A review: Radiographic iodinated contrast media-induced thyroid dysfunction

Journal of Clinical Endocrinology and Metabolism

Volumn 100, Issue 2, 2015, Pages 376-383

  Lee, Sun Y ^a   Rhee, Connie M ^b   Leung, Angela M ^c   Braverman, Lewis E ^a   Brent, Gregory A ^c   Pearce, Elizabeth N ^a  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA ADRENERGIC RECEPTOR BLOCKING AGENT; IOXAGLIC ACID; LEVOTHYROXINE; MEGLUMINE DIATRIZOATE; MEGLUMINE IOTALAMATE; PERCHLORATE; THIAMAZOLE; CONTRAST MEDIUM;

COMPUTER ASSISTED TOMOGRAPHY; CONTRAST INDUCED HYPERTHYROIDISM; CONTRAST INDUCED HYPOTHYROIDISM; CONTRAST INDUCED THYROID DYSFUNCTION; DISEASE PREDISPOSITION; DOSE RESPONSE; DRUG DOSE TITRATION; DRUG EFFECT; DRUG EXPOSURE; DRUG SAFETY; ENDOCRINE DISEASE; EUTHYROIDISM; HUMAN; HYPERTHYROIDISM; HYPOTHYROIDISM; IODINE INDUCED HYPERTHYROIDISM; IODINE INDUCED HYPOTHYROIDISM; KIDNEY FAILURE; NONHUMAN; OSMOLARITY; PRIORITY JOURNAL; REVIEW; RISK ASSESSMENT; THYROID DISEASE; THYROID FUNCTION; TREATMENT PLANNING; VULNERABLE POPULATION; WOLFF CHAIKOFF EFFECT; CHEMICALLY INDUCED; THYROID FUNCTION TEST;

CONTRAST MEDIA; HUMANS; THYROID DISEASES; THYROID FUNCTION TESTS;

EID: 84922570751     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jc.2014-3292     Document Type: Review

References (78)

