Benzofuran-derived benzylpyridinium bromides as potent acetylcholinesterase inhibitors

European Journal of Medicinal Chemistry

Volumn 93, Issue , 2015, Pages 196-201

  Baharloo, Farzaneh ^a   Moslemin, Mohammad Hossein ^a   Nadri, Hamid ^b   Asadipour, Ali ^c   Mahdavi, Mohammad ^d   Emami, Saeed ^e   Firoozpour, Loghman ^f   Mohebat, Razieh ^a   Shafiee, Abbas ^d   Foroumadi, Alireza ^c,d  

^a ISLAMIC AZAD UNIVERSITY   (Iran)

^b SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c KERMAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^d TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^e MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^f TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Acetylcholinesterase; Alzheimer's disease; Benzofuran; Docking study; Pyridinium

Indexed keywords

2 [(PYRIDIN 4 YL) METHOXY]BENZALDEHYDE; 4 (BENZOFURAN 2 YL) PYRIDINE DERIVATIVE; BENZOFURAN DERIVATIVE; BROMINE DERIVATIVE; CHOLINESTERASE INHIBITOR; DONEPEZIL; N (2 METHYLBENZYL) 4 (BENZOFURAN 2 YL)PYRIDINIUM BROMIDE; N (2 NITROBENZYL) 4 (BENZOFURAN 2 YL)PYRIDINIUM BROMIDE; N (3 BROMOBENZYL) 4 (7 METHOXYBENZOFURAN 2 YL)PYRIDINIUM BROMIDE; N (3 FLUOROBENZYL) 4 (5 BROMOBENZOFURAN 2 YL)PYRIDINIUM BROMIDE; N (3 FLUOROBENZYL) 4 (7 METHOXYBENZOFURAN 2 YL)PYRIDINIUM BROMIDE; N (3,5 DIMETHYLBENZYL) 4 (BENZOFURAN 2 YL)PYRIDINIUM BROMIDE; N (4 BROMOBENZYL) 4 (5 BROMOBENZOFURAN 2 YL)PYRIDINIUM BROMIDE; N (4 BROMOBENZYL) 4 (7 METHOXYBENZOFURAN 2 YL)PYRIDINIUM BROMIDE; N (4 BROMOBENZYL) 4 (BENZOFURAN 2 YL)PYRIDINIUM BROMIDE; N (4 FLUOROBENZYL) 4 (5 BROMOBENZOFURAN 2 YL)PYRIDINIUM BROMIDE; N (4 NITROBENZYL) 4 (5 BROMOBENZOFURAN 2 YL)PYRIDINIUM BROMIDE; N (4 NITROBENZYL) 4 (7 METHOXYBENZOFURAN 2 YL)PYRIDINIUM BROMIDE; N (4 NITROBENZYL) 4 (BENZOFURAN 2 YL)PYRIDINIUM BROMIDE; N BENZYL 4 (5 BROMOBENZOFURAN 2 YL)PYRIDINIUM BROMIDE; N BENZYL 4 (7 METHOXYBENZOFURAN 2 YL)PYRIDINIUM BROMIDE; N BENZYL 4 (BENZOFURAN 2 YL)PYRIDINIUM BROMIDE; PYRIDINIUM DERIVATIVE; UNCLASSIFIED DRUG; ACETYLCHOLINESTERASE;

ANTICHOLINERGIC EFFECT; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; DRUG DESIGN; DRUG SYNTHESIS; IC50; IN VITRO STUDY; MOLECULAR DOCKING; MOLECULAR MODEL; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION; ALZHEIMER DISEASE; CHEMICAL STRUCTURE; CHEMISTRY; ENZYMOLOGY; HUMAN; METABOLISM; SYNTHESIS;

ACETYLCHOLINESTERASE; ALZHEIMER DISEASE; BENZOFURANS; CHOLINESTERASE INHIBITORS; DRUG DESIGN; HUMANS; MOLECULAR DOCKING SIMULATION; MOLECULAR STRUCTURE; PYRIDINIUM COMPOUNDS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84922628509     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2015.02.009     Document Type: Article

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