Maladaptive remodeling is associated with impaired survival in women but not in men after aortic valve replacement

JACC: Cardiovascular Imaging

Volumn 7, Issue 11, 2014, Pages 1073-1080

  Petrov, George ^a,b   Dworatzek, Elke ^b   Schulze, Tabea Marie ^a   Dandel, Michael ^a,b   Kararigas, Georgios ^b   Mahmoodzadeh, Shokufeh ^b   Knosalla, Christoph ^a,b   Hetzer, Roland ^a,b   Regitz Zagrosek, Vera ^a,b  

^a DEUTSCHES HERZZENTRUM BERLIN   (Germany)

^b DZHK GERMAN CENTRE FOR CARDIOVASCULAR RESEARCH   (Germany)

Author keywords

Aortic valve replacement; Aortic valve stenosis; Cardiac fibrosis; Gender; Hypertrophy regression; Sex; Survival

Indexed keywords

SMAD2 PROTEIN; TRANSCRIPTION FACTOR RUNX2; TRANSFORMING GROWTH FACTOR BETA1; BIOLOGICAL MARKER; CELL ADHESION MOLECULE; POSTN PROTEIN, HUMAN; SMAD3 PROTEIN; SMAD3 PROTEIN, HUMAN; TGFB1 PROTEIN, HUMAN;

AGED; AORTA VALVE REPLACEMENT; AORTA VALVE STENOSIS; ARTICLE; ECHOCARDIOGRAPHY; FEMALE; HEART LEFT VENTRICLE HYPERTROPHY; HEART LEFT VENTRICLE MASS; HEART MUSCLE FIBROSIS; HEART VENTRICLE OVERLOAD; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SEX DIFFERENCE; SURVIVAL; VASCULAR REMODELING; ADVERSE EFFECTS; AORTA VALVE; AORTIC VALVE STENOSIS; COMPARATIVE STUDY; COMPLICATION; ECHOGRAPHY; FACTORIAL ANALYSIS; FIBROSIS; HEART LEFT VENTRICLE FUNCTION; HEART VALVE REPLACEMENT; HEART VENTRICLE REMODELING; HYPERTROPHY, LEFT VENTRICULAR; METABOLISM; MIDDLE AGED; MORTALITY; PATHOPHYSIOLOGY; PHOSPHORYLATION; PROSPECTIVE STUDY; RISK FACTOR; TIME; TREATMENT OUTCOME; VERY ELDERLY;

AGED; AGED, 80 AND OVER; AORTIC VALVE; AORTIC VALVE STENOSIS; BIOLOGICAL MARKERS; CELL ADHESION MOLECULES; FACTOR ANALYSIS, STATISTICAL; FEMALE; FIBROSIS; HEART VALVE PROSTHESIS IMPLANTATION; HUMANS; HYPERTROPHY, LEFT VENTRICULAR; MALE; MIDDLE AGED; PHOSPHORYLATION; PROSPECTIVE STUDIES; RISK FACTORS; SEX FACTORS; SMAD3 PROTEIN; SURVIVAL ANALYSIS; TIME FACTORS; TRANSFORMING GROWTH FACTOR BETA1; TREATMENT OUTCOME; VENTRICULAR FUNCTION, LEFT; VENTRICULAR REMODELING;

EID: 84922537709     PISSN: 1936878X     EISSN: 18767591     Source Type: Journal    
DOI: 10.1016/j.jcmg.2014.06.017     Document Type: Article

References (24)

