Medial temporal lobe atrophy and depressive symptoms in elderly patients with and without alzheimer disease

Journal of Geriatric Psychiatry and Neurology

Volumn 28, Issue 1, 2015, Pages 40-48

  Enache, Daniela ^a,b   Cavallin, Lena ^a,c   Lindberg, Olof ^a   Farahmand, Bahman ^a   Kramberger, Milica Gregoric ^a,d   Westman, Eric ^a   Jelic, Vesna ^a,c   Eriksdotter, Maria ^a,c   Ballard, Clive ^e   Winblad, Bengt ^a,c   Wahlund, Lars Olof ^a,c   Aarsland, Dag ^a,c,f  

^a KAROLINSKA INSTITUTE   (Sweden)

^b CAROL DAVILA UNIVERSITY OF MEDICINE AND PHARMACY   (Romania)

^c KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^d UNIVERSITY MEDICAL CENTRE LJUBLJANA   (Slovenia)

^e KING'S COLLEGE LONDON   (United Kingdom)

^f STAVANGER UNIVERSITY HOSPITAL   (Norway)

Author keywords

Alzheimer disease; depression; elderly; hippocampus

Indexed keywords

ANTIDEPRESSANT AGENT;

ADULT; AGED; ALZHEIMER DISEASE; ARTICLE; BRAIN ATROPHY; BRAIN SIZE; COGNITIVE DEFECT; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; CORNELL SCALE FOR DEPRESSION IN DEMENTIA; DEPRESSION; FEMALE; GERIATRIC PATIENT; HIPPOCAMPUS; HUMAN; ICD-10-CM; MAJOR CLINICAL STUDY; MALE; MEDIAL TEMPORAL LOBE ATROPHY; MIDDLE AGED; MILD COGNITIVE IMPAIRMENT; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; TEMPORAL LOBE; ATROPHY; CASE CONTROL STUDY; NEUROPSYCHOLOGICAL TEST; PATHOLOGY; PREDICTIVE VALUE; PROCEDURES; PROGNOSIS; PSYCHOLOGY; STATISTICS AND NUMERICAL DATA; VERY ELDERLY;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; ATROPHY; CASE-CONTROL STUDIES; COGNITION DISORDERS; DEPRESSION; FEMALE; HIPPOCAMPUS; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; MILD COGNITIVE IMPAIRMENT; NEUROPSYCHOLOGICAL TESTS; PREDICTIVE VALUE OF TESTS; PROGNOSIS; TEMPORAL LOBE;

EID: 84922511068     PISSN: 08919887     EISSN: 15525708     Source Type: Journal    
DOI: 10.1177/0891988714541873     Document Type: Article

References (42)

