메뉴 건너뛰기




Volumn 25, Issue 8, 2014, Pages 788-795

Preventive sublingual immunotherapy in preschool children: First evidence for safety and pro-tolerogenic effects

Author keywords

Allergen specific immunotherapy; Allergy prevention; IgE sensitization; Skin prick test; Specific IgE

Indexed keywords

GRASS POLLEN EXTRACT; HOUSE DUST ALLERGEN; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; INTERLEUKIN 10; PLACEBO; TRANSFORMING GROWTH FACTOR BETA; ALLERGEN;

EID: 84922546566     PISSN: 09056157     EISSN: 13993038     Source Type: Journal    
DOI: 10.1111/pai.12310     Document Type: Article
Times cited : (58)

References (31)
  • 1
    • 33845927938 scopus 로고    scopus 로고
    • Long-lasting effects of sublingual immunotherapy for house dust mites in allergic rhinitis with bronchial hyperreactivity: a long-term (13-year) retrospective study in real life
    • Marogna M, Bruno M, Massolo A, Falagiani P. Long-lasting effects of sublingual immunotherapy for house dust mites in allergic rhinitis with bronchial hyperreactivity: a long-term (13-year) retrospective study in real life. Int Arch Allergy Immunol 2007: 142: 70-8.
    • (2007) Int Arch Allergy Immunol , vol.142 , pp. 70-78
    • Marogna, M.1    Bruno, M.2    Massolo, A.3    Falagiani, P.4
  • 2
    • 0037328916 scopus 로고    scopus 로고
    • Long-lasting effect of sublingual immunotherapy in children with asthma due to house dust mite: a 10-year prospective study
    • Di Rienzo V, Marcucci F, Puccinelli P, et al. Long-lasting effect of sublingual immunotherapy in children with asthma due to house dust mite: a 10-year prospective study. Clin Exp Allergy 2003: 33: 206-10.
    • (2003) Clin Exp Allergy , vol.33 , pp. 206-210
    • Di Rienzo, V.1    Marcucci, F.2    Puccinelli, P.3
  • 3
    • 0036217348 scopus 로고    scopus 로고
    • Long-term efficacy of preseasonal grass pollen immunotherapy in children
    • Eng PA, Reinhold M, Gnehm HP. Long-term efficacy of preseasonal grass pollen immunotherapy in children. Allergy 2002: 57: 306-12.
    • (2002) Allergy , vol.57 , pp. 306-312
    • Eng, P.A.1    Reinhold, M.2    Gnehm, H.P.3
  • 4
    • 0033549827 scopus 로고    scopus 로고
    • Long-term clinical efficacy of grass-pollen immunotherapy
    • Durham SR, Walker SM, Varga EM, et al. Long-term clinical efficacy of grass-pollen immunotherapy. N Engl J Med 1999: 341: 468-75.
    • (1999) N Engl J Med , vol.341 , pp. 468-475
    • Durham, S.R.1    Walker, S.M.2    Varga, E.M.3
  • 5
    • 34047163404 scopus 로고    scopus 로고
    • Mechanisms of allergen-specific immunotherapy
    • Akdis M, Akdis CA. Mechanisms of allergen-specific immunotherapy. J Allergy Clin Immunol 2007: 119: 780-91.
    • (2007) J Allergy Clin Immunol , vol.119 , pp. 780-791
    • Akdis, M.1    Akdis, C.A.2
  • 6
    • 33749016485 scopus 로고    scopus 로고
    • Immunological mechanisms of allergen-specific immunotherapy
    • Larche M, Akdis CA, Valenta R. Immunological mechanisms of allergen-specific immunotherapy. Nat Rev Immunol 2006: 6: 761-71.
    • (2006) Nat Rev Immunol , vol.6 , pp. 761-771
    • Larche, M.1    Akdis, C.A.2    Valenta, R.3
  • 7
    • 0035726457 scopus 로고    scopus 로고
    • Prevention of new sensitizations in monosensitized subjects submitted to specific immunotherapy or not. A retrospective study
    • Purello-D'Ambrosio F, Gangemi S, Merendino RA, et al. Prevention of new sensitizations in monosensitized subjects submitted to specific immunotherapy or not. A retrospective study. Clin Exp Allergy 2001: 31: 1295-302.
    • (2001) Clin Exp Allergy , vol.31 , pp. 1295-1302
    • Purello-D'Ambrosio, F.1    Gangemi, S.2    Merendino, R.A.3
  • 8
    • 0030903223 scopus 로고    scopus 로고
    • Immunotherapy with a standardized Dermatophagoides pteronyssinus extract. VI. Specific immunotherapy prevents the onset of new sensitizations in children