1. Dai G, Levy O, Carrasco N. Cloning and characterization of the thyroid iodide transporter. Nature. 1996; 379(6564): 458-460.
2. Bizhanova A, Kopp P. Minireview: the sodium-iodide symporter NIS and pendrin in iodide homeostasis of the thyroid. Endocrinology. 2009; 150(3): 1084-1090.
3. Medicare Payment Advisory Commission. A Data Book: Health Care Spending and the Medicare Program, June 2013. Available at: http://medpac.gov/documents/June13DataBookEntireReport.pdf. Accessed September 19, 2013.
4. Smith-Bindman R, Lipson J, Marcus R, et al. Radiation dose associated with common computed tomography examinations and the associated lifetime attributable risk of cancer. Arch Intern Med. 2009; 169: 2078-2086.
5. World Health Organization. Assessment of iodine deficiency disorders and monitoring their elimination: a guide for programme managers. 3rd ed. 2007. http://whqlibdoc.who.int/publications/2007/9789241595827-eng.pdf. Accessed September 19, 2013.
6. National Academy of Sciences, Institute of Medicine, Food and Nutrition Board. Dietary reference intakes for vitamin A, vitamin K, arsenic, boron, chromium, copper, iodine, iron, manganese, molybdenum, nickel, silicon, vanadium, and zinc. Washington, DC: National Academy Press; 2001. http://www.nap.edu/catalog.php?record-id=10026. Accessed September 23, 2013.
7. Otten JJ, Hellwig JP, Meyers LD. Dietary Reference Intakes: The Essential Guide to Nutrient Requirements. Washington, DC: National Academies Press; 2006.
8. McClennan BL, Preston M. Hickey memorial lecture. Ionic and nonionic iodinated contrast media: evolution and strategies for use. AJR Am J Roentgenol. 1990; 155(2): 225-233.
9. Solomon R, Briguori C, Bettmann M. Selection of contrast media. Kidney Int Suppl. 2006; 100: S39-S45.
10. Katzberg RW, Haller C. Contrast-induced nephrotoxicity: clinical landscape. Kidney Int Suppl. 2006; 100: S3-S7.
11. van der Molen AJ, Thomsen HS, Morcos SK. Effect of iodinated contrast media on thyroid function in adults. Eur Radiol. 2004; 14(5): 902-907.
12. Moisey RS, McPherson S, Wright M, Orme SM. Thyroiditis and iodide mumps following an angioplasty. Nephrol Dial Transplant. 2007; 22(4): 1250-1252.
13. Lee SY, Chang DLF, He X, Pearce EN, Braverman LE, Leung AM. Urinary iodineexcretion and changes in thyroid hormone levels after computer tomography scan with iodinated contrast administration. Poster presented at: 84th Annual Meeting of American Thyroid Association; October 29-November 2, 2014; Coronado, CA.
14. Nimmons GL, Funk GF, Graham MM, Pagedar NA. Urinary iodine excretion after contrast computed tomography scan: implications for radioactive iodine use. JAMA Otolaryngol Head Neck Surg. 2013; 139(5): 479-482.
15. Padovani RP, Kasamatsu TS, Nakabashi CC, et al. One month is sufficient for urinary iodine to return to its baseline value after the use of water-soluble iodinated contrast agents in post-thyroidectomy patients requiring radioiodine therapy. Thyroid. 2012; 22(9): 926-930.
16. Wolff J, Chaikoff IL. Plasma inorganic iodide as a homeostatic regulator of thyroid function. J Biol Chem. 1948; 174(2): 555-564.
17. Wolff J, Chaikoff IL. The inhibitory action of iodide upon organic binding of iodine by the normal thyroid gland. J Biol Chem. 1948; 172(2): 855.
18. Raben MS The paradoxical effects of thiocyanate and of thyrotropin on the organic binding of iodine by the thyroid in the presence of large amounts of iodide. Endocrinology. 1949; 45(3): 296-304.
19. Markou K, Georgopoulos N, Kyriazopoulou V, Vagenakis AG. Iodine-induced hypothyroidism. Thyroid. 2001; 11(5): 501-510.
20. Lamas L, Ingbar SH. The effect of varying iodine content on the susceptibility of thyroglobulin to hydrolysis by thyroid acid protease. Endocrinology. 1978; 102(1): 188-197.
21. Bagchi N, Brown T, Shivers B, Mack RE. Effect of inorganic iodide on thyroglobulin hydrolysis in cultured thyroid glands. Endocrinology. 1977; 100(4): 1002-1007.
22. Becks GP, Eggo MC, Burrow GN. Regulation of differentiated thyroid function by iodide: preferential inhibitory effectofexcess iodide on thyroid hormone secretion in sheep thyroid cell cultures. Endocrinology. 1987; 120(6): 2569-2575.
23. Wolff J, Chaikoff IL. The temporary nature of the inhibitory action of excess iodine on organic iodine synthesis in the normal thyroid. Endocrinology. 1949; 45(5): 504-513, illust.
24. Braverman LE, Ingbar SH. Changes in thyroidal function during adaptation to large doses of iodide. J Clin Invest. 1963; 42: 1216-1231.
25. Eng PH, Cardona GR, Fang SL, et al. Escape from the acute Wolff-Chaikoff effect is associated with a decrease in thyroid sodium/iodide symporter messenger ribonucleic acid and protein. Endocrinology. 1999; 140(8): 3404-3410.