1. Diniz BS, Butters MA, Albert SM, Dew MA, Reynolds CF. Late-life depression and risk of vascular dementia and Alzheimer's disease: systematic review and meta-analysis of community-based cohort studies. Br J Psychiatry. 2013 ; 202 (5). 329-335
2. Enache D, Winblad B, Aarsland D. Depression in dementia: epidemiology, mechanisms, and treatment. Curr Opin Psychiatry. 2011 ; 24 (6). 461-472
3. Ownby RL, Acevedo A, Harwood DG, Barker WW, Duara R. Patterns of depression in Spanish- and English-speaking patients with Alzheimer's disease. J Geriatr Psychiatry Neurol. 2008 ; 21 (1). 47-55
4. Saczynski JS, Beiser A, Seshadri S, Auerbach S, Wolf PA, Au R. Depressive symptoms and risk of dementia: the Framingham heart study. Neurology. 2010 ; 75 (1). 35-41
5. Li G, Wang LY, Shofer JB, et al. Temporal relationship between depression and dementia: findings from a large community-based 15-year follow-up study. Arch Gen Psychiatry. 2011 ; 68 (9). 970-977
6. Soennesyn H, Oppedal K, Greve OJ, et al. White matter hyperintensities and the course of depressive symptoms in elderly people with mild dementia. Dement Geriatr Cogn Dis Extra. 2012 ; 2: 97-111
7. Duman RS, Voleti B. Signaling pathways underlying the pathophysiology and treatment of depression: novel mechanisms for rapid-acting agents. Trends Neurosci. 2012 ; 35 (1). 47-56
8. Kim JJ, Diamond DM. The stressed hippocampus, synaptic plasticity and lost memories. Nat Rev Neurosci. 2002 ; 3 (6). 453-462
9. Geldenhuys WJ, Van der Schyf CJ. Role of serotonin in Alzheimer's disease a new therapeutic target?. CNS Drugs. 2011 ; 25 (9). 765-781
10. Walsh DM, Selkoe DJ. Deciphering the molecular basis of memory failure in Alzheimer's disease. Neuron. 2004 ; 44 (1). 181-193
11. Zubenko GS, Moossy J. Major depression in primary dementia - clinical and neuropathologic correlates. Arch Neurol. 1988 ; 45 (11). 1182-1186
12. Rapp MA, Schnaider-Beeri M, Grossman HT, et al. Increased hippocampal plaques and tangles in patients with Alzheimer disease with a lifetime history of major depression. Arch Gen Psychiatry. 2006 ; 63 (2). 161-167
13. Rapp MA, Schnaider-Beeri M, Purohit DP, Perl DP, Haroutunian V, Sano M. Increased neurofibrillary tangles in patients with Alzheimer disease with comorbid depression. Am J Geriatr Psychiatry. 2008 ; 16 (2). 168-174
14. Ballmaier M, Narr KL, Toga AW, et al. Hippocampal morphology and distinguishing late-onset from early-onset elderly depression. Am J Psychiatry. 2008 ; 165 (2). 229-237
15. Steffens DC, McQuoid DR, Payne ME, Potter GG. Change in hippocampal volume on magnetic resonance imaging and cognitive decline among older depressed and nondepressed subjects in the neurocognitive outcomes of depression in the elderly study. Am J Geriatr Psychiatry. 2011 ; 19 (1). 4-12
16. Tsopelas C, Stewart R, Savva GM, et al. Neuropathological correlates of late-life depression in older people. Br J Psychiatry. 2011 ; 198 (2). 109-114
17. Weber K, Giannakopoulos P, Delaloye C, et al. Volumetric MRI changes, cognition and personality traits in old age depression. J Affect Disord. 2010 ; 124 (3). 275-282
18. Kohler S, Thomas AJ, Lloyd A, Barber R, Almeida OP, O'Brien JT. White matter hyperintensities, cortisol levels, brain atrophy and continuing cognitive deficits in late-life depression. Br J Psychiatry. 2010 ; 196 (2). 143-149
19. Charney DS, Manji HK. Life stress, genes, and depression: multiple pathways lead to increased risk and new opportunities for intervention. Sci STKE. 2004 ; 2004 (225). re5
20. Jorm AF. The informant questionnaire on cognitive decline in the elderly (IQCODE): a review. Int Psychogeriatr. 2004 ; 16 (3). 275-293
21. Li F, Jia XF, Jia J. The informant questionnaire on cognitive decline in the elderly individuals in screening mild cognitive impairment with or without functional impairment. J Geriatr Psychiatry Neurol. 2012 ; 25 (4). 227-232
