatory cells in tumor invasion and angiogenesis J Cell Physiol 189 2001 197 206
24. H.T. Petrie, L.W. Klassen, and H.D. Kay Inhibition of human cytotoxic T lymphocyte activity in vitro by autologous peripheral blood granulocytes J Immunol 134 1985 230 234
25. A. el-Hag, and R.A. Clark Immunosuppression by activated human neutrophils. Dependence on the myeloperoxidase system J Immunol 139 1987 2406 2413
26. H.W. Bruckner, P.T. Lavin, and S.C. Plaxe Absolute granulocyte, lymphocyte, and monocyte counts. Useful determinants of prognosis for patients with metastatic cancer of the stomach JAMA 247 1982 1004 1006
27. E.G. Elias, J.M. Leuchten, and B.S. Buda Prognostic value of initial mononucleated cell percentages in patients with epidermoid carcinoma of the head and neck Am J Surg 152 1986 487 490
28. H. Cho, H.W. Hur, and S.W. Kim Pretreatment neutrophil to lymphocyte ratio is elevated in epithelial ovarian cancer and predicts survival after treatment Cancer Immunol Immunother 58 2009 15 23
29. M. Hirashima, S. Higuchi, and K. Sakamoto The ratio of neutrophils to lymphocytes and the phenotypes of neutrophils in patients with early gastric cancer J Cancer Res Clin Oncol 124 1998 329 334