    • Des Roches A, Paradis L, Menardo JL, Bouges S, Daures JP, Bousquet J. Immunotherapy with a standardized Dermatophagoides pteronyssinus extract. VI. Specific immunotherapy prevents the onset of new sensitizations in children. J Allergy Clin Immunol 1997: 99: 450-3.
    • (1997) J Allergy Clin Immunol , vol.99 , pp. 450-453
    • Des Roches, A.1    Paradis, L.2    Menardo, J.L.3    Bouges, S.4    Daures, J.P.5    Bousquet, J.6
  • 9
    • 0034847103 scopus 로고    scopus 로고
    • Prevention of new sensitizations in asthmatic children monosensitized to house dust mite by specific immunotherapy. A six-year follow-up study
    • 3.
    • Pajno GB, Barberio G, De Luca F, Morabito L, Parmiani S. Prevention of new sensitizations in asthmatic children monosensitized to house dust mite by specific immunotherapy. A six-year follow-up study. Clin Exp Allergy 2001: 31: 1392-37.
    • (2001) Clin Exp Allergy , vol.31 , pp. 1392-1397
    • Pajno, G.B.1    Barberio, G.2    De Luca, F.3    Morabito, L.4    Parmiani, S.5
  • 10
    • 34447132918 scopus 로고    scopus 로고
    • Specific immunotherapy has long-term preventive effect of seasonal and perennial asthma: 10-year follow-up on the PAT study
    • Jacobsen L, Niggemann B, Dreborg S, et al. Specific immunotherapy has long-term preventive effect of seasonal and perennial asthma: 10-year follow-up on the PAT study. Allergy 2007: 62: 943-8.
    • (2007) Allergy , vol.62 , pp. 943-948
    • Jacobsen, L.1    Niggemann, B.2    Dreborg, S.3
  • 11
    • 34247270109 scopus 로고    scopus 로고
    • Prevention of new sensitizations by specific immunotherapy in children with rhinitis and/or asthma monosensitized to house dust mite
    • Inal A, Altintas DU, Yilmaz M, Karakoc GB, Kendirli SG, Sertdemir Y. Prevention of new sensitizations by specific immunotherapy in children with rhinitis and/or asthma monosensitized to house dust mite. J Investig Allergol Clin Immunol 2007: 17: 85-91.
    • (2007) J Investig Allergol Clin Immunol , vol.17 , pp. 85-91
    • Inal, A.1    Altintas, D.U.2    Yilmaz, M.3    Karakoc, G.B.4    Kendirli, S.G.5    Sertdemir, Y.6
  • 12
    • 34047150705 scopus 로고    scopus 로고
    • Successful sublingual immunotherapy with birch pollen has limited effects on concomitant food allergy to apple and the immune response to the Bet v 1 homolog Mal d 1
    • Kinaciyan T, Jahn-Schmid B, Radakovics A, et al. Successful sublingual immunotherapy with birch pollen has limited effects on concomitant food allergy to apple and the immune response to the Bet v 1 homolog Mal d 1. J Allergy Clin Immunol 2007: 119: 937-43.
    • (2007) J Allergy Clin Immunol , vol.119 , pp. 937-943
    • Kinaciyan, T.1    Jahn-Schmid, B.2    Radakovics, A.3
  • 13
    • 34548237449 scopus 로고    scopus 로고
    • Sublingual immunotherapy induces IL-10-producing T regulatory cells, allergen-specific T-cell tolerance, and immune deviation
    • Bohle B, Kinaciyan T, Gerstmayr M, Radakovics A, Jahn-Schmid B, Ebner C. Sublingual immunotherapy induces IL-10-producing T regulatory cells, allergen-specific T-cell tolerance, and immune deviation. J Allergy Clin Immunol 2007: 120: 707-13.
    • (2007) J Allergy Clin Immunol , vol.120 , pp. 707-713
    • Bohle, B.1    Kinaciyan, T.2    Gerstmayr, M.3    Radakovics, A.4    Jahn-Schmid, B.5    Ebner, C.6
  • 14
    • 84896706033 scopus 로고    scopus 로고
    • Advances in allergen-microarray technology for diagnosis and monitoring of allergy: the MeDALL allergen-chip
    • Lupinek C, Wollmann E, Baar A, et al. Advances in allergen-microarray technology for diagnosis and monitoring of allergy: the MeDALL allergen-chip. Methods 2013: 66: 106-119.
    • (2013) Methods , vol.66 , pp. 106-119
    • Lupinek, C.1    Wollmann, E.2    Baar, A.3
  • 15
    • 33644900473 scopus 로고    scopus 로고
    • Twelve-year follow-up after discontinuation of preseasonal grass pollen immunotherapy in childhood