1. Bruckenberger E. Herzbericht 2010. Hannover: Bruckenberger E, 2011.
2. Hill JA, Olson EN. Cardiac plasticity. N Engl J Med 2008;358:1370-80.
3. Kupari M, Turto H, Lommi J. Left ventricular hypertrophy in aortic valve stenosis: preventive or promotive of systolic dysfunction and heart failure Eur Heart J 2005;26:1790-6.
4. Gavina C, Falcao-Pires I, Rocha-Goncalves F, Leite-Moreira A. Left ventricular hypertrophy in isolated aortic stenosis: primetime for the ventricle. Curr Pharm Biotechnol 2012;13:2503-14.
5. Carroll JD, Carroll EP, Feldman T, et al. Sexassociated differences in left ventricular function in aortic stenosis of the elderly. Circulation 1992; 86:1099-107.
6. Douglas PS, Otto CM, Mickel MC, Labovitz A, Reid CL, Davis KB. Gender differences in left ventricle geometry and function in patients undergoing balloon dilatation of the aortic valve for isolated aortic stenosis. NHLBI Balloon Valvuloplasty Registry. Br Heart J 1995;73:548-54.
7. Villari B, Campbell SE, Schneider J, Vassalli G, Chiariello M, Hess OM. Sex-dependent differences in left ventricular function and structure in chronic pressure overload. Eur Heart J 1995;16:1410-9.
8. Petrov G, Regitz-Zagrosek V, Lehmkuhl E, et al. Regression of myocardial hypertrophy after aortic valve replacement: faster in women Circulation 2010;122:S23-8.
9. Stansfield WE, Charles PC, Tang RH, et al. Regression of pressure-induced left ventricular hypertrophy is characterized by a distinct gene expression profile. J Thorac Cardiovasc Surg 2009; 137:232-8, 238e1-8.
10. Sharma UC, Barenbrug P, Pokharel S, Dassen WR, Pinto YM, Maessen JG. Systematic review of the outcome of aortic valve replacement in patients with aortic stenosis. Ann Thorac Surg 2004;78:90-5.
11. Villar AV, Merino D, Wenner M, et al. Myocardial gene expression of microRNA-133a and myosin heavy and light chains, in conjunction with clinical parameters, predict regression of left ventricular hypertrophy after valve replacement in patients with aortic stenosis. Heart 2011;97:1132-7.
12. Milano AD, Faggian G, Dodonov M, et al. Prognostic value of myocardial fibrosis in patients with severe aortic valve stenosis. J Thorac Cardiovasc Surg 2012;144:830-7.
13. Hayashida K, Morice MC, Chevalier B, et al. Sex-related differences in clinical presentation and outcome of transcatheter aortic valve implantation for severe aortic stenosis. J Am Coll Cardiol 2012;59:566-71.
14. Stangl V, Baldenhofer G, Knebel F, et al. Impact of gender on three-month outcome and left ventricular remodeling after transfemoral transcatheter aortic valve implantation. Am J Cardiol 2012;110:884-90.
15. Hamed O, Persson PJ, Engel AM, McDonough S, Smith JM. Gender differences in outcomes following aortic valve replacement surgery. Int J Surg 2009;7:214-7.
16. Lang RM, Bierig M, Devereux RB, et al. Recommendations for chamber quantification: a report from the American Society of Echocardiography's Guidelines and Standards Committee and the Chamber Quantification Writing Group, developed in conjunction with the European Association of Echocardiography, a branch of the European Society of Cardiology. J Am Soc Echocardiogr 2005;18: 1440-63.
17. Fliegner D, Schubert C, Penkalla A, et al. Female sex and estrogen receptor-beta attenuate cardiac remodeling and apoptosis in pressure overload. Am J Physiol Regul Integr Comp Physiol 2010;298:R1597-606.
18. Kararigas G, Bito V, Tinel H, et al. Transcriptome characterization of estrogen-treated human myocardium identifies myosin regulatory light chain interacting protein as a sex-specific element influencing contractile function. J Am Coll Cardiol 2012;59:410-7.
19. Villar AV, Llano M, Cobo M, et al. Gender differences of echocardiographic and gene expression patterns in human pressure overload left ventricular hypertrophy. J Mol Cell Cardiol 2009; 46:526-35.
20. Snider P, Standley KN, Wang J, Azhar M, Doetschman T, Conway SJ. Origin of cardiac fibroblasts and the role of periostin. Circ Res 2009; 105:934-47.
21. Zhao S, Wu H, Xia W, et al. Periostin expression is upregulated and associated with myocardial fibrosis in human failing hearts. J Cardiol 2014;63:373-8.
22. Meyer S, van der Meer P, Massie BM, et al. Sexspecific acute heart failure phenotypes and outcomes from PROTECT. Eur J Heart Fail 2013;15:1374-81.
23. Stansfield WE, Andersen NM, Tang RH, Selzman CH. Periostin is a novel factor in cardiac remodeling after experimental and clinical unloading of the failing heart. Ann Thorac Surg 2009;88:1916-21.
24. Ullah S, Finch CF. Applications of functional data analysis: a systematic review. BMC Med Res Methodol 2013;13:43.