Hepatic and fecal metabolomic analysis of the effects of lactobacillus rhamnosus GG on alcoholic fatty liver disease in mice

Journal of Proteome Research

Volumn 14, Issue 2, 2015, Pages 1174-1182

  Shi, Xue ^a   Wei, Xiaoli ^a   Yin, Xinmin ^a   Wang, Yuhua ^b   Zhang, Min ^b   Zhao, Cuiqing ^b   Zhao, Haiyang ^b   McClain, Craig J ^b,c   Feng, Wenke ^b   Zhang, Xiang ^a,b  

^a UNIVERSITY OF LOUISVILLE   (United States)

^b University of Louisville School of Medicine   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

alcohol liver disease; GC GC TOF MS; liver; metabolomics; probiotics

Indexed keywords

ALCOHOL; ISOLEUCINE; LONG CHAIN FATTY ACID; MEDIUM CHAIN FATTY ACID; MONOUNSATURATED FATTY ACID; POLYUNSATURATED FATTY ACID; PROBIOTIC AGENT; SHORT CHAIN FATTY ACID;

ALCOHOLIC FATTY LIVER; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHEMOMETRIC ANALYSIS; CONTROLLED STUDY; ENDOTOXEMIA; FATTY ACID SYNTHESIS; FECES ANALYSIS; GAS CHROMATOGRAPHY; LACTOBACILLUS RHAMNOSUS; LIPID STORAGE; MALE; METABOLITE; METABOLOME; METABOLOMICS; MOUSE; NONHUMAN; PRIORITY JOURNAL; SUPERNATANT; TIME OF FLIGHT MASS SPECTROMETRY; ANIMAL; FECES; LIVER; MASS FRAGMENTOGRAPHY; METABOLISM;

ANIMALIA; BACTERIA (MICROORGANISMS); LACTOBACILLUS RHAMNOSUS; MUS;

ANIMALS; FATTY LIVER, ALCOHOLIC; FECES; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; LACTOBACILLUS RHAMNOSUS; LIVER; METABOLOMICS; MICE;

EID: 84922624751     PISSN: 15353893     EISSN: 15353907     Source Type: Journal    
DOI: 10.1021/pr501121c     Document Type: Article

References (31)