26. Pramyothin P, Leung AM, Pearce EN, Malabanan AO, Braverman LE. Clinical problem-solving. A hidden solution. N Engl J Med. 2011; 365(22): 2123-2127.
27. Serrano-Nascimento C, da Silva Teixeira S, Nicola JP, Nachbar RT, Masini-Repiso AM, Nunes MT. The acute inhibitory effect of iodide excess on sodium/iodide symporter expression and activity involves the PI3K/Akt signaling pathway. Endocrinology. 2014; 155(3): 1145-1156.
28. Braverman LE Iodine and the thyroid: 33 years of study. Thyroid. 1994; 4(3): 351-356.
29. Leung AM, Braverman LE. Iodine-induced thyroid dysfunction. Curr Opin Endocrinol Diabetes Obes. 2012; 19(5): 414-419.
30. Coindet J. Nouvelles recherches sur les effets de l'iode, et sur les precautions a suivre dans le traitement de goitre par le nouveau remede. Bibl Univ Sci Belle-Lettres Arts. 1821; 16(140).
31. Braverman LE Effects of iodine on thyroid function in man. Trans Am Clin Climatol Assoc. 1991; 102: 143-151;discussion 151-152
32. Roti E, Uberti ED. Iodine excess and hyperthyroidism. Thyroid. 2001; 11(5): 493-500.
33. Braverman LE, Woeber KA, Ingbar SH. Induction of myxedema by iodide in patients euthyroid after radioiodine or surgical treatment of diffuse toxic goiter. N Engl J Med. 1969; 281(15): 816-821.
34. Braverman LE, Ingbar SH, Vagenakis AG, Adams L, Maloof F. Enhanced susceptibility to iodide myxedema in patients with Hashimoto's disease. J Clin Endocrinol Metab. 1971; 32(4): 515-521.
35. Roti E, Vagenakis AG. Effect of excess iodide: clinical aspects. In: Braverman LE, Cooper DS, eds. Werner & Ingbar's The Thyroid: A Fundamental and Clinical Text. 10th ed. Philadelphia, PA: Lippincott, Williams & Wilkins; 2012: 242-256.
36. Breuel HP, Breuel C, Emrich D, Fischer P, Gilak A, Winkler C. Changes in thyroid function after application of iodinated contrast media to normal subjects [in German]. Med Klin. 1979; 74(41): 1492-1496.
37. Conn JJ, Sebastian MJ, Deam D, Tam M, Martin FI. A prospective study of the effect of nonionic contrast media on thyroid function. Thyroid. 1996; 6(2): 107-110.
38. Nygaard B, Nygaard T, Jensen LI, et al. Iohexol: effects on uptake of radioactive iodine in the thyroid and on thyroid function. Acad Radiol. 1998; 5(6): 409-414.
39. Özkan S, Oysu AS, Kayata K, et al. Thyroid functions after contrast agent administration for coronary angiography: a prospective observational study in euthyroid patients. Anadolu Kardiyol Derg. 2013; 13(4): 363-369.
40. Mushtaq U, Price T, Laddipeerla N, Townsend A, Broadbridge V. Contrast induced hyperthyroidism due to iodine excess. BMJ Case Rep. 2009; 2009: pii: bcr06.2009.1982.
41. Rhee CM, Bhan I, Alexander EK, Brunelli SM. Association between iodinated contrast media exposure and incident hyperthyroidism and hypothyroidism. Arch Intern Med. 2012; 172(2): 153-159.
42. Rhee CM, Lynch KE, Zandi-Nejad K, Pearce EN, Alexander EK, Brunelli SM. Iodinated contrast media exposure and incident hyperthyroidism and hypothyroidism in a community-based cohort [published online October 2, 2013]. Endocrinol Stud. doi.org/10.4081/es.2013.e8.
43. Marraccini P, Bianchi M, Bottoni A, et al. Prevalence of thyroid dysfunction and effect of contrast medium on thyroid metabolism in cardiac patients undergoing coronary angiography. Acta Radiol. 2013; 54(1): 42-47.
44. Koroscil TM, Pelletier PR, Slauson JW, Hennessey J. Short-term effects of coronary angiographic contrast agents on thyroid function. Endocr Pract. 1997; 3(4): 219-221.
45. Jaffiol C, Baldet L, Bada M, Vierne Y. The influence on thyroid function of two iodine-containing radiological contrast media. Br J Radiol. 1982; 55(652): 263-265.
46. Bürgi H, Wimpfheimer C, Burger A, Zaunbauer W, Rösler H, Lemarchand-Béraud T. Changes of circulating thyroxine, triiodothyronine and reverse triiodothyronine after radiographic contrast agents. J Clin Endocrinol Metab. 1976; 43(6): 1203-1210.
47. Wu SY, Chopra IJ, Solomon DH, Bennett LR. Changes in circulating iodothyronines in euthyroid and hyperthyroid subjects given ipodate (Oragrafin), an agent for oral cholecystography. J Clin Endocrinol Metab. 1978; 46(4): 691-697.
48. Gartner W, Weissel M. Do iodine-containing contrast media induce clinically relevant changes in thyroid function parameters of euthyroid patients within the first week? Thyroid. 2004; 14(7): 521-524.
49. Oppenheimer JH, McPherson HT. The syndrome of iodide-induced goiter and myxedema. Am J Med. 1961; 30: 281-288.
50. Paley KR, Sobel ES, Yalow RS. Some aspects of thyroidal iodine metabolism in a case of iodine-induced hypothyroidism. J Clin Endocrinol Metab. 1958; 18(1): 79-90.