    • Eng PA, Borer-Reinhold M, Heijnen IA, Gnehm HP. Twelve-year follow-up after discontinuation of preseasonal grass pollen immunotherapy in childhood. Allergy 2006: 61: 198-201.
    • (2006) Allergy , vol.61 , pp. 198-201
    • Eng, P.A.1    Borer-Reinhold, M.2    Heijnen, I.A.3    Gnehm, H.P.4
  • 16
    • 84884906703 scopus 로고    scopus 로고
    • Prophylactic use of sublingual allergen immunotherapy in high-risk children: a pilot study
    • e1.
    • Holt PG, Sly PD, Sampson HA, et al. Prophylactic use of sublingual allergen immunotherapy in high-risk children: a pilot study. J Allergy Clin Immunol 2013: 132: 991-3.e1.
    • (2013) J Allergy Clin Immunol , vol.132 , pp. 991-993
    • Holt, P.G.1    Sly, P.D.2    Sampson, H.A.3
  • 17
    • 0030068998 scopus 로고    scopus 로고
    • Regulation of house dust mite responses by intranasally administered peptide: transient activation of CD4+ T cells precedes the development of tolerance in vivo
    • Hoyne GF, Askonas BA, Hetzel C, Thomas WR, Lamb JR. Regulation of house dust mite responses by intranasally administered peptide: transient activation of CD4+ T cells precedes the development of tolerance in vivo. Int Immunol 1996: 8: 335-42.
    • (1996) Int Immunol , vol.8 , pp. 335-342
    • Hoyne, G.F.1    Askonas, B.A.2    Hetzel, C.3    Thomas, W.R.4    Lamb, J.R.5
  • 18
    • 77649248142 scopus 로고    scopus 로고
    • Toward improved prediction of risk for atopy and asthma among preschoolers: a prospective cohort study
    • 59.e1-59.e7.
    • Holt PG, Rowe J, Kusel M, et al. Toward improved prediction of risk for atopy and asthma among preschoolers: a prospective cohort study. J Allergy Clin Immunol 2010: 125: 653-9, 59.e1-59.e7.
    • (2010) J Allergy Clin Immunol , vol.125 , pp. 653-659
    • Holt, P.G.1    Rowe, J.2    Kusel, M.3
  • 19
    • 84857797855 scopus 로고    scopus 로고
    • SQ-standardized sublingual grass immunotherapy: confirmation of disease modification 2 years after 3 years of treatment in a randomized trial
    • e5.
    • Durham SR, Emminger W, Kapp A, et al. SQ-standardized sublingual grass immunotherapy: confirmation of disease modification 2 years after 3 years of treatment in a randomized trial. J Allergy Clin Immunol 2012: 129: 717-25.e5.
    • (2012) J Allergy Clin Immunol , vol.129 , pp. 717-725
    • Durham, S.R.1    Emminger, W.2    Kapp, A.3
  • 20
    • 63449090874 scopus 로고    scopus 로고
    • Mechanisms and treatment of allergic disease in the big picture of regulatory T cells
    • quiz 47-8.
    • Akdis CA, Akdis M. Mechanisms and treatment of allergic disease in the big picture of regulatory T cells. J Allergy Clin Immunol 2009: 123: 735-46; quiz 47-8.
    • (2009) J Allergy Clin Immunol , vol.123 , pp. 735-746
    • Akdis, C.A.1    Akdis, M.2
  • 21
    • 79551504195 scopus 로고    scopus 로고
    • Long-term tolerance after allergen immunotherapy is accompanied by selective persistence of blocking antibodies
    • e1-5.
    • James LK, Shamji MH, Walker SM, et al. Long-term tolerance after allergen immunotherapy is accompanied by selective persistence of blocking antibodies. J Allergy Clin Immunol 2011: 127: 509-16.e1-5.
    • (2011) J Allergy Clin Immunol , vol.127 , pp. 509-516
    • James, L.K.1    Shamji, M.H.2    Walker, S.M.3
  • 22
    • 33645033082 scopus 로고    scopus 로고
    • Absence of systemic immunologic changes during dose build-up phase and early maintenance period in effective specific sublingual immunotherapy in children
    • Dehlink E, Eiwegger T, Gerstmayr M, et al. Absence of systemic immunologic changes during dose build-up phase and early maintenance period in effective specific sublingual immunotherapy in children. Clin Exp Allergy 2006: 36: 32-9.
    • (2006) Clin Exp Allergy , vol.36 , pp. 32-39
    • Dehlink, E.1    Eiwegger, T.2    Gerstmayr, M.3
  • 23
    • 84870205595 scopus 로고    scopus 로고
    • Allergen-specific CD4+ T cell responses in peripheral blood do not predict the early onset of clinical efficacy during grass pollen sublingual immunotherapy