22. Winblad B, Palmer K, Kivipelto M, et al. Mild cognitive impairment - beyond controversies, towards a consensus: report of the international working group on mild cognitive impairment. J Intern Med. 2004 ; 256 (3). 240-246
23. Alexopoulos GS, Abrams RC, Young RC, Shamoian CA. Cornell scale for depression in dementia. Biol Psychiatry. 1988 ; 23 (3). 271-284
24. Alexopoulos GS, Abrams RC, Young RC, Shamoian CA. Use of the cornell scale in nondemented patients. J Am Geriatr Soc. 1988 ; 36 (3). 230-236
25. Knapskog AB, Barca ML, Engedal K. A Comparison of the validity of the cornell scale and the MADRS in detecting depression among memory clinic patients. Dement Geriatr Cogn Disord. 2011 ; 32 (4). 287-294
26. Wattjes MP, Henneman WJ, van der Flier WM, et al. Diagnostic imaging of patients in a memory clinic: comparison of MR imaging and 64-detector row CT. Radiology. 2009 ; 253 (1). 174-183
27. Scheltens P, Leys D, Barkhof F, et al. Atrophy of medial temporal lobes on MRI in "probable" Alzheimer's disease and normal ageing: diagnostic value and neuropsychological correlates. J Neurol Neurosurg Psychiatry. 1992 ; 55 (10). 967-972
28. Cavallin L, Bronge L, Zhang Y, et al. Comparison between visual assessment of MTA and hippocampal volumes in an elderly, non-demented population. Acta Radiol. 2012 ; 53 (5). 573-579
29. Malykhin NV, Bouchard TP, Ogilvie CJ, Coupland NJ, Seres P, Camicioli R. Three-dimensional volumetric analysis and reconstruction of amygdala and hippocampal head, body and tail. Psychiatry Res. 2007 ; 155 (2). 155-165
30. Eritaia J, Wood SJ, Stuart GW, et al. An optimized method for estimating intracranial volume from magnetic resonance images. Magn Reson Med. 2000 ; 44 (6). 973-977
31. Jack CR, Twomey CK, Zinsmeister AR, Sharbrough FW, Petersen RC, Cascino GD. Anterior temporal lobes and hippocampal formations - normative volumetric measurements from mr images in young-adults. Radiology. 1989 ; 172 (2). 549-554
32. Lindberg O, Ostberg P, Zandbelt BB, et al. Cortical morphometric subclassification of frontotemporal lobar degeneration. Am J Neuroradiol. 2009 ; 30 (6). 1233-1239
33. Westman E, Cavallin L, Muehlboeck JS, et al. Sensitivity and specificity of medial temporal lobe visual ratings and multivariate regional MRI classification in Alzheimer's disease. PLoS One. 2011 ; 6 (7). e22506
34. Striepens N, Scheef L, Wind A, et al. Volume loss of the medial temporal lobe structures in subjective memory impairment. Dement Geriatric Cognitive Disord. 2010 ; 29 (1). 75-81
35. Kim MJ, Seo SW, Kim GH, et al. Less depressive symptoms are associated with smaller hippocampus in subjective memory impairment. Arch Gerontol Geriatr. 2013 ; 57 (1). 110-115
36. Weisenbach SL, Boore LA, Kales HC. Depression and cognitive impairment in older adults. Curr Psychiatry Rep. 2012 ; 14 (4). 280-288
37. Trivedi MH, Greer TL. Cognitive dysfunction in unipolar depression: implications for treatment. J Affect Disord. 2014 ; 152-154: 19-27
38. Kramberger MG, Jelic V, Kareholt I, et al. Cerebrospinal fluid alzheimer markers in depressed elderly subjects with and without Alzheimer's disease. Dement Geriatr Cogn Dis Extra. 2012 ; 2 (1). 48-56
39. Royall DR, Palmer RF. Alzheimer's disease pathology does not mediate the association between depressive symptoms and subsequent cognitive decline. Alzheimers Dement. 2013 ; 9 (3). 318-325
40. Gerritsen L, Comijs HC, van der Graaf Y, Knoops AJ, Penninx BW, Geerlings MI. Depression, hypothalamic pituitary adrenal axis, and hippocampal and entorhinal cortex volumes - the SMART Medea study. Biol Psychiatry. 2011 ; 70 (4). 373-380
41. Braak H, Braak E. Neuropathological staging of Alzheimer-related changes. Acta Neuropathologica. 1991 ; 82 (4). 239-259
42. Banerjee S, Hellier J, Dewey M, et al. Sertraline or mirtazapine for depression in dementia (HTA-SADD): a randomised, multicentre, double-blind, placebo-controlled trial. Lancet. 2011 ; 378 (9789). 403-411