1. Kirpich, I. A.; McClain, C. J. Probiotics in the treatment of the liver diseases J. Am. Coll. Nutr. 2012, 31, 14-23
2. Wang, Y.; Kirpich, I.; Liu, Y.; Ma, Z.; Barve, S.; McClain, C. J.; Feng, W. Lactobacillus rhamnosus GG treatment potentiates intestinal hypoxia-inducible factor, promotes intestinal integrity and ameliorates alcohol-induced liver injury Am. J. Pathol. 2011, 179, 2866-2875
3. Forsyth, C. B.; Farhadi, A.; Jakate, S. M.; Tang, Y.; Shaikh, M.; Keshavarzian, A. Lactobacillus GG treatment ameliorates alcohol-induced intestinal oxidative stress, gut leakiness, and liver injury in a rat model of alcoholic steatohepatitis Alcohol (N.Y., NY, U.S.) 2009, 43, 163-172
4. Kelishadi, R.; Farajian, S.; Mirlohi, M. Probiotics as a novel treatment for non-alcoholic fatty liver disease; a systematic review on the current evidences Hepatitis Mon. 2013, 13, e7233
5. Wang, Y.; Liu, Y.; Kirpich, I.; Ma, Z.; Wang, C.; Zhang, M.; Suttles, J.; McClain, C.; Feng, W. Lactobacillus rhamnosus GG reduces hepatic TNFα production and inflammation in chronic alcohol-induced liver injury J. Nutr. Biochem. 2013, 24, 1609-1615
6. Wang, Y.; Liu, Y.; Sidhu, A.; Ma, Z.; McClain, C.; Feng, W. Lactobacillus rhamnosus GG culture supernatant ameliorates acute alcohol-induced intestinal permeability and liver injury Am. J. Physiol. 2012, 303, G32-G41
7. Zhang, M.; Wang, C.; Wang, C.; Zhao, H.; Zhao, C.; Wang, Y.; McClain, C.; Feng, W. Enhanced AMPK phosphorylation contributes to the beneficial effects of Lactobacillus rhamnosus GG supernatant on chronic alcohol-induced fatty liver disease J. Nutr. Biochem 2014, 10.1016/j.jnutbio.2014.10.016
8. Douillard, F. P.; Ribbera, A.; Kant, R.; Pietila, T. E.; Jarvinen, H. M.; Messing, M.; Randazzo, C. L.; Paulin, L.; Laine, P.; Ritari, J.; Caggia, C.; Lahteinen, T.; Brouns, S. J. J.; Satokari, R.; von Ossowski, I.; Reunanen, J.; Palva, A.; de Vos, W. M. Comparative genomic and functional analysis of 100 Lactobacillus rhamnosus strains and their comparison with strain GG PLoS Genet. 2013, 9, e1003683
9. Koskenniemi, K.; Laakso, K.; Koponen, J.; Kankainen, M.; Greco, D.; Auvinen, P.; Savijoki, K.; Nyman, T. A.; Surakka, A.; Salusjarvi, T.; de Vos, W. M.; Tynkkynen, S.; Kalkkinen, N.; Varmanen, P. Proteomics and transcriptomics characterization of bile stress response in probiotic Lactobacillus rhamnosus GG Mol. Cell. Proteomics 2011, 10, M110.002741
10. Hong, Y. S.; Hong, K. S.; Park, M. H.; Ahn, Y. T.; Lee, J. H.; Huh, C. S.; Lee, J.; Kim, I. K.; Hwang, G. S.; Kim, J. S. Metabonomic understanding of probiotic effects in humans with irritable bowel syndrome J. Clin. Gastroenterol. 2011, 45, 415-425
11. Thomas, C. M.; Hong, T.; van Pijkeren, J. P.; Hemarajata, P.; Trinh, D. V.; Hu, W. D.; Britton, R. A.; Kalkum, M.; Versalovic, J. Histamine derived from probiotic Lactobacillus reuteri suppresses TNF via modulation of PKA and ERK signaling PLoS One 2012, 7, e31951
12. Ewaschuk, J. B.; Walker, J. W.; Diaz, H.; Madsen, K. L. Bioproduction of conjugated linoleic acid by probiotic bacteria occurs in vitro and in vivo in mice J. Nutr. 2006, 136, 1483-1487
13. Ralston-Hooper, K.; Hopf, A.; Oh, C.; Zhang, X.; Adamec, J.; Sepulveda, M. S. Development of GC×GC/TOF-MS metabolomics for use in ecotoxicological studies with invertebrates Aquat. Toxicol. 2008, 88, 48-52
14. Mohler, R. E.; Dombek, K. M.; Hoggard, J. C.; Pierce, K. M.; Young, E. T.; Synovec, R. E. Comprehensive analysis of yeast metabolite GC×GC-TOFMS data: combining discovery-mode and deconvolution chemometric software Analyst 2007, 132, 756-67
15. Huang, X.; Regnier, F. E. Differential metabolomics using stable isotope labeling and two-dimensional gas chromatography with time-of-flight mass spectrometry Anal. Chem. 2008, 80, 107-14