    • Bonvalet M, Moussu H, Wambre E, et al. Allergen-specific CD4+ T cell responses in peripheral blood do not predict the early onset of clinical efficacy during grass pollen sublingual immunotherapy. Clin Exp Allergy 2012: 42: 1745-55.
    • (2012) Clin Exp Allergy , vol.42 , pp. 1745-1755
    • Bonvalet, M.1    Moussu, H.2    Wambre, E.3
  • 24
    • 0035173208 scopus 로고    scopus 로고
    • Infection: friend or foe in the development of atopy and asthma? The epidemiological evidence
    • von Mutius E. Infection: friend or foe in the development of atopy and asthma? The epidemiological evidence. Eur Respir J 2001: 18: 872-81.
    • (2001) Eur Respir J , vol.18 , pp. 872-881
    • von Mutius, E.1
  • 25
    • 42149117632 scopus 로고    scopus 로고
    • The importance of early complementary feeding in the development of oral tolerance: concerns and controversies
    • Prescott SL, Smith P, Tang M, et al. The importance of early complementary feeding in the development of oral tolerance: concerns and controversies. Pediatr Allergy Immunol 2008: 19: 375-80.
    • (2008) Pediatr Allergy Immunol , vol.19 , pp. 375-380
    • Prescott, S.L.1    Smith, P.2    Tang, M.3
  • 26
    • 79951972586 scopus 로고    scopus 로고
    • Exposure to environmental microorganisms and childhood asthma
    • Ege MJ, Mayer M, Normand AC, et al. Exposure to environmental microorganisms and childhood asthma. N Engl J Med 2011: 364: 701-9.
    • (2011) N Engl J Med , vol.364 , pp. 701-709
    • Ege, M.J.1    Mayer, M.2    Normand, A.C.3
  • 27
    • 0034544450 scopus 로고    scopus 로고
    • T cell epitope-containing hypoallergenic recombinant fragments of the major birch pollen allergen, Bet v 1, induce blocking antibodies
    • Vrtala S, Akdis CA, Budak F, et al. T cell epitope-containing hypoallergenic recombinant fragments of the major birch pollen allergen, Bet v 1, induce blocking antibodies. J Immunol 2000: 165: 6653-9.
    • (2000) J Immunol , vol.165 , pp. 6653-6659
    • Vrtala, S.1    Akdis, C.A.2    Budak, F.3
  • 28
    • 84904445872 scopus 로고    scopus 로고
    • Heterogeneity of antibody responses among clinical responders during grass pollen sublingual immunotherapy
    • Baron-Bodo V, Horiot S, Lautrette A, et al. Heterogeneity of antibody responses among clinical responders during grass pollen sublingual immunotherapy. Clin Exp Allergy 2013: 43: 1362-73.
    • (2013) Clin Exp Allergy , vol.43 , pp. 1362-1373
    • Baron-Bodo, V.1    Horiot, S.2    Lautrette, A.3
  • 29
    • 84884987212 scopus 로고    scopus 로고
    • An assay that may predict the development of IgG enhancing allergen-specific IgE binding during birch immunotherapy
    • Selb R, Eckl-Dorna J, Vrtala S, Valenta R, Niederberger V. An assay that may predict the development of IgG enhancing allergen-specific IgE binding during birch immunotherapy. Allergy 2013: 68: 1199-202.
    • (2013) Allergy , vol.68 , pp. 1199-1202
    • Selb, R.1    Eckl-Dorna, J.2    Vrtala, S.3    Valenta, R.4    Niederberger, V.5
  • 30
    • 84869100612 scopus 로고    scopus 로고
    • Does eczema in infancy cause hay fever, asthma, or both in childhood? Insights from a novel regression model of sibling data
    • e1.
    • Hopper JL, Bui QM, Erbas B, et al. Does eczema in infancy cause hay fever, asthma, or both in childhood? Insights from a novel regression model of sibling data. J Allergy Clin Immunol 2012: 130: 1117-22.e1.
    • (2012) J Allergy Clin Immunol , vol.130 , pp. 1117-1122
    • Hopper, J.L.1    Bui, Q.M.2    Erbas, B.3
  • 31
    • 80051734103 scopus 로고    scopus 로고
    • Mechanisms of immunotherapy to aeroallergens
    • Shamji MH, Durham SR. Mechanisms of immunotherapy to aeroallergens. Clin Exp Allergy 2011: 41: 1235-46.
    • (2011) Clin Exp Allergy , vol.41 , pp. 1235-1246
    • Shamji, M.H.1    Durham, S.R.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.