51. Atwell TD, Lteif AN, Brown DL, McCann M, Townsend JE, Leroy AJ. Neonatal thyroid function after administration of IV iodinated contrast agentto 21pregnant patients. AJR AmJ Roentgenol. 2008; 191(1): 268-271.
52. Theodoropoulos T, Braverman LE, Vagenakis AG. Iodide-induced hypothyroidism: a potential hazard during perinatal life. Science. 1979; 205(4405): 502-503.
53. Webb JA, Thomsen HS, Morcos SK. The use of iodinated and gadolinium contrast media during pregnancy and lactation. Eur Radiol. 2005; 15(6): 1234-1240.
54. Kochi MH, Kaloudis EV, Ahmed W, Moore WH. Effect of in utero exposure of iodinated intravenous contrast on neonatal thyroid function. J Comput Assist Tomogr. 2012; 36(2): 165-169.
55. Rajaram S, Exley CE, Fairlie F, Matthews S. Effect of antenatal iodinated contrast agent on neonatal thyroid function. Br J Radiol. 2012; 85(1015): e238-e242.
56. Bourjeily G, Chalhoub M, Phornphutkul C, Alleyne TC, Woodfield CA, Chen KK. Neonatal thyroid function: effect of a single exposure to iodinated contrast medium in utero. Radiology. 2010; 256(3): 744-750.
57. Semba RD, Delange F. Iodine in human milk: perspectives for infant health. Nutr Rev. 2001; 59(8): 269-278.
58. Shumer DE, Mehringer JE, Braverman LE, Dauber A. Acquired hypothyroidism in an infant related to excessive maternal iodine intake: food for thought. Endocr Pract. 2013; 19(4): 729-731.
59. Connelly KJ, Boston BA, Pearce EN, et al. Congenital hypothyroidism caused by excess prenatal maternal iodine ingestion. J Pediatr. 2012; 161(4): 760-762.
60. Thaker VV, Leung AM, Braverman LE, Brown RS, Levine B. Iodine-induced hypothyroidism in full-term infants with congenital heart disease: more common than currently appreciated? J Clin Endocrinol Metab. 2014; 99(10): 3521-3526.
61. del Cerro Marín M, Fernández Ruiz A, García-Guereta L, et al. Thyroid function alterations in children with congenital cardiac disease after catheterization with iodinated contrast agents [in Spanish]. Rev Esp Cardiol. 2000; 53(4): 517-524.
62. Ahmet A, Lawson ML, Babyn P, Tricco AC. Hypothyroidism in neonates post-iodinated contrast media: a systematic review. Acta Pædiatrica. 2009; 98(10): 1568-1574.
63. Iglesias P, Díez JJ. Thyroid dysfunction and kidney disease. Eur J Endocrinol. 2009; 160(4): 503-515.
64. Lo JC, Chertow GM, Go AS, Hsu CY. Increased prevalence of sub-clinical and clinical hypothyroidism in persons with chronic kidney disease. Kidney Int. 2005; 67(3): 1047-1052.
65. Chonchol M, Lippi G, Salvagno G, Zoppini G, Muggeo M, Targher G. Prevalence of subclinical hypothyroidism in patients with chronic kidney disease. Clin J Am Soc Nephrol. 2008; 3(5): 1296-1300.
66. Kaptein EM Thyroid hormone metabolism and thyroid diseases in chronic renal failure. Endocr Rev. 1996; 17(1): 45-63.
67. Kutlay S, Atli T, Koseogullari O, Nergizoglu G, Duman N, Gullu S. Thyroid disorders in hemodialysis patients in an iodine-deficient community. Artif Organs. 2005; 29(4): 329-332.
68. Lin CC, Chen TW, Ng YY, Chou YH, Yang WC. Thyroid dysfunction and nodular goiter in hemodialysis and peritoneal dialysis patients. Perit Dial Int. 1998; 18(5): 516-521.
69. Ng YY, Wu SC, Lin HD, et al. Prevalence of clinical and subclinical thyroid disease in a peritoneal dialysis population. Perit Dial Int. 2012; 32(1): 86-93.
70. Sanai T, Inoue T, Okamura K, et al. Reversible primary hypothyroidism in Japanese patients undergoing maintenance hemodialysis. Clin Nephrol. 2008; 69(2): 107-113.
71. Takeda S, Michigishi T, Takazakura E. Iodine-induced hypothyroidism in patients on regular dialysis treatment. Nephron. 1993; 65(1): 51-55.
72. Brough R, Jones C. Iatrogenic iodine as a cause of hypothyroidism in infants with end-stage renal failure. Pediatr Nephrol. 2006; 21(3): 400-402.
73. Morcos SK, Thomsen HS, Webb JA. Dialysis and contrast media. Eur Radiol. 2002; 12(12): 3026-3030.
74. Rendl J, Saller B. Schilddrüse und Röntgenkontrastmittel: Pathophysiologie, Häufigkeit und Prophylaxe der jodinduzierten Hyperthyreose. Dtsch Arztebl. 2001; 98: A-402/B-339/C-316.
75. Arum SM, He X, Braverman LE. Excess iodine from an unexpected source. N Engl J Med. 2009; 360(4): 424-426.
76. Fricke E, Fricke H, Esdorn E, et al. Scintigraphy for risk stratification of iodine-induced thyrotoxicosis in patients receiving contrast agent for coronary angiography: a prospective study of patients with low thyrotropin. J Clin Endocrinol Metab. 2004; 89(12): 6092-6096.
77. Nolte, Muller R, Siggelkow H, Emrich D, Hufner M. Prophylactic application of thyrostatic drugs during excessive iodine exposure in euthyroid patients with thyroid autonomy: a randomized study. Eur J Endocrinol. 1996; 134(3): 337-341.
78. Canaris GJ, Manowitz NR, Mayor G, Ridgway E. The Colorado thyroid disease prevalence study. Arch Intern Med. 2000; 160(4): 526-534.