16. Liu, S. M.; Miller, D. M.; Roberts, R. F. Cloning of genes encoding colicin E2 in Lactococcus lactis subspecies lactis and evaluation of the colicin-producing transformants as inhibitors of Escherichia coli O157:H7 during milk fermentation J. Dairy Sci. 2011, 94, 1146-1154
17. Godsey, H. S.; Oviatt, C. G.; Miller, D. M.; Chan, M. A. Stratigraphy and chronology of offshore to nearshore deposits associated with the Provo shoreline, Pleistocene Lake Bonneville, Utah Palaeogeogr., Palaeoclimatol., Palaeoecol. 2011, 310, 442-450
18. Koo, I.; Zhang, X.; Kim, S. Wavelet- and Fourier-transform-based spectrum similarity approaches to compound identification in gas chromatography/mass spectrometry Anal. Chem. 2011, 83, 5631-5638
19. Wei, X.; Shi, X.; Koo, I.; Kim, S.; Schmidt, R. H.; Arteel, G. E.; Watson, W. H.; McClain, C.; Zhang, X. MetPP: a computational platform for comprehensive two-dimensional gas chromatography time-of-flight mass spectrometry-based metabolomics Bioinformatics 2013, 29, 1786-92
20. Zhang, J.; Fang, A. Q.; Wang, B.; Kim, S. H.; Bogdanov, B.; Zhou, Z. X.; McClain, C.; Zhang, X. iMatch: a retention index tool for analysis of gas chromatography-mass spectrometry data J. Chromatogr. A 2011, 1218, 6522-6530
21. Shi, X.; Wei, X.; Koo, I.; Schmidt, R. H.; Yin, X.; Vaughn, A.; Kim, S. H.; McClain, C. J.; Arteel, G. E.; Zhang, X.; Watson, W. H. Metabolomic analysis of the effects of chronic arsenic exposure in a mouse model of diet-induced fatty liver disease J. Proteome Res. 2014, 13, 547-554
22. Rao, M. S.; Reddy, J. K. Peroxisomal β-oxidation and steatohepatitis Semin. Liver Dis. 2001, 21, 43-55
23. Morris, L.; Arata, D.; Cederquist, D. C. Fatty livers in weanling rats fed a low protein, threonine-deficient diet. I. Effect of various diet fats J. Nutr. 1965, 85, 362-366
24. Charlton, M. Branched-chain amino acid enriched supplements as therapy for liver disease J. Nutr. 2006, 136, 295S-298S
25. Calvey, H.; Davis, M.; Williams, R. Controlled trial of nutritional supplementation, with and without branched chain amino acid enrichment, in treatment of acute alcoholic hepatitis J. Hepatol. 1985, 1, 141-51
26. Kirpich, I. A.; Feng, W.; Wang, Y.; Liu, Y.; Barker, D. F.; Barve, S. S.; McClain, C. J. The type of dietary fat modulates intestinal tight junction integrity, gut permeability, and hepatic toll-like receptor expression in a mouse model of alcoholic liver disease Alcohol.: Clin. Exp. Res. 2012, 36, 835-46
27. Chen, P.; Loomba, R.; Torralba, M.; DePew, J.; Nelson, K. E.; Tan, J.; Embree, M.; Zengler, K.; Starkel, P.; Pijkeren, J.-P. v.; Ho, S. B.; Bajaj, J. S.; Mutlu, E. A.; Keshavarzian, A.; Tsukamoto, H.; Fouts, D. E.; Schnabl, B. Supplementation of saturated long-chain fatty acids maintains intestinal eubiosis and reduces ethanol-induced liver injury in mice Gastroenterology 2015, 148, 203-214
28. Aggarwal, S.; Suzuki, T.; Taylor, W. L.; Bhargava, A.; Rao, R. K. Contrasting effects of ERK on tight junction integrity in differentiated and under-differentiated Caco-2 cell monolayers Biochem. J. 2011, 433, 51-63
29. Bull-Otterson, L.; Feng, W.; Kirpich, I.; Wang, Y.; Qin, X.; Liu, Y.; Gobejishvili, L.; Joshi-Barve, S.; Ayvaz, T.; Petrosino, J.; Kong, M.; Barker, D.; McClain, C.; Barve, S. Metagenomic analyses of alcohol induced pathogenic alterations in the intestinal microbiome and the effect of Lactobacillus rhamnosus GG treatment PLoS One 2013, 8, e53028
30. Koo, I.; Kim, S.; Zhang, X. Comparative analysis of mass spectral matching-based compound identification in gas chromatography mass spectrometry J. Chromatogr. A 2013, 1298, 132-138
31. Kim, S.; Koo, I.; Jeong, J.; Wu, S.; Shi, X.; Zhang, X. Compound identification using partial and semipartial correlations for gas chromatography-mass spectrometry data Anal. Chem. 2012, 84, 6